scholarly journals Hubungan Anemia pada Ibu Hamil dengan Kejadian Persalinan Prematur di RSUD Dr. Moewardi Surakarta

2020 ◽  
Vol 3 (2) ◽  
pp. 68
Author(s):  
Saskia Nandatari ◽  
Yudhistya N Insan ◽  
Widardo Widardo
Keyword(s):  
Pregnant Women ◽  
Preterm Labor ◽  
Stress Hormones ◽  
Case Control ◽  
Observational Research ◽  
Premature Labor ◽  
Research Subjects ◽  
Purposive Sampling ◽  
Control Approach ◽  
Significant Difference

<p><strong>Pendahuluan</strong>: Persalinan prematur adalah persalinan yang terjadi pada usia kehamilan sebelum 37 minggu. Persalinan prematur disebabkan oleh berbagai faktor, salah satunya yaitu anemia. Anemia dalam kehamilan merupakan masalah yang cukup sering terjadi terutama di negara berkembang. Anemia dalam kehamilan merupakan keadaan dimana nilai Hemoglobin ibu hamil dibawah 11 g/dl. Keadaan ini mengakibatkan penurunan jumlah oksigen yang dibawa ke janin sehingga mengakibatkan terjadinya hipoksia pada janin. Tujuan penelitian ini adalah untuk mengetahui hubungan antara anemia pada ibu hamil dengan kejadian persalinan prematur di RSUD Dr. Moewardi Surakarta.</p><p><strong>Metode Penelitian</strong>: Penelitian observasional analitik dengan pendekatan <em>case control,</em> dilakukan pada bulan Agustus-September 2019 di RSUD Dr. Moewardi. Subjek penelitian adalah pasien yang mengalami persalinan prematur dan persalinan tidak prematur dalam kurun waktu Juni 2017 sampai dengan Juni 2019 di RSUD Dr. Moewardi. Penelitian dilakukan dengan mengolah data rekam medis. Pada penelitian dipilih sebanyak 70 sampel penelitian, yang terdiri masing-masing 35 sampel untuk kelompok kasus dan kontrol. Sampel diambil menggunakan <em>purposive sampling. </em>Data kemudian dianalisis menggunakan uji Korelasi Koefisien Kontingensi<em> </em>Uji Kappa dan uji T-<em>test</em> Tidak Berpasangan.</p><p><strong>Hasil</strong>: Didapatkan korelasi antara anemia dengan kejadian persalinan prematur bermakna secara statistik. Nilai korelasi sebesar 0,031 menunjukkan korelasi positif dengan kekuatan korelasi yang signifikan dan bermakna secara klinis. Selain itu, didapatkan perbedaan yang bermakna dan signifikan antara rata-rata nilai Hemoglobin ibu hamil dengan persalinan prematur dan tidak prematur, dengan nilai p sebesar 0,003.</p><p><strong>S</strong><strong>impulan</strong>: Terdapat hubungan yang signifikan dan bermakna secara klinis antara anemia pada ibu hamil dengan kejadian persalinan prematur di RSUD Dr. Moewardi Surakarta pada Juni 2017 – Juni 2019.</p><p> </p><p>Background: Premature labor is labor that occurs at gestational age before 37 weeks. Premature labor is caused by various factors, one of which is anemia. Anemia in pregnancy, hemoglobin condition of pregnant women under 11 g / dl which is quite common, especially in developing countries. This situation results in a decrease in the amount of oxygen carried to the fetus, resulting in hypoxia in the fetus and stimulates stress hormones associated with labor induction. The purpose of this study was to determine the relationship between anemia in pregnant women with the incidence of preterm labor in Dr. Moewardi Surakarta.</p><p>Methods: This study was analytic observational research with case-control approach, conducted in August-September 2019 at Dr. Moewardi. Research subjects were patients who experienced preterm labor and non-preterm labor in the period June 2017 to June 2019 at the RSUD Dr. Moewardi. The study was conducted by processing medical record data. In this study 70 research samples were chosen, consisting of 35 samples for the case and control groups. Samples were taken using purposive sampling. Data were then analyzed using the Kappa Test Contingency Coefficient Correlation test and the unpaired T-test.</p><p>Result: The correlation between anemia and preterm labor was statistically significant. Correlation value (p=0.031) shows a positive correlation with the strength of the correlation that is significant and clinically meaningful. In addition, a significant and significant difference was found between the average hemoglobin value of pregnant women with preterm and non-preterm labor, with a value (p = 0.003).</p><p>Conclusion: There is a significant and significant relationship between anemia in pregnant women and the incidence of preterm labor in Dr. Moewardi Surakarta in June 2017 - June 2019, where anemia in pregnant women increases the risk of preterm labor.</p>

scholarly journals Tingkat Stres Berhubungan dengan Premenstrual Syndrome pada Siswi SMK Islam

2020 ◽  
Vol 8 (2) ◽  
pp. 109
Author(s):  
Wiwin Eva Nuvitasari ◽  
Susilaningsih Susilaningsih ◽  
Agnis Sabat Kristiana
Keyword(s):  
High School ◽  
Young Woman ◽  
Study Design ◽  
Stress Level ◽  
Premenstrual Syndrome ◽  
Case Control ◽  
Vocational High School ◽  
Positive Direction ◽  
Purposive Sampling ◽  
Control Approach

Gejala premenstrual syndrome dialami 23% remaja putri di Indonesia. Premenstrual syndrome timbul pada siswi oleh beberapa faktor, salah satunya yaitu meningkatnya stres atau tekanan yang dipengaruhi oleh usia, kelas, dan gaya hidup. Stres adalah reaksi tubuh terhadap tuntutan atau beban yang bersifat non spesifik. Tujuan penelitian ini adalah untuk mengetahui hubungan tingkat stres dengan premenstrual syndrome pada siswi SMK Islam. Penelitian ini menggunakan desain korelasional study dengan pendekatan case control. Populasi penelitian ini adalah siswi SMK Islam yang berjumlah 64 siswi. Sampel yang diambil yaitu berjumlah 40 responden dengan menggunakan teknik purposive sampling. Analisa bivariat yang digunakan dalam penelitian ini adalah uji spearman. Hasil analisis menggunakan software menunjukkan nilai ρ = 0,0001 dimana nilai ρ < α = 0,05, artinya bahwa Hα diterima. Nilai koefisien korelasi 0,681 menurut tabel inteprestasi korelasi yaitu tingkat hubungan kuat dan arah korelasi positif. Kesimpulan yang diperoleh adalah ada hubungan positif antara tingkat stres dengan premenstrual syndrome, yaitu semakin basar nilai tingkat stres maka semakin besar pula nilai premenstrual syndrome. Kata kunci: remaja,  premenstrual syndrome, stres STRESS LEVEL CONNECTED WITH PREMENSTRUAL SYNDROME ON STUDENT IN ISLAMIC VOCATIONAL HIGH SCHOOL ABSTRACTThe premenstrual syndrome symptoms experienced by 23% of young woman in Indonesia. Premenstrual syndrome are generated by some factors, one of which is increase in stress influenced by age, class, and lifestyle. Stress is the body’s reaction to nonspecific demands or load. The purpose of this research was to investigated the correlation between the stress level with the premenstrual syndrome among student in Islamic Vocational High School. The study using a correlational study design with case control approach. The population of this research is student in Islamic Vocational High School which totaled 64 student. Samples have taken from total 40 respondent by using purposive sampling techiques. The study used spearman tes for bivariat analysis. The result using a software showed ρ value = 0,0001 where the ρ value < α = 0,05, it means Hα was accepted. The value correlation 0,681 that level of correlation strong with positive direction. The conclusion are any positive correlation between stress level with premenstrual syndrome, if the value of stress level was higher the value of premenstrual syndrome (PMS) was higher too. Keywords: premenstrual syndrome, stress, teenagers 

Are Anti-β2 Glycoprotein 1 Antibodies Associated with Placenta-Mediated Pregnancy Complications? A Nested Case–Control Study

2018 ◽  
Vol 35 (11) ◽  
pp. 1093-1099 ◽  
Author(s):  
Leslie Skeith ◽  
Karim Abou-Nassar ◽  
Mark Walker ◽  
Tim Ramsay ◽  
Ronald Booth ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Complications ◽  
Case Control Study ◽  
Late Pregnancy ◽  
Case Control ◽  
Immunoglobulin M ◽  
Enzyme Linked Immunosorbent Assay ◽  
Significant Difference ◽  
Antibody Positivity ◽  
Control Study

Background While anti-β2 glycoprotein 1 (anti-β2GP1) antibody positivity is included in the diagnostic criteria for antiphospholipid syndrome (APS), the association between anti-β2GP1 and the obstetrical complications of APS has been inconsistently reported and remains unclear. Objective We completed a case–control study nested within the Canadian Ottawa and Kingston (OaK) Birth Cohort to evaluate the association between anti-β2GP1 antibody positivity and placenta-mediated pregnancy complications. Study Design Five hundred cases were randomly selected among pregnant women who experienced any of the following independently adjudicated placenta-mediated pregnancy complications: preeclampsia, placental abruption, late pregnancy loss (≥ 12 weeks' gestation), and birth of a small-for-gestational age (SGA) infant < 10th percentile. Five hundred pregnant women without any placenta-mediated pregnancy complications were selected as controls. Stored blood samples were analyzed for the presence of anti-β2GP1 antibodies by enzyme-linked immunosorbent assay. Results Anti-β2GP1 immunoglobulin G (IgG) and/or immunoglobulin M (IgM) antibodies in titers ≥ 20 G/M units (> 99th percentile) were present in 24 of 497 (4.8%) of controls and 33 of 503 (6.6%) of cases. There was no significant difference between cases and controls for the composite outcome of any placenta-mediated pregnancy complications (odds ratio, 1.38, 95% confidence interval [CI], 0.8–2.37, p = 0.25). Conclusion Our results call into question the association between anti-β2GP1 antibodies and placenta-mediated pregnancy complications, with further research needed.

scholarly journals The Effect of Moringa oleifera on Pregnant Women and Breastfeeding Mothers toward Social-personal Development of Children Aged 18–23 Months in Jeneponto, South Sulawesi

2020 ◽  
Vol 8 (B) ◽  
pp. 747-751
Author(s):  
Hastuti Hastuti ◽  
Veni Hadju ◽  
Citrakesumasari Citrakesumasari ◽  
Martira Maddeppungeng ◽  
Ikeu Tanziha ◽  
...  
Keyword(s):  
Folic Acid ◽  
Pregnant Women ◽  
Personal Development ◽  
Moringa Oleifera ◽  
Physical Growth ◽  
Research Subjects ◽  
South Sulawesi ◽  
The Social ◽  
Significant Difference ◽  
Iron Folic Acid

BACKGROUND: Insufficient nutrition intake at the age of <2 years has an impact on decreasing physical growth and development. AIM: Analyzing the effect of giving Moringa leaves on pregnant women and breastfeeding mothers toward the social development of children aged 18–23 months in Jeneponto, South Sulawesi. METHODS: This study was a longitudinal study after supplementation for pregnant women and breastfeeding mothers with Moringa oleifera or folic acid, and iron. Research subjects were children whose was monitored from the age of 18–23 months in Jeneponto District. The number of samples that met the inclusion criteria at the age of 23 months was 344 children. The sample was divided into three groups: A group of children of mothers who got Moringa leaf powder supplements, iron-folic acid supplements, and Moringa leaf extract. Child development was measured using the denver development screening test. Data were analyzed statistically with Chi-square. RESULTS: There were 107 children (91.5%) with normal social-personal development in the Moringa leaves powder (MLP) group. This number was more than the children in the iron folic acid (IFA) group of 103 children (86.6%) and the Moringa leaves extract (MLE) group of 95 children (88.0%). Differences were also found in the social-personal development of children who were suspect in the IFA group more than children who were suspect in the MLP group or the MLE group. CONCLUSION: There was no significant difference in children’s social-personal development between the three study groups.

scholarly journals STATUS PSIKOLOGIS IBU DENGAN PERSALINAN PREMATUR

2019 ◽  
Vol 6 (1) ◽  
pp. 13
Author(s):  
Istioningsih Istioningsih ◽  
Linda Wariska ◽  
Linda Wariska ◽  
Yuni Puji Widiastuti
Keyword(s):  
Pregnant Women ◽  
Health Workers ◽  
Psychological Status ◽  
Premature Labor ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Purposive Sampling ◽  
Psychological Conditions ◽  
Risk Of Death ◽  
Fetal Organs

Persalinan prematur merupakan kondisi janin lahir sebelum genap 37 minggu, dan pada janin yang lahir kurang dari 32 minggu beresiko mengalami kematian 70 kali lebih besar akibat imaturitas organ tubuh janin, berdasarkan hal tersebut prematuritas merupakan kondisi penyebab utama mortalitas dan morbiditas pada neonatus. Tujuan dari penelitian ini untuk mengetahui gambaran status psikologis responden pada persalinan prematur. Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross sectional. Jumlah sampel sebanyak 54 responden dengan purposive sampling. Hasil penelitian didapatkan: usia terendah responden adalah 14 tahun dan usia tertinggi adalah 48 tahun rerata usia responden adalah 26 tahun. Sebagian besar responden merupakan pada kategori usia yang aman sebesar 57,4%. Sebagian besar respondenmengalami stress sejumlah 83,3% baik itu stress ringan, sedang maupun parah. Sebesar 81,5% responden mengalami anxiety dari ringan sampai sangat parah. Status psikologis depresi pasien sebagian besar sebanyak 79,6% adalah normal dan ada sejumlah 20,4% mengalami depresi. Tenaga kesehatan disarankan melakukan upaya promotif dan preventif dalam bentuk pemberian pendidikan kesehatan, mempersiapkan pendidikan psikologis ibu hamil untuk mencegah persalinan prematur. Ibu hamil juga disarankan untuk mempersiapkan kondisi fisik dan psikologis sebelum kehamilan. Kata kunci: Persalinan Prematur, Psikologis THE PSYCHOLOGICAL STATUS OF MOTHER WITH PREMATURE LABOR ABSTRACTPremature labor is a condition of the fetus born before even 37 weeks, and in fetuses born less than 32 weeks the risk of death is 70 times greater due to immaturity of fetal organs, based on this prematurity is the main cause of mortality and morbidity in neonates. The purpose of this study is to describe the psychological status of respondents in preterm labor. This research is a descriptive study with a cross sectional approach. The number of samples was 54 respondents with purposive sampling. The results were obtained: the lowest age of respondents was 14 years and the highest age was 48 years the average age of respondents was 26 years. Most of the respondents were in the safe age category of 57.4%. Most of the respondents experienced 83.3% stress, both mild, moderate and severe stress. 81.5% of respondents experienced anxiety from mild to very severe. The psychological status of depressed patients is mostly 79.6% is normal and there are a number of 20.4% experiencing depression. Health workers are advised to carry out promotive and preventive efforts in the form of providing health education, preparing psychological education for pregnant women to prevent premature labor. Pregnant women are also advised to prepare physical and psychological conditions before pregnancy. Keywords: Premature labor, psychology

scholarly journals Sildenafil Citrate Versus Nifedipine and Dydrogesreone in Prevention of Preterm Labor with Short Cervix

2018 ◽  
Vol 2 (1) ◽  
pp. 01-05
Author(s):  
Abd El-Naser Abd El-Gaber Ali ◽  
Khaled M Abdallah ◽  
Ahmed Abdelhamid
Keyword(s):  
Pregnant Women ◽  
Preterm Labor ◽  
Cervical Length ◽  
Sildenafil Citrate ◽  
Health Concern ◽  
P Value ◽  
Short Cervix ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

Background: Prevention of the premature birth occurrence remains is considered one of the most tough challenges for obstetricians worldwide, mainly to avoid neonatal prematurity complications leading to short and long term morbidities additionally prematurity prevention will reduce premature neonatal mortality rates which is considered a major health concern of obstetricians, neonatologists and families. Objective: To compare and contrast the efficacy of Sildenafil citrate, Nifedipine and Dydrogesrone in prevention of premature labor in gestations with short cervix. Setting: Obstetrics & Gynecology Departments, Faculties of medicine, south Valley and Al-Azhar (Asyut) Universities, Egypt. Duration: from September 2014 to March 2018. Patients And Methds: the study was conducted on 300 pregnant women who randomly divided into three groups: Group I included 100 cases received Sildenafil citrate (Respatio tablet 20mg twice daily orally), Group II included 100 cases received Nifedipine (Epilat retard tablets 20mg twice daily orally) and Group III included 100 pregnant women received dydrogesreone 10 mg (Duphaston) twice daily orally. Results: incidence of preterm labor was (9.37, 8.51 and 14.28) in (Group I, Group II and Group II) respectively. Mean ± SD of cervical length at 32 weeks of gestation was mildly statistically significant among groups (p value <0.05) but no significance in neonatal outcome (p value >0.05) except birth weight which had a highly statistically significant difference (p value < 0.001). There was a highly statistically significant difference among studied groups as regard to drug side effects in (p value <0.001). Conclusion: Sildenafil citrate was as effective as Nifedipine and better than oral Dydrogesterone on myometrial relaxation and prevention of preterm birth in pregnant women who had short cervix.

scholarly journals Threatened Preterm Labor: Which are become Preterm Labor?

2020 ◽  
pp. 216-222
Author(s):  
Cut M. Yeni ◽  
Rismawati Tambunan ◽  
Hasanuddin
Keyword(s):  
Pregnant Women ◽  
Preterm Labor ◽  
Case Control ◽  
Cervical Length ◽  
Wilcoxon Test ◽  
Fetal Fibronectin ◽  
Whitney Test ◽  
Vaginal Ph ◽  
Chi Squared ◽  
Threatened Preterm Labor

Objective: The research was aimed to show about characteristics of subject, fetal fibronectin, vaginal pH, cervical length of women with threatened preterm labor, and which are become preterm labor? Preterm labor is occurs most often in 20 weeks gestation to less than 37 weeks gestation. This condition is concerned about Obstetric problem and associated with significant neonatal morbidity and mortality.Methods: This study used the design of case control where preterm pregnant women who become research subjects divided into two groups with threat and without the threat of pre-term labor. Fetal fibronectin , vaginal pHand cervical length than in both groups were evaluated as a risk factor for preterm labor. Mann-Whitney test , Wilcoxon test and Chi-squared test were used as statistical tests with a confidence level of 95%.Results: A total of 86 preterm pregnant women involved in this study with an average age 30 , 5 ± 6.25 (group threat) 32.16 ± 5.25 (non-threatening). Comparison of fetal fibronectin (p = 0.005), vaginal PH(p <0.001) and length of the cervix (p <0.001) between the two groups showed a significant difference. A total of 8 subjects of the 43 in the group of pregnant women with the threat pretem labor experiencing preterm labor .Conclusion: The size of a short cervical length, an increase in the pH of the vaginal secretions and increased levels of fetal fibronectin  is a clinical indicator for screening during pregnancy to assess the risk of a preterm labor .Keywords: cervical length, fetal fibronectin, pretermlabor , vaginal pH of the secretions. Abstrak Tujuan: Persalinan preterm adalah persalinan yang terjadi padausia kehamilan 20 hingga kurang dari37 minggu. Kondisi inimerupakanpermasalahan yang sangat mengkhawatirkan dalam bidang kebidanan dan dikaitkan dengan morbiditas dan kematian neonatal yang signifikan. Evaluasi dan skrining terhadap berbagai faktor resiko terjadinya ancaman persalinan preterm adalah hal terpenting dalam mencegah berbagai komplikasi yang mungkin timbul.Metode: Penelitian ini menggunakan desain case control dimana wanita hamil preterm yang menjadi subjek penelitian terbagi menjadi dua yakni kelompok dengan ancaman dan tanpa ancaman persalinan preterm. Fetal fibronectin, pH sekret vagina dan panjang serviks dibandingkan diatara kedua kelompok sebagai faktor resiko ancaman persalinan preterm. Mann-Whitney test, Wilcoxon test dan Chi – squared digunakan sebagai uji statistik dengan tingkat kepercayaan 95%.Hasil: Sebanyak 86 wanita hamil preterm terlibat dalam penelitian ini dengan rerata usia 30,5 ± 6,25 (kelompok ancaman) 32,16 ± 5,25 (tanpa ancaman). Perbandingan Fetal fibronectin (p=0,005), pH sekret vagina (p<0,001) dan panjang serviks (p<0,001) antar kedua kelompok menunjukkan adanya perbedaan yang bermakna. Sebanyak 8 subjek dari 43 pada kelompok wanita hamil pretem dengan ancaman persalinan preterm yang mengalami persalinan pretermKesimpulan:Ukuran panjang serviks yang pendek, peningkatan pH sekret vagina dan peningkatan kadar fetal fibronectin merupakan indikator klinis untuk skrining selama kehamilan guna menilai resiko terjadinya persalinan pretermKata kunci: fetal fibronectin, persalinan preterm, Ph vagina, panjang cerviks  

scholarly journals The Rate of Asymptomatic Bacteriuria is Similar in Term and Preterm Delivery

2016 ◽  
Author(s):  
Riska Amelia
Keyword(s):  
Pregnant Women ◽  
Preterm Delivery ◽  
Preterm Labor ◽  
Obstet Gynecol ◽  
Urine Analysis ◽  
Urine Culture ◽  
Asymptomatic Bacteriuria ◽  
Significant Difference ◽  
Term Delivery ◽  
The Subject

Objectives: To show the prevalence of asymptomatic bacteriuria in pregnant women and to find its correlation with preterm labor. Methods: This research was performed in Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. A total of 78 subjects joined this research. The first group consisted of 39 subjects that were having preterm delivery and the second group consisted of 39 subjects that were having term delivery. Urine analysis and culture were done in both groups. The subject was being considered to have asymptomatic bacteriuria if the urine culture showed a minimum of 100,000 bacteria/ml without any symptoms or signs of urinary tract infection. The number was then analyzed to reveal the correlation of asymptomatic bacteriuria with preterm delivery. Results: There were a significantly higher number of preterm deliveries in subjects whose age ranged between 15-19 year-old (28.20% vs 12.8%; p=0.033). While on the contrary, there was a significantly lower number of preterm delivery in subjects whose age ranged between 30-34 year-old (25.6% vs 5.12%; p=0.020).The incidence number of asymptomatic bacteriuria among all subjects is 21.79%. There was no significant difference of asymptomatic bacteriuria between preterm and a term delivery (23.07% vs 20.51%; p=0.784). Conclusions: There was no significant difference of asymptomatic bacteriuria between the subject with preterm delivery and term delivery, but the incidence of asymptomatic bacteriuria in pregnant women in this study was quite high, reaching eight times higher than those stated in other study. Thus, routine urine culture screening policy in early pregnancy still cannot be omitted, considering that asymptomatic bacteriuria can lead to pyelonephritis which can cause maternal and fetal morbidity. [Indones J Obstet Gynecol; 37-1: 8-11] Keywords: asymptomatic bacteriuria, urine analysis, urine culture, preterm delivery

scholarly journals Toxoplasma gondiiInfection in Pregnant Women: A Seroprevalence and Case-Control Study in Eastern China

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Wei Cong ◽  
Xiao-Yan Dong ◽  
Qing-Feng Meng ◽  
Na Zhou ◽  
Xiang-Yang Wang ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Case Control Study ◽  
Eastern China ◽  
Case Control ◽  
Limited Information ◽  
Serum Samples ◽  
Igm Antibodies ◽  
Control Subjects ◽  
Significant Difference ◽  
Control Study

Very limited information is available concerning the epidemiology ofT. gondiiinfection in pregnant women in eastern China. Therefore, a case-control study was conducted to estimate the seroprevalence of toxoplasmosis in this population group and to identify risk factors and possible routes of contamination. Serum samples were collected from 965 pregnant women and 965 age-matched nonpregnant control subjects in Qingdao and Weihai between October 2011 and July 2013. These were screened with enzyme linked immunoassays for the presence of anti-ToxoplasmaIgG and anti-ToxoplasmaIgM antibodies. 147 (15.2%) pregnant women and 167 (17.3%) control subjects were positive for anti-T. gondiiIgG antibodies, while 28 (2.9%) pregnant women and 37 (3.8%) controls were positive for anti-T. gondiiIgM antibodies (P=0.256). There was no significant difference between pregnant women and nonpregnant controls with regard to the seroprevalence of either anti-T. gondiiIgG or IgM antibodies. Multivariate analysis showed thatT. gondiiinfection was associated with location, cats in home, contact with cats and dogs, and exposure to soil. The results indicated that the seroprevalence ofT. gondiiinfection in pregnant women is high compared to most other regions of China and other East Asian countries with similar climatic conditions.

scholarly journals Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Xuefeng Pan ◽  
Benjie Wei ◽  
Hong Wang ◽  
Lingyu Ma ◽  
Zhaoli Du ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Late Onset ◽  
Case Control ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Targeted Next Generation Sequencing ◽  
Significant Difference ◽  
Novel Association ◽  
Multiple Interaction ◽  
Early Onset Preeclampsia

Abstract Background Both genetic susceptibility and dysregulated lipid metabolism are important susceptibilities to preeclampsia. In the study, we devote to investigate the associations of FOXO3 and TLR7 genetic polymorphisms with preeclampsia in a Chinese population. Methods This case-control study involved 335 Han Chinese pregnant women, including 177 pregnant women with preeclampsia and 158 healthy controls. The preeclampsia group was further sub-grouped into early-onset preeclampsia (EOPE, n = 70)and late-onset preeclampsia (LOPE, n = 107. Three single nucleotide polymorphisms (SNPs), including FOXO3 (rs2232365, rs3761548), and TLR7 rs3853839 were genotyped by multiplex PCR for targeted next-generation sequencing. The χ2 test and multiple interaction effect analyses were performed to determine the association of three SNPs with serum lipid levels and thyroid function in women with preeclampsia. Results The genotype (CC vs. TT + CT) distribution of rs2232365 revealed a significant association with LOPE (P = 0.004, odds ratio = 3.525 (0.95 CI: 1.498–8.164)). No significant difference was found in the genotype and allele frequencies of rs3761548 and rs3853839 between controls and cases (P > 0.05). Moreover, the genotype CT/TT of rs2232365 was significantly correlated with increased TG/HDL levels in the LOPE group (p = 0.014). Conclusions The polymorphisms of rs2232365 are associated with the risk of LOPE and may modulate TG/HDL levels in pregnant women with LOPE.

scholarly journals Obstetric, maternal, and neonatal outcomes in COVID-19 compared to healthy pregnant women in Iran: a retrospective, case-control study

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Seyed-Abdolvahab Taghavi ◽  
Solmaz Heidari ◽  
Shayesteh Jahanfar ◽  
Shakiba Amirjani ◽  
Amireh Aji-ramkani ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Incidence Rate ◽  
Preterm Labor ◽  
Case Control Study ◽  
Case Control ◽  
Neonatal Outcomes ◽  
Obstetric Outcomes ◽  
Premature Delivery ◽  
Maternal And Neonatal Outcomes ◽  
Control Study

Abstract Background The purpose of the present study was to evaluate obstetric, maternal, and neonatal outcomes in COVID-19 compared to healthy pregnant women in Iran. Results A case-control study was conducted on 55 COVID-19 as the case and 55 matched control pregnant women in Hormozgan, Iran. Patients were considered to be cases if they had a positive COVID-19 test plus a positive chest X-ray result. Our measures were COVID-19 symptoms, including laboratory evaluations, clinical symptoms, and maternal and neonatal outcomes. The most prevalent symptoms related to COVID-19 were fever (69.09%) and cough (58.18%). Less common symptoms included fatigue, diarrhea, shortness of breath, sore throat, and myalgia. Hydroxychloroquine/chloroquine (58.18%) and antibiotic therapy (45.45%) were the most prevalent management in COVID-19 patients. Based on our findings, maternal and obstetric outcomes—neonatal in case groups—such as mode of delivery, premature rupture of membrane, postpartum hemorrhage, perineal resection rate, neonates’ birth weight, Apgar score, and neonatal asphyxia rate were similar to pregnant women without COVID-19. We observed a higher incidence rate of premature delivery in COVID-19 cases (25 vs. 10%) (p < 0.05). In the present study, we found that women with COVID-19 had a more than twofold increased odds of preterm labor. History of preterm delivery was also associated with high twofold odds of preterm labor. Conclusion We observed a higher incidence rate of premature delivery in COVID-19 cases. Women with COVID-19 had a more than twofold increased odds of preterm labor. Considering prematurity has high morbidity and is regarded as the primary cause of mortality in children under 5 years old, more case-control studies are needed to ascertain the results.

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