Pfannenstiel und Quante, Effect of neosalvarsan and germanine on bactericidal activity in rabbit blood. A message to the question of the indirect action of these chemotherapeutic agents. Ztschr. f. Immunitätsf., Bd 88, H 1/2 1936)

1937 ◽  
Vol 33 (5) ◽  
pp. 634-634

The authors believe that the decisive role in the chemotherapeutic effect belongs to the organotropy, and not the parasitotropy of the medicinal substance. However, it cannot be denied that the parasite's cell is able to capture the chemotherapeutic substance or its decay products. Therefore, the chemotherapeutic index is an expression, on the one hand, of the weakening of the parasite, and on the other hand, of the strengthening of the protective function of the organism.

2008 ◽  
Vol 19 (3) ◽  
pp. 273-291
Author(s):  
Milotka Molnar-Sivc

Although the question of relationship between basic concepts of traditional ontology and central concepts of fundamental ontology is not a topic which is systematically dealt with in Being and Time, it is obvious that some of the theses which are crucial not only for Heidegger's interpretation of philosophical tradition, but also for the whole project of fundamental ontology, concern this 'conceptual scheme'. In fact, the backbone of Heidegger's critical confrontation with dominant philosophical conceptions is the question of relationship between the concept of 'substance' and the concept of 'Being', i.e. the discussion of philosophical doctrines in which 'Being' is reduced to 'substance'. Besides this context, which concerns the ontological problematics in the strict sense, it is possible to show that the refutation of the basic categories of traditional ontology is an issue which has a decisive role in more concrete phases of the realization of the project of fundamental ontology. This is especially confirmed in Heidegger's discussion of the concept of 'Being-There'. The interpretation of Heidegger's treatment of the relationship between the concepts of 'Being-there', 'existence' and 'existentials' on the one hand, and the concepts of 'substance', 'essence' and 'categories' on the other, shows that one of Heidegger's basic theses is that a transformation of concepts of traditional ontology is necessary for an appropriate understanding of human being.


2021 ◽  
Vol 28 (4) ◽  
pp. 305-323
Author(s):  
Kinga Moras-Olaś

The right to disconnect as an employees’ fundamental right The ongoing COVID-19 pandemic and the associated possibilities for the employers to order employees to perform their work remotely has caused the widespread perception of the employee’s right to be offline outside its working hours (also referred to as a “right to disconnect”) as a fundamental right. This article contains a synthetic analysis of the institution of remote working as the main source of threat to employees’ rights as well as considerations with regard to proposed solutions aimed at protecting the employee against such threat. On the one hand, remote work has a protective function being instrumental in safeguarding the continuity of businesses and the employee’s workplace despite the pandemic, but on the other hand, it significantly interferes with the private sphere and may lead to violations of the regulations on working time. The European Parliament’s proposals on the right to be offline should be assessed positively, although they undoubtedly only guarantee an absolute minimum level of protection. The analysis was carried out following the formal dogmatic method also taking into account comparative tools.


2019 ◽  
Vol 52 (1/2) ◽  
pp. 673
Author(s):  
Mikel Pozo Flores

This work looks at the classical subject of 5th Century Historiography, the famous Bagaudae Conflict mentioned in Hydatius' Chronicle. Having briefly introduced the events and historiographical explanations, we will analyze the texts by looking at the features of intellectual production in the Late Antiquity. To be precise, we will study the meaning of the term bagaudae in work by other authors prior to Hydatius, in particular Orosius, and the parallelisms in the accounts of these authors. On the one hand we look to confirm the existence of a certain consolidated tradition amongst the intellectuals of the Antiquity in the meaning and usage of the term and on the other hand, hold that Hydatius did not refer to bagaudae as rebel peasants, as was hitherto maintained, but as a certain type of local troop known as rustici. This interpretation is in line with the decisive role that the rustici had in the evolution of Post-Roman Vasconia according to an in depth explanation being prepared for publication.


ARCHALP ◽  
2021 ◽  
Author(s):  
Chiara Rizzi

The aphorism lentius, profundius, suavius of Alexander Langer overturns the most famous citius, altius, fortius. It is both a program and a vision to face the most urgent challenges of our time. Outdoor is the priority action context to design possible ways of reconciliation with the environment, the only way to rediscover the balanced integration with nature that Adriano Olivetti indicated as an antidote to the harmfulness of the urban environment. Nature plays a decisive role in our society. According to the German philosopher Gernot Böhme, this general reference to nature on the one hand is indicative of a desire to compensate for a lifestyle that is increasingly distant from its rhythms and its essence, on the other it represents a profound and radical removal. The pandemic has definitively undermined some of the dominant paradigms, leading to the establishment of a new phenomenology of nature based on perception. The health issue has quickly, and perhaps irreversibly, changed our lifestyles and our relationships with nature. In high-altitude contexts, the archetypes of architecture become the concepts through which architecture redefines its dialogue with the landscape by innovating its grammar and semantic relationships. A complex dialogue that triggers new genealogies and belonging in which design solutions become an opportunity for experimenting and innovating processes, forms and technologies. The following projects address these issues with respect to two founding themes of architecture: the refuge and the threshold.


2019 ◽  
Vol 71 (2) ◽  
pp. 102-119
Author(s):  
Ralf Koerrenz

AbstractThis article argues in the form of an essay that there is a specifically Hebrew grounding of democracy. It is based on an interpretation of the Torah. The different structure of the covenant with Noah and Abraham on the one hand and with the people in the context of the Exodus on the other hand plays the decisive role in this question. In the Exodus, the covenant between God and Israel may be implemented only with the consent of all the people to its social, legal and cultic contents. All this happens, however, under the auspices of a negative anthropology. In principle, only a life in the postparadiesiam, “false” structures of any given political constitution is possible for humanity. These, however, can be shaped above all by legal and social regulations in such a way that the consequences of alienation are positively minimized and the possibility of a flourishing life within such “false” structures can emerge.


1975 ◽  
Vol 26 ◽  
pp. 395-407
Author(s):  
S. Henriksen

The first question to be answered, in seeking coordinate systems for geodynamics, is: what is geodynamics? The answer is, of course, that geodynamics is that part of geophysics which is concerned with movements of the Earth, as opposed to geostatics which is the physics of the stationary Earth. But as far as we know, there is no stationary Earth – epur sic monere. So geodynamics is actually coextensive with geophysics, and coordinate systems suitable for the one should be suitable for the other. At the present time, there are not many coordinate systems, if any, that can be identified with a static Earth. Certainly the only coordinate of aeronomic (atmospheric) interest is the height, and this is usually either as geodynamic height or as pressure. In oceanology, the most important coordinate is depth, and this, like heights in the atmosphere, is expressed as metric depth from mean sea level, as geodynamic depth, or as pressure. Only for the earth do we find “static” systems in use, ana even here there is real question as to whether the systems are dynamic or static. So it would seem that our answer to the question, of what kind, of coordinate systems are we seeking, must be that we are looking for the same systems as are used in geophysics, and these systems are dynamic in nature already – that is, their definition involvestime.


Author(s):  
Stefan Krause ◽  
Markus Appel

Abstract. Two experiments examined the influence of stories on recipients’ self-perceptions. Extending prior theory and research, our focus was on assimilation effects (i.e., changes in self-perception in line with a protagonist’s traits) as well as on contrast effects (i.e., changes in self-perception in contrast to a protagonist’s traits). In Experiment 1 ( N = 113), implicit and explicit conscientiousness were assessed after participants read a story about either a diligent or a negligent student. Moderation analyses showed that highly transported participants and participants with lower counterarguing scores assimilate the depicted traits of a story protagonist, as indicated by explicit, self-reported conscientiousness ratings. Participants, who were more critical toward a story (i.e., higher counterarguing) and with a lower degree of transportation, showed contrast effects. In Experiment 2 ( N = 103), we manipulated transportation and counterarguing, but we could not identify an effect on participants’ self-ascribed level of conscientiousness. A mini meta-analysis across both experiments revealed significant positive overall associations between transportation and counterarguing on the one hand and story-consistent self-reported conscientiousness on the other hand.


2005 ◽  
Vol 44 (03) ◽  
pp. 107-117
Author(s):  
R. G. Meyer ◽  
W. Herr ◽  
A. Helisch ◽  
P. Bartenstein ◽  
I. Buchmann

SummaryThe prognosis of patients with acute myeloid leukaemia (AML) has improved considerably by introduction of aggressive consolidation chemotherapy and haematopoietic stem cell transplantation (SCT). Nevertheless, only 20-30% of patients with AML achieve long-term diseasefree survival after SCT. The most common cause of treatment failure is relapse. Additionally, mortality rates are significantly increased by therapy-related causes such as toxicity of chemotherapy and complications of SCT. Including radioimmunotherapies in the treatment of AML and myelodyplastic syndrome (MDS) allows for the achievement of a pronounced antileukaemic effect for the reduction of relapse rates on the one hand. On the other hand, no increase of acute toxicity and later complications should be induced. These effects are important for the primary reduction of tumour cells as well as for the myeloablative conditioning before SCT.This paper provides a systematic and critical review of the currently used radionuclides and immunoconjugates for the treatment of AML and MDS and summarizes the literature on primary tumour cell reductive radioimmunotherapies on the one hand and conditioning radioimmunotherapies before SCT on the other hand.


2017 ◽  
Vol 47 (188) ◽  
pp. 487-494
Author(s):  
Daniel Mullis

In recent years, political and social conditions have changed dramatically. Many analyses help to capture these dynamics. However, they produce political pessimism: on the one hand there is the image of regression and on the other, a direct link is made between socio-economic decline and the rise of the far-right. To counter these aspects, this article argues that current political events are to be understood less as ‘regression’ but rather as a moment of movement and the return of deep political struggles. Referring to Jacques Ranciere’s political thought, the current conditions can be captured as the ‘end of post-democracy’. This approach changes the perspective on current social dynamics in a productive way. It allows for an emphasis on movement and the recognition of the windows of opportunity for emancipatory struggles.


1996 ◽  
pp. 13-23
Author(s):  
Mykhailo Babiy

Political ideological pluralism, religious diversity are characteristic features of modern Ukrainian society. On the one hand, multiculturalism, socio-political, religious differentiation of the latter appear as important characteristics of its democracy, as a practical expression of freedom, on the other - as a factor that led to the deconsocialization of society, gave rise to "nodal points" of tension, confrontational processes, in particular, in political and religious spheres.


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