Analysis of the effectiveness of medical and laser treatment of patients with diabetic retinopathy

2012 ◽  
Vol 93 (4) ◽  
pp. 594-597
Author(s):  
V V Kuzovnikov ◽  
V A Nevmerzhitskaya ◽  
V I Lazarenko
Keyword(s):  
Diabetic Retinopathy ◽  
Laser Treatment ◽  
Standard Treatment ◽  
Central Field ◽  
Nonproliferative Diabetic Retinopathy ◽  
Field Of Vision ◽  
New Treatment ◽  
One Year ◽  
Positive Effect ◽  
Observation Period

Aim. To evaluate the effectiveness of traditional medical and laser treatment of nonproliferative and preproliferative diabetic retinopathy. Methods. Examined was a total of 80 eyes of 66 patients with nonproliferative and preproliferative diabetic retinopathy. In accordance with the stage of the disease and the type of treatment, all patients were divided into two groups. The first group consisted of 34 individuals (39 eyes) with nonproliferative diabetic retinopathy who received medical treatment, the second group - 32 individuals (41 eyes) with preproliferative diabetic retinopathy who received medical and laser treatment. The patients had visual acuity measurement, biomicroscopy, ophthalmoscopy, refractometry, perimetry, a study of the central field of vision, and rheoophthalmography performed before surgery, after surgery (at discharge), 10 days, 6 months and 1 year postoperatively. Results. The indices of visual functions, the hemodynamic and electrophysiological parameters have the same dynamics in the first and second groups throughout the observation period. In both groups a positive effect of the performed treatment was noted, which is almost entirely offset by 6-month post-treatment, and by one year after treatment a negative dynamic develops, which is associated with the progressive course of the disease. Conclusion. The lack of effectiveness of the standard treatment of nonproliferative and preproliferative diabetic retinopathy is the justification for a search for new treatment methods.

One-Year Progression of Diabetic Subclinical Macular Edema in Eyes with Mild Nonproliferative Diabetic Retinopathy: Location of the Increase in Retinal Thickness

2015 ◽  
Vol 54 (3) ◽  
pp. 118-123 ◽  
Author(s):  
Amparo Navea Tejerina ◽  
Stela Vujosevic ◽  
Monica Varano ◽  
Catherine Egan ◽  
Sobha Sivaprasad ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Macular Edema ◽  
Retinal Thickness ◽  
Nonproliferative Diabetic Retinopathy ◽  
One Year

Small dense low-density lipoprotein cholesterol is an effective target marker for predicting cardiovascular events and laser treatment for retinopathy in diabetic patients

2020 ◽  
Author(s):  
Atsuko Nakayama ◽  
Hiroyuki Morita ◽  
Tatsuyuki Sato ◽  
Takuya Kawahara ◽  
Norifumi Takeda ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Laser Treatment ◽  
Cardiovascular Events ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
One Year ◽  
Sensitive Marker

Abstract Background Small dense low-density lipoprotein cholesterol (sdLDL-C) has been recently reported as a sensitive marker for cardiovascular diseases. Objective We explored the superiority of sdLDL-C as a marker for predicting cardiovascular (CV) events and the need for laser treatment in patients with hypercholesterolemia and diabetic retinopathy. Methods We performed a sub-analysis of the intEnsive statin therapy for hyper-cholesteroleMic Patients with diAbetic retinopaTHY (EMPATHY) study (n = 5042), in which patients were assigned randomly to intensive or standard statin therapy targeting low-density lipoprotein cholesterol < 70 mg/dl or 100–120 mg/dl. Using the Cox hazard analysis and Kaplan-Meier analysis, the risks for CV events and the need for laser treatment were evaluated according to the following lipids: total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, apolipoprotein B (ApoB), and sdLDL-C one year after registration. Results The patients were 63 ± 11 years old and 48% of them were male. LDL-C and sdLDL-C levels were 98 ± 25 and 32 ± 14 mg/dl, respectively, one year after registration. The sdLDL-C level had a strong positive correlation with ApoB level (r = 0.83). SdLDL-C was a sensitive marker for predicting CV events when comparing among the quartiles according to sdLDL-C levels (hazard ratios: HR for quartiles 1–4 were 1.0, 1.4, 1.6, and 2.5, respectively; p for trend < 0.01). Also, sdLDL-C was a sensitive marker for predicting the need for laser treatment among lipids (log rank, p = 0.009), especially in patients with elderly (> 65 yrs) and obesity (BMI > 25 kg/m2). Conclusions SdLDL-C is a sensitive target marker to predict cardiovascular events as well as the need for laser treatment in patients with hypercholesterolemia and diabetic retinopathy. Trial registration: UMIN000003486, www.umin.ac.jp/ctr/.

Соматические дисфункции у детей с задержкой речи

2017 ◽  
pp. 61-65
Author(s):  
E. L. Kuznetsova ◽  
L. A. Dultsev ◽  
E. V. Safin
Keyword(s):  
Standard Treatment ◽  
Control Group ◽  
Complex Therapy ◽  
Osteopathic Treatment ◽  
Positive Effect ◽  
Experimental Group

Goal of research - the study aims to examine the osteopathic profi le of children with dysarthria and to develop recommendations for osteopathic correction of somatic dysfunctions in 2-3 year old children presenting this pathology.Materials and methods. 30 2-3 year old children with the symptoms of dysarthria took part in the research. All the children were divided into 2 groups: the control group of 15 children received standard treatment, and the experimental group of 15 children received both standard and osteopathic treatment. The dysarthria severity and the osteopathic profi le were evaluated with account of the number of somatic dysfunctions at global, regional, and local levels.Results. The osteopathic correction was shown to have a positive effect on dysarthria severity. The study established a correlation between the dysarthria severity in children and the number of somatic dysfunctions at the local level.Conclusion. The study suggests using osteopathic correction of somatic dysfunctions in the complex therapy of dysarthria in children.

Pengaruh Likuiditas, Pertumbuhan Kredit, Efisiensi, dan Kecukupan Modal Terhadap Profitabilitas

2020 ◽  
Vol 1 (1) ◽  
pp. 27-35
Author(s):  
Lia Hendrawati ◽  
Said Djamaludin
Keyword(s):  
Stock Exchange ◽  
Growth Efficiency ◽  
Research Data ◽  
Capital Adequacy ◽  
Annual Data ◽  
Significant Positive Effect ◽  
Credit Growth ◽  
Negative Effect ◽  
Positive Effect ◽  
Observation Period

This study to examine and analyze the effect of liquidity, credit growth, efficiency, and capital adequacy on the Bank’s profitability listed on the IDX partially and simultaneously. The research data are annual data for the 5-year observation period (2009-2013). This research was conducted at 33 banks listed on Indonesia Stock Exchange. Banks Analyzed that met the population criteria were 23 banks. The analytical method used in multiple linier regression. The results showed that liquidity, credit growth, efficiency, and capital adequacy together (simultaneously) significantly influence profitability. Partially,  liquidity has a significant positive effect on profitability, while efficiency has a significant negative effect. Credit growth and capital adequacy have no significant effect on profitability. Liquidity is the variable that has the biggest effect on the Bank’s profitability. 

Proteomic Analysis of the Vitreous Body in Proliferative and Non-Proliferative Diabetic Retinopathy

2020 ◽  
Vol 17 ◽  
Author(s):  
Van-An Duong ◽  
Jeeyun Ahn ◽  
Na-Young Han ◽  
Jong-Moon Park ◽  
Jeong-Hun Mok ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Microvascular Complications ◽  
Treatment Options ◽  
Vitreous Body ◽  
Control Group ◽  
Diabetic Patients ◽  
Protein Protein Interaction ◽  
Alpha Beta ◽  
New Treatment

Background: Diabetic Retinopathy (DR), one of the major microvascular complications commonly occurring in diabetic patients, can be classified into Proliferative Diabetic Retinopathy (PDR) and Non-Proliferative Diabetic Retinopathy (NPDR). Currently available therapies are only targeted for later stages of the disease in which some pathologic changes may be irreversible. Thus, there is a need to develop new treatment options for earlier stages of DR through revealing pathological mechanisms of PDR and NPDR. Objective: The purpose of this study was to characterize proteomes of diabetic through quantitative analysis of PDR and NPDR. Methods: Vitreous body was collected from three groups: control (non-diabetes mellitus), NPDR, and PDR. Vitreous proteins were digested to peptide mixtures and analyzed using LC-MS/MS. MaxQuant was used to search against the database and statistical analyses were performed using Perseus. Gene ontology analysis, related-disease identification, and protein-protein interaction were performed using the differential expressed proteins. Results: Twenty proteins were identified as critical in PDR and NPDR. The NPDR group showed different expressions of kininogen-1, serotransferrin, ribonuclease pancreatic, osteopontin, keratin type II cytoskeletal 2 epidermal, and transthyretin. Also, prothrombin, signal transducer and activator of transcription 4, hemoglobin subunit alpha, beta, and delta were particularly up-regulated proteins for PDR group. The up-regulated proteins related to complement and coagulation cascades. Statherin was down-regulated in PDR and NPDR compared with the control group. Transthyretin was the unique protein that increased its abundance in NPDR compared with the PDR and control group. Conclusion: This study confirmed the different expressions of some proteins in PDR and NPDR. Additionally, we revealed uniquely expressed proteins of PDR and NPDR, which would be differential biomarkers: prothrombin, alpha-2-HS-glycoprotein, hemoglobin subunit alpha, beta, and transthyretin.

Venular oxygen saturation is increased in young patients with type 1 diabetes and mild nonproliferative diabetic retinopathy

2020 ◽  
Vol 98 (8) ◽  
pp. 800-807 ◽  
Author(s):  
Nina C.B.B. Veiby ◽  
Aida Simeunovic ◽  
Martin Heier ◽  
Cathrine Brunborg ◽  
Naila Saddique ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Oxygen Saturation ◽  
Young Patients ◽  
Nonproliferative Diabetic Retinopathy

The Association Between Obstructive Sleep Apnea and Cotton-Wool Spots in Nonproliferative Diabetic Retinopathy

2021 ◽  
pp. 247412642198957
Author(s):  
Halward M.J. Blegen ◽  
Grant A. Justin ◽  
Bradley A. Bishop ◽  
Anthony R. Cox ◽  
James K. Aden ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Obstructive Sleep Apnea ◽  
Diabetic Retinopathy ◽  
Sleep Apnea ◽  
Body Mass ◽  
Smoking Status ◽  
Cotton Wool ◽  
Nonproliferative Diabetic Retinopathy ◽  
Cotton Wool Spots ◽  
Obstructive Sleep

Purpose: This work reports the association of obstructive sleep apnea (OSA) and cotton-wool spots (CWS) seen in patients with nonproliferative diabetic retinopathy (DR). Methods: A random sample of patients diagnosed with DR between January 1, 2015 and December 31, 2018, were selected from medical-billing codes. Dilated funduscopic examination findings and medical history were analyzed by reviewing medical records. Results: CWS were present in 12 of 118 patients without OSA, compared with 11 of 32 patients with OSA (10.2% vs 34.4%, respectively; P = .002). OSA was more common in men (68.8%, P = .03) and associated with a higher body mass index (30.0 ± 5.0 without OSA vs 33.6 ± 5.5 with OSA, P < .001). When comparing those with and without OSA, there was no association with age; glycated hemoglobin A1c; stage of DR; insulin dependence; presence of diabetic macular edema; smoking status; or a history of hypertension, hyperlipidemia, cardiovascular disease, or other breathing disorder. Conclusions: The presence of OSA is associated with CWS in patients with DR, as well as male sex and a higher body mass index. Further research is needed to determine the ophthalmologist’s role in the timely referral of patients with CWS for OSA evaluation.

The estimated healthcare cost of diabetic retinopathy in Indonesia and its projection for 2025

2019 ◽  
Vol 104 (4) ◽  
pp. 487-492 ◽  
Author(s):  
Muhammad Bayu Sasongko ◽  
Firman Setya Wardhana ◽  
Gandhi Anandika Febryanto ◽  
Angela Nurini Agni ◽  
Supanji Supanji ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Laser Treatment ◽  
Healthcare Cost ◽  
Cost Of Illness ◽  
Public Health Intervention ◽  
Transportation Cost ◽  
Population Based ◽  
State Budget ◽  
Illness Model ◽  
The Cost

PurposeTo estimate the total healthcare cost associated with diabetic retinopathy (DR) in type 2 diabetes in Indonesia and its projection for 2025.MethodsA prevalence-based cost-of-illness model was constructed from previous population-based DR study. Projection for 2025 was derived from estimated diabetes population in 2025. Direct treatment costs of DR were estimated from the perspective of healthcare. Patient perspective costs were obtained from thorough interview including only transportation cost and lost of working days related to treatment. We developed four cost-of-illness models according to DR severity level, DR without necessary treatment, needing laser treatment, laser +intravitreal (IVT) injection and laser + IVT +vitrectomy. All costs were estimated in 2017 US$.ResultsThe healthcare costs of DR in Indonesia were estimated to be $2.4 billion in 2017 and $8.9 billion in 2025. The total cost in 2017 consisted of the cost for no DR and mild–moderate non-proliferative DR (NPDR) requiring eye screening ($25.9 million), severe NPDR or proliferative DR (PDR) requiring laser treatment ($0.25 billion), severe NPDR or PDR requiring both laser and IVT injection ($1.75 billion) and advance level of PDR requiring vitrectomy ($0.44 billion).ConclusionsThe estimated healthcare cost of DR in Indonesia in 2017 was considerably high, nearly 2% of the 2017 national state budget, and projected to increase significantly to more than threefold in 2025. The highest cost may incur for DR requiring both laser and IVT injection. Therefore, public health intervention to delay or prevent severe DR may substantially reduce the healthcare cost of DR in Indonesia.

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