scholarly journals Influence of age-related and vascular factors on the state of external and internal liquoroconductive spaces of brain

2000 ◽  
Vol XXXII (3-4) ◽  
pp. 40-43
Author(s):  
M. V. Kovalyova ◽  
M. Yu. Martinov ◽  
T. P. Gorina
Keyword(s):  
Risk Factors ◽  
Comparative Analysis ◽  
Brain Aging ◽  
Reference Group ◽  
The State ◽  
Vascular Risk ◽  
Age Related ◽  
Vascular Insufficiency ◽  
Analysis Of Results ◽  
Subarachnoid Spaces

A comparative analysis of results of examination of patients with chronic brain vascular insufficiency and findings on reference group was carried out. The significance of age-related and vascular risk factors in development of changes in external and internal liquoroconductive spaces is stated. It is noted that insignificant and moderate dilatation of subarachnoid spaces and ventricular systems mainly indicate natural involutional processes. Heterogeneity of anterior and posterior regions involvement of subarachnoid spaces in brain aging are revealed. Influence of silent ischemic insults on the state of ventricular system is mentioned.

scholarly journals The impact of vascular risk factors on the thickness and volume of the choroid in AMD patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Elżbieta Krytkowska ◽  
Aleksandra Grabowicz ◽  
Katarzyna Mozolewska-Piotrowska ◽  
Zofia Ulańczyk ◽  
Krzysztof Safranow ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vascular Risk Factors ◽  
Age Related Macular Degeneration ◽  
Control Group ◽  
Vascular Risk ◽  
Average Volume ◽  
Central Ring ◽  
Age Related ◽  
The Impact ◽  
Wet Amd

AbstractDisturbances in choroidal microcirculation may lead to the onset and progression of age-related macular degeneration (AMD). We aimed to assess changes in the choroidal volume and thickness in the macular region in AMD eyes and to investigate whether coexisting vascular risk factors alter choroidal status. We enrolled 354 AMD patients (175 dry, 179 wet AMD) and 121 healthy controls. All participants underwent a complete ophthalmologic examination and assessment of choroidal thickness and volume. A multivariate analysis adjusted for age, sex, and smoking status revealed that wet AMD was an independent factor associated with higher average thickness of the central ring area (ATC) and average volume of the central ring area (AVC) and lower choroidal vascularity index (CVI) compared to controls (β =  + 0.18, p = 0.0007, β =  + 0.18, p = 0.0008, respectively) and to dry AMD (β =  + 0.17, p = 0.00003 for both ATC and AVC and β =  − 0.30 p < 0.0001 for CVI). ATC, AVC and average volume (AV) were lower in AMD patients with hypertension and ischaemic heart disease (IHD). The duration of hypertension was inversely correlated with ATC, AVC and AV (Rs =  − 0.13, p < 0.05; Rs =  − 0.12; p < 0.05, Rs =  − 0.12; p < 0.05, respectively) while IHD duration negatively correlated with AV (Rs =  − 0.15, p < 0.05). No such associations were observed in the control group. Our findings show that the choroidal vascular system in eyes with AMD is much more susceptible to damage in the presence than in the absence of systemic vascular disease.

Comparative analysis of ultrasound biomicroscopy between femto-assisted and ultrasound cataract removal in case of lens subluxation

2021 ◽  
pp. 7-9
Author(s):  
K. Ait Ahmed ◽  
◽  
V. Maksimov ◽  
M. Maksimov ◽  
G. Akchurin ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Objective Assessment ◽  
Ultrasound Biomicroscopy ◽  
The State ◽  
Success Factor ◽  
Lens Subluxation ◽  
Age Related ◽  
Significant Difference ◽  
Before And After ◽  
Lens Surgery

Purpose of the study to carry out a comparative analysis of the state of the zonular fibers before and after surgery on UBM between femtolaser assisted and classical ultrasound cataract removal. Material and methods. 19 patients (38 eyes) with age-related cataracts. 22 eyes were with pseudo-exfoliative syndrome. All patients were examined with grade 1 lens subluxation. The first group of 19 eyes underwent cataract femto-phacoemulsification. The second group included 19 eyes without using a femtolaser. The state of the fibers was determined on the UBM on the fifth day after the operation at the end of antibiotic therapy. Results. The data showed the presence of a statistically significant difference between the group with femto-assistance and the group without it. In the first group, UBM analysis showed that the state of the zonular fibers remained in the same state in 16 of 19 eyes. In the second group, 11 of 19 eyes required ring implantation with suturing to the sclera and 3 required IOL implantation with seamless fixation to the sclera and vitrectomy. Conclusions. The appropriate path to surgery depends on the most accurate objective assessment of the condition of the lens ligaments, since the position of the IOL is one of the main factors for a good result expected by the patient after surgery. Reducing the «trauma» of the eye with lens surgery has been a key success factor and femtolaser guidance provides valuable assistance in obtaining it. Key words: lens subluxation, femtosecond laser, UBM.

Risk factors for development of community-acquired pneumonia in workers of main occupations in production of chrysotile asbestos

2019 ◽  
pp. 113-116 ◽  
Author(s):  
T. V. Bushueva ◽  
N. A. Roslaya
Keyword(s):  
Risk Factors ◽  
Comparative Analysis ◽  
Respiratory Infections ◽  
Reference Group ◽  
Community Acquired Pneumonia ◽  
Upper Respiratory Tract ◽  
Chrysotile Asbestos ◽  
Response Factors ◽  
Chi Square ◽  
The Past

Inpatient examination covered 46 workers of main occupations in chrysotile asbestos production, with diagnosed occupational disease “asbestosis”, and reference group comprising 20 healthy workers of the same enterprise. Th e results present comparative analysis of clinical and anamnesis data in dependence on the past pneumonia, studies of immune state in the asbestosis patients and the healthy workers, data on high occurrence of pneumonia in the workers, comparative analysis of respiratory infections occurrence and concomitant diseases according to the outpatients records and medical examinations. Findings are reliable diff erences and earlier respiratory manifestations in the past-pneumonia workers exposed to chrysotile asbestos, higher occurrence (1.3-fold) of chronic bronchitis and severe disorders of bronchial patency. Immune response factors were characterized as pathogenetic links of pneumococcus infectious invasion. Additional risk factors of pneumonia appeared to be frequent respiratory infections, chronic diseases of upper respiratory tract and middle ear, lower functional state of neutrophils, increased auto-reactivity. To evaluate signifi cance of risk factors infl uence, the authors used fi tt ing criterion X2 (chi-square). Intensity of relationships between the risk factor and outcome was evaluated by contingency coeffi  cient of Pearson. Signifi cance level (p) for all the calculation was accepted less than 0.05.

scholarly journals Brain deep medullary veins on 3-T MRI in a population-based cohort

2020 ◽  
pp. 0271678X2091846
Author(s):  
Dong-Hui Ao ◽  
Ding-Ding Zhang ◽  
Fei-Fei Zhai ◽  
Jiang-Tao Zhang ◽  
Fei Han ◽  
...  
Keyword(s):  
Risk Factors ◽  
Brain Atrophy ◽  
Small Vessel Disease ◽  
Population Based ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Neurodegenerative Process ◽  
Age Related ◽  
Deep Medullary Veins

Our aim is to investigate whether vascular risk factors are associated with cerebral deep medullary veins (DMVs) and whether DMVs are associated with MRI markers of cerebral small vessel disease (CSVD) or risk of stroke. In a community-based cohort of 1056 participants (mean age 55.7 years), DMVs were identified on susceptibility-weighted imaging (SWI) and counted in periventricular regions. Neuroimaging markers including lacunes, whiter matter hyperintensity (WMH), microbleeds, enlarged perivascular space, and brain atrophy were evaluated. The number of DMVs decreased with age (p = 0.007). After adjusting for age and sex, the number of DMVs was not associated with traditional vascular risk factors. Fewer DMVs was associated with increase of WMH and lacunes, but the association vanished after adjustment for vascular risk factors. However, fewer DMVs were independently associated with brain atrophy (p < 0.001). DMVs were not associated with three-year risk of stroke. Our results suggest that DMV is significantly different from other MRI markers of CSVD regarding risk factors, association with other CSVD markers, and risk of stroke. Nonetheless, the significant association between DMV and brain atrophy suggested the potential role of venules in age-related neurodegenerative process, which deserves further investigation.

The spatial distribution of age-related white matter changes as a function of vascular risk factors—Results from the LADIS study

NeuroImage ◽  
2012 ◽  
Vol 60 (3) ◽  
pp. 1597-1607 ◽  
Author(s):  
E. Rostrup ◽  
A.A. Gouw ◽  
H. Vrenken ◽  
E.C.W. van Straaten ◽  
S. Ropele ◽  
...  
Keyword(s):  
Risk Factors ◽  
Spatial Distribution ◽  
White Matter ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
White Matter Changes ◽  
Age Related

Can older “at risk” adults benefit from psychoeducation targeting healthy brain aging?

2010 ◽  
Vol 23 (3) ◽  
pp. 413-424 ◽  
Author(s):  
Louisa M. Norrie ◽  
Keri Diamond ◽  
Ian B. Hickie ◽  
Naomi L. Rogers ◽  
Samantha Fearns ◽  
...  
Keyword(s):  
Risk Factors ◽  
At Risk ◽  
Cognitive Decline ◽  
Repeated Measures ◽  
Brain Aging ◽  
Self Report ◽  
Control Group ◽  
Vascular Risk ◽  
Late Life Depression

ABSTRACTBackground:Multifactorial strategies that prevent or delay the onset or progress of cognitive decline and dementia are needed, and should include education regarding recognized risk factors. The current study sought to investigate whether older adults “at risk” of cognitive decline benefit from psychoeducation targeting healthy brain aging.Methods:65 participants (mean age 64.8 years, SD 9.6) with a lifetime history of major depression; vascular risk as evidenced by at least one vascular risk factor; and/or subjective or objective memory impairment were allocated to weekly psychoeducation sessions or a waitlist control group. The small group sessions were conducted over ten weeks by a team of medical and allied health professionals with expertise in late-life depression and cognition. Sessions focused on modifiable risk factors for cognitive decline including vascular risk, diet, exercise, depression, anxiety and sleep disturbance, as well as providing practical strategies for memory and cognition. Both the psychoeducation and waitlist group completed a 20-item knowledge test at baseline and follow-up. Participants in the psychoeducation group were asked to complete follow-up self-report satisfaction questionnaires.Results:Repeated measures ANOVA showed a significant interaction effect depicting improvements in knowledge associated with psychoeducation, corresponding to an improvement of 15% from baseline. Satisfaction data additionally showed that 92.3% of participants rated the program as “good” to “excellent”, and over 90% suggested they would recommend it to others.Conclusions:A group-based psychoeducation program targeting healthy brain aging is effective in improving knowledge. Additionally, it is acceptable and rated highly by participants.

scholarly journals Late-onset depressive disorders: a preventable variant of cerebrovascular disease?

1998 ◽  
Vol 28 (5) ◽  
pp. 1007-1013 ◽  
Author(s):  
IAN HICKIE ◽  
ELIZABETH SCOTT
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Depressive Disorders ◽  
Late Onset ◽  
Late Life ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Late Life Depression ◽  
Age Related ◽  
Medical Morbidity

The severe depressive disorders of late life are associated with high rates of medical morbidity and mortality, cognitive impairment, suicide, disability, complex treatment regimens, institutionalization and high costs to the community (Murphy, 1983; Murphy et al. 1988; Bruce & Leaf, 1989; NIH Consensus Development Panel, 1992; Alexopoulos et al. 1993a, b; Brodaty et al. 1993; Bruce et al. 1994; Forsell et al. 1994; Hickie et al. 1995; Blazer, 1996). Those disorders that are accompanied by cognitive impairment and/or concurrent medical morbidity have a particularly poor outcome (Bruce & Leaf, 1989; Alexopoulos et al. 1993b; Hickie et al. 1995, 1997a). Although psychosocial models of late-life depression place considerable importance on age-related psychological and social risk factors, those who survive into later life may actually be characterized by psychological resilience (Henderson, 1994; Blazer, 1997).Current aetiological research in late-life depression, therefore, places particular emphasis on the potential role of biological risk factors. The potential importance of vascular risk factors is receiving renewed attention and may provide opportunities for specific prevention and intervention strategies in high-risk populations. This emphasis on possible vascular risk factors, and the wider importance of vascular pathologies in late-life neuropsychiatric disorders, mirrors the emphasis of much earlier clinico-pathological studies (Binswanger, 1894; Alzheimer, 1895). The specific focus on the importance of small progressive changes within the subcortical white matter, as distinct from more discrete cortical infarcts (Olszewski, 1962), is now supported by the emerging neuroimaging literature and theoretical constructs in late-life depression (Krishnan, 1991, 1993; Hickie et al. 1996, 1997b; Krishnan et al. 1997).

scholarly journals Detrimental effect of systemic vascular risk factors on brain hemodynamic function assessed with MRI

2018 ◽  
Vol 31 (3) ◽  
pp. 253-261 ◽  
Author(s):  
Kevin S King ◽  
Min Sheng ◽  
Peiying Liu ◽  
Christopher D Maroules ◽  
Craig D Rubin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Rate ◽  
Systolic Blood Pressure ◽  
Vascular Risk Factors ◽  
Oxygen Extraction Fraction ◽  
Vascular Risk ◽  
High Systolic Blood Pressure ◽  
Cerebral Metabolic Rate ◽  
Vascular Insufficiency

Background and purpose Vascular risk factors have been associated with decreased cerebral blood flow (CBF) but this is etiologically nonspecific and may result from vascular insufficiency or a response to decreased brain metabolic activity. We apply new MRI techniques to measure oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen consumption (CMRO2), hypothesizing that decreased CBF related to these vascular risk factors will be associated with increased OEF, confirming a primary vascular insufficiency. Methods 3T MRI was obtained on 70 community-based participants in this IRB-approved study with informed consent, with previous assessment of systolic blood pressure, hypertension medication, elevated serum triglycerides, low serum HDL, and diabetes mellitus. CBF was measured using phase contrast adjusted for brain volume (ml/100 g/min), OEF (%) was obtained from T2-Relaxation-Under-Spin-Tagging (TRUST), and CMRO2 (μmol/100 g/min) was derived using the Fick principle. Stepwise linear regression identified optimal predictors of CBF with age, sex, and hematocrit included for adjustment. This predictive model was then evaluated against OEF and CMRO2. Results Hypertriglyceridemia was associated with low CBF and high OEF. High systolic blood pressure was associated with high CBF and low OEF, which was primarily attributable to those with pressures above 160 mmHg. Neither risk factor was associated with significant differences in cerebral metabolic rate. Conclusion Low CBF related to hypertriglyceridemia was accompanied by high OEF with no significant difference in CMRO2, confirming subclinical vascular insufficiency. High CBF related to high systolic blood pressure likely reflected limitations of autoregulation at higher blood pressures.

Abstract 51: Effects of Vascular Risk Factors on Microstructural White Matter: A Voxel-Based Longitudinal Diffusion Tensor Imaging Study

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Pauline Maillard ◽  
Evan Fletcher ◽  
Owen Carmichael ◽  
Dan Mungas ◽  
Bruce Reed ◽  
...  
Keyword(s):  
Risk Factors ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Brain Aging ◽  
Diffusion Tensor ◽  
Brain Mri ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Local Contraction

Background: Diabetes mellitus type II (DMT2) and hypertension (HTN) have been reported as increasing the risk of dementia. Because recent cross-sectional diffusion tensor imaging (DTI) studies have identified association between vascular risk factors (VRF) and microstructural white matter (WM) abnormalities in elderly, longitudinal DTI studies are needed to determine whether VRF may be associated with accelerated WM degeneration over time. Methods: 114 cognitively normal participants from University of California, Davis Alzheimer’s Disease Center, aged 73.9±6.7, received a comprehensive clinical evaluation and brain MRI including T1-weighted and DTI sequences on two dates (mean delay: 3.3 years). Baseline and follow-up FA maps were calculated, aligned, and subtracted to provide FA change ([[Unable to Display Character: &#8710;]]FA) maps and warped to a common template (MDT). Coregistration of baseline and follow-up T1 maps to MDT enabled computation of Jacobian images (i.e. the local contraction factor). VRF score (VRFS) was computed as the sum of DMT2, HTN and hyperlipidemia (HYP) incidence based on the subject’s medical history. We then used voxel-based linear regressions to relate annual [[Unable to Display Character: &#8710;]]FA and Jacobian determinants to VRFS, adjusting for potential confounders. Resulting T maps were corrected for multiple comparisons. Results: Poorer VRF score was associated with higher rate of [[Unable to Display Character: &#8710;]]FA loss and of GM atrophy with regions most heavily implicated including the corpus callosum and the frontal GM (see Figure1). Conclusions: This is one of very few studies of longitudinal DTI change in the elderly. DMT2, HTH and HYP are associated with accelerated WM degeneration and GM atrophy in areas whose integrity is known to be reduced in mild cognitive impairment and dementia. Future work should clarify the independent role of these vascular risk factors in accelerating brain aging.

Sign in / Sign up

Export Citation Format

Share Document