scholarly journals The nature of relationship between some health parameters in infants born with hypoplastic type mild intrauterine growth retardation

2020 ◽  
Vol 11 (2) ◽  
pp. 15-24
Author(s):  
Dmitry O. Ivanov ◽  
Vitaly V. Derevtsov
Keyword(s):  
Body Weight ◽  
Body Length ◽  
Growth Retardation ◽  
Sympathetic Activity ◽  
Intrauterine Growth Retardation ◽  
Atrioventricular Conduction ◽  
Stress Index ◽  
Healthy Children ◽  
Intraventricular Conduction ◽  
Intrauterine Growth

Objective. Assessing the relationship between health indicators in infants born with intrauterine growth retardation (JGR) of hypoplastic type of mild severity among themselves, compared with infants born without IGR, and with practically healthy infants from practically healthy mothers. Materials and methods. Under the supervision were 109 infants. From mothers with a burdened somatic and obstetric-gynecological history, 84 children were born: 15 (gr. 1) with mild of hypo-plastic type IGR, 69 (gr. 2) without IGR. The control group (gr. 3) consisted of 25 healthy children born to healthy mothers. All observed babies were born full-term. They were examined in dynamics at the age of 1 (n = 104), 3 (n = 98), 6 (n = 92), 12 (n = 94) months. Outcome recording methods were a comprehensive case history analysis, physical examination, assessment of electrocar-diography and cardiointervalography. Distribution-free statistical analysis methods. Results. A correlation was found at 23 days between weight and body length (r = 0.63), body weight and stress index (r = 0.56), sympathetic activity and stress index (r = 0.84), intraatrial and atrioventricular conductivity (r = 0.64); at 1 month between sympathetic activity and stress index (r = 0.62); at 3 months between weight and body length (r = 0.79), sympathetic activity and stress index (r = 0.87), sympathetic activity and intraventricular conduction (r = 0.67), intraatrial and atrioventricular conduction (r = 0.71); at 6 months between weight and body length (r = 0.81), body weight and intraatrial conduction (r = 0.65), body weight and electric systole (r = 0.58), sympathetic activity and stress index (r = 0.92); at 12 months between body length and intraatrial (r = 0.74), body length and atrioventricular conduction (r = 0.76), sympathetic activity and stress index (r = 0.94), sympathetic activity and electrical systole (r = 0.71), stress index and intraventricular conduction (r = 0.68), stress index and electric systole (r = 0.69), intraatrial and stress index (r = 0.9), atrioventricular conduction and electric systole (r = 0.63). Conclusions. The revealed correlation communications between of some studied parameters allow doctors to allocate groups of dispensary observation, to diagnose changes at early stages of the pathological process, conduct correctional actions with assessment of their efficiency.

scholarly journals Morphofunctional features of platelets in premature newborns with very low and extremely low body weight

2021 ◽  
Vol 12 (2) ◽  
pp. 35-41
Author(s):  
Anastasia V. Budalova ◽  
Natalia V. Kharlamova ◽  
Galina N. Kuzmenko
Keyword(s):  
Body Weight ◽  
Platelet Count ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Gestational Age ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Distress Syndrome ◽  
Premature Newborns ◽  
Intrauterine Growth

Background. Currently, the development of medicine in the field of perinatology is aimed at improving the quality of medical care for newborns, especially those born prematurely. Premature newborns are most likely to develop hemorrhagic disorders, which often aggravates their condition and determines high morbidity and mortality. On modern hematological analyzers, it has become possible to evaluate a larger number of blood parameters, including platelet parameters, however, there are a small number of studies devoted to the study of platelet parameters in premature newborns. The aim was to study the morphofunctional features of platelets in premature newborns with very low and extremely low body weight. Materials and methods. The study included 78 newborns born at 2534 weeks of gestation, with a body weight of less than 1500 grams. On the 3rd5th day of life, a clinical blood test was performed on the Advia 2120i hematological analyzer (Siemens), with the determination of platelet parameters: PLT, 103 cells/l, PCT, %, PDW, %, Large Plt, 103 cells/l, MPC, g/dl, MRM, pg. Results. In newborns with ELBW, a decrease in the number and granularity of platelets in the blood, an increase in the average dry mass of platelets was found. Newborns with intrauterine growth retardation have a reduced platelet count and reduced thrombocrit. In premature newborns with a gestational age of 2527 weeks, blood circulation of platelets with a reduced volume was established, and in newborns who were born at a gestational age of 3234 weeks with increased granularity. In the absence of antenatal prevention of respiratory distress syndrome in newborns, there is a decrease in thrombocrit, the number of platelets, including large forms in the blood. In premature newborns born in a state of severe asphyxia, a decrease in platelet granularity was noted. The use of high concentrations of O2 in the oxygen-air mixture during respiratory therapy leads to a decrease in the number of platelets in the blood. Conclusions. Factors determining the morphofunctional state of platelets in premature newborns were established: the presence of a full course of antenatal prevention of respiratory distress syndrome of newborns, gestational age, the severity of asphyxia at birth, as well as the concentration of O2 in the oxygen-air mixture used in respiratory therapy. Newborns with ELBW have a reduced platelet count, low-granulated platelets, and an increased average dry platelet mass. Newborns with intrauterine growth retardation have a reduced number of platelets and thrombocrit in the blood. The revealed morphofunctional features of platelets allow us to clarify the nature of changes in the platelet link of hemostasis in premature newborns for the timely prevention of complications during the underlying disease.

scholarly journals Features of adaptation of newborns with intrauterine growth retardation

2003 ◽  
Vol 52 (4) ◽  
pp. 23-27
Author(s):  
I. I. Evsyukova ◽  
B. A. Fomenko ◽  
А. А. Andreeva ◽  
O. V. Kovalchuk-Kovalevskaya ◽  
D. S. Dodkhoev ◽  
...  
Keyword(s):  
Body Weight ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Intrauterine Infection ◽  
Multiple Organ ◽  
The Body ◽  
Psychomotor Development ◽  
Intrauterine Growth ◽  
Symmetrical Form ◽  
Reflex Reactions

The morbidity, adaptation characteristics, production of melatonin and creatine kinase in newborns with intrauterine growth retardation were studied. It was found that with a symmetrical form of IUGR in newborns, there is not only a lag in growth, body weight, and the formation of postural and reflex reactions from the given gestational age, but also pronounced multiple organ failure, which significantly complicates their postnatal adaptation and, probably, determines a high frequency somatic pathology and disorders of psychomotor development in the following months of life. Children who have a lag in growth and body weight combined with a delay in the formation of postural and reflex reactions as a result of intrauterine infection and placental insufficiency of infectious genesis need therapy aimed at restoring and compensating for the impaired functions of the central nervous system and other functional systems of the body.

scholarly journals Neonatal hypoglycemia in children with risk factors

2022 ◽  
pp. 80-84
Author(s):  
E. V. Antsiferova ◽  
T. E. Taranushenko ◽  
N. G. Kiseleva ◽  
E. A. Belyaeva ◽  
T. I. Donskaya
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Blood Glucose ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Neonatal Period ◽  
Large Body ◽  
Neonatal Hypoglycemia ◽  
Intrauterine Growth ◽  
Early Neonatal Period

Objective: The analysis of clinical-laboratory peculiarities and the dynamics of glycemia clarifying the terms of blood glucose stabilization during the early neonatal period in children having risk factors of the development of such state.Methods: Open, retrospective , continuous, single-center study was conducted. It was aimed at getting preliminary data that is important for planning further tactics of examining newborns having risk factors on hypoglycemia development (kids having large body weight at birth, children whose mothers have diabetes, newborns having intrauterine growth retardation).The target group of the survey included 522 newborns of both genders in the early neonatal period (from 0 to 7 days of life).Results: There is data on the frequency of first indicated hypoglycemia in newborns having risk factors of the development of such state, clinicallaboratory peculiarities, the dynamics of glycemia during early neonatal period, and also the period of blood glucose stabilization (the age of reaching normoglycemia). Neonatal hypoglycemia was detected in 40.2% of examined children. Laboratory manifestation during the first day of life was noticed 62.9% of cases with the further normalization of glucose level in blood in 24 hours in 73.3% of newborns. Significant reduction of blood glucose was observed in 54.8% of cases requiring hypoglycemia therapy with parenteral prescription of 10% glucose solution. Hypoglycemia jugulated against oral correction of 5% glucoses solution in 40.5 % of cases. 4.8% of children got the level of glucose stabilized after introduction of supplementary feeding.Conclusion: The results of the newborns having risk factors on hypoglycemia development (kids having large body weight at birth, children whose mothers have diabetes, newborns having intrauterine growth retardation) examinations are presented. The peculiarities of neonatal hypoglycemia are: the absence of a typical clinical symptoms among 89% of children. Asymptomatic course of hypoglycemia confirms the importance and necessity of glycemia monitoring in the early neonatal period in order to conduct timely and adequate therapy.

scholarly journals Vegetative regulation in the first three months of life in premature infants born with intrauterine growth retardation

2018 ◽  
Vol 9 (4) ◽  
pp. 36-43
Author(s):  
Elena A. Bliznetsova ◽  
Liudmila K. Antonova ◽  
Alexandr N. Malinin
Keyword(s):  
Body Weight ◽  
Preterm Infants ◽  
Premature Infants ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Wave Spectrum ◽  
High Frequency Component ◽  
Control Group ◽  
Intrauterine Growth ◽  
Vegetative Regulation

Goal. To study the dynamics of vegetative states in preterm infants with intrauterine growth retardation (IUGR) during the first three months of life. Materials and methods. Examined 34 preterm infants with IUGR – 1st group (GA – 33,3 ± 1,4 weeks, body weight – 1557,8 ± 63,8 g, length – 41,2 ± 1,7 cm) at the age of 5 days and 3 months of life; 51 premature infants without IUGR (GA – 33,2 ± 1,02 weeks, body weight 2062,0 ± 63,9 grams, length – 44,0 ± 1,4 cm) – 2nd group; a control group included 31 healthy full-term infants (GA – 38,8 ± 1,5 weeks, body weight – 3355,4 ± 147,6 grams, length – 52,7 ± 2,3 cm). The vegetative tester “Polispektr-8E/88” (2000 Hz, 12 bit), from the Russian firm “Neurosoft”, was used. Indicators of the cardiointervalogram (CIG) and spectrogram were determined in the baseline sample and in the orthostatic test (tilt-test). Results. Among the indicators of CIG there was a noticeable decrease of mode (Mo, s) in 2 groups of preterm infants at 5 days of life (p < 0,05) and an increase in stress-index by 3 months of age in 1 group (p < 0,05). The study revealed the predominance in the structure of the wave spectrum of the VLF-component in all groups of children to 3 months; children 1 group had a lower value of this indicator, but they also had a higher proportion of high frequency component (HF, %) (p < 0,05). Vagotonic initial vegetative tonus (IVT) was defined only in 1 group, while the frequency of sympathicotonic and hypersympathicotonic IVT decreased (p < 0,05). Asympathicotonia vegetative reactivity (AST VR) in premature infants with IUGR was increased from 38, to 72,7% to 3 months (p < 0,05). Conclusion. The study revealed the lack of influence of the Central contour vegetative regulation, more intense adaptation and high exhaustion of the functional reserve in preterm infants with IUGR to 3 months of life.

Imbalance in the system L-arginin-NO in pathogenesis of obstetric complications and intrauterine growth retardation (Literature review)

2016 ◽  
pp. 43-47
Author(s):  
O.V. Basystyi ◽  
Keyword(s):  
Nitric Oxide ◽  
Literature Review ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Obstetric Complications ◽  
Pathogenetic Role ◽  
Intrauterine Growth ◽  
System L ◽  
Nitric Oxide Deficiency

The data of domestic and foreign literature on etiology, pathogenesis and intrauterine growth retardation diagnosis are presented in the paper. It highlights pathogenetic role of nitric oxide deficiency in case of obstetric complications and intrauterine growth retardation. Key words: intrauterine growth retardation (IUGR), system L-arginin–NO, obstetric complications.

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