scholarly journals Clinico-laboratory efficacy of the drug Viferon® in viral lesions of the gastroin-testinal tract in children

2018 ◽  
Vol 9 (3) ◽  
pp. 41-48 ◽  
Author(s):  
Vladimir N. Timchenko ◽  
Maria D. Subbotina ◽  
Tatyana A. Kaplina ◽  
Oksana V. Bulina ◽  
Vera F. Sukhovetskaya ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Clinical Course ◽  
Severe Form ◽  
Rotavirus Infection ◽  
Viral Diarrhea ◽  
Intestinal Infections ◽  
Urgent Task ◽  
Polymerase Chain ◽  
Rectal Suppositories ◽  
Children Under 5

In recent years, viral lesions of the gastrointestinal tract take the leading place in the etiological structure of acute intestinal infections. The study of the clinical course and treatment of viral diarrhea in children is an urgent task in modern conditions. We analyzed the disease of 2568 children aged 1 month to 17 years who were hospitalized in a Hospital No 3 in St. Petersburg in the period of 2016-2017. All patients underwent a standard laboratory examination. The etiological interpretation was carried out with the help of polymerase chain reaction, bacteriological and serological methods of investigation. Of the 2568 children in 1502 (58.5%) patients, the diagnosis was confirmed. The share of bacterial diarrhea was 31.8%, viral lesions of the gastrointestinal tract – 68.2%. Among the decoded viral lesions of the gastrointestinal tract, the share of rotavirus infection was 52.8%, norovirus infection – 24.8%, mixed infection – 19.6%. A high proportion of viral lesions of the gastrointestinal tract was established in children under 3 years of age (71.7%). The main reason for hospitalization of children under 5 years of age is rotavirus infection, from 5 to 12 years – norovirus infection. Almost always (87.6%), viral diarrhea proceeded in a moderate form. In infants, mixed viral infection was recorded in severe form. The use of Viferon® in the form of rectal suppositories to supplement the basic therapy of viral intestinal infections significantly reduces the duration of intoxication syndrome, fever, diarrhea, catarrhal syndrome, the duration elimination of viruses, and the length of stay in the hospital.

scholarly journals Clinical characteristics and cellular immunity in children with rotavirus infection

2021 ◽  
Vol 66 (5) ◽  
pp. 75-81
Author(s):  
S. G. Gorbunov ◽  
L. N. Mazankova ◽  
A. N. Oskin ◽  
S. A. Lugovskaya ◽  
E. V. Naumova ◽  
...  
Keyword(s):  
Young Children ◽  
Cellular Immunity ◽  
Immune Status ◽  
Clinical Course ◽  
Watery Diarrhea ◽  
Rotavirus Infection ◽  
Clinical Methods ◽  
Simultaneous Activation ◽  
Polymerase Chain ◽  
Adaptive Nature

Objective. To determine clinical course and state of cellular immunity in young children with rotavirus infection.Children characteristics and research methods. The scientists examined children without infectious pathology and with rotavirus infection (20 patients in each group) using general clinical methods. Rotavirus infection was diagnosed by polymerase chain reaction and immunochromatography. Cellular immunity parameters were determined by flow cytometry.Results. All the children under observation had a moderate form of the disease with symptoms of exsicosis of the II degree. Changes in the immune status were mainly of a regulatory, adaptive nature, which contributed to the favorable course of rotavirus infection in children, however, the dynamics of the number of cells expressing Toll-like receptors indicates the immunosuppressive properties of rotavirus.Conclusion. Currently, rotavirus infection in young children is typical with watery diarrhea as the most pronounced and long-lasting clinical symptom. Shifts in immunogram indices in general indicate a deficiency of the cellular link of immunity and a violation of its regulation with simultaneous activation of the immune system in an effort to achieve the eradication of the rotavirus with immunosuppressive properties.

scholarly journals СОВРЕМЕННЫЕ МЕТОДЫ ДИАГНОСТИКИ И ЛЕЧЕНИЯ РОТАВИРУСНЫХ КИШЕЧНЫХ ЗАБОЛЕВАНИЙ

Innova ◽  
2019 ◽  
Vol 15 ◽  
pp. 6-13
Author(s):  
Ёдгорова Н.Т. ◽  
◽  
Халилов З.С. ◽  
Жумамуродов С.Т.
Keyword(s):  
Polymerase Chain Reaction ◽  
Enzyme Immunoassay ◽  
Chain Reaction ◽  
Treatment Methods ◽  
Rotavirus Infection ◽  
Intestinal Infections ◽  
Polymerase Chain

This article provides an analysis of data on modern diagnostics, treatment methods and the value of rotoviruses in acute intestinal infections. According to modern data, rotavirus infection accounts for 20-60% of acute intestinal infections. Determination of rotaviruses in feces extract by enzyme immunoassay and polymerase chain reaction, are widely used today.

scholarly journals Rotavirus infection. the possibilities of timely vaccination

2018 ◽  
pp. 215-219
Author(s):  
O. A. Rychkova ◽  
М. A. Grakhova ◽  
A. S. Sagitova ◽  
L. A. Kozhevnikova ◽  
O. V. Starostina ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
High Resistance ◽  
International Market ◽  
Etiologic Factor ◽  
Rotavirus Infection ◽  
Rotavirus Gastroenteritis ◽  
Rotavirus Vaccines ◽  
Pentavalent Vaccine ◽  
Intestinal Infections ◽  
Children Under 5

The incidence of acute intestinal infections in Russia is ranked 3rd 4th among all infectious diseases, and rotavirus is the most frequent etiologic factor in children under 5 years old. Almost 40% of children under the age of two have three episodes of rotavirus infection, the same group undergo the most severe course of the disease. Rotavirus gastroenteritis causes 197,000 annual deaths, 23 children die due to this infection every hour. The high resistance of rotavirus in the environment, the ease of transmission and the large number of asymptomatic carriers predetermine the need for timely vaccination. There are 2 licensed oral live attenuated rotavirus vaccines on the international market, one of which is RotaTeq pentavalent vaccine.

scholarly journals СОВРЕМЕННЫЕ МЕТОДЫ ДИАГНОСТИКИ И ЛЕЧЕНИЯ РОТАВИРУСНЫХ КИШЕЧНЫХ ЗАБОЛЕВАНИЙ

Innova ◽  
2019 ◽  
Vol 15 ◽  
pp. 6-13
Author(s):  
Ёдгорова Н.Т. ◽  
◽  
Халилов З.С. ◽  
Жумамуродов С.Т.
Keyword(s):  
Polymerase Chain Reaction ◽  
Enzyme Immunoassay ◽  
Chain Reaction ◽  
Treatment Methods ◽  
Rotavirus Infection ◽  
Intestinal Infections ◽  
Polymerase Chain

This article provides an analysis of data on modern diagnostics, treatment methods and the value of rotoviruses in acute intestinal infections. According to modern data, rotavirus infection accounts for 20-60% of acute intestinal infections. Determination of rotaviruses in feces extract by enzyme immunoassay and polymerase chain reaction, are widely used today.

scholarly journals THE BURDEN OF ROTAVIRUS GASTROENTERITIS, AS THE RATIONALE FOR ROUTINE VACCINATION

2017 ◽  
pp. 73-78 ◽  
Author(s):  
S M. KHARIT ◽  
M. K. BEKHTEREVA ◽  
J. V. LOBZIN ◽  
A. V. RUDAKOVA ◽  
A. T. PODKOLZIN ◽  
...  
Keyword(s):  
Acute Gastroenteritis ◽  
Comparison Group ◽  
Clinical Manifestations ◽  
Routine Vaccination ◽  
Rotavirus Infection ◽  
Rotavirus Gastroenteritis ◽  
Intestinal Infections ◽  
Severity Of The Disease ◽  
First Year Of Life ◽  
Children Under 5

Rotavirus infection is the second after pneumococcal cause in the incidence of diseases and mortality in children under 5 years. That has defined the who’s recommendation for the introduction of vaccination against rotavirus infection in the vaccination schedules of all countries of the world. In our country that vaccination recommended for epidemic indications for introduction into the regional program. However, vaccination is carried out only in certain regions. One of the reasons for low uptake of this vaccine is the underestimation of the burden of disease.The aim the study. To assess the significance of rotavirus gastroenteritis in the structure of acute gastroenteritis in children under 5 years receiving treatment in outpatient clinics, to study the genetic diversity of rotaviruses, to compare the costs associated with the treatment of acute rotavirus and non-rotavirus gastroenteritis.Methods. Prospective, observational, epidemiological study. The inclusion of participants under the age of 5 years with the symptoms of acute gastroenteritis who meet the criteria of inclusion/exclusion. Examination, medical history, samples of faeces were carried out in the first day of treatment (day of inclusion in the study). Parents were given a questionnaire for 14 days. The severity of the disease was determined according to the scale of Vesicare, the disease dynamics was assessed by the answers of the questionnaire. Examination of feces samples was carried out centrally by PCR. Rotavirus positive samples were genotypically PCR and in case of detection of rare genotypes have been sequenced genomic RNA.Results. The study included 501 baby — boys — 286 (57,1%), girls — 215 (42,9%). The average age was 22.6 ± 15.2 months. 50 children (10.0 per cent) mentioned various background pathology, the others were deemed healthy. Rotavirus was diagnosed in 151 patients 31.4% (95% CI: 26.9 percent - 35.3 percent), which accounted 66,52% (151 of 227) among all cases with confirmed etiology. Genotyping was prevalent G1P [8] to 34.5%, and G4P[8] — 39,2%. Clinical manifestations in rotavirus gastroenteritis was more severe, severe course observed in 65.5% of cases in the comparison group -at 30.4%. Significantly more often than in the comparison group (Р χ2 < 0,001) was observed vomiting (140cases из151 — 93,3%, compared to 239 of 336 -71,1%) and elevated temperature (146 of 151 — 97,3% compared with 254 of 336 — 75,6%). The average temperature was 38,5 ± 0,6 OS in the comparison group — 38,0 ± 2,2 OS, remained 3,1 ± 1,4 and 2.5 ± 1.2 day, respectively. The frequency of episodes of diarrhoea in the first day of illness was 6.4 ± 2.7 times, in comparison with 5.2 ± 2.8, duration of diarrhea was 6.3 ± 3.2 days and 4.5 ± 2.6 days. The costs for parents of patients with acute rotavirus gastroenteritis was (M ± SD) 2873.4 ± 2276.4 rubles, against 2007.4 ± 2150.4 rubles in the comparison group (t = 3.965; p= < 0,001, as amended by Starlite for inequality of variances).Conclusion. The introduction of routine vaccination of children in the first year of life will reduce by more than a third of the number of appeals to medical institutions about intestinal infections and partially prevent the costs associated with the treatment of this pathology.

scholarly journals Gastrointestinal Tract Disorders in COVID-19 Infected Children

2020 ◽  
pp. 154-157
Author(s):  
R. V. Popova ◽  
T. A. Ruzhentsova ◽  
D. A. Khavkina ◽  
P. V. Chukhlyaev ◽  
A. A. Garbuzov ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Medical Records ◽  
Clinical Status ◽  
Pharmaceutical Products ◽  
Community Acquired Pneumonia ◽  
Infectious Disease Department ◽  
Intestinal Infections ◽  
Polymerase Chain ◽  
Age Range ◽  
Additional Therapy

Objective of the work was to investigate the peculiarities of gastrointestinal tract disorders in children with coronavirus disease caused by SARS-CoV-2 virus.Materials and methods. We have analyzed the frequency, terms of emergence, duration and character of gastrointestinal disorders on the basis of medical records of 36 children receiving the treatment for community-acquired pneumonia of coronavirus etiology (positive for SARS-CoV-2 virus) in the children’s infectious disease department of Moscow State Clinical Hospital, Mytishchi. The majority of patients had moderate form of the disease (97 %), severe cases were not registered. The age range of the children – 8 months to17 years old. All patients were subjected to supplementary examination on Day 1 in accordance with the current recommendations. Children were treated in hospital settings for 8–15 days. Assessment of clinical status was performed at least once a day over the stated period, supplementary survey – at least once in a week, upon indications – more frequently. SARSCoV-2 virus was identified using polymerase chain reaction. All patients received standard therapy in compliance with advanced methodological recommendations, upon indications – other pharmaceutical products.Results and discussion. Gastro-intestinal disorders in 23 children (64 %) emerged on Day 4–5, in 8 children (22 %) – before the start of the treatment; they lasted 3–5 days. In most of the patients diarrhea (64 %) and stomachaches (57 %) were observed. 67 % of the children demonstrated other symptoms indicative of gastrointestinal dysfunction. The disorders were characteristic for most of the children hospitalized with community-acquired pneumonia caused by SARS-CoV-2 virus. The symptoms are contained when the main course of therapy is conducted, indicated for treatment of COVID-19, and additional therapy recommended for management of gastro-intestinal infections is performed. 

Updates in the Prevalence of Rotavirus Gastroenteritis in Babylon City

2018 ◽  
pp. 1-12
Keyword(s):  
Health Care Providers ◽  
Rural Areas ◽  
Causative Organism ◽  
Care Providers ◽  
Sample Collection ◽  
Rotavirus Infection ◽  
Rotavirus Gastroenteritis ◽  
Age Range ◽  
Latex Test ◽  
Children Under 5

Background: Diarrhea is a main cause of morbidity and mortality in children under 5 years old. Globally it is responsible for approximately four billion cases and three million deaths annually. In developing countries, it causes two million deaths each year. The major causative organism is rotavirus which is responsible for one-third of hospitalizations with approximately 40% mortality. Objectives: To determine the prevalence and demographic characteristics of rotavirus infection in Babylon city, Iraq. Materials and Methods: Fecal samples were taken from children with age range of 6 months to 5 years complained of diarrhea during the period beginning in October 2016 till August 2017. The age, gender, residence, the type of feeding, place of the sample collection and duration of diarrhea were recorded. Specimens were analyzed by Latex test for detection of rotavirus. Results: A total of 349 children presented with diarrhea, the rotavirus antigen was detected in 169 fecal specimens from children with diarrhea (48%). More percentages of positive rotavirus specimens were seen in the 5year of age. No gender differences were observed, meanwhile samples obtained from rural areas and breastfed children showed less rotavirus positive infection. Conclusion: The present study confirms that rotavirus infection is still currently a prevalent gastroenteritis causative agent and required careful clinical attention. Pediatricians and health care providers are needed to be encouraged to take into account the children who at risk for developing rotavirus infection including age, residence and type of feeding.

Updates in the Prevalence of Rotavirus Gastroenteritis in Babylon City

2018 ◽  
pp. 1-12
Keyword(s):  
Health Care Providers ◽  
Rural Areas ◽  
Causative Organism ◽  
Care Providers ◽  
Sample Collection ◽  
Rotavirus Infection ◽  
Rotavirus Gastroenteritis ◽  
Age Range ◽  
Latex Test ◽  
Children Under 5

Background: Diarrhea is a main cause of morbidity and mortality in children under 5 years old. Globally it is responsible for approximately four billion cases and three million deaths annually. In developing countries, it causes two million deaths each year. The major causative organism is rotavirus which is responsible for one-third of hospitalizations with approximately 40% mortality. Objectives: To determine the prevalence and demographic characteristics of rotavirus infection in Babylon city, Iraq. Materials and Methods: Fecal samples were taken from children with age range of 6 months to 5 years complained of diarrhea during the period beginning in October 2016 till August 2017. The age, gender, residence, the type of feeding, place of the sample collection and duration of diarrhea were recorded. Specimens were analyzed by Latex test for detection of rotavirus. Results: A total of 349 children presented with diarrhea, the rotavirus antigen was detected in 169 fecal specimens from children with diarrhea (48%). More percentages of positive rotavirus specimens were seen in the 5year of age. No gender differences were observed, meanwhile samples obtained from rural areas and breastfed children showed less rotavirus positive infection. Conclusion: The present study confirms that rotavirus infection is still currently a prevalent gastroenteritis causative agent and required careful clinical attention. Pediatricians and health care providers are needed to be encouraged to take into account the children who at risk for developing rotavirus infection including age, residence and type of feeding.

Serum immunoglobulins for acute intestinal infections in young children

1982 ◽  
Vol 63 (6) ◽  
pp. 57-58
Author(s):  
N. A. Romanova ◽  
R. M. Khasanova
Keyword(s):  
Young Children ◽  
Severe Form ◽  
Mild Form ◽  
Serum Immunoglobulins ◽  
Intestinal Infections

The aim of the work was to study the dynamics of serum immunoglobulins in children of the first three years of life, patients with salmonellosis, coli infection and dysentery. Of 129 children, 58 had salmonellosis typhimurium, 39 had coli infection caused by Escherichia of the 1st category, 32 had dysentery Sonne. Among patients with salmonellosis, 7 had a mild form, 44 had a moderate form, and 7 had a severe form. 16, among the most severe - in 19, severe - in 4 children. With dysentery, a mild form was observed in 13 children, a moderate form in 19. Children from 6 months to 1 year old were 69, from a year to 3 years old - 60.

scholarly journals A study of rotavirus infection in acute diarrhoea in children less than 5 years of age

2021 ◽  
Vol 8 (4) ◽  
pp. 321-326
Author(s):  
Pramod N Sambrani ◽  
Pooja Mansabdar ◽  
Mahesh Kumar S
Keyword(s):  
Acute Diarrhoea ◽  
High Sensitivity ◽  
Childhood Mortality ◽  
Major Morbidity ◽  
Rotavirus Infection ◽  
Stool Samples ◽  
Diarrhoeal Diseases ◽  
Rotavirus Diarrhea ◽  
A Prospective Study ◽  
Children Under 5

: Diarrhoeal diseases account for an estimated 1.5 million deaths globally every year making it the second leading cause of childhood mortality. In India 1 out of every 250 children die of rotavirus diarrhea each year.: To find out the incidence of rotavirus infection in acute diarrhoeal cases in children under 5 years of age.: A prospective study was conducted on 100 non repetetive stool samples of Children under 5 years of age, presenting with acute diarrhea and hospitalized in the pediatric ward, during December 2015 to November 2016. Stool samples were processed according to premier rotaclone enzyme immunoassay protocol for the detection of rotavirus antigen, adhering to standard laboratory precautions.: The incidence of acute diarrhoeal diseases was 5.86% in our setting. was detected in 29% cases by ELISA method.The antigen detection by EIA is a reliable test, as it is quantitative and also has high sensitivity and specificity. Hence, can be routinely employed to prevent major morbidity and mortality among children, especially less than 5 years of age.

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