A wide range of pharmacological properties of melatonin

2021 ◽  
Vol 19 (1) ◽  
pp. 103-106
Author(s):  
Eduard B. Arushanian ◽  
Stanislav S. Naumov
Keyword(s):  
Pineal Gland ◽  
Pharmacological Activity ◽  
Experimental Work ◽  
Pharmacological Properties ◽  
Wide Range ◽  
Anti Inflammatory

The pineal gland hormone melatonin has various pharmacological activity. In experimental work, he revealed anti-anxiety, antidepressant, neuroprotective, anti-pain and anti-inflammatory properties.

Pharmacologically potentials of different substituted coumarin derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Benzene Ring ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Pharmacological Properties ◽  
Coumarin Derivatives ◽  
Wide Range ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

A Brief Review on the Development of Novel Potentially Active Azetidin-2-ones Against Cancer

2020 ◽  
Vol 24 (5) ◽  
pp. 473-486 ◽  
Author(s):  
Ligia S. da Silveira Pinto ◽  
Thatyana R. Alves Vasconcelos ◽  
Claudia Regina B. Gomes ◽  
Marcus Vinícius N. de Souza
Keyword(s):  
Side Effects ◽  
Anticancer Agents ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Present Review ◽  
Pharmacological Properties ◽  
Important Group ◽  
Wide Range ◽  
Anti Inflammatory

Azetidin-2-ones (β-lactams) and its derivatives are an important group of heterocyclic compounds that exhibit a wide range of pharmacological properties such as antibacterial, anticancer, anti-diabetic, anti-inflammatory and anticonvulsant. Efforts have been made over the years to develop novel congeners with superior biological activities and minimal potential for undesirable side effects. The present review aimed to highlight some recent discoveries (2013-2019) on the development of novel azetidin-2-one-based compounds as potential anticancer agents.

Phytochemicals of Gentianaceae: A Review of Pharmacological Properties

1970 ◽  
Vol 1 (1) ◽  
pp. 33-36 ◽  
Author(s):  
Amritpal Singh
Keyword(s):  
Pharmacological Activity ◽  
Review Paper ◽  
Therapeutic Agents ◽  
Pharmacological Properties ◽  
Topoisomerase Inhibition ◽  
The Family ◽  
Secoiridoid Glycosides ◽  
Anti Inflammatory

Aim of the review paper is to give an enlightenment on potential phyto-constituents of Gentianaceae.  Bitter principles (secoiridoid glycosides) and xanthones are widely distributed among plants belonging to the family Gentianaceae. Phytochemicals like amarogentin, bellidifolin, gentianine and swerchirin have been reported to possess significant anti-inflammatory, analgesic, anti-asthmatic, anticonvulsant, antihistaminic, antimalarial, antiamoebic, cytoprotective, diuretic, hepatoprotective and hypoglycemic properties. Topoisomerase inhibition is significant pharmacological activity reported from amarogentin. Further investigations exploring possible use of these phytochemicals as therapeutic agents are warranted. The articles reviews certain pharmacological investigations carried out on phytochemicals reported from Gentianaceae

Research Progress on the Identification and Pharmacological Activity of the Active Components of the Rhododendron Species

2021 ◽  
Vol 18 (3) ◽  
pp. 543-565
Author(s):  
Myong- Hun Han ◽  
Kwang Yong Kim
Keyword(s):  
Traditional Medicine ◽  
Pharmacological Activity ◽  
Present Review ◽  
Research Progress ◽  
Pharmacological Properties ◽  
Medicine Use ◽  
Active Components ◽  
Wide Range ◽  
History Of ◽  
Phytochemical Compounds

Rhododendron is one of the plants with the broadest spectrum species, the most extended history of traditional medicine use, and the wide range of pharmacological properties. In 2013, a report was published to summarize the studies reported from 1898 to 2012. Many phytochemical compounds and their various treatment effects of over 40 Rhododendron species were mentioned in the present review. This review aims to evaluate the newly discovered and observed phytochemical compounds in recent years and their activities in some Rhododendron species.

Progress in Synthesis and Bioactivity Evaluation of Pyrazoloquinazolines

2020 ◽  
Vol 17 (2) ◽  
pp. 104-113
Author(s):  
Hui Zhao ◽  
Xiaoxia Hu ◽  
Yue Zhang ◽  
Chunlei Tang ◽  
Bainian Feng
Keyword(s):  
Present Article ◽  
Research Progress ◽  
Synthesis Methods ◽  
Pharmacological Properties ◽  
Recent Advances ◽  
Wide Range ◽  
Significant Interest ◽  
Antiviral Activities ◽  
Anti Inflammatory ◽  
Derivatives Of

Background: This paper reviews the research progress of pyrazoloquinazolines which widely used in the field of medicine and pesticide in recent years. Five types of pyrazoloquinazolines are introduced: pyrazolo [4,3-h]quinazolines, pyrazolo[1,5-c]quinazolines, pyrazolo[4,3-f]quinazolines, pyrazolo[1,5-a] quinazolines , pyrazolo[1,5-b]quinazolines, and their new progress in the synthesis methods and treatment of diseases. Methodology: The derivatives of pyrazoloquinazolines exhibit a wide range of pharmacological properties such as antibacterial, anticancer, antioxidants, anti-inflammatory, anti-diabetic, antiviral activities. Consequently, their syntheses have attracted significant interest. Various methodologies have been developed for the synthesis and functionalization of these class of compounds. Conclusion: In the present article, the relevant and recent advances in the field will be briefly covered.

scholarly journals Review on Natural Coumarin Lead Compounds for Their Pharmacological Activity

2013 ◽  
Vol 2013 ◽  
pp. 1-14 ◽  
Author(s):  
K. N. Venugopala ◽  
V. Rashmi ◽  
B. Odhav
Keyword(s):  
Natural Product ◽  
Pharmacological Activity ◽  
Dietary Exposure ◽  
Herbal Remedies ◽  
Pharmacological Properties ◽  
Lead Compounds ◽  
Natural Coumarin ◽  
Low Toxicity ◽  
Anti Inflammatory

Coumarin (2H-1-benzopyran-2-one) is a plant-derived natural product known for its pharmacological properties such as anti-inflammatory, anticoagulant, antibacterial, antifungal, antiviral, anticancer, antihypertensive, antitubercular, anticonvulsant, antiadipogenic, antihyperglycemic, antioxidant, and neuroprotective properties. Dietary exposure to benzopyrones is significant as these compounds are found in vegetables, fruits, seeds, nuts, coffee, tea, and wine. In view of the established low toxicity, relative cheapness, presence in the diet, and occurrence in various herbal remedies of coumarins, it appears prudent to evaluate their properties and applications further.

scholarly journals A Review on Synthesis and Biological Activity of Thiazole and its Derivatives

2021 ◽  
Vol 70 (1) ◽  
Author(s):  
Namitha TH ◽  
Saranya S Nair ◽  
Dr.Arun Kumar ◽  
Dr.Vinod B ◽  
Dr.Daisy P A
Keyword(s):  
Biological Activity ◽  
Pharmacological Activity ◽  
Biological Activities ◽  
Synthetic Compounds ◽  
The Past ◽  
Current Review ◽  
Heteroaromatic Ring ◽  
Wide Range ◽  
Anti Inflammatory

Thiazole, a five-membered heteroaromatic ring, is an important framework of a large number of synthetic compounds. Its diverse pharmacological activity is mirrored in many clinically approved thiazole-containing molecules with, wide range of biological activities, such as antibacterial, antifungal, antiviral, anthelmintic, antitumor, and anti-inflammatory effects. The current review provides an overview of the biological activities of thiazole during the past years.

scholarly journals A Succinct Exploration on Bilwa (Aegle marmelos) Plant – A Literature Review

2021 ◽  
pp. 1-5
Author(s):  
R. Sai Nath Pillai ◽  
R. Manu ◽  
T. S. Remesh Chandran
Keyword(s):  
Literature Review ◽  
Gastric Ulcers ◽  
Pharmacological Properties ◽  
Aegle Marmelos ◽  
Wide Range ◽  
Medicinal Properties ◽  
Anti Inflammatory ◽  
Prehistoric Time

Aegle marmelos (L) Correa (family: Rutaceae) is used to treat a wide range of ailments. This plant has been around since prehistoric time. As it produces a number of alkaloids, all aspects of the plant, including fruits, leaves, bark, stem, and root, are used to treat variety of diseases. Antidiarrheal, antidysenteric, antipyretic, and anti-inflammatory properties are some of the most important medicinal properties of Bilwa. Fruit-derived compounds have been shown to have biological promise in the treatment of diseases such as diabetes, gastric ulcers, and hyperlipidaemia. Many experiments have been conducted on its medical properties and uses which demonstrate its importance in today's environment. The anatomy, distribution, dietary action, Ayurveda applications, and pharmacological properties of this plant is outlined in this review manuscript.

Puerarin: A Review on the Pharmacological Activity, Chemical Properties and Pharmacokinetics of Main Isoflavonoid

2020 ◽  
Vol 10 ◽  
Author(s):  
Oluwafemi Adeleke Ojo ◽  
Adebola Busola Ojo ◽  
Charles Obiora Nwonuma ◽  
Oluwakemi Josephine Awakan ◽  
Rotdelmwa Filibus Maimako ◽  
...  
Keyword(s):  
Chemical Properties ◽  
Developed Countries ◽  
The Body ◽  
Neuroprotective Activity ◽  
Pharmacological Properties ◽  
Toxic Side Effect ◽  
Alternative Medicines ◽  
Biotransformation Process ◽  
Wide Range ◽  
Anti Inflammatory

: Conventional drugs as a means of alternative medicines have been in use in Asian and African nations and some developed countries for the treatment of ailment and curing of diseases. Objective: Puerarin a naturally occurring isoflavone in numerous plants is one of the conventional medications that possess anti-inflammatory and immunoregulatory properties for the treatment of cardiac illnesses, osteonecrosis, Parkinson’s ailments, Alzheimer’s disorders, and other circulatory and cardiac conditions. Puerarin is extensively distributed in numerous organs comprising the kidney, mammary gland, femur, tibia, stomach, liver, pancreas, brain, and lungs but at a low rate because of its poor availability. However, when co-administered with compounds like gastrodin that can covey it into the cell, it shows a wide range of pharmacological properties including antioxidant, antidiabetic, antimicrobial, antiviral, anti-inflammatory, anticancer, anti-Alzheimer, hepatoprotective, and neuroprotective activity. The biotransformation process of puerarin showed that is well metabolized with daidzein being the main hydrolyzed product. Puerarin is well tolerated in the body and dosage of up to 250 mg/kg per day does not initiate any toxic side effect but rather sows a wide range of its beneficial and pharmacological properties.

scholarly journals Potential and Possible Therapeutic Effects of Melatonin on SARS-CoV-2 Infection

Antioxidants ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 140
Author(s):  
Evgeny Shchetinin ◽  
Vladimir Baturin ◽  
Eduard Arushanyan ◽  
Albert Bolatchiev ◽  
Dmitriy Bobryshev
Keyword(s):  
Mechanisms Of Action ◽  
Therapeutic Use ◽  
Therapeutic Effects ◽  
Pharmacological Properties ◽  
Pharmacological Interventions ◽  
Clinical Observations ◽  
Wide Range ◽  
Prevention And Treatment ◽  
Anti Inflammatory ◽  
Effective Drugs

The absence of effective drugs for COVID-19 prevention and treatment requires the search for new candidates among approved medicines. Fundamental studies and clinical observations allow us to approach an understanding of the mechanisms of damage and protection from exposure to SARS-CoV-2, to identify possible points of application for pharmacological interventions. In this review we presented studies on the anti-inflammatory, antioxidant, and immunotropic properties of melatonin. We have attempted to present scientifically proven mechanisms of action for the potential therapeutic use of melatonin during SARS-CoV-2 infection. A wide range of pharmacological properties allows its inclusion as an effective addition to the methods of prevention and treatment of COVID-19.

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