scholarly journals Features of the clinical course of a new coronavirus infection in students who were observed in the observator in the first and second wave of morbidity increasing

2021 ◽  
Vol 25 (1) ◽  
pp. 27-33
Author(s):  
Olga Yu. Kuznetsova ◽  
Anna V. Lubimova ◽  
Karina V. Ovakimyan ◽  
Olga I. Frolova ◽  
Olga S. Zamyatina ◽  
...  
Keyword(s):  
Primary Care Physicians ◽  
Clinical Course ◽  
Nasal Congestion ◽  
Clinical Manifestations ◽  
The North ◽  
Treatment And Prevention ◽  
General Weakness ◽  
Coronavirus Infection ◽  
Two Stages ◽  
Second Wave

INTRODUCTION: The sudden appearance of a new coronavirus infection in the world has posed difficult challenges for science to determine the main clinical manifestations of this disease, as well as to approve standards for diagnosis, treatment and prevention. Research of the symptoms of mild COVID-19 is continuing. The data obtained in such studies are particularly relevant for primary care physicians. THE AIM: To evaluate the features of the clinical course of COVID-19 among students of the North-Western State Medical University named after I.I. Mechnikov, placed in the observatory, during the first and second waves of rising morbidity. MATERIALS AND METHODS: The study was conducted on the basis of the observatory of the NWSMU named after I.I. Mechnikov in two stages: in the period from 21.04.2020 to 31.08.2020 (the first wave) and from 16.09.2020 to 31.12.2020 (the second wave). Demographic, epidemiological, and clinical-anamnestic data were recorded in all participants of the study. RESULTS: The study involved 309 people: 39.8% men (n = 123) and 58.9% women (n = 182). The average age of the respondents was 21.5 2.6 years. The number of participants in the first and second waves was 113 and 196 people, respectively. The average age of participants with COVID-19 in the first wave was 1.5 years less and was 21.2 2.5 years (р 0.001). There was a significant increase in the frequency of the following symptoms: dry cough, loss of smell, headache, general weakness, increased body temperature to 38.0 С, nasal congestion (р 0.05) in students who were monitored in the second wave of increased incidence of COVID-19 compared to the first. The frequency of symptoms such as chest congestion, lower back pain, and fever above 38.0 С significantly decreased (р 0.05). There was a significant decrease in the incidence of viral pneumonia in patients who were observed during the second wave, compared with the data obtained during the first wave (р 0.001).

scholarly journals Clinical case of SARS-CoV-2-associated multisystem inflammatory syndrome

2021 ◽  
pp. 51-54
Author(s):  
Ye.Ye. Pohorila ◽  
Keyword(s):  
Clinical Course ◽  
Clinical Manifestations ◽  
Ethics Committee ◽  
Probable Case ◽  
General Weakness ◽  
Symptom Complex ◽  
Coronavirus Infection ◽  
Helsinki Declaration ◽  
Course Features ◽  
Inflammatory Syndrome

The clinical course, features of diagnostic examinations and difficulties in verification of the new nosology of multisystem inflammatory syndrome associated with SARS-CoV-2 in 15-year-old girls are described. The girl was taken to the Kyiv Regional Children's Hospital No. 2 with complaints of fever, intoxication syndrome, general weakness, dizziness, vertigo, lack of urine during the day. The child was examined by a consilium of doctors, examined in the laboratory and instrumentally, after a carefully collected epidemiological history revealed possible contact with a patient with coronavirus infection at the place of study and identified a probable case of multisystem inflammatory syndrome associated with SARS-CoV-2. According to the results of our own observations during the pandemic, this nosology was found in patients who relapsed into coronavirus infection in clinical or subclinical form and for the period of hospitalization had a clinical symptom complex of Kawasaki with similar symptoms. This disease is new today, has a variety of clinical manifestations and pathological features that are a problem for clinicians. After all, at present there are no unified protocols for the diagnosis and treatment of MIS-C (multisystem inflammatory syndrome) and each doctor relies on their own experience and previously described cases. This case of multisystem inflammatory syndrome will help practicing clinicians in the early stages to diagnose the disease and provide qualified care to patients. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local ethics committee of all participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the author. Key words: multisystem used for setting fire syndrome, 15-year-old girl, kawasaky-like symptoms, SARS-CoV-2, intravenous immunoprotein, acetophene, glucocorticosteroids.

scholarly journals Peculiarities of clinical manifestations of the new COVID-19 coronavirus infection in patients hospitalized during the epidemic depending on their age

2021 ◽  
Vol 17 (7) ◽  
pp. 32-36
Author(s):  
V.I. Trykhlib ◽  
N.R. Tsiurak ◽  
K.P. Beliaeva ◽  
T.I. Lysenko ◽  
A.O. Yeroshenko ◽  
...  
Keyword(s):  
Chest Pain ◽  
Age Groups ◽  
Young Patients ◽  
Clinical Manifestations ◽  
Productive Cough ◽  
Thoracic Pain ◽  
Average Temperature ◽  
General Weakness ◽  
Significant Difference ◽  
Coronavirus Infection

This article presents a review of the literature and data from a personal study concerning the clinical manifestations of new coronavirus infection in patients hospitalized during the COVID-19 epidemic depending on their age. It was found that most patients complained about dry or low-productive cough, moderate general weakness. The patients aged 18–30 years old more frequently experienced no cough. The patients aged 31–40 years old significantly more frequently complained about dry cough (p < 0.05). Low-productive cough was less frequent but typical in all age groups and more frequent in patients aged 51–60 years. Moist cough was more frequent in patients over 60 years. Chest pain was registered in patients over 60 years (p < 0.05). The frequency of dyspnea was found to increase with age. More often dyspnea was registered in patients older than 60 years old. No dyspnea was noted in young patients aged 18–30 years. Half of the patients aged 18–30 years had no fever. At hospitalization, the average temperature was within normal or subfebrile, which predominated in patients aged 41–50 years (p < 0.05). The frequency of febrile fever increased in patients with age. There was no significant difference in the frequency of pyretic temperature among all age groups. The patients aged over 30 years complained more about moderate weakness, and patients aged over 40 years complained more about severe weakness. Younger patients more often complained about a sore throat, while older patients had practically no symptoms (p > 0.05). Thoracic pain was significantly more frequently registered in patients older than 60 years old. Young patients aged 18–30 years and 31–40 years had no chest pain.

scholarly journals Features of clinical manifestations of new coronavirus infection in patients at hospitalization during the COVID-19 epidemic depending on the severity

2021 ◽  
Vol 17 (8) ◽  
pp. 73-80
Author(s):  
V.I. Trykhlib ◽  
N.R. Tsiurak ◽  
K.P. Beliaeva ◽  
T.I. Lysenko ◽  
A.O. Yeroshenko ◽  
...  
Keyword(s):  
Respiratory Rate ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Clinical Manifestations ◽  
Normal Range ◽  
Average Temperature ◽  
General Weakness ◽  
Number Of Patients ◽  
Significant Difference ◽  
Coronavirus Infection

The article presents a review of the literature sources and results of a personal study. It was found that in our group, there were more persons aged 18–30 years among those who were in inpatient treatment, and among those who were treated in the ICU, the patients were aged 60 years or over. On average, patients who were treated in the ICU were admitted on the 6th day of illness. Most patients complained of dry or unproductive cough, moderate general weakness. Relatively more often moderate general weakness was registered in patients with a moderate course, and moderate and pronounced was typical for patients with a severe course (p < 0.05). Dyspnea was predominantly found in severely ill patients (in one-third of patients during exercise, in 17.7 % patients at rest). In patients with a non-serious course, a small number of patients had dyspnea on exertion (4.3 to 12.1 %). On admission, the average temperature was within normal or subfebrile, which predominated in patients with a moderate course (p < 0.05). With a mild course, half of the patients had a temperature within the normal range. Febrile fever was more often registered in the moderate and severe course. Pyretic body temperature was most typical for a severe course (p < 0.05). It is noteworthy that even in those patients who were treated in the intensive care unit, at admission a quarter of the patients had a normal temperature, and 41.2 % — subfebrile. On ave-rage, the duration of fever before admission in critically ill patients was 5 days, and in those who died — 2 days. Dry cough was significantly more common in severe patients (p < 0.05). In the mild course, only one-fifth of patients complained of dry or unproductive cough. In the moderate course, the dry or unproductive cough was symptomatic for one-third of patients. There was no significant difference in the frequency of complaints of sore throat (p > 0.05). On average, a respiratory rate on admission in critically ill patients did not differ between those who survived and those who died, while those who died more often presented with a respiratory rate of 30/min or more, tachycardia, and more reduced saturation values.

scholarly journals Conservative treatment of the longitudinal flatfeet in children

2021 ◽  
Vol 11 (7) ◽  
pp. 298-309
Author(s):  
O. Shulga
Keyword(s):  
Conservative Treatment ◽  
Muscle Tone ◽  
Clinical Manifestations ◽  
Physiological Effect ◽  
Traditional Methods ◽  
Treatment And Prevention ◽  
Serial Casting ◽  
Long Term Result ◽  
Two Stages ◽  
Severity Degree

Introduction. A significant percentage of the musculoskeletal system pathology in children is currently fall on the foot pathology – longitudinal flatfeet, which is not only a medical, but also a social problem. The incidence of this pathology is up to 58% of the total orthopedic foot pathology. Traditional methods of treatment and prevention of mild (I– II severity) longitudinal flatfeet (LF), which are known today (massage, physiotherapy exercises, the use of orthopedic devices, electromyostimulation) do not give a significant effect and a stable, long-term result. This makes us look for more effective methods of conservative treatment of LF of the I– II severity degree, which have a pathogenic orientation and physiological effect. Purpose of the work: to develop the most effective algorithm for the complex conservative treatment of LF, depending on the severity, hemodynamic disorders, deformity options, foot rigidity. Materials and methods. Conservative treatment was carried out in 62 patients aged 10– 18 years with LF of the I– II severity degree. Depending on the clinical manifestations and examination results, the treatment was carried out in two stages. At the first stage, serial casting was used (in the presence of concomitant deformations – silicone pelottes were used). Results. The results of the two-stage conservative treatment of LF demonstrate the effectiveness of serial casting in combination with the use of silicone pelottes and biostimulators in comparison with traditional methods of foot correction. Conclusions. Algorithms for conservative treatment of LF were developed, depending on the severity, nature of the deformity, hemodynamic disorders and muscle tone of the lower leg and foot.

ANALYSIS OF COMPLICATIONS AMONG PATIENTS AFTER PREVIOUS NEW CORONOVIRAL COVID-19 INFECTION

2021 ◽  
pp. 15-23
Author(s):  
Дмитрий Валериевич Судаков ◽  
Олег Валериевич Судаков ◽  
Артём Николаевич Шевцов ◽  
Евгений Владимирович Белов ◽  
Оксана Александровна Андросова
Keyword(s):  
Lung Tissue ◽  
Tissue Damage ◽  
Clinical Manifestations ◽  
Physical Exertion ◽  
Treatment And Prevention ◽  
Organ Systems ◽  
Coronavirus Infection ◽  
Group 2 ◽  
Almost All ◽  
Lung Tissue Damage

Статья посвящена анализу возникающих осложнений различных органов и систем органов у пациентов перенесших новую коронавирусную инфекцию. Данная тематика в настоящее время представляет большой интерес для врачей самых разнообразных специальностей. Подобный интерес обусловлен тем, что пандемия Covid-19 возникла лишь в 2020 году. Врачам и ученым, несмотря на все прилагаемые ими усилия еще не удалось полностью расшифровать природу вирусной инфекции, не удалось определить все аспекты этиологии и патогенеза. В настоящее время множество ресурсов различного плана практически во всех странах мира направлены, как на решение данных аспектов, так и на изучение основных клинических проявлений новой коронавирусной инфекции, вариантов ее лечения и предупреждения возможных осложнений, изучение которых и стало целью данной работы. Объектами исследования послужило 200 пациентов, мужчин и женщин трудоспособного возраста, перенесших Covid-19 и обращающихся в стационар и в поликлинику с различными жалобами. Все больные были разделены на 4 группы по 50 человек. 1 группу составили пациенты, которые перенесли данную инфекцию бессимптомно или в легкой форме, зачастую узнав о болезни по результатам определения антител в крови (иммуноглобулины G). 2 группу составили больные, которым был поставлен диагноз «пневмония» 1 степени (по объему поражения легочной ткани). 3 группу составили пациенты, которым был поставлен диагноз «пневмония» 2 степени (по объему поражения легочной ткани). 4 группу составили больные, которым был поставлен диагноз «пневмония» 3 степени (по объему поражения легочной ткани). Было установлено, что наиболее часто встречались осложнения дыхательной, сердечно-сосудистой и пищеварительной систем. Осложнения на нервную систему, опорно-двигательную и выделительную у данных испытуемых встречались гораздо реже. При этом по отдельным нозологиям и симптомам наиболее часто выделяли: дыхательная система - кашель и одышка при физической нагрузки (которой ранее не наблюдалось); сердечно-сосудистая система - боли в области сердца и различные нарушения ритма; пищеварительная система - симптоматика панкреатита и холецистита. Подобное исследование может быть интересным не только для врачей, занимающихся лечением пациентов с Covid-19, но и для врачей, занимающихся лечением последствий данной инфекции The article is devoted to the analysis of emerging complications of various organs and organ systems in patients who have undergone a new coronavirus infection. This topic is currently of great interest for doctors of various specialties. This interest is due to the fact that the Covid-19 pandemic only emerged in 2020. Doctors and scientists, despite all their efforts, have not yet been able to fully decipher the nature of the viral infection, have not been able to determine all aspects of the etiology and pathogenesis. Currently, many resources of various kinds in almost all countries of the world are aimed both at solving these aspects and at studying the main clinical manifestations of a new coronavirus infection, options for its treatment and prevention of possible complications, the study of which became the purpose of this work. The objects of the study were 200 patients, men and women of working age, who had undergone Covid-19 and went to a hospital and a polyclinic with various complaints. All patients were divided into 4 groups of 50 people. Group 1 consisted of patients who underwent this infection asymptomatically or in a mild form, often learning about the disease by the results of the determination of antibodies in the blood (immunoglobulins G). Group 2 consisted of patients who were diagnosed with pneumonia of the 1st degree (by the volume of lung tissue damage). Group 3 consisted of patients who were diagnosed with grade 2 pneumonia (by the volume of lung tissue damage). Group 4 consisted of patients who were diagnosed with grade 3 pneumonia (by the volume of lung tissue damage). It was found that the most common complications of the respiratory, cardiovascular and digestive systems. Complications of the nervous system, musculoskeletal and excretory systems were much less common in these subjects. At the same time, according to individual nosologies and symptoms, the following were most often distinguished: respiratory system - cough and shortness of breath during physical exertion (which was not previously observed); cardiovascular system - pain in the heart and various rhythm disturbances; digestive system - symptoms of pancreatitis and cholecystitis. Such a study may be interesting not only for doctors treating patients with Covid-19, but also for doctors treating the consequences of this infection

scholarly journals New coronavirus infection in the practice of an otolaryngologist

2020 ◽  
Vol 19 (4) ◽  
pp. 8-12
Author(s):  
V. I. Egorov ◽  
◽  
D. M. Mustafaev ◽  
A. O. Kochneva ◽  
Zh. E. Komarova ◽  
...  
Keyword(s):  
Nasal Congestion ◽  
Clinical Manifestations ◽  
Olfactory Dysfunction ◽  
Shortness Of Breath ◽  
Acute Tonsillitis ◽  
Cervical Lymph Nodes ◽  
Global Pandemic ◽  
Important Symptom ◽  
Coronavirus Infection ◽  
Upper Respiratory

Coronavirus disease 2019 (COVID-19) is a global pandemic that affects millions of people and kills hundreds of thousands of people. Chinese researchers found that the most common clinical manifestations of the disease were: fever, dry cough, shortness of breath, muscle weakness, muscle pain and various degrees of respiratory disorders. But despite this, a more in-depth understanding of COVID-19 revealed many other clinical manifestations. Cough, shortness of breath, sore throat, rhinorrhea, nasal congestion, acute tonsillitis, enlarged cervical lymph nodes, or dizziness are symptoms that an otolaryngologist may encounter when examining patients with COVID-19. And olfactory dysfunction has recently been recognized as an important symptom of COVID-19 and is increasingly being used as a tool to identify patients with COVID-19, particularly in cases of asymptomatic carriers who may unknowingly be the main cause of the spread of the disease. The analysis of detected cases of coronavirus infection and the diagnosis of upper respiratory pathologies in these patients, including olfactory dysfunction, allowed us to understand the frequency of their occurrence in the Moscow region, to compare with world data, and to evaluate their role, in the aspect of early diagnosis of COVID-19.

scholarly journals 2019 Novel Coronavirus Infection in Children and Infants: Where We Are and What We Know?

2020 ◽  
Vol 15 (5) ◽  
Author(s):  
Niloofar Deravi ◽  
Shirin Yaghoobpoor ◽  
Mobina Fathi ◽  
Kimia Vakili ◽  
Elahe Ahsan ◽  
...  
Keyword(s):  
High Mortality ◽  
Current Knowledge ◽  
Clinical Manifestations ◽  
Mortality And Morbidity ◽  
Treatment And Prevention ◽  
Therapy Strategy ◽  
The World ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Almost All

: Since the outbreak of coronavirus disease 2019 (COVID-19), in Wuhan, China, there were more than 10,021,401 confirmed infected cases. This infection has spread to almost all countries around the world with reported high mortality and morbidity. Infections in children and infants have been reported as well. The condition of the infected children was mostly mild. To date, there have been reported deaths in pediatrics testing positive for COVID-19 in countries such as China, Italy and America. The therapy strategy for the children who suffer coronavirus disease (COVID-19) has been based on the adult experience. The present review summarizes current knowledge of the etiology, epidemiology, clinical manifestations, transmission, diagnosis, treatment, and prevention of COVID-19 infection in children and infants.

Measles (Morbilli) today: problems, statistics, and clinical manifestations in children and adults

2020 ◽  
Vol 15 (4) ◽  
pp. 54-61
Keyword(s):  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Preventive Measure ◽  
Inosine Pranobex ◽  
Treatment And Prevention ◽  
Disease Characteristics ◽  
The World ◽  
Acute Infectious Disease ◽  
Coronavirus Infection ◽  
New Treatment

Doctors are currently observing an increase in the incidence of measles in Moscow and other cities in Russia and all over the world. Such an increase is primarily caused by parent's refusal to accept vaccination for their children. We have reviewed the main issues related to this acute infectious disease, analyzed the epidemiological situation in different countries (including Russia), and presented the main preventive measure, which is vaccination. In addition to that, some authors reported various types of exanthema, including measles-like, in patients with coronavirus infection, which is widespread now. The aim of this article is to draw the attention of practitioners to the typical initial and main clinical symptoms of measles, stages of rash, specific disease characteristics in patients of different ages, and complications. We have provided a rationale for a new treatment regimen for measles that includes a recombinant α-interferon (Viferon) and an immunomodulator with antiviral action (inosine pranobex; Groprinosin) Key words: measles, children, incidence, clinical forms, complications, treatment and prevention, inosine pranobex (Groprinosin)

scholarly journals Pediatric COVID-19 and the Factors That May Mitigate Its Clinical Course

2020 ◽  
Vol 10 (01) ◽  
pp. e137-e140
Author(s):  
Mosaad Abdel-Aziz ◽  
Nada M. Abdel-Aziz ◽  
Dina M. Abdel-Aziz ◽  
Noha Azab
Keyword(s):  
Clinical Features ◽  
Clinical Symptoms ◽  
Clinical Course ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Angiotensin Converting Enzyme 2 ◽  
Compulsory Vaccination ◽  
Specific Factors ◽  
Novel Coronavirus ◽  
Radiographic Data

AbstractThe clinical manifestations of novel coronavirus disease 2019 (COVID-19) vary from mild flu-like symptoms to severe fatal pneumonia. However, children with COVID-19 may be asymptomatic or may have mild clinical symptoms. The aim of this study was to investigate clinical features of pediatric COVID-19 and to search for the factors that may mitigate the disease course. We reviewed the literature to realize the clinical features, laboratory, and radiographic data that may be diagnostic for COVID-19 among children. Also, we studied the factors that may affect the clinical course of the disease. Fever, dry cough, and fatigue are the main symptoms of pediatric COVID-19, sometimes flu-like symptoms and/or gastrointestinal symptoms may be present. Although some infected children may be asymptomatic, a recent unusual hyperinflammatory reaction with overlapping features of Kawasaki's disease and toxic shock syndrome in pediatric COVID-19 has been occasionally reported. Severe acute respiratory syndrome-coronvirus-2 (SARS-CoV-2) nucleic acid testing is the corner-stone method for the diagnosis of COVID-19. Lymphocyte count and other inflammatory markers are not essentially diagnostic; however, chest computed tomography is highly specific. Factors that may mitigate the severity of pediatric COVID-19 are home confinement with limited children activity, trained immunity caused by compulsory vaccination, the response of the angiotensin-converting enzyme 2 receptors in children is not the same as in adults, and that children are less likely to have comorbidities. As infected children may be asymptomatic or may have only mild respiratory and/or gastrointestinal symptoms that might be missed, all children for families who have a member diagnosed with COVID-19 should be investigated.

scholarly journals A Stochastic Kinetic Type Reactions Model for COVID-19

Mathematics ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1221
Author(s):  
Giorgio Sonnino ◽  
Fernando Mora ◽  
Pasquale Nardone
Keyword(s):  
Real Data ◽  
Stochastic Noise ◽  
Mathematical Basis ◽  
Sis Model ◽  
Theoretical Predictions ◽  
Coronavirus Infection ◽  
Massive Distribution ◽  
Second Wave ◽  
Stochastic Sis Model

We propose two stochastic models for the Coronavirus pandemic. The statistical properties of the models, in particular the correlation functions and the probability density functions, were duly computed. Our models take into account the adoption of lockdown measures as well as the crucial role of hospitals and health care institutes. To accomplish this work we adopt a kinetic-type reaction approach where the modelling of the lockdown measures is obtained by introducing a new mathematical basis and the intensity of the stochastic noise is derived by statistical mechanics. We analysed two scenarios: the stochastic SIS-model (Susceptible ⇒ Infectious ⇒ Susceptible) and the stochastic SIS-model integrated with the action of the hospitals; both models take into account the lockdown measures. We show that, for the case of the stochastic SIS-model, once the lockdown measures are removed, the Coronavirus infection will start growing again. However, the combined contributions of lockdown measures with the action of hospitals and health institutes is able to contain and even to dampen the spread of the SARS-CoV-2 epidemic. This result may be used during a period of time when the massive distribution of vaccines in a given population is not yet feasible. We analysed data for USA and France. In the case of USA, we analysed the following situations: USA is subjected to the first wave of infection by Coronavirus and USA is in the second wave of SARS-CoV-2 infection. The agreement between theoretical predictions and real data confirms the validity of our approach.

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