scholarly journals Peculiarities of clinical manifestations of the new COVID-19 coronavirus infection in patients hospitalized during the epidemic depending on their age

2021 ◽  
Vol 17 (7) ◽  
pp. 32-36
Author(s):  
V.I. Trykhlib ◽  
N.R. Tsiurak ◽  
K.P. Beliaeva ◽  
T.I. Lysenko ◽  
A.O. Yeroshenko ◽  
...  
Keyword(s):  
Chest Pain ◽  
Age Groups ◽  
Young Patients ◽  
Clinical Manifestations ◽  
Productive Cough ◽  
Thoracic Pain ◽  
Average Temperature ◽  
General Weakness ◽  
Significant Difference ◽  
Coronavirus Infection

This article presents a review of the literature and data from a personal study concerning the clinical manifestations of new coronavirus infection in patients hospitalized during the COVID-19 epidemic depending on their age. It was found that most patients complained about dry or low-productive cough, moderate general weakness. The patients aged 18–30 years old more frequently experienced no cough. The patients aged 31–40 years old significantly more frequently complained about dry cough (p < 0.05). Low-productive cough was less frequent but typical in all age groups and more frequent in patients aged 51–60 years. Moist cough was more frequent in patients over 60 years. Chest pain was registered in patients over 60 years (p < 0.05). The frequency of dyspnea was found to increase with age. More often dyspnea was registered in patients older than 60 years old. No dyspnea was noted in young patients aged 18–30 years. Half of the patients aged 18–30 years had no fever. At hospitalization, the average temperature was within normal or subfebrile, which predominated in patients aged 41–50 years (p < 0.05). The frequency of febrile fever increased in patients with age. There was no significant difference in the frequency of pyretic temperature among all age groups. The patients aged over 30 years complained more about moderate weakness, and patients aged over 40 years complained more about severe weakness. Younger patients more often complained about a sore throat, while older patients had practically no symptoms (p > 0.05). Thoracic pain was significantly more frequently registered in patients older than 60 years old. Young patients aged 18–30 years and 31–40 years had no chest pain.

scholarly journals Features of clinical manifestations of new coronavirus infection in patients at hospitalization during the COVID-19 epidemic depending on the severity

2021 ◽  
Vol 17 (8) ◽  
pp. 73-80
Author(s):  
V.I. Trykhlib ◽  
N.R. Tsiurak ◽  
K.P. Beliaeva ◽  
T.I. Lysenko ◽  
A.O. Yeroshenko ◽  
...  
Keyword(s):  
Respiratory Rate ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Clinical Manifestations ◽  
Normal Range ◽  
Average Temperature ◽  
General Weakness ◽  
Number Of Patients ◽  
Significant Difference ◽  
Coronavirus Infection

The article presents a review of the literature sources and results of a personal study. It was found that in our group, there were more persons aged 18–30 years among those who were in inpatient treatment, and among those who were treated in the ICU, the patients were aged 60 years or over. On average, patients who were treated in the ICU were admitted on the 6th day of illness. Most patients complained of dry or unproductive cough, moderate general weakness. Relatively more often moderate general weakness was registered in patients with a moderate course, and moderate and pronounced was typical for patients with a severe course (p < 0.05). Dyspnea was predominantly found in severely ill patients (in one-third of patients during exercise, in 17.7 % patients at rest). In patients with a non-serious course, a small number of patients had dyspnea on exertion (4.3 to 12.1 %). On admission, the average temperature was within normal or subfebrile, which predominated in patients with a moderate course (p < 0.05). With a mild course, half of the patients had a temperature within the normal range. Febrile fever was more often registered in the moderate and severe course. Pyretic body temperature was most typical for a severe course (p < 0.05). It is noteworthy that even in those patients who were treated in the intensive care unit, at admission a quarter of the patients had a normal temperature, and 41.2 % — subfebrile. On ave-rage, the duration of fever before admission in critically ill patients was 5 days, and in those who died — 2 days. Dry cough was significantly more common in severe patients (p < 0.05). In the mild course, only one-fifth of patients complained of dry or unproductive cough. In the moderate course, the dry or unproductive cough was symptomatic for one-third of patients. There was no significant difference in the frequency of complaints of sore throat (p > 0.05). On average, a respiratory rate on admission in critically ill patients did not differ between those who survived and those who died, while those who died more often presented with a respiratory rate of 30/min or more, tachycardia, and more reduced saturation values.

FEATURES OF THE COURSE AND TACTICS OF MANAGING CHILDREN WITH KIDNEYS AND URINARY TRACT DISEASES DURING THE PANDEMIC OF NEW CORONAVIRUS INFECTION COVID-19

2021 ◽  
Vol 100 (4) ◽  
pp. 74-79
Author(s):  
I.M. Kagantsov ◽  
◽  
V.V. Sizonov ◽  
V.G. Svarich ◽  
K.P. Piskunov ◽  
...  
Keyword(s):  
Age Groups ◽  
Clinical Manifestations ◽  
Routine Care ◽  
The Novel ◽  
Urinary System ◽  
Death Rates ◽  
Global Pandemic ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Significant Health

The novel coronavirus infection (SARS-CoV-2), which first appeared in Wuhan, China in December 2019, has been declared a global pandemic by WHO. COVID-19 affects people of all age groups. The disease in children is usually asymptomatic or mild compared to adults, and with a significantly lower death rates. Data on kidney damage in children with COVID-19, as well as the effect of coronavirus infection on the course of diseases of the genitourinary system, are limited, the risks of contracting a new coronavirus infection in children with significant health problems, including those with chronic kidney disease, remain uncertain. The pandemic has affected the activities of surgeons treating diseases of the urinary system in children. Since the prospects for the end of the pandemic are vague, it is necessary to formulate criteria for selecting patients who can and should be provided with routine care in the pandemic. The purpose of this review is to highlight the features of the clinical manifestations and treatment of children with COVID-19, occurring against the background of previous renal pathology or complicating its course.

Clinical and molecular epidemic characterization of rotavirus infection among children under five years old in Shandong province, China.

2021 ◽  
Author(s):  
Shixiao Dong ◽  
Deyu Huang ◽  
Zheng Wang ◽  
Guanyou Zhang ◽  
Fengjuan Zhang ◽  
...  
Keyword(s):  
Lower Incidence ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Shandong Province ◽  
Rotavirus Infection ◽  
National Immunization ◽  
Significant Difference ◽  
The Mean ◽  
And Control

Abstract Rotavirus was the an important causative agent of acute gastroenteritis in children. In China, rotavirus was positive in approximately 30% of the diarrhea children and become a serious public problem. This study was carried out to investigate the clinical and molecular epidemic characterization of rotavirus infection among children under 5 years old with acute diarrhea in Shandong province, China. From July 2017 to June 2018, a total of 1211 fecal specimens were detected and the prevalence of rotavirus infection was 32.12%. The mean age of positive children was 12.2 ± 10.9 months and the highest infection rate was observed in children aged 7–12 months with a rate of 41.64%. G9P[8] (76.61%) was the most prevalent combinations followed by G2P[4] (7.20%), G3P[8] (3.60%) and G9P[4] (2.06%). In addition to diarrhea, vomiting, fever and dehydration were the most common accompanied symptoms. In general, there was no significant difference in clinical manifestations among different age groups. However, the clinical manifestations between vaccinated and unvaccinated children were significantly different. Vaccinated children showed lower incidence and frequency of vomiting, lower incidence and degree of dehydration, lower incidence of severe cases than unvaccinated children. The findings suggested necessary to continue rotavirus strains surveillance in order to monitor the change of prevalent genotype. Moreover, introducing vaccine into national immunization program to prevent and control rotavirus infections is needed in China.

Features of mahagment of a patient with a new coronaviral infection in the observator on the basis of student’s dormitory

2020 ◽  
Vol 24 (2) ◽  
pp. 45-51
Author(s):  
Olga Yu. Kuznetsova ◽  
Alexandr V. Meltser ◽  
Anna V. Lubimova ◽  
Zhanna V. Pleshanova ◽  
Olga S. Zamyatina ◽  
...  
Keyword(s):  
Young Patients ◽  
Clinical Manifestations ◽  
Hypochromic Anemia ◽  
Lung Damage ◽  
Outpatient Basis ◽  
History Of ◽  
Complicated Course ◽  
Coronavirus Infection ◽  
Inflammatory Syndrome ◽  
Severe Weakness

The article is devoted to the peculiarities of clinical manifestations and the severity of a new coronary virus infection in a university student transferred to an observatory organized in a hotel-type hostel to prevent the spread of COVID-19 among students living in hostels. The data on the epidemiological history of the patient, the results of clinical observation and examination are provided. The tactics of managing a patient with a suspected of COVID-19 on an outpatient basis, symptoms that determine the indications for hospitalization, the results of examination and treatment in a hospital, and further observation at the observatory are considered. A new coronavirus infection can lead to a rapid deterioration in the condition of young patients, which does not correlate with indicators indicating lung damage on the 5th day of the disease. Persistent hyperthermia and severe weakness with anorexia can be indicators of the complicated course of the disease, including the development of hyperactive inflammatory syndrome. Hypochromic anemia can be another disease, which is an unfavorable background for the development of COVID-19. The course of the new coronavirus infection in young patients requires careful attention and further study.

Coccidiosis in goats: Pathological observations on intestinal developmental stages and anticoccidial efficacy of amprolim

2018 ◽  
Author(s):  
Sukhmeet Kaur ◽  
L.D. Singla ◽  
B. S Sandhu ◽  
M. S. Bal ◽  
P. Kaur
Keyword(s):  
Developmental Stages ◽  
Age Groups ◽  
Eimeria Species ◽  
General Weakness ◽  
Significant Difference ◽  
Coprological Examination ◽  
History Of ◽  
Coccidial Infection ◽  
Pre Treatment ◽  
Papillary Hyperplasia

In an outbreak of coccidiosis at a goat farm having 200 animals of different age groups (0-3 months, 4-6 months and 7-9 months), kept under stall fed conditions, mortality of 2 kids aged 2-3 months in a span of 2-3 days was seen. The kids were having a history of severe diarrhoea, anorexia and general weakness. Standard qualitative and quantitative coprological examination of randomly collected faecal samples from 60 goats of different age groups revealed that 58 (96.66%) were infected with coccidian oocysts. Among positive samples, 25(43.10%) were heavily infected (OPG=5000-1,23,000), 22(37.93%) had a moderate (OPG=1000-5000) and 11(18.96%) had a mild (OPG=100-1000) infection. Significant difference (P less than 0.05) observed in the mean OPG between the 3 age categories with highest infection in kids with the age group of less than or equal to 3 months,followed by 4-6 months and 7-9 months. Mixed infection of five Eimeria species, namely E. arloingi, E. ninakohlyakimovae, E. christenseni, E. hirci and E. alijevi was seen and E. arloingi was most predominant species among them. Systematic necropsies of naturally died kids of coccidial infection revealed small whitish non-pedunculated nodules in the small intestine. Histopathologically, these nodules revealed papillary hyperplasia of the mucosal epithelium with mild to moderate inflammatory reaction with the presence of developmental stages of Eimeria including trophozoites, schizonts, microgamonts, macrogamonts and oocysts in the epithelium of affected intestinal villi and crypts. The affected animals were successfully treated with amprolium @ dose rate of 2g/40kg body weight. Significant reduction in the oocysts count (P less than 0.01) 7 days post treatment 610.52±201.17 was seen compared to pre treatment values (10685.96±3128.22).

scholarly journals Russian Experience of Transport Extracorporeal Membrane Oxygenation

2021 ◽  
Vol 9 (4) ◽  
pp. 521-528
Author(s):  
D. A. Shelukhin ◽  
A. V. Karpov ◽  
M. V. Ketskalo ◽  
K. K. Gubarev
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
Clinical Experience ◽  
Russian Federation ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Practical Experience ◽  
Hospital Survival ◽  
Membrane Oxygenation ◽  
Significant Difference ◽  
The Russian Federation

Relevance. The present time can be called a period of accumulation of experience of national health systems in different countries of the world in the application of transport extracorporeal membrane oxygenation (ECMO) technology at the pre- and inter-hospital stages of evacuation of patients to specialized ECMO-therapy centers. The role of such centers is to provide timely advice and, if necessary, perform inter-hospital evacuation.Material and methods. The study summarized and analyzed with the help of the national register “RosECMO” the own experience of 13 hospitals in the Russian Federation, who performed 68 inter-hospital evacuations under ECMO conditions by different modes of transport in patients of different age groups with symptoms of circulatory and respiratory failure. The following parameters were evaluated: characteristics of transport ECMO, clinical manifestations of potentially negative effects of transport, hospital survival, as well as the effect of experience (less and more than 10 cases of transport ECMO) of the presented clinics on the difference in the results obtained.Results. Connecting patients to the ECMO device reduces the likelihood of death on the SOFA and APACHE IV scales by 1.2 times (p <0.0001) and 1.4 times (p<0.0001), respectively. Despite the absence of deaths during inter-hospital transportation of patients under ECMO conditions, 14.93% of patients died within 3 days from the moment of their execution, without a significant difference in clinics with different practical experience. The overall hospital survival rate of ECMO transport scenarios in all 13 clinics of the Russian Federation was comparable to the data of the international register 48.52% versus 48.81%, at the same time it was significantly lower (1.3 times) in the group of clinics with less clinical experience 40% versus 52.08% (p<0.0001).Conclusion. The results of the first stage of the study we obtained indicate the prospects of using the method of extracorporeal membrane oxygenation at the stage of inter-hospital evacuation, due to the effective stabilization of the patient’s condition and a significant reduction in the risks of the likelihood of death. Clinics with less clinical experience showed significantly worse results of hospital survival of patients who underwent inter-hospital transportation under conditions of extracorporeal membrane oxygenation compared to clinics with more clinical experience, which can be a significant argument in adopting a model for the development of specialized regional centers for extracorporeal membrane oxygenation. The experience accumulated over the past six years and the analysis of new data from the register of transport cases of extracorporeal membrane oxygenation of the national healthcare system will make it possible to formulate the correct trajectory for the development of the method of extracorporeal membrane oxygenation and its application, including at the stage of pre- and inter-hospital evacuations of patients.

scholarly journals Clinical case of a young patient with ischemic stroke and obesity

2021 ◽  
Vol 23 (4) ◽  
pp. 347-357
Author(s):  
Fatima Kh. Dzgoeva ◽  
◽  
Evgenia V. Ekusheva ◽  
Evgenia V. Ekusheva ◽  
Diana S. Rafikova ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Clinical Case ◽  
Age Groups ◽  
Young Patients ◽  
Clinical Manifestations ◽  
Economic Problem ◽  
Stroke In Young Adults ◽  
History Of ◽  
The Difference ◽  
History Of Obesity

Stroke in young adults is a serious medical and socio-economic problem. The relevance and complexity of the problem of ischemic stroke (IS) in young patients is due to insufficient knowledge of this issue, the complexity of medical and diagnostic aspects, as well as the difference in the causes of strokes from those in older age groups. Due to the variety of clinical manifestations, IS is of big interest for cardiologists, neurologists, obstetriciansgynecologists, hematologists, rheumatologists and is also relevant for endocrinologists and nutritionists. This article examines a clinical case of a patient with IS at a young age and a history of obesity and confirmed hemophilia.

scholarly journals Clinical and pathological features of urothelial carcinoma in pediatric practice

2020 ◽  
Vol 13 (4) ◽  
pp. 18-22
Author(s):  
V.Yu. Startsev ◽  
◽  
G.V. Kondratiev ◽  
A.E. Balashov ◽  
◽  
...  
Keyword(s):  
Risk Factors ◽  
Urothelial Carcinoma ◽  
Molecular Subtype ◽  
Molecular Genetic ◽  
Age Groups ◽  
Young Patients ◽  
Clinical Manifestations ◽  
Older Age ◽  
Medical Community ◽  
Journal Citation Reports

Introduction. This review of the literature presents the results of the analysis of studies on the etiology, pathogenesis, methods of diagnosis and treatment of urothelial carcinoma in persons under 20 years of age. Worldwide, the number of such patients is small, and special programs of treatment and diagnostic measures, as well as molecular genetic panels for these patients have not yet been developed. Materials. Relevant publications indexed in PubMed, Web of Sciences Core Collection, and Journal Citation Reports were searched. Data on risk factors and molecular-genetic changes that contribute to malignancy of the urinary epithelium, early clinical manifestations, as well as features of radiation, endoscopic, morphological diagnostics and treatment of this class of tumors are analyzed. Results. Risk factors for urothelial carcinoma in patients younger than 20 years and older age groups are similar, however, there is a smaller role of occupational factors in young patients. Differences in the molecular subtype of tumors were found in these age groups with a predominance of urothelium-like subtype A among young patients, which leads to a more favorable prognosis of the disease and a lower rate of recurrence in individuals under 20 years of age. The main method of treatment of these neoplasms in both age groups remains transurethral resection of the bladder (TURMP), which allows radical removal of the tumor. Adjuvant treatment involving intra – bubble or systemic chemo-or immunotherapy in the postoperative period is indicated when detecting tumors with a high malignant potential, due to the risk of its metastasis and the high probability of the need for organ-carrying surgery. In clinical practice, recommendations developed for the treatment of cancer patients in the older age group are used, since there are no special guidelines for the diagnosis, treatment, and follow-up of younger patients. Conclusions. The development of methods for the timely diagnosis, treatment and Rehabilitation of children's patients with verified bladder tumors by representatives of the medical community (oncologists, oncologists, pediatricians) remains an urgent task in the near future.

scholarly journals MANAGEMENT OF YOUNG PATIENTS WITH MARFAN SYNDROME

2019 ◽  
Vol 22 (6) ◽  
pp. 395-400
Author(s):  
Ekaterina B. Luneva ◽  
E. G. Malev
Keyword(s):  
Marfan Syndrome ◽  
Beta Blockers ◽  
Angiotensin Receptor Blockers ◽  
Relevant Literature ◽  
Age Groups ◽  
Young Patients ◽  
Clinical Manifestations ◽  
Wide Range ◽  
Receptor Blockers ◽  
Musculoskeletal Systems

Marfan syndrome is a hereditary, autosomal disease with a relatively high prevalence in the general population. Numerous manifestations of Marfan syndrome are expressed in a wide range of disorders involving cardiovascular, ocular and musculoskeletal systems. The article describes the principles of management of the syndrome in children and adolescents. Clinical manifestations of the disease are evaluated in young patients of different age groups. There are presented data on the main medicines used in the therapy of Marfan syndrome, such as beta-blockers, angiotensin receptor blockers, statins. Relevant literature was searched using the databases PubMed, MedLine, Scopus, Web of Science. The article will be interesting to a wide range of specialists: pediatricians, cardiologists, general practitioners and other specialties

scholarly journals Early initiation of PD therapy in elderly patients is associated with increased risk of death

2020 ◽  
Author(s):  
Yuan Peng ◽  
Hongjian Ye ◽  
Chunyan Yi ◽  
Xi Xiao ◽  
Xuan Huang ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Age Groups ◽  
Young Patients ◽  
Early Initiation ◽  
Elderly Age ◽  
Risk Of Death ◽  
Increased Risk ◽  
Significant Difference ◽  
Late Initiation ◽  
Late Start

Abstract Background The effect of early initiation of dialysis on outcomes of patients with end-stage renal disease (ESRD) remains controversial. We conducted this study to investigate the association between the timing of peritoneal dialysis (PD) initiation and mortality in different age groups. Methods In this single-centre cohort study, incident patients receiving PD from 1 January 2006 to 31 December 2016 were enrolled. Patients were categorized into three groups according to the estimated glomerular filtration rate (eGFR) at the initiation of PD, with early, mid and late initiation of PD defined as eGFR ≥7.5, 5–7.5 and &lt;5 mL/min/1.73 m2, respectively. Results A total of 2133 incident patients receiving PD were enrolled with a mean age of 47.1 years, 59.6% male and 25.3% with diabetes, of whom 1803 were young (age &lt;65 years) and 330 were elderly (age ≥65 years). After multivariable adjustment, the overall and cardiovascular (CV) mortality risks for young patients receiving PD were not significantly different between these three groups. However, for elderly patients, early initiation of PD therapy was associated with increased risks of all-cause {hazard ratio [HR} 1.54 [95% confidence interval (CI) 1.06–2.25]} and CV [HR 2.07 (95% CI 1.24–3.48)] mortality compared with late initiation of PD, while no significant difference was observed in overall or CV mortality between the mid- and late-start groups. Conclusions No significant difference in mortality risk was found among the three levels of eGFR at PD therapy initiation in young patients, while early initiation of PD was associated with a higher risk of overall and CV mortality among elderly patients.

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