Nível de Conhecimento dos Adolescentes das Escolas do Município de Itajaí-SC Sobre o Vírus Papiloma Humano (HPV)

2018 ◽  
pp. 2
Author(s):  
Fernanda Suélly Schuaisa Badotti ◽  
Renata Barth Almeida ◽  
Maria Regina Orofino Kreugera
Keyword(s):  
Hpv Infection ◽  
Cancer Development ◽  
Knowledge Level ◽  
Human Papillomavirus Vaccination ◽  
Prophylactic Measures ◽  
Increased Risk ◽  
Transmission Prevention ◽  
Cervical Cancer Development ◽  
Almost All ◽  
Main Factor

  A adolescência constitui um período de maior risco de infecção pelo HPV, sendo esse considerado o principal fator de desenvolvimento do câncer de colo uterino. A fim de avaliar o nível de conhecimento de estudantes de escolas do município de Itajaí-SC acerca do HPV e suas vacinas, promover a difusão das informações sobre medidas profiláticas, formas de infecção e prevenção do HPV, realizou-se este estudo direcionado aos alunos do Ensino Fundamental e Médio de três colégios do município de Itajaí-SC, contando com 315 participantes, de idades variando entre 10 e 19 anos. O levantamento ocorreu através de questionário realizado nas próprias salas de aula. O estudo revelou que quase a totalidade dos alunos já ouviu sobre o HPV, e apontaram as relações sexuais como principal maneira de transmissão. Somente metade dos participantes afirma que ambos os sexos podem ser infectados. Menos da metade dos participantes confirma ter recebido a vacinação. A pesquisa apontou que há predomínio de participantes com compreensão das informações básicas sobre o HPV e suas vacinas. Conquanto, o conhecimento é menor sobre as formas de transmissão, prevenção e do fato de que ambos os sexos podem ser infectados e vacinados.Palavras-chave: Adolescência, Papiloma Vírus Humano. Vacinação.AbstractAdolescence is a period of increased risk of HPV infection, which is considered the main factor in the cervical cancer development. In order to evaluate the students’ knowledge level of the municipality of Itajaí-SC on HPV and its vaccines, promote the dissemination of information on prophylactic measures, forms of infection and prevention of HPV, this guided study was performed to students of the three schools in the municipality of Itajaí-SC, with 315 participants, ranging from 10 to 19 years old. The survey was carried out through the questionnaire performed in the classrooms. The study revealed that almost all of the students have heard about HPV, and point out how sexual intercourse is the main transmission mode. Less than half of the participants stated the two sexes that can be infected. Less than half of the participants confirmed having received the vaccine . The research is based on knowledge about participants with information about HPV and its vaccines. However, knowledge is shorter about forms of transmission, prevention and the fact that both sexes can be infected and vaccinated.Keywords: Adolescence. Human papillomavirus. Vaccination.

scholarly journals Role of inflammasome genetics in susceptibility to HPV infection and cervical cancer development

2016 ◽  
Vol 88 (9) ◽  
pp. 1646-1651 ◽  
Author(s):  
A. Pontillo ◽  
P. Bricher ◽  
V.N.C. Leal ◽  
S. Lima ◽  
P.R.E. Souza ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Hpv Infection ◽  
Cancer Development ◽  
Cervical Cancer Development

scholarly journals Association study of relationships of polymorphisms in the miR-21, miR-26b, miR-221/222 and miR-126 genes with cervical intraepithelial neoplasia and cervical cancer

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jia Yang ◽  
Zhiling Yan ◽  
Yingying Wang ◽  
Jinmei Xu ◽  
Rui Li ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cervical Intraepithelial Neoplasia ◽  
Additive Model ◽  
Intraepithelial Neoplasia ◽  
Recessive Model ◽  
Cancer Development ◽  
Nucleotide Polymorphisms ◽  
Mirna Genes ◽  
Increased Risk ◽  
Cervical Cancer Development

Abstract Background miR-21, miR-26b, miR-221/222 and miR-126 play crucial roles in cervical cancer development. Studies have shown that polymorphisms in miRNA genes can affect miRNA expression, which might be associated with cancer development. Methods Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. Results Our results showed significant differences for the rs2297538 genotypes between the CIN and CC groups (P = 0.001). In addition, our results also showed significant differences for the rs2297537 alleles between the CIN and CC groups (P = 0.003), and the C allele of rs2297537 might be associated with a decreased risk of CC (OR = 0.72, 95%CI: 0.58–0.90). At the inheritance analysis, between the CIN and control groups, the T/T-T/C genotype in rs1292037 and A/A-A/T genotype in rs13137 might be associated with an increased risk of CIN in the recessive model (OR = 1.61, 95% CI: 1.17–2.20 and OR = 1.58, 95% CI: 1.15–2.15). In addition, the C/C-T/T genotype of rs2745709 might be associated with a decreased risk of CIN in the overdominant model (OR = 0.66, 95% CI: 0.52–0.82). Between, CIN and CC group, the T/T-C/C genotype in rs1292037 and A/A-T/T genotype in rs13137 might be associated with an increased risk of CC in the overdominant model (OR = 1.43, 95% CI: 1.12–1.81 and OR = 1.42, 95% CI: 1.12–1.80). The rs2297538 G/G-A/G genotype might be associated with an increased risk of CC in the recessive model (OR = 2.83, 95% CI: 1.52–5.25). The rs2297537 2C/C + C/G genotype might be associated with a decreased risk of CC (OR = 0.71, 95% CI: 0.57–0.89) in the log-additive model. The rs2745709 T/T-C/C genotype might be associated with an increased risk of CC (OR = 1.44, 95% CI: 1.13–1.83) in the overdominant model. Conclusion Our results indicate that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222, may have important roles in the development of CIN or CC.

scholarly journals The Preventive Effect of Dietary Antioxidants on Cervical Cancer Development

Medicina ◽  
2020 ◽  
Vol 56 (11) ◽  
pp. 604
Author(s):  
Ayumi Ono ◽  
Masafumi Koshiyama ◽  
Miwa Nakagawa ◽  
Yumiko Watanabe ◽  
Eri Ikuta ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Nutrient Intake ◽  
Continuous Process ◽  
Relevant Literature ◽  
Hpv Infection ◽  
Cancer Development ◽  
Dietary Antioxidants ◽  
Cervical Cancer Development

Cervical cancer results from a continuous process, starting from a normal cervical epithelium after human papillomavirus (HPV) infection and progressing to cervical intraepithelial neoplasia (CIN), before finally developing into invasive squamous carcinoma (ISC). In recent decades, dietary antioxidants, such as vitamins, have received much attention in relation to cancer prevention. We reviewed the relevant literature to investigate the dietary and nutrient intake on cervical cancer. The intake of vitamins A and D and carotenoids may inhibit early cervical cancer development. The intake of folate may prevent or inhibit HPV infection rom progressing to various grades of CIN. The intake of vitamins C and E may widely inhibit the process of cervical cancer development. Polyphenols are often used in cases of cervical cancer in combination chemotherapy and radiation therapy. Regarding nutrients, different antioxidants may have differing abilities to intervene in the natural history of cervical diseases associated with HPV infection. Regarding foods, the intake of both vegetables and fruits containing multiple vitamins may widely suppress cervical cancer development. Most previous papers have described epidemiological studies. Thus, further research using in vitro and in vivo approaches will be needed to clarify the effects of the dietary and nutrient intake in detail.

Human papillomavirus infection and increased risk of breast cancer in north of Iran.

2011 ◽  
Vol 29 (27_suppl) ◽  
pp. 28-28
Author(s):  
F. Naghshvar ◽  
A. Sigaroodi ◽  
S. A. Nadji ◽  
G. Janbabaei
Keyword(s):  
Breast Cancer ◽  
Hpv Infection ◽  
Human Papillomaviruses ◽  
Cancer Development ◽  
Breast Cancer Patients ◽  
Mazandaran Province ◽  
Breast Cancer Development ◽  
Increased Risk ◽  
Hpv Genotypes ◽  
North Part

28 Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer deaths among women worldwide. Human papillomaviruses have been related to the pathogenesis of breast cancer. In this study, we have analyzed the possible relevance of HPV infection for breast cancer risk among Iranian women from north part of Iran, Mazandaran province. Methods: Polymerase chain reaction method with three different primer sets was applied for detection of HPVs in formalin-fixed paraffin-embedded breast cancer and breast fibroadema as case and control tissues, respectively. HPV genotypes were determined by phylogenetic analysis of viral genome sequences. Results: Of the 58 women with breast cancer, 25.9% (15 isolates) had positive test results for HPV DNA in breast tumor samples in contrast to 2.4% of women (1 out of 41) with non cancer status (P + 0.002). The infection of HPV had an OR of 14.247 (95% CI 1.558-130.284; P + 0.019). The HPV genotypes in samples of breast cancer patients were 26.67% for HPV-16 (4 isolates) and HPV-18 (4 isolates), 13.3% for HPV-23 (2 isolates) and HPV-6 (2 isolates), 6.67% for HPV-11 (1 isolate), HPV-15 (1 isolate) and HPV-124 (1 isolate) and one isolate could not be genotyped compared to HPV reference sequences, while the sole detected HPV in control specimens was HPV-124. Conclusions: Our study reveals that HPV infection and age are the risk factors in breast cancer development in the north part of Iran, Mazandaran province. The association between risk of breast cancer development and viral infection is open and deserves further investigation.

scholarly journals The function of histone acetylation in cervical cancer development

2019 ◽  
Vol 39 (4) ◽  
Author(s):  
Shanshan Liu ◽  
Weiqin Chang ◽  
Yuemei Jin ◽  
Chunyang Feng ◽  
Shuying Wu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Histone Acetylation ◽  
Gene Sequence ◽  
Hpv Infection ◽  
Cancer Development ◽  
Post Translational Modifications ◽  
Cellular Life ◽  
Lysine Residues ◽  
Cervical Cancer Development ◽  
Gene Expression Levels

AbstractCervical cancer is the fourth most common female cancer in the world. It is well known that cervical cancer is closely related to high-risk human papillomavirus (HPV) infection. However, epigenetics has increasingly been recognized for its role in tumorigenesis. Epigenetics refers to changes in gene expression levels based on non-gene sequence changes, primarily through transcription or translation of genes regulation, thus affecting its function and characteristics. Typical post-translational modifications (PTMs) include acetylation, propionylation, butyrylation, malonylation and succinylation, among which the acetylation modification of lysine sites has been studied more clearly so far. The acetylation modification of lysine residues in proteins is involved in many aspects of cellular life activities, including carbon metabolism, transcriptional regulation, amino acid metabolism and so on. In this review, we summarize the latest discoveries on cervical cancer development arising from the aspect of acetylation, especially histone acetylation.

scholarly journals Human papillomavirus and other risk factors in Lithuanian cervical carcinoma patients

2010 ◽  
Vol 17 (3-4) ◽  
pp. 106-115
Author(s):  
Živilė GUDLEVIČIENĖ ◽  
Alė SMILGEVIČIŪTĖ-IVSHIN ◽  
Aurelija VAITKUVIENĖ ◽  
Agnė ŠEPETIENĖ ◽  
Janina DIDŽIAPETRIENĖ
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Cancer Risk ◽  
Hpv Infection ◽  
Cancer Development ◽  
Cancer Risk Factors ◽  
Cervical Cancer Risk ◽  
Hpv Prevalence ◽  
Geographical Regions ◽  
Cervical Cancer Development

Background. Cervical cancer is the second biggest cause of female cancer mortality worldwide and the most common cancer in women in Lithuania. The incidence of cervical cancer is strongly associated with HPV prevalence. However, not only HPV infection plays a crucial role in cervical cancer development; other risk factors which vary in different populations and geographical regions as well as HPV prevalence are important. The aim of this study was to detect the HPV, its type’s prevalence and other cervical cancer risk factors for Lithuanian women. Materials and methods. 191 women with primary diagnosed invasive cervical cancer (cases group) and 397 control women were invited to participate in the study. All women were interviewed and samples for HPV testing were taken. Results. In the cases group, 92.7% of women and in the control group 26.7% were infected by HPV (p < 0.0001). HPV 16 was the most common type in both groups. HPV infection increases the risk of cervical cancer 75 times (OR = 75.39; 95% CI 33.61–192.98). Women with lower education, workers, those who started sexual intercourses before 20 years of age, at older age of the first menstrual period, 3–5 or more childbirths, smokers and with a long ago or never performed Pap test are at a significantly higher risk of cervical cancer development. Other non-HPV risk factors were not associated with cervical cancer risk. Conclusions. Data of our study show a high prevalence of HPV in Lithuanian population. It may have an impact on the biggest cervical cancer incidence. The other risk factors are similar as in other lower economic resource countries. Keywords: HPV, cervical cancer, risk factors

scholarly journals Prevention of cervical cancer development through early detection of HPV using novelty molecular applications

Bionatura ◽  
2019 ◽  
Vol 02 (Bionatura Conference Serie) ◽  
Author(s):  
Kerly León-Ordóñez ◽  
Sofía Abad-Sojos
Keyword(s):  
Cervical Cancer ◽  
Early Detection ◽  
High Sensitivity ◽  
Hpv Infection ◽  
Molecular Techniques ◽  
Cancer Development ◽  
Viral Oncoproteins ◽  
Hpv E6 ◽  
E6 And E7 ◽  
Cervical Cancer Development

Human Papillomavirus (HPV) is the predominant cause of cervical cancer worldwide. The infections with HPVs 16 and 18 have a high oncogenic risk for cancer development. Besides, the genes E6 and E7 encode viral oncoproteins associated with infection. New molecular techniques for HPV detection, show important advantages such as high sensitivity, recognition capacity, reliability, among others. These techniques allow the standardization of new protocols associated with the detection in a variety of substances and samples. The stretch relationship between the virus and the disease open a new field to study early detection of the HPV infection. Additionally, less concentration of the sample is needed. Considering the significance of the detection, the present paper explains five novelty molecular applications for the prevention cervical cancer and early detection of HPV such as RNA in situ Hybridization for the detection of HPV E6/E7, genosensors, electrochemical DNA biosensor, PCR-based urine assay and a semen assay for detection of HPV. All the methods related to DNA samples could be used for both genders, there are more acceptable and easy to collect.

scholarly journals miR-34a and miR-125b Expression in HPV Infection and Cervical Cancer Development

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Joana Ribeiro ◽  
Joana Marinho-Dias ◽  
Paula Monteiro ◽  
Joana Loureiro ◽  
Inês Baldaque ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Expression Analysis ◽  
Reference Group ◽  
Invasive Cervical Cancer ◽  
Hpv Infection ◽  
Cancer Development ◽  
Cervical Lesions ◽  
Normal Epithelium ◽  
Normal Cervix ◽  
Cervical Cancer Development

We aimed to characterize miR-125b and miR-34a expression in 114 women with different cervical lesions: normal epithelium with (n= 20) and without (n= 29) HPV infection; LSIL (n= 28); HSIL (n= 29); and ICC (n= 8). miRNA expression analysis was performed by comparing the distinct groups with the reference group (women with normal epithelium without HPV). For miR-125b, we observed a twofold (2-ΔΔCt= 2.11;P= 0.038) increased expression among women with normal epithelium with HPV infection and a trend of downregulation in different cervical lesions including an 80% reduction (2-ΔΔCt= 0.21;P= 0.004) in ICC. Similarly, miR-34a expression analysis revealed an increased expression (2-ΔΔCt= 1.69;P= 0.049) among women with normal cervix and HPV infection, and despite no significant correlation with cervical lesions, its expression was increased by twofold (2-ΔΔCt= 2.08;P= 0.042) in ICC. Moreover, miR-125b levels were able to predict invasive cancers with 88% sensitivity and 69% specificity. Results showed that while miR-34a expression seems to be correlated with invasive cervical cancer, miR-125b expression is significantly changed within the different cervical lesions and their levels should be further investigated as possible predictive/prognostic biomarkers using a noninvasive approach.

Bowel ischaemia after endovascular aneurysm repair

VASA ◽  
2018 ◽  
Vol 47 (4) ◽  
pp. 273-277
Author(s):  
Christopher Lowe ◽  
Oussama El Bakbachi ◽  
Damian Kelleher ◽  
Imran Asghar ◽  
Francesco Torella ◽  
...  
Keyword(s):  
Case Reports ◽  
Endovascular Aneurysm Repair ◽  
Artery Occlusion ◽  
Bibliographic Databases ◽  
Bowel Ischaemia ◽  
Prophylactic Measures ◽  
Increased Risk ◽  
Prisma Statement ◽  
Meta Analyses ◽  
Aneurysm Repair

Abstract. The aim of this review was to investigate presentation, aetiology, management, and outcomes of bowel ischaemia following EVAR. We present a case report and searched electronic bibliographic databases to identify published reports of bowel ischaemia following elective infra-renal EVAR not involving hypogastric artery coverage or iliac branch devices. We conducted our review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement standards. In total, five cohort studies and three case reports were included. These studies detailed some 6,184 infra-renal elective EVARs, without procedure-related occlusion of the hypogastric arteries, performed between 1996 and 2014. Bowel ischaemia in this setting is uncommon with an incidence ranging from 0.5 to 2.8 % and includes a spectrum of severity from mucosal to transmural ischaemia. Due to varying reporting standards, an overall proportion of patients requiring bowel resection could not be ascertained. In the larger series, mortality ranged from 35 to 80 %. Atheroembolization, hypotension, and inferior mesenteric artery occlusion were reported as potential causative factors. Elderly patients and those undergoing prolonged procedures appear at higher risk. Bowel ischaemia is a rare but potentially devastating complication following elective infra-renal EVAR and can occur in the setting of patent mesenteric vessels and hypogastric arteries. Mortality ranges from 35 to 80 %. Further research is required to identify risk factors and establish prophylactic measures in patients that have an increased risk of developing bowel ischaemia after standard infra-renal EVAR.

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