scholarly journals The Preventive Effect of Dietary Antioxidants on Cervical Cancer Development

Medicina ◽  
2020 ◽  
Vol 56 (11) ◽  
pp. 604
Author(s):  
Ayumi Ono ◽  
Masafumi Koshiyama ◽  
Miwa Nakagawa ◽  
Yumiko Watanabe ◽  
Eri Ikuta ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Nutrient Intake ◽  
Continuous Process ◽  
Relevant Literature ◽  
Hpv Infection ◽  
Cancer Development ◽  
Dietary Antioxidants ◽  
Cervical Cancer Development

Cervical cancer results from a continuous process, starting from a normal cervical epithelium after human papillomavirus (HPV) infection and progressing to cervical intraepithelial neoplasia (CIN), before finally developing into invasive squamous carcinoma (ISC). In recent decades, dietary antioxidants, such as vitamins, have received much attention in relation to cancer prevention. We reviewed the relevant literature to investigate the dietary and nutrient intake on cervical cancer. The intake of vitamins A and D and carotenoids may inhibit early cervical cancer development. The intake of folate may prevent or inhibit HPV infection rom progressing to various grades of CIN. The intake of vitamins C and E may widely inhibit the process of cervical cancer development. Polyphenols are often used in cases of cervical cancer in combination chemotherapy and radiation therapy. Regarding nutrients, different antioxidants may have differing abilities to intervene in the natural history of cervical diseases associated with HPV infection. Regarding foods, the intake of both vegetables and fruits containing multiple vitamins may widely suppress cervical cancer development. Most previous papers have described epidemiological studies. Thus, further research using in vitro and in vivo approaches will be needed to clarify the effects of the dietary and nutrient intake in detail.

scholarly journals The Effects of the Dietary and Nutrient Intake on Gynecologic Cancers

Healthcare ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 88 ◽  
Author(s):  
Koshiyama
Keyword(s):  
Ovarian Cancer ◽  
Cervical Cancer ◽  
Risk Factor ◽  
Nutrient Intake ◽  
Relevant Literature ◽  
Gynecologic Cancer ◽  
Hpv Infection ◽  
Obese Women

The contribution of diet to cancer risk has been considered to be higher in advanced countries than in developing countries. In this paper, I review the current issues (a review of the relevant literature), and the effects of the dietary and nutrient intake on three types of gynecologic cancer (cervical, endometrial and ovarian cancers). In cervical cancer, the most important roles of diet/nutrition in relation to cancer are prophylaxis and countermeasures against human papillomavirus (HPV) infection. The main preventive and reductive factors of cervical cancer are antioxidants, such as vitamin A, C, D and E, carotenoids, vegetables and fruits. These antioxidants may have different abilities to intervene in the natural history of diseases associated with HPV infection. For endometrial cancer, the increase in peripheral estrogens as a result of the aromatization of androgens to estrogens in adipose tissue in obese women and insulin resistance are risk factors. Thus, we must mainly take care to avoid the continuous intake of fat energy and sugar. In ovarian cancer, the etiology has not been fully understood. To the best of our knowledge, the long-term consumption of pro-inflammatory foods, including saturated fat, carbohydrates and animal proteins is a risk factor. The intake of acrylamide is also a risk factor for both endometrial and ovarian cancer. Most papers have been epidemiological studies. Thus, further research using in vitro and in vivo approaches is needed to clarify the effects of the dietary and nutrient intake in detail.

scholarly journals Role of inflammasome genetics in susceptibility to HPV infection and cervical cancer development

2016 ◽  
Vol 88 (9) ◽  
pp. 1646-1651 ◽  
Author(s):  
A. Pontillo ◽  
P. Bricher ◽  
V.N.C. Leal ◽  
S. Lima ◽  
P.R.E. Souza ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Hpv Infection ◽  
Cancer Development ◽  
Cervical Cancer Development

scholarly journals LncRNA CAR10 Upregulates PDPK1 to Promote Cervical Cancer Development by Sponging miR-125b-5p

2020 ◽  
Vol 2020 ◽  
pp. 1-16 ◽  
Author(s):  
Tingting Hu ◽  
Qian Zhang ◽  
Lingxue Gao
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Target Gene ◽  
Malignant Tumors ◽  
Factors Affecting ◽  
New Strategy ◽  
Cervical Cancer Cells ◽  
Cervical Cancer Development

Cervical cancer is one of the malignant tumors that seriously threaten women’s health. The mechanism of development needs to be deeply studied. In recent years, lncRNA has been identified as one of the important factors affecting the malignant progression of tumors. In this study, we illustrated the important mechanism of lncRNA CAR10 in the development of cervical cancer. We found that CAR10 is significantly increased in4 cervical cancer tissues and cells, which can promote the proliferation of cervical cancer cells in vitro and in vivo, indicating that CAR10 is involved in the progression of cervical cancer as an oncogene. Further studies showed that CAR10 is a target gene of miR-125b-5p, and miR-125b-5p can inhibit the effect of CAR10 on the proliferation of cervical cancer cells. In addition, we also found that 3-phosphoinositide-dependent protein kinase 1 (PDPK1) is also a target gene of miR-125b-5p, and CAR10 can upregulate the expression level of PDPK1. The results showed that CAR10 acts as a ceRNA to upregulate the expression of PDPK1 by sponging miR-125b-5p. Knockdown of PDPK1 can inhibit the effect of CAR10 on cervical cancer cells. Our study demonstrates that, based on ceRNA mechanism, CAR10/miR-125b-5p/PDPK1 network can regulate the proliferation of cervical cancer cells and play an important role in the development of cervical cancer. In addition, our study also suggests that intervention of CAR10/miR-125b-5p/PDPK1 network may be a new strategy for targeted therapy of cervical cancer.

scholarly journals Synergistic effects of exosomal crocin or curcumin compounds and HPV L1-E7 polypeptide vaccine construct on tumor eradication in C57BL/6 mouse model

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258599
Author(s):  
Elnaz Abbasifarid ◽  
Azam Bolhassani ◽  
Shiva Irani ◽  
Fattah Sotoodehnejadnematalahi
Keyword(s):  
Cervical Cancer ◽  
Mouse Model ◽  
Tumor Cells ◽  
Synergistic Effects ◽  
Low Cost ◽  
Hpv Infection ◽  
Therapeutic Effects ◽  
T Cell Immune Responses

Cervical cancer is the most common malignant tumor in females worldwide. Human papillomavirus (HPV) infection is associated with the occurrence of cervical cancer. Thus, developing an effective and low-cost vaccine against HPV infection, especially in developing countries is an important issue. In this study, a novel HPV L1-E7 fusion multiepitope construct designed by immunoinformatics tools was expressed in bacterial system. HEK-293T cells-derived exosomes were generated and characterized to use as a carrier for crocin and curcumin compounds. The exosomes loaded with crocin and curcumin compounds as a chemotherapeutic agent (ExoCrocin and ExoCurcumin) were used along with the L1-E7 polypeptide for evaluation of immunological and anti-tumor effects in C57BL/6 mouse model. In vitro studies showed that ExoCrocin and ExoCurcumin were not cytotoxic at a certain dose, and they could enter tumor cells. In vivo studies indicated that combination of the L1-E7 polypeptide with ExoCrocin or ExoCurcumin could produce a significant level of immunity directed toward Th1 response and CTL activity. These regimens showed the protective and therapeutic effects against tumor cells (the percentage of tumor-free mice: ~100%). In addition, both ExoCrocin and ExoCurcumin represented similar immunological and anti-tumor effects. Generally, the use of exosomal crocin or curcumin forms along with the L1-E7 polypeptide could significantly induce T-cell immune responses and eradicate tumor cells.

scholarly journals The function of histone acetylation in cervical cancer development

2019 ◽  
Vol 39 (4) ◽  
Author(s):  
Shanshan Liu ◽  
Weiqin Chang ◽  
Yuemei Jin ◽  
Chunyang Feng ◽  
Shuying Wu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Histone Acetylation ◽  
Gene Sequence ◽  
Hpv Infection ◽  
Cancer Development ◽  
Post Translational Modifications ◽  
Cellular Life ◽  
Lysine Residues ◽  
Cervical Cancer Development ◽  
Gene Expression Levels

AbstractCervical cancer is the fourth most common female cancer in the world. It is well known that cervical cancer is closely related to high-risk human papillomavirus (HPV) infection. However, epigenetics has increasingly been recognized for its role in tumorigenesis. Epigenetics refers to changes in gene expression levels based on non-gene sequence changes, primarily through transcription or translation of genes regulation, thus affecting its function and characteristics. Typical post-translational modifications (PTMs) include acetylation, propionylation, butyrylation, malonylation and succinylation, among which the acetylation modification of lysine sites has been studied more clearly so far. The acetylation modification of lysine residues in proteins is involved in many aspects of cellular life activities, including carbon metabolism, transcriptional regulation, amino acid metabolism and so on. In this review, we summarize the latest discoveries on cervical cancer development arising from the aspect of acetylation, especially histone acetylation.

scholarly journals Human papillomavirus and other risk factors in Lithuanian cervical carcinoma patients

2010 ◽  
Vol 17 (3-4) ◽  
pp. 106-115
Author(s):  
Živilė GUDLEVIČIENĖ ◽  
Alė SMILGEVIČIŪTĖ-IVSHIN ◽  
Aurelija VAITKUVIENĖ ◽  
Agnė ŠEPETIENĖ ◽  
Janina DIDŽIAPETRIENĖ
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Cancer Risk ◽  
Hpv Infection ◽  
Cancer Development ◽  
Cancer Risk Factors ◽  
Cervical Cancer Risk ◽  
Hpv Prevalence ◽  
Geographical Regions ◽  
Cervical Cancer Development

Background. Cervical cancer is the second biggest cause of female cancer mortality worldwide and the most common cancer in women in Lithuania. The incidence of cervical cancer is strongly associated with HPV prevalence. However, not only HPV infection plays a crucial role in cervical cancer development; other risk factors which vary in different populations and geographical regions as well as HPV prevalence are important. The aim of this study was to detect the HPV, its type’s prevalence and other cervical cancer risk factors for Lithuanian women. Materials and methods. 191 women with primary diagnosed invasive cervical cancer (cases group) and 397 control women were invited to participate in the study. All women were interviewed and samples for HPV testing were taken. Results. In the cases group, 92.7% of women and in the control group 26.7% were infected by HPV (p < 0.0001). HPV 16 was the most common type in both groups. HPV infection increases the risk of cervical cancer 75 times (OR = 75.39; 95% CI 33.61–192.98). Women with lower education, workers, those who started sexual intercourses before 20 years of age, at older age of the first menstrual period, 3–5 or more childbirths, smokers and with a long ago or never performed Pap test are at a significantly higher risk of cervical cancer development. Other non-HPV risk factors were not associated with cervical cancer risk. Conclusions. Data of our study show a high prevalence of HPV in Lithuanian population. It may have an impact on the biggest cervical cancer incidence. The other risk factors are similar as in other lower economic resource countries. Keywords: HPV, cervical cancer, risk factors

scholarly journals Attenuated Salmonella carrying plasmid co-expressing HPV16 L1 and siRNA-E6 for cervical cancer therapy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Junyu Chen ◽  
Shuhua Zhao ◽  
Wenxi Tan ◽  
Taiwei Wang ◽  
Shan Wu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lower Cost ◽  
Hpv Infection ◽  
Effective Prevention ◽  
E7 Gene ◽  
Prophylactic Vaccines ◽  
E6 And E7 ◽  
Prevention Method

AbstractHuman papillomavirus (HPV) infection is the major etiological factor for cervical cancer. HPV prophylactic vaccines based on L1 virus-like particles have been considered as an effective prevention method. However, existing recombination vaccines are too expensive for developing countries. DNA vaccines might be a lower-cost and effective alternative. In this study, a plasmid (pcDNA3.1-HPV16-L1) and a co-expressing plasmid (pcDNA3.1-HPV16-L1-siE6) carried by attenuated Salmonella were constructed and their prevention and treatment effect on cervical cancer were observed, respectively. The results showed that pcDNA3.1-HPV16-L1 carried by attenuated Salmonella could induce the production of HPV16-L1 antibodies, IL-2 and INF-γ in mice serum, which presented its prevention effect on HPV. Subsequently, E6 and E7 gene silencing by pCG-siE6 inhibited the growth of cervical cancer both in vitro and in vivo. Furthermore, L1 up-regulation and E6/E7 down-regulation caused by co-expressing plasmid (pcDNA3.1-HPV16-L1-siE6) contributed to a significant anti-tumor effect on the mice. This study suggests that pcDNA3.1-HPV16-L1-siE6 carried by attenuated Salmonella has a synergistic effect of immune regulation and RNA interference in cervical cancer treatment.

scholarly journals Prevention of cervical cancer development through early detection of HPV using novelty molecular applications

Bionatura ◽  
2019 ◽  
Vol 02 (Bionatura Conference Serie) ◽  
Author(s):  
Kerly León-Ordóñez ◽  
Sofía Abad-Sojos
Keyword(s):  
Cervical Cancer ◽  
Early Detection ◽  
High Sensitivity ◽  
Hpv Infection ◽  
Molecular Techniques ◽  
Cancer Development ◽  
Viral Oncoproteins ◽  
Hpv E6 ◽  
E6 And E7 ◽  
Cervical Cancer Development

Human Papillomavirus (HPV) is the predominant cause of cervical cancer worldwide. The infections with HPVs 16 and 18 have a high oncogenic risk for cancer development. Besides, the genes E6 and E7 encode viral oncoproteins associated with infection. New molecular techniques for HPV detection, show important advantages such as high sensitivity, recognition capacity, reliability, among others. These techniques allow the standardization of new protocols associated with the detection in a variety of substances and samples. The stretch relationship between the virus and the disease open a new field to study early detection of the HPV infection. Additionally, less concentration of the sample is needed. Considering the significance of the detection, the present paper explains five novelty molecular applications for the prevention cervical cancer and early detection of HPV such as RNA in situ Hybridization for the detection of HPV E6/E7, genosensors, electrochemical DNA biosensor, PCR-based urine assay and a semen assay for detection of HPV. All the methods related to DNA samples could be used for both genders, there are more acceptable and easy to collect.

scholarly journals miR-34a and miR-125b Expression in HPV Infection and Cervical Cancer Development

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Joana Ribeiro ◽  
Joana Marinho-Dias ◽  
Paula Monteiro ◽  
Joana Loureiro ◽  
Inês Baldaque ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Expression Analysis ◽  
Reference Group ◽  
Invasive Cervical Cancer ◽  
Hpv Infection ◽  
Cancer Development ◽  
Cervical Lesions ◽  
Normal Epithelium ◽  
Normal Cervix ◽  
Cervical Cancer Development

We aimed to characterize miR-125b and miR-34a expression in 114 women with different cervical lesions: normal epithelium with (n= 20) and without (n= 29) HPV infection; LSIL (n= 28); HSIL (n= 29); and ICC (n= 8). miRNA expression analysis was performed by comparing the distinct groups with the reference group (women with normal epithelium without HPV). For miR-125b, we observed a twofold (2-ΔΔCt= 2.11;P= 0.038) increased expression among women with normal epithelium with HPV infection and a trend of downregulation in different cervical lesions including an 80% reduction (2-ΔΔCt= 0.21;P= 0.004) in ICC. Similarly, miR-34a expression analysis revealed an increased expression (2-ΔΔCt= 1.69;P= 0.049) among women with normal cervix and HPV infection, and despite no significant correlation with cervical lesions, its expression was increased by twofold (2-ΔΔCt= 2.08;P= 0.042) in ICC. Moreover, miR-125b levels were able to predict invasive cancers with 88% sensitivity and 69% specificity. Results showed that while miR-34a expression seems to be correlated with invasive cervical cancer, miR-125b expression is significantly changed within the different cervical lesions and their levels should be further investigated as possible predictive/prognostic biomarkers using a noninvasive approach.

A Review on Melatonin’s Effects in Cancer: Potential Mechanisms

2018 ◽  
Vol 18 (7) ◽  
pp. 985-992 ◽  
Author(s):  
Aysegul Hanikoglu ◽  
Ertan Kucuksayan ◽  
Rana Cagla Akduman ◽  
Tomris Ozben
Keyword(s):  
Systematic Review ◽  
Antioxidant Activity ◽  
Membrane Receptors ◽  
Cancer Development ◽  
Secretory Product ◽  
Prevention And Treatment ◽  
G Protein Coupled

This systematic review aims to elucidate the role of melatonin (N-acetyl-5-metoxy-tryptamine) (MLT) in the prevention and treatment of cancer. MLT is a pineal gland secretory product, an evolutionarily highly conserved molecule; it is also an antioxidant and an impressive protector of mitochondrial bioenergetic activity. MLT is characterized by an ample range of activities, modulating the physiology and molecular biology of the cell. Its physiological functions relate principally to the interaction of G Protein-Coupled MT1 and MT2 trans-membrane receptors (GPCRs), a family of guanidine triphosphate binding proteins. MLT has been demonstrated to suppress the growth of various tumours both, in vivo and in vitro. In this review, we analyze in depth, the antioxidant activity of melatonin, aiming to illustrate the cancer treatment potential of the molecule, by limiting or reversing the changes occurring during cancer development and growth.

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