scholarly journals Thiazide and Thiazide-Like Diuretics in Therapy of Arterial Hypertension

Kardiologiia ◽  
2019 ◽  
Vol 59 (11) ◽  
pp. 84-94
Author(s):  
Ya. A. Orlova ◽  
N. V. Kurlykina ◽  
E. M. Seredenina
Keyword(s):  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Clinical Studies ◽  
Metabolic Effects ◽  
Efficacy And Safety ◽  
Comparative Aspect ◽  
Clinical Recommendation

The review presents results of clinical studies of efficacy and safety of thiazide and thiazide-like diuretics in the treatment of patients with arterial hypertension. In this work we have compared the role of diuretics in modern clinical recommendation on control of arterial pressure, and assessed in comparative aspect metabolic effects of thiazide-like diuretics.

scholarly journals Role of Endothelin-1 Receptor Antagonist in Reducing Perioperative Pulmonary Arterial Hypertension after Surgical Correction of Ventricular Septal Defect

2016 ◽  
Vol 9 (1) ◽  
pp. 55-59
Author(s):  
Rampada Sarker ◽  
ASMS Islam ◽  
SC Mandal ◽  
Kazi Abul Hasan ◽  
Manoz Kumar Sarker ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Ventricular Septal Defect ◽  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Septal Defect ◽  
Pulmonary Arterial Pressure ◽  
Surgical Correction ◽  
Endothelin 1 ◽  
Pulmonary Arterial

Background: This study was designed to determine the role of oral ambrisentan, an endothelin-1 receptor, in reducing perioperative pulmonary arterial hypertension during surgical correction of ventricular septal defect.Methods: This study was carried out among 54 patients of ventricular septal defect with pulmonary arterial hypertension undergoing surgical correction. The patients were divided into two groups; study group received oral ambrisentan, an endothelin-1 receptor antagonist peri-operatively, starting one week before surgery. Pulmonary arterial pressure was measured by echocardiography, cardiac catheterization and directly from pulmonary artery during surgical procedure.Results: Pulmonary arterial pressure was reduced significantly in the group in which oral amrisentan was given perioperatively. There was further reduction of pulmonary arterial pressure at discharge from hospital and at one month follow-up.Conclusion: Oral ambrisentan can reduce pulmonary arterial pressure perioperatively in patients underwent surgical correction of ventricular septal defect.Cardiovasc. j. 2016; 9(1): 55-59

scholarly journals Generalized data of criteria of risk factors for the use of the drug torasemide from the materials of its preclinical studies

2020 ◽  
Author(s):  
Natalia A. Anisimova ◽  
Natalia O. Selizarova ◽  
Grigory A. Plisko ◽  
Evgeny D. Semivelichenko ◽  
Svetlana M. Napalkova
Keyword(s):  
Risk Factors ◽  
Arterial Hypertension ◽  
Clinical Studies ◽  
Generic Drugs ◽  
Preclinical Studies ◽  
Efficacy And Safety ◽  
Cardiovascular Pathology ◽  
Pharmacological Studies ◽  
Search For Information ◽  
Preclinical And Clinical Studies

This study presents the review and analysis of materials, the summary of the data on the results of experimental (preclinical) pharmacological studies of the drug Torasemide and the results of clinical studies of the original drug Demadex, based on risk factors influencing the outcomes of hypertension in people. The information on the efficacy and safety of the drugs based on Torasemide is also presented in the relevant sections of the article. The search for information sources for the review was carried out using domestic and international databases elibrary and PubMed, applying contextual queries, including international non-proprietary names, terms of preclinical studies of pharmacokinetics, pharmacodynamics, and animal species used. This review considers the aspects of safety, pharmacokinetics, primary and secondary pharmacodynamics of Torasemide, available in various sources describing its preclinical studies. The summarized data presented in the study, in our opinion, may be used by researchers who are engaged in preclinical and clinical studies, as well as the issues of studying the efficacy and safety of generic drugs used in the treatment of patients with arterial hypertension and other cardiovascular pathology. The information on the advantages of Torasemide in comparison with Furosemide in the treatment of animals with simulated arterial hypertension deserves special consideration.

scholarly journals The role of risk factors and endothelium dysfunction in the pathogenesis of the high normal arterial preassure and clinical signs of the vegetative disturbances in children

2015 ◽  
Vol 12 (4) ◽  
pp. 6-10
Author(s):  
N A Maksimovich
Keyword(s):  
Risk Factors ◽  
Arterial Pressure ◽  
Arterial Hypertension ◽  
High Frequency ◽  
Clinical Signs ◽  
Normal Pressure ◽  
Early Diagnostics ◽  
Endothelium Dysfunction ◽  
High Level

As a result of investigation of the children the dysfunction of endothelium at high normal arterial pressure is the cause of the hemodynamic disturbances of children, equal of the arterial hypertension. As a result the children with high normal arterial pressure are the groups of the risk for arterial hypertension wich need the complex of correction of theses disturbances, early diagnostics of the arterial hypertension and its profylaxis. AT high level risk factors and vasoconstrictive properties at children with high normal arterial pressure the more high frequency of headache, the heart pain, both pains and the episodes of high normal pressure.

The effect of educational programs on effectiveness of treatment of arterial hypertension at out-patient stage of medical care rendering

2016 ◽  
Vol 22 (4) ◽  
pp. 207-212
Author(s):  
Aleksandr V. Melekhov ◽  
E. I Emelina ◽  
O. Yu Andreeva ◽  
G. E Gendlin ◽  
L. V Sokolovskaya
Keyword(s):  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Educational Program ◽  
Systolic Arterial Pressure ◽  
Educational Programs ◽  
Self Control ◽  
Target Values ◽  
Mercury Column ◽  
Hypotensive Therapy

The increasing of effectiveness of treatment of arterial hypertension is a key issue of prevention of complications of this disease. The level of target arterial pressure is achieved far from all patients treated because of arterial pressure. The article presents data concerning 55 individuals with office systolic arterial pressure higher than 140 mm of mercury column who in spite of hypotensive therapy prescribed by physician, demonstrated no achievement of target values of arterial pressure. Out of this group, 24 patients were acquainted with educational program including an hour lecture concerning arterial hypertension, techniques of self-control of arterial pressure, effect of non-pharmaceutical modes of treatment and role of patients themselves in therapy of this diseases. The educational program was ignored by 31 patient. All patients at the start and the completion of examination were measured office arterial pressure, monitored day arterial pressure. Also evaluation of compliance to indicated hypotensive medicinal therapy was carried out. At the second control visit after 1-3 months, in patients who attended the lecture, significant decreasing of arterial pressure was established according both office measurement and data of indices of systolic arterial pressure. Moreover, the same patients developed compliance to applied treatment. No such effects were observed in 31 patients who ignored lecture mentioned above. It is assumed that the important part of activities concerning treatment of patients with arterial hypertension from the very beginning of interaction with physician is to become increasing of awareness of patients about disease, modes of its control, importance of non-medicinal measures, regular pharmacotherapy attended by physician. It is appropriate to actively implement these measures in practical health care considering expressed clinical and social economical effectiveness of educational programs for patients with arterial hypertension.

scholarly journals ß-adrenoblockers in essential hypertension: Overview of the third millenium

2005 ◽  
Vol 11 (1) ◽  
pp. 13-16 ◽  
Author(s):  
A. O. Konradi ◽  
E. R. Berngardt ◽  
Ye. N. Smirnova
Keyword(s):  
Heart Failure ◽  
Essential Hypertension ◽  
Elderly Patients ◽  
Arterial Hypertension ◽  
Metabolic Effects ◽  
Beneficial Effects ◽  
The Third ◽  
Patients With Heart Failure

The paper presents the data available in the literature and the authors' findings on the role of ß-blockers in the treatment of arterial hypertension, on negative metabolic effects, and ways of their overcome The advantages of nebivolol in the treatment of essential hypertension are demonstrated The data of the SENIORS study on the beneficial effects in the treatment of elderly patients with heart failure are given

Daily arterial pressure profile in young individuals with hereditary burden due to arterial hypertension

2019 ◽  
Vol 17 (2) ◽  
pp. 42-48
Author(s):  
I. A. Grebenkina ◽  
◽  
A. A. Popova ◽  
S. D. Mayanskaya ◽  
S. V. Tretyakov ◽  
...  
Keyword(s):  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Pressure Profile

Capabilities of daily monitoring of arterial pressure and tests with dosed physical load in diagnostics of arterial hypertension in young athletes

2019 ◽  
Vol 17 (2) ◽  
pp. 74-79 ◽  
Author(s):  
A. A. Shirokova ◽  
◽  
L. A. Balykova ◽  
S. A. Ivyanskiy ◽  
K. N. Varlashina ◽  
...  
Keyword(s):  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Physical Load ◽  
Young Athletes ◽  
Daily Monitoring

Role of genetic factors in the development of hypertension in young patients with metabolic syndrome

2020 ◽  
pp. 23-32
Author(s):  
Elena Korneeva ◽  
Mikhail Voevoda ◽  
Sergey Semaev ◽  
Vladimir Maksimov
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
Arterial Hypertension ◽  
Genetic Factors ◽  
Young Patients ◽  
Integrin Αiibβ3 ◽  
Ace Gene ◽  
The Metabolic Syndrome

Results of the study related to polymorphism of ACE gene (rs1799752)‎, integrin αIIbβ3, and CSK gene (rs1378942) influencing development of arterial hypertension in young patients with metabolic syndrome are presented. Hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. Prevalence of mutant alleles of the studied genes among the examined patients was quite high, so homozygous DD genotype was found in 21.6%, and mutant D allele of the ACE gene in 47.4%. A high risk of hypertension in patients with MS was detected in carriers of the T allele of the CSK (rs1378942) gene – 54.8%, which was most often observed in a combination of polymorphic ACE and CSK gene loci (p = 0.0053).

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