scholarly journals Assessment of Risk Factors for Atherosclerosis in Individuals of Different Categories of Cardiovascular Risk Using the Aterostop Calculator

Kardiologiia ◽  
2021 ◽  
Vol 61 (3) ◽  
pp. 12-17
Author(s):  
M. Y. Zubareva ◽  
P. P. Malyshev ◽  
A. A. Ansheles ◽  
I. V. Sergienko
Keyword(s):  
Risk Factors ◽  
Comprehensive Evaluation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Lipid Lowering ◽  
Cross Sectional ◽  
National Medical ◽  
Extreme Risk ◽  
First Results

Aim        To analyze first results of using the Aterostop calculator for a comprehensive evaluation of the risk for cardiovascular diseases (CVD).Material and methods        A cross-sectional study analyzed major and additional risk factors in 460 subjects without apparent disease and in patients with documented CVD of atherosclerotic origin using the application (calculator) Aterostop developed in the National Medical Research Center of Cardiology in Moscow, Russia.Results   45.4% of evaluated persons belonged to the categories of very high and extreme risk. Age and frequencies of smoking, arterial hypertension, and diabetes mellitus (DM) increased with the increase in risk; the growth of DM was exponential. 129 (28%) individuals used lipid-lowering medications at the time of study. Their plasma levels of low-density lipoprotein cholesterol (LDL-C) were significantly lower than in those who did not received this treatment. However, achieving the target level was inversely proportional to the risk: the greatest proportion of individuals who reached the LDL-C target was in the category of low risk and the smallest proportion was in the category of extreme risk (75 % vs. 3.7 %, respectively).Conclusion            The results obtained with the calculator Aterostop were consistent with earlier reports of insufficient effectiveness of primary and secondary prevention of atherosclerotic CVDs, which requires more tight and fruitful cooperation of the physician and the patient.

scholarly journals The Prevalence of Cardiovascular Risk Factors among Polish Soldiers: The Results from the MIL-SCORE Program

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Grzegorz Gielerak ◽  
Paweł Krzesiński ◽  
Katarzyna Piotrowicz ◽  
Piotr Murawski ◽  
Andrzej Skrobowski ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Pressure Control ◽  
Cross Sectional Study ◽  
Lipoprotein Cholesterol ◽  
Risk Scores ◽  
Cross Sectional

The MIL-SCORE (Equalization of Accessibility to Cardiology Prophylaxis and Care for Professional Soldiers) program was designed to assess the prevalence and management of cardiovascular risk factors in a population of Polish soldiers. We aimed to describe the prevalence of cardiovascular risk factors in the MIL-SCORE population with respect to age. This observational cross-sectional study enrolled 6440 soldiers (97% male) who underwent a medical history, physical examination, and laboratory tests to assess cardiovascular risk. Almost half of the recruited soldiers were past or current smokers (46%). A sedentary lifestyle was reported in almost one-third of those over 40 years of age. The prevalence of hypertension in a subgroup over 50 years of age was almost 45%. However, the percentage of unsatisfactory blood pressure control was higher among soldiers below 40 years of age. The prevalence of overweight and obese soldiers increased with age and reached 58% and 27%, respectively, in those over 50 years of age. Total cholesterol was increased in over one-half of subjects, and the prevalence of abnormal low-density lipoprotein cholesterol was even higher (60%). Triglycerides were increased in 36% of soldiers, and low high-density lipoprotein cholesterol and hyperglycemia were reported in 13% and 16% of soldiers, respectively. In the >50 years of age subgroup, high and very high cardiovascular risk scores were observed in almost one-third of soldiers. The relative risk assessed in younger subgroups was moderate or high. The results from the MIL-SCORE program suggest that Polish soldiers have multiple cardiovascular risk factors and mirror trends seen in the general population. Preventive programs aimed at early cardiovascular risk assessment and modification are strongly needed in this population.

scholarly journals Dietary phytochemical index associated with cardiovascular risk factor in patients with type 1 diabetes mellitus

2021 ◽  
Author(s):  
Saeideh Delshad Aghdam ◽  
Fereydoun Siassi ◽  
Ensieh Nasli Esfahani ◽  
Mostafa Qorbani ◽  
Asadollah Rajab ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Lipoprotein Cholesterol ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Cross Sectional ◽  
The Relationship

Abstract Background Dietary phytochemical index (DPI) is useful and inexpensive method to identify the role of phytochemicals on cardiovascular disease (CVD) risk factors. This study aimed to assess the relationship between DPI and CVD risk factors in patients with type1 diabetes mellitus (T1DM). Methods A total of 261 participants aged 18–35 years with T1DM were enrolled in this cross-sectional study to assess the relationship between DPI and CVD risk factors. Anthropometric measurements, blood lipids, glucose, and antioxidant level were measured. Food intakes were determined using a food frequency questionnaire to calculate DPI. Logistic regression was used. Results The mean age of participants was 25 years. After adjustment for potential confounders, participants in the highest tertile of DPI had 88% lower chance of hyperglycemia (P for trend = 0.020), 81% lower chance of low high-density lipoprotein cholesterol (HDL-C) (P for trend = 0.030) and 98% lower chance of high low-density lipoprotein cholesterol to HDL-C ratio (P for tend = 0.040). There were no relationships between DPI and other CVD risk factors. Conclusions Although higher intake of phytochemical-rich foods had a beneficial effect on some risk factors of CVD, more studies more studies are warranted to corroborate the present findings.

scholarly journals Dyslipidemia and cardiovascular risk in Afro-descendants: a study of the Quilombola communities in Maranhão, Brazil

2015 ◽  
Vol 10 (36) ◽  
Author(s):  
Maria do Carmo Lacerda Barbosa ◽  
José Bonifácio Barbosa ◽  
Luis Felipe Alves Guerra ◽  
Mirza Ferreira Lima Barbosa ◽  
Felipe Lacerda Barbosa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Lipoprotein Cholesterol ◽  
Cardiovascular Risks ◽  
Cross Sectional ◽  
Factors Associated ◽  
Low Prevalence

Objective: to evaluate the prevalence of cardiovascular risk factors associated with dyslipidemia in Quilombola communities in Maranhão, Brazil. Methods: a cross-sectional study was performed from February 2010 to November 2011. A total of 202 individuals belonging to the Quilombola communities in Codó, Maranhão were assessed. Risk factors associated with dyslipidemia and metabolic syndrome (MS) were evaluated. Results: the results showed a high prevalence of dyslipidemia (72.28%) and hypertension (43.07%). Isolated hypertriglyceridemia (38.61%) with normal levels of high-density lipoprotein cholesterol and low-density lipoprotein cholesterol was present in most individuals. Furthermore, the prevalence of MS and the estimated cardiovascular risks were low in this population. Conclusion: dyslipidemia, at the expense of triglycerides, and hypertension was highly prevalent. However, the frequency of other risk factors for cardiovascular events was low. A low prevalence of MS and cardiovascular risk according to the Framingham score for cardiovascular diseases was also identified.

Abstract P179: Uncontrolled Cholesterol Levels In Patients With Severe Hypercholesterolemia

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Nicole Groth ◽  
Catherine P Benziger
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Heart Association ◽  
Cross Sectional Study ◽  
Lipid Lowering ◽  
Lipid Lowering Therapy ◽  
Cross Sectional ◽  
Lowering Therapy ◽  
Cholesterol Guidelines ◽  
European Society Of Cardiology

Introduction: The 2018 American Heart Association/American College of Cardiology cholesterol guidelines recommends patients who have phenotypic severe hypercholesterolemia (SH), defined as a low-density lipoprotein-cholesterol (LDL-c) > 190 mg/dL, be started on maximally tolerated statin therapy without further risk stratification due to high risk for cardiovascular disease (CVD). SH patients on guideline-directed medical therapy (GDMT) should have 50% reduction in their LDL-c levels, with optimal being < 100 mg/dL for primary prevention and <70 mg/dL for secondary prevention. The 2019 European Society of Cardiology/European Atherosclerosis Society cholesterol guidelines recommend an optimal LDL-c level < 55 mg/dL. Hypothesis: LDL-c levels vary by intensity of medication and are not at target in patients with SH in a large rural healthcare system. Methods: We used an electronic medical record-based SH registry defined by ever having an LDL-c > 190 mg/dL since 01/01/2000 (n=17,925) at Essentia Health (MN, WI, and ND). In this cross-sectional study, patients were excluded if they had: no recent visit within the past 5 years (n=209), <20 or >75 years (n=3,153), listed as being on a statin but intensity was unavailable (n=1,934), or had no recent lab (n=998). Methods: We included 12,283 patients (68.5%)(mean age 59.4 + 10.1 years; 59.5% female) with SH and of these only 22.9% were on a high-intensity statin or proprotein convertase subtilisin/kexin type 9 inhibitor. Of the patients that were not on any lipid-lowering therapy (n=4,971; 40.5%), only 16.8% (n=837) had a statin allergy or intolerance documented. Figure 1 shows the most recent LDL-c levels; <10% of patients in each group had a most-recent LDL-c <70 mg/dL, and 9.4% had an LDL-c <55mg/dL. Conclusions: Most SH patients remain untreated or undertreated with GDMT with recent LDL-c levels above target. More aggressive lipid-lowering therapy in patients with SH is needed to reduce risk of CVD.

scholarly journals Interaction between CETP polymorphism and dietary insulin index and load in relation to cardiovascular risk factors in diabetic adults

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Faezeh Abaj ◽  
Masoumeh Rafiee ◽  
Fariba Koohdani
Keyword(s):  
Risk Factors ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional

AbstractGene–diet interactions may play an important role in the inter individual diversity observed in on cardiovascular disease (CVD) risk factors. Therefore, in the current study, we examined the interaction of CETP TaqB1 polymorphism with dietary insulin index and load (DII and DIL), in altering on CVD risk factors among type 2 diabetes mellitus (T2DM). In this cross-sectional study, blood samples were collected from 220 type 2 diabetic patients (134 females and 86 male) with a mean age of 52.24 years in Tehran, Iran. DIL and DII were obtained via validated food-frequency questionnaire (FFQ). Taq1B polymorphism was genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Biochemical markers including total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), superoxide dismutase (SOD), C-reactive protein (CRP), total antioxidant capacity (TAC), pentraxin-3 (PTX3), isoprostaneF2α (PGF2α). interleukin 18 (IL18), leptin and ghrelin were measured by standard protocol. Patients with B1B1 genotype had lower lipid profiles include LDL/HDL (P < 0.001) and TG (P = 0.04) when they consumed diets higher on the DIL and DII index. Moreover, carriers of B2B2 genotype who were in the last tertile of DIL had higher antioxidant and inflammatory markers include SOD (P = 0.01), PGF2α (P = 0.04) and CRP (P = 0.02). Further, a significant interaction between CETP TaqB1 and DII was shown in terms of WC (P = 0.01), where the highest WC were observed in B2B2 genotype carriers following a DII score. However, the highest inflammatory and antioxidant markers include CRP (P = 0.04), TAC (P = 0.01), SOD (P = 0.02), and PGF2α (P = 0.02) were observed in B2B2 genotype carriers when they consumed diets higher on the DII index. Based on the current study, it could be proposed that CETP polymorphism may be associated with CVD risk factors in T2DM patients with high following insulin indices, including DII and DIL. It seems that CETP Taq1B polymorphism can invert the result produced by insulin. This conclusion illustrates that the CETP Taq1B B1 allele could counteract the CVD risk induced by high DII and DIL.

scholarly journals The Distribution of Cardiovascular-Related Comorbidities in Different Adult-Onset Cancers and Related Risk Factors: Analysis of 10 Year Retrospective Data

2021 ◽  
Vol 8 ◽  
Author(s):  
Qingsong Li ◽  
Fei Liu ◽  
Yuqi Tang ◽  
Sharen Lee ◽  
Chao Lang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Thyroid Cancer ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Record System ◽  
Cross Sectional ◽  
Cardiovascular Comorbidities ◽  
Related Risk ◽  
Significant Burden

Introduction: Understanding the epidemiology of cardiovascular disease (CVD) related comorbidity is a key strategy for improving the outcomes of patients with cancer. Therefore, this study aimed to assess the distribution of cardiovascular comorbidities and cardiovascular risk factors (CVRF) among five cancer sites.Methods: This is a single-centered, cross-sectional study performed in Dalian, China. Between 2008 and 2018, all newly diagnosed cancer in the First Affiliated Hospital of Dalian Medical University, China were screened. Clinical data were extracted from a comprehensive electronic health record system.Results: 35861 patients with lung, colorectal, gastric, breast, and thyroid cancer were collected retrospectively. The most prevalent CVDs in descending order were hypertension (21.9%), followed by coronary heart disease (6.5%), atrial fibrillation (2.9%), and heart failure (1%). The prevalence of hypertension significantly varies between lung (21.3%), colorectal (27.3%), gastric (22.5%), breast (16.7%), and thyroid cancer (22.4%) (P &lt; 0.001). CVRF varies with cancer sites. Age, sex, total cholesterol, triglyceride, low-density lipoprotein cholesterol, systolic blood pressure, smoking, alcohol use, and diabetes mellitus (DM) are common risk factors associated with CVD at different cancer sites. The association between DM and presence of CVD was strong in breast (odds ratio [OR] = 4.472, 95% confidence interval [CI]: 3.075–6.504, P &lt; 0.001), lung (OR = 3.943; 95% CI: 3.270–4.754, P &lt; 0.001), colorectal (OR = 3.049; 95% CI: 2.326–3.996, P &lt; 0.001), and gastric (OR = 2.508; 95% CI: 1.927–3.264, P &lt; 0.001) cancer.Conclusion: Cancer patients had a significant burden of CVD and increased CVRF. The prevalence of CVRF and CVD comorbidity differ for cancer types. DM remains significantly associated with CVD at different cancer sites except for thyroid cancer.

scholarly journals Screening Cardiovascular Risk Factors of Diabetes Patients in the Primary Diabetes Clinics

2020 ◽  
Author(s):  
Lingwang An ◽  
Yanlei Wang ◽  
Chenxiang Cao ◽  
Tao Chen ◽  
Yonghong Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Diabetes Care ◽  
Glycosylated Hemoglobin ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Ascvd Risk ◽  
Atherosclerotic Cardiovascular Diseases

Abstract Aim:To evaluate the atherosclerotic cardiovascular diseases (ASCVD) risk factors in type 2 diabetes (T2DM) patients from the primary diabetes clinics for further comprehensive intervention in China.Methods:A cross-sectional study was conducted in 5 primary diabetes chain hospitals in Beijing, Lanzhou, Harbin, Chengdu and Taiyuan in continuous patients with T2DM from March 2016 to December 2019. The data collected at the first visit were analyzed, and proportions of patients reached the targets (glycosylated hemoglobin (HbA1C) < 7%, blood pressure < 130 / 80mmHg, and low-density lipoprotein cholesterol (LDL-C) < 2.6mmol/l) were calculated. The differences among different hospitals, different treatment and numbers of aggregated ASCVD risk factors were compared.Results:A total of 20,431 participants, including 11,363 men (55.6%), with an average age of (59.4 ± 10.4) years were enrolled. Nearly 95% diabetes had one or more ASCVD risk factors other than hyperglycemia. The control rates of HbA1C, blood pressure, and LDL-C were 26.5%, 27.9%, and 42.6%, respectively. Only 4.1% patients achieved all 3 targets. Diabetes duration, family history and overweight/obesity were associated with the number of aggregated ASCVD risk factors. And the patients with short duration, no overweight/obesity, not smoking, less ASCVD risk factors and lived in Chengdu were associated with a higher control rates.Conclusions:In confront of poor control status, global management of ASCVD risk factors including weight loss and smoking stopping must be emphasized in the primary diabetes care settings.Highlights:The prevalence of ASCVD risk factors was high and control rates were low in the primary diabetes care hospitals in China.Overweight/obesity, smoking and resident area were associated with the aggregated ASCVD risk factors and worse control.Trial registration:Current ClinicalTrial.gov protocol ID NCT03707379. Date of Registration: October 16, 2018.https://clinicaltrials.gov

scholarly journals Prevalence of Dyslipidemia in Patients with Acute Coronary Syndrome Admitted at Tertiary Care Hospital in Nepal: A Descriptive Cross-sectional Study

2020 ◽  
Vol 58 (224) ◽  
Author(s):  
Sahadeb Prasad Dhungana ◽  
Arun Kumar Mahato ◽  
Rinku Ghimire ◽  
Rupesh Kumar Shreewastav
Keyword(s):  
Risk Factors ◽  
Acute Coronary Syndrome ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Lipoprotein Cholesterol ◽  
Low Density Lipoprotein Cholesterol ◽  
Cross Sectional ◽  
Coronary Syndrome ◽  
The Mean

Introduction: Dyslipidemia is one of the major risk factors for acute coronary syndrome. Dyslipidemiawith an increase in total cholesterol, low-density lipoprotein cholesterol, triglycerides and decrease inhigh-density lipoprotein cholesterol is one of the major risk factors for the acute coronary syndromeand alone account for more than 50% of population attributable risk. This study was conducted tofind out the prevalence of dyslipidemia. Methods: This descriptive cross-sectional study was conducted in 105 patients admitted at thetertiary care center with a diagnosis of acute coronary syndrome from July 2018 to March 2019 afterapproval from the institutional review committee (Ref no. 205/2018). Fasting serum lipid profilewas obtained within 24 hours of hospitalization with the convenient sampling method. Data wereanalyzed with the help of the Statistical Package for Social Sciences version 20. Point estimation at95% Confidence interval was calculated along with frequency and proportion for binary data. Results: Out of 105 people, dyslipidemia was present in 51 (48.6%). The mean age of the participantswas 59.19±12.69 years. The majority 81 (77.1%) were male. The mean total cholesterol, triglycerides,low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were 183.43±35.9 mg/dl, 140.59±46.83 mg/dl, 109.9±26.38 mg/dl and 41.17±4.78 mg/dl respectively. High total cholesteroland triglyceride were found in 34 (32.4%) each, low high-density lipoprotein in 31 (29.5%) and highlow-density lipoprotein in 22 (21%).  Conclusions: Dyslipidemia is a significant risk factor in patients with acute coronary syndromeand commonly associated with other risk factors. Careful attention to its management may help toreduce further events.

scholarly journals ASSOCIATION OF SELECTED RISK FACTORS OF CORONARY HEART DISEASE WITH LIPID PROFILE

2018 ◽  
Vol 11 (2) ◽  
pp. 366
Author(s):  
Trilochan Sahu ◽  
Lipilekha Patnaik ◽  
Venkata Rao E ◽  
Subhashree Ray ◽  
Sandeep Kumar Panigrahi
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Total Cholesterol ◽  
Blood Sugar ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Community Based Education

 Objective: The objectives of this study is to assess the association of selected risk factors for coronary heart disease (CHD) with lipid profile.Methods: A cross-sectional study was conducted during May 2013–April 2014 among 350 subjects of 25–64 years selected by systematic random sampling. Data on sociodemographic and medical and personal history along with anthropometric measurements were collected through house-to-house visit. Blood sample was analyzed for fasting blood sugar and lipid profile.Results: In this study, 38.58% belong to the age group of 25–35 years and 58% were female. Majority (45.43%) of the participants belonged to lower socioeconomic status, followed by the middle (40.57%) and upper class (14%). It was observed that total cholesterol was significantly associated with blood sugar (p=0.0008), blood pressure (p=0.001), and body mass index (BMI) (p=0.018). There was no significant association among the risk factors of CHD such as smoking and alcohol with total cholesterol. Low-density lipoprotein level was significantly associated with BMI (p=0.0001) and blood sugar (p=0.003). There was a significant association among the risk factors for CHD such as smoking (p=0.002), alcohol, (p=0.017) blood sugar (p=0.004), and BMI (p=0.014) with triglyceride level.Conclusion: It was concluded from this study that various risk factors for CHD were associated with lipid abnormalities. Hence, a community-based education in this regard is of paramount importance.

scholarly journals The Association of rs1898830 in Toll-Like Receptor 2 with Lipids and Blood Pressure

2020 ◽  
Vol 7 (3) ◽  
pp. 24
Author(s):  
Pia Chedid ◽  
Ali Salami ◽  
Said El Shamieh
Keyword(s):  
Risk Factors ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Biological Data ◽  
Lipoprotein Cholesterol ◽  
Power Calculation ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Cross Sectional

Background and Objective: Toll-like receptors (TLRs) are important components of the innate immune system, involved in establishing immunity to infections. Apart from being implicated in immunity, numerous studies have reported that many TLRs, including TLR2, are involved in the pathogenesis of cardiovascular diseases and their risk factors. Since rs1898830 is associated with TLR2-mediated cellular activation, we aimed to study its association with CVD risk factors, such as lipid levels and hypertension. Methods: A cross-sectional study was conducted on 460 individuals free from chronic diseases. Clinical and biological data were collected and DNA was extracted and genotyped using Kompetitive allele specific PCR (KASP™). Multiple logistic regression models, adjusted for six covariates, were used. A power calculation analysis was also performed. Results: We found that rs1898830 in TLR2 was positively associated with hypertension (OR = 2.18, p = 0.03) and negatively associated with high-density lipoprotein cholesterol (OR = 0.66, p = 0.05). In contrast, no relation was found with total cholesterol and low-density lipoprotein cholesterol. Conclusion: The present results provide additional evidence supporting the implication of TLR2 in CVD risk factors.

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