scholarly journals CPK: The new tool in the diagnosis of ectopic pregnancy

2017 ◽  
Vol 6 (6) ◽  
pp. 2507
Author(s):  
Suvarna Jyothi Ganta ◽  
Sunanda R. Kulkarni ◽  
Vidya Muralidhar
Keyword(s):  
Maternal Mortality ◽  
Ectopic Pregnancy ◽  
Diagnostic Dilemma ◽  
Diagnostic Efficacy ◽  
Mortality And Morbidity ◽  
Appropriate Treatment ◽  
Future Fertility ◽  
Maternal Mortality And Morbidity ◽  
The Mean ◽  
Ectopic Pregnancies

Background: Ectopic pregnancy is still a diagnostic dilemma presenting with various complaints. The classic triad of amenorrhea, abdominal pain, vaginal bleeding and /or syncope is not always seen. Misdiagnosis can lead to delay in treatment, blood loss is found to be the major cause of death. Early and accurate diagnosis is critical in bringing down the maternal mortality and morbidity. Prompt and effective treatment of an ectopic pregnancy can help preserve the chances of future healthy pregnancies. Aim of present study was to investigate whether creatinine phosphokinase (cpk) can be used as an effective diagnostic tool in the early diagnosis of ectopic pregnancy which can help in decreasing the maternal mortality and morbidityMethods: This observational comparative three group clinical study was conducted at Chinmaya Mission Hospital, Bangalore, between May 2016 to January 2017.120 women in their early trimester were studied of which 40 were diagnosed cases of ectopic pregnancies, 40 women presented with intrauterine abortive pregnancies and 40 women had normal healthy pregnancies. Serum CPK, serum B-HCG, vaginal scans were done in all, along with routine investigations.Results: The mean CPK values in normal, abortive and ectopic pregnancies were 36.92±6.44, 43.95±11.96 and 91.55±30.43 respectively. It was found to be significantly higher in ectopic Pregnancies. Also, the mean CPK in ruptured and unruptured ectopic pregnancy were 97.26±25.97 and 63.82±34.92 respectively.Conclusions: Present study shows that maternal CPK levels are significantly higher in women with ectopic pregnancies. CPK can serve as the reliable biochemical marker to diagnose ectopic pregnancy particularly ruptured. CPK can be used to increase the diagnostic efficacy in ectopic pregnancy, which followed by rapid and appropriate treatment can reduce the mortality, morbidity and preserve future fertility.

scholarly journals Ectopic pregnancy and epithelial to mesenchymal transition: is there a link?

Reproduction ◽  
2020 ◽  
Author(s):  
Heather Flannagan ◽  
Chih-Jen Lin ◽  
Lisa L. Campbell ◽  
Paddy Horner ◽  
Andrew W Horne ◽  
...  
Keyword(s):  
Protein Expression ◽  
Maternal Mortality ◽  
Ectopic Pregnancy ◽  
Epithelial To Mesenchymal Transition ◽  
First Trimester ◽  
Mortality And Morbidity ◽  
Mesenchymal Transition ◽  
Maternal Mortality And Morbidity

Ectopic pregnancy (EP) is defined as the implantation of an embryo outside of the uterus and is a leading cause of first trimester maternal mortality and morbidity. This article discusses a possible role for epithelial to mesenchymal transition in the pathogenesis of EP, given the notable similarity of protein expression between the two processes.

Twelve Week Ruptured Interstitial Ectopic Pregnancy

2020 ◽  
Vol 1 (1) ◽  
pp. 23-26
Author(s):  
Sadık Kükrer ◽  
Ayfer Pepekal Kukrer ◽  
Eren Haytoğlu ◽  
Erdal Yılmaz
Keyword(s):  
Maternal Mortality ◽  
Ectopic Pregnancy ◽  
Reproductive Age ◽  
Tubal Ectopic Pregnancy ◽  
Mortality And Morbidity ◽  
Life Threatening ◽  
Gestational Sac ◽  
Interstitial Ectopic Pregnancy ◽  
Ectopic Pregnancies ◽  
Related Mortality

Despite advancements in management and diagnosis, ruptured ectopic pregnancy is still a major reason for pregnancy-related mortality and morbidity. 2% of all pregnancies are ectopic pregnancy and interstitial ectopic pregnancy rate is 2-4% among all ectopic pregnancies. We should consider about it as an essential characteristic in each female of reproductive age that presents with the triad of amenorrhoea, unusual vaginal bleeding and abdominal irritation. It ruptures at a more sophisticated stage of gestation when compared with tubal ectopic pregnancy. Bleeding in interstitial ectopic pregnancy rupture is above that other ectopic pregnancies, also its life-threatening. Interstitial ectopic pregnancy rupture is two to five times greater compared to maternal mortality rate than tubal ectopic pregnancy rupture. Developing gestational sac causes uterine disruption and following hemorrhagic shock, resulting in morbidity and mortality. Clinics that aim to reduce maternal mortality should be much more concerned about convenient disclosure of this abnormal pregnancy condition.

scholarly journals Dilemma in diagnosing ovarian ectopic pregnancy

2020 ◽  
Vol 9 (3) ◽  
pp. 1296
Author(s):  
Harsha Rajpal ◽  
Harvinder Kaur ◽  
Urvashi Miglani
Keyword(s):  
Early Diagnosis ◽  
Maternal Mortality ◽  
Ectopic Pregnancy ◽  
Histopathological Examination ◽  
Wedge Resection ◽  
The Other ◽  
Provisional Diagnosis ◽  
Mortality And Morbidity ◽  
Life Saving ◽  
Maternal Mortality And Morbidity

To study different presentation of ovarian ectopic pregnancy and its management. All the 4 patients of ovarian ectopic pregnancy presented in our hospital in the month of April 2019 were analysed. We reported 4 cases with a pre-operative provisional diagnosis of ruptured ectopic pregnancy and intra-operative diagnosis of? ovarian ectopic pregnancy, however histopathological examination confirmed the diagnosis of ovarian ectopic pregnancy in only 2 of the cases while the other 2 were ruptured corpus luteal cyst. Wedge resection was performed in all 4 patients. Ovarian ectopic pregnancy is rare and can be missed radiologically and intra-operatively. Establishing early diagnosis is a challenge to the clinician, it commonly mimics tubal ectopic or ruptured corpus luteal cyst. Provisional diagnosis can be made intra-operatively when a hemorrhage mass is seen near the ovary with a normal fallopian tube but can be confirmed by histopathological examination. The chief goal of the treatment remains life-saving intervention by early diagnosis to reduce maternal mortality and morbidity.

Fetomaternal Outcome of Eclampsia

KYAMC Journal ◽  
2018 ◽  
Vol 9 (3) ◽  
pp. 120-124
Author(s):  
Fatema Begum ◽  
Bedoura Sharmin ◽  
Umme Hafsa Zakia ◽  
Farhana Dewan ◽  
SM Asaduzzaman
Keyword(s):  
Maternal Mortality ◽  
Neonatal Intensive Care ◽  
Test Statistics ◽  
College Hospital ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Medical College ◽  
Maternal Mortality And Morbidity ◽  
Risk Patients ◽  
The Mean

Background: Eclampsia is a leading cause of maternal mortality and morbidity and adverse neonatal outcome. Healthcare system must be enhance to improve fetomaternal outcome.Objective: To find out the proportion and fetomaternal outcome of eclampsia.Materials and Methods: A cross sectional descriptive study was conducted to assess the fetomaternal outcome of eclampsia. The study was carried out at the Eclampsia unit, Dhaka Medical College Hospital, Dhaka over aperiod of six months from 1st July 2008 to 31st December 2008. A total of 48 patients with diagnosis of antepartum and intrapartum eclampsia were consecutively taken in the study. The test statistics used to analyse the data were descriptive statistics.Results: About 7% of patients developed acute renal failure,16.7% CVA,14.6% HELLP syndrome and 39.6% pulmonary oedema. The mean hospital stay was 9.5 ± 3.3 days. Majority (93.8%) of the patients recovered while 6.3% died. Twenty-seven (54.2%) neonates had to be referred to neonatal intensive care unit for better management. Of them 24 recovered following resuscitation. The mean weight of baby was 2.2±0.3 kg.Conclusion: Eclampsia is still a major cause of maternal mortality and morbidity in Bangladesh. Monitoring of high-risk patients may reduce the complication rate.KYAMC Journal Vol. 9, No.-3, October 2018, Page 120-124

scholarly journals Maternal Mortality and Morbidity in the United States: Where Are We Now?

2014 ◽  
Vol 23 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Andreea A. Creanga ◽  
Cynthia J. Berg ◽  
Jean Y. Ko ◽  
Sherry L. Farr ◽  
Van T. Tong ◽  
...  
Keyword(s):  
United States ◽  
Maternal Mortality ◽  
The United States ◽  
Mortality And Morbidity ◽  
Maternal Mortality And Morbidity

scholarly journals Ectopic pregnancy at the Gambian Tertiary hospital

2021 ◽  
Vol 21 (1) ◽  
pp. 295-303
Author(s):  
Matthew Anyanwu ◽  
Grace Titilope
Keyword(s):  
Risk Factors ◽  
Ectopic Pregnancy ◽  
Tertiary Hospital ◽  
Clinical Feature ◽  
Chi Square ◽  
Mortality And Morbidity ◽  
Significant Burden ◽  
Incidence Risk ◽  
Ectopic Pregnancies ◽  
The Tropics

Background/Aims: Ectopic pregnancy is a gynaecological emergency with significant burden of maternal mortality and morbidity in the tropics. The incidence reported in the literature range from 1:60 to 1:250 pregnancies. The aim was to determine incidence and risk factors of ectopic pregnancy in the Gambia. Methodology: A longitudinal study of ectopic pregnancy at Gambian tertiary hospital from January 2016 to April 2018. Data was collected from patients’ folders, entered into SPSS version 20 and analysed with de- scriptive statistics. The test of variation and significance was by ANOVA and Chi-square respectively with error margin set at 0.05 and confidence interval of 95%. Results: A total number of 2562 pregnancies were recorded, 43 were ectopic pregnancies. The estimated incidence was 0.2%. Majority of the patients were between 26 – 35 years (56%), primiparous (32%), heterogeneous marriage (82%) and housewives (86%). Occupation was not associated with ruptured or unruptured ectopic pregnancy (p-0.421). Low parity was associated with more ectopic pregnancy than high parity (p-0.001). The commonest clinical feature was abdominal pain (65.1%), whilst the most prominent risk factors were pelvic inflamma- tory disease (27.9%) and previous abortion (23.3%). Ectopic pregnancy was seasonal. Conclusion: The incidence rate of 0.2% was in the range reported in the literature. Low parity, previous abortion and pelvic inflammatory disease were the risk factors. Keywords: Ectopic; pregnancy; incidence; risk factors.

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