scholarly journals Correlation between β-HCG and Doppler in post molar surveillance

Author(s):  
Priyadarsini S. ◽  
Gigi A.

Background: Gestational trophoblastic disease encompass a spectrum of neoplastic disorders that arise from placental trophoblastic tissue after abnormal fertilisation. Most molar pregnancies spontaneously resolve after uterine evacuation with no further sequelae. However, at any time during or after gestation malignant transformation may occur in approximately 10% to 20% of molar pregnancies. Quantification of βHCG is considered as the ideal method of post molar surveillance. The regression of the disease could be reliably assessed by observing the changes in low resistance flow which paralleled the gradual decrements in serial βHCG levels. To correlate uterine artery blood flow characteristics to serum βHCG levels in the follow up of patients with gestational trophoblastic disease after molar evacuation.Methods: 50 patients with gestational trophoblastic disease after evacuation were followed up by serum βHCG titres and Doppler ultrasonography of uterine arteries. The relationship between the Doppler indices and the serum βHCG titres were evaluated by paired –t test and Pearsons correlation analysis.Results: Significant negative correlations were observed between Systolic/Diastolic (S/D) ratios, Resistance Indices(RI) and Pulsatility indices (PI) and the absolute values of serum βHCG levels, with correlation coefficients of -0.5, -0.46 and -0.40 (p<0.01). The mean values of βHCG showed a decreasing trend from 1st week to 4th week. The mean value of RI, PI and S/D Ratio showed an increasing trend from 1st week to 4th week. However, the difference in mean values of βHCG and Doppler indices at 1st week and 4th week were analysed by paired t test and found to be statistically insignificant(p>0.05) in patients with spontaneous remission.Conclusion: Uterine artery Doppler indices can be used as an adjunct to βHCG for the surveillance of patients with gestational trophoblastic disease after molar evacuation to predict remission of the disease.

1991 ◽  
Vol 66 (3) ◽  
pp. 974-985 ◽  
Author(s):  
H. Nishijo ◽  
R. Norgren

1. A total of 51 single neurons was recorded from the pontine parabrachial nuclei of three rats being given sapid stimuli either via intraoral infusions or during spontaneous licking behavior. In 46 neurons, sapid stimuli elicited significant taste responses; of these, 28 responded best to NaCl, 15 to sucrose, 2 to citric acid, and 1 to quinine HCl. The remaining five neurons responded significantly only to water. The mean spontaneous rate of taste neurons during the intraoral infusion and licking sessions was 11.1 +/- 1.1 and 10.8 +/- 1.2 (SE) spikes/s, respectively. 2. Of the 39 neurons tested during both licking and intraoral infusions, four responded significantly only to water via either route. The remaining 35 neurons responded significantly to at least some sapid stimuli. The best-stimulus categories remained the same regardless of the route of fluid delivery (24 NaCl best, 10 sucrose best, 1 citric acid best). When the rats were licking the stimuli, nine taste neurons responded significantly to only one sapid chemical [6 Na specific (Ns) and 3 sucrose specific (Ss)] but were more broadly tuned during intraoral infusions. Conversely, three taste neurons that responded specifically during intraoral infusions (3 Na specific) were not as specific when the animal licked the same fluids. 3. Thirty-five taste neurons were tested via both stimulus routes. These data were compared in three ways. First, for each neuron, the responses elicited during licking and intraoral infusions were compared for each of the four standard sapid stimuli. The Pearson correlation coefficients for the 35 taste neurons ranged from 0.9997 to 0.6785, with a mean at 0.953 +/- 0.012 (SE). The second comparison was between stimulus routes across chemicals. With the use of raw responses, the correlation coefficients for NaCl, sucrose, citric acid, and QHCl ranged from 0.925 to 0.778 (t test, P less than 0.0001). With the activity elicited by water subtracted (corrected responses), the correlation coefficients for NaCl, sucrose, citric acid, and QHCl were 0.900, 0.795, 0.369, and 0.211, respectively. The coefficient for QHCl was not significant (t test, P greater than 0.05). Finally, the mean responses to NaCl, sucrose, and citric acid delivered by both routes were compared and found not to differ (paired t test, P greater than 0.05). 4. In separate hierarchical cluster analyses for the licking and infusion data, the largest cluster in each contained all of the Na-best neurons and the next largest, all of the sucrose-best cells.(ABSTRACT TRUNCATED AT 400 WORDS)


2021 ◽  
Vol 7 (3) ◽  
pp. 223-228
Author(s):  
Sanda Aamani ◽  
Hemanth M ◽  
Sharmada B K ◽  
Karthik J Kabbur ◽  
Goutham Kalladka

There is a lack of accurate three-dimensional studies to locate malar prominence for specified population, this study aims to locate the malar prominence using stable landmarks using CBCT. To derive a novel method to accurately locate the malar prominence and to assess and compare the malar prominence between males and females among Bangalore population using 3D CBCT study. All CBCT scans of study subjects belong to Bangalore population were collected from the pre-existing data available in Radiology imaging Solutions (CBCT centre), Bangalore during the period of September 10th to October 10th 2020. This is a descriptive study. A total of 42 subjects including 21 Males and 21 females were assessed using full skull CBCT scans which were converted to DICOM format and reconstructed into 3D images using NEMOCEPH 3D software. Landmarks used to locate the malar prominence were Fzs, Z, Zm and Ans. The intersection of these landmarks is considered to be as constructed maxillozygion(My). For the accuracy of the constructed Maxillozygion point (My), the distance between the actual Maxillozygion (Mzy) and constructed Maxillozygion (My) is measured and calculated between left and right halves of males and females. Three Orthogonal planes constructed were Midsagittal, Axial and Coronal Planes and the linear measurements with reference to all three reference planes in both the groups are measured. Student paired t- Test, Independent Student t Test, Mann Whitney Test. The mean distance from Mzy and my between right and left half of the face was compared using student paired t- Test. There is no significant difference (p=0.35).The mean values of the constructed anatomical landmark (maxillozygion) coordinated to three orthogonal planes between right and left sides of the face is compared using student paired T test and for both the genders (males and females) was compared using Independent Student t Test, and it is significantly higher in males as compared to females and it is statistically significant at (p=0.01). The location of malar prominence using CBCT by a novel method for Bangalore population is found which can be helpful in diagnosis and treatment planning for malar augmentation, camouflage treatment in subjects with midface deficiencies.


2021 ◽  
Vol 8 (1) ◽  
pp. 49-60
Author(s):  
I Nyoman Artayasa

Lampit is one of the traditional means of cultivating rice fields, which functions to level the land for planting rice. The operation of lampit can increase the work pulse up to 50% above the resting pulse and is included in the category of moderate to heavy workloads. At the end of the operation of lampit, it may cause complaints, especially on the buttocks and back, which is caused by the small and hardness of the lampit rod. There was an improvement to the lampit seating design by adding foam pads and adjusting the pressure lever found on the lampit stem to overcome this problem. This research is an experimental study using the same subject design, selected 30 research subjects from farmers in Dusun Semaja Antosari Tabanan Bali. The workload is evaluated based on the work pulse measured using the ten pulses method. In addition, the pulse was measured before and after the improvement of the lampit design. The data compared were the mean values before and after improvement, which were analyzed using paired t test (α = 0.05). The result is a significant decrease in the work rate of 19.35% (p <0.05). Thus, it can be concluded that the improved design of the lampit can reduce the workload. Therefore, farmers should continue using and perfecting the improved lampit.


Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 4193-4193
Author(s):  
Lisa J Wakeman ◽  
John O Lewis ◽  
Keith Morris ◽  
Ann Benton ◽  
Roger C Munro ◽  
...  

Abstract Introduction: Paraproteins cause interference in many assays systems due to increased viscosity and/or by non-specific binding to either analytes or reagents which may variably affect the results. There is abundant evidence to indicate that performance characteristics of automated, competitive protein-binding assays for folate assays are normally sound, but there is a paucity of data comparing folate assays in patients with paraproteinaemia compared to normals. Method: Serum samples were prepared from venous blood taken into Greiner Vacuette containers (code: 456018) in fifty patients with paraproteinaemia (IgG Kappa, n = 20: IgG Lambda, n = 9: IgM Kappa, n = 6: IgM Lambda, n = 4: IgA Kappa, n = 5: IgA Lambda, n = 3: multiclonal, n = 3). Serum folate assays were measured according to manufacturer’s instructions on Beckman-Coulter Access and Abbott Architect haematinics analysers on the day of sample collection. Results: The ratio of means of serum protein concentrations in the paraprotein sub-groups compared to the mean values of age/gender related reference ranges were: IgG = 1.57: IgM = 7.8: IgA = 6.3. Serum albumin concentration was normal in all patients. Mean serum folate results (±1SD) for paraprotein patients and normals controls (laboratory personnel) are shown in the table below: Serum Folate (μg/L) Access Architect paired t-test Normal controls (n = 50) 5.98 (±3.57) 5.01 (±3.14) p&lt;0.05 Paraprotein patients (n = 50) 5.08 (±2.79) 5.01 (±3.03) p0.700 When analysed using the paired-t-test serum folate was significantly different in normal subjects using the Access compared to the Architect. However, no such significant difference between the two systems was observed in the paraproteinaemia group. Although the mean serum folate in normals was higher compared to the paraprotein group as analysed by the Access, this difference was not significant when analysed using the two-sample t-test. Interestingly the mean serum folate when analysed in the two groups using the Architect gave identical mean values. There were no statistically significant differences between the two methods in any of the paraprotein sub-types (p&gt;0.05 in each case). Conclusions: The complex and variable mixture of proteins present in paraproteinaemias pose potential erroneous measurement in immunoassay systems. This is because they may interfere with the associated antigen-antibody reactions which are dependant on complimentary matching shapes being assumed by the antibody variable regions of the immunoglobulin. Despite this, our data using two distinct chemiluminescence analysers for folate measurement indicate no statistically significant difference for this parameter between patients with paraproteinaemia compared to normal controls. However, it has yet to be determined whether differing results between these two groups are generated using different analytical techniques.


2019 ◽  
Author(s):  
Daniel Schiltz ◽  
Natalie Kiermeier ◽  
Dominik Eibl ◽  
Christoph Koch ◽  
Karolina Müller ◽  
...  

BACKGROUND Exact quantification of volumetric changes of the extremities is difficult. There are several direct and indirect methods to assess extremity volume. As water displacement volumetry is rarely viable in a clinical setting and circumference measurements are prone to errors due to poor reproducibility and high inter- and intra-observer variability, an objective and easily reproducible method is indispensable. OBJECTIVE The aim of this study was to establish a standardized method based on 3D scans with defined caudal and cranial landmarks of the lower leg which allows for measurements of exactly the same body area. Furthermore, this study tests the method in terms of reproducibility and evaluates volume changes after surgical therapy in patients suffering from lymphedema. METHODS 3D-scans of the lower limb were performed with a mobile 3D-scanner. Volumetric calculation was done digitally. “Repeatability“ and “Inter-observer reliability” of digital volumetry were tested. Furthermore, the method was applied on 31 patients suffering from chronic lymphedema. ANOVA (analyses of variance) was conducted to compare the digital volumetric measurements. To assess the sensitivity to changes in digital volumetry, the mean volume of 31 patients before and 3 months after therapy were compared by a paired t-Test. RESULTS Calculations of repeatability of the volume based on 20 3D-scans of the same lower leg showed a mean volume of 2,488 ± 0,011 liters (range: 2,470 – 2,510). The mean volume of the 7 measurements of the 3 examiners did not differ significantly (F(2,18) = 1,579, p = .233). The paired t-Test showed a significant mean volume decrease of 375ml (95% CI = 245/505ml) between pre and post treatment (t (30) =5,892, p < .001). CONCLUSIONS 3D-Volumetry is a noninvasive, easy and quick method to assess volume changes of the lower leg. Other than the costs, it is reproducible and precise and therefore ideal for evolution of therapy in lymphedema.


2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1078.1-1079
Author(s):  
I. Yoshii

Background:Patient’s global assessment (PGA) is one important component of Boolean composite criteria for remission in treat with rheumatoid arthritis (RA). However, PGA no more than 10mm is sometimes obstacle to attain clinical remission. In recent few years, one opinion that PGA no more than 20mm may be comparable as no more than 10mm.Objectives:The aim of this study is to analyze how difference of these PGA level affect disease activity and daily activities in living, and evaluate which is optimal for the remission with Boolean remission criteria from real world setting.Methods:RA patients who were followed up for more than three years in the institute were picked up in the study. Each patient was monitored with tenderness joint count (TJC), swollen joint count (SJC), PGA, evaluator’s global assessment (EGA), serum C-reactive protein level (CRP), calculated disease activity score with simplified disease activity index(SDAI), Health Assessment Questionnaire Disability Index (HAQ-DI), and pain score using visual analog scale (PS-VAS) every consulted time from the first encounter (Baseline). Patients were classified according to achievement of Boolean remission criteria. Group 1: a patient group who attained Boolean remission wih TJC≦1, SJC≦1, CRP≦1mg/dl, and PGA≦1 (G-1), Group 2: a patient group who could not attained the Boolean remission used in the G-1 evaluation, but could attained another Boolean remission with TJC≦1, SJC≦1, CRP≦1mg/dl, and PGA≦2 (G-2), and Group 3: a patient group who could not attain Boolean remission for neither criterion.Mean values of measured parameters at Baseline and after the Baseline were compared statistically with Student T-test. Mean values of the same parameters in the G-1 and G-2 at the time of attain Boolean remission for each criteria, mean values of each of these parameters thereafter, and changes of these parameters were compared statistically with Student T-test.Results:A total of 438 patients 385 in the G-1 group, 16 in the G-2 group, and 37 in the G-3 group, were recruited. In parameters at Baseline, level of TJC, SJC, PGA, EGA, SDAI, and HAQ-DI in the G-1 was significantly lower than in the G-3, whereas no significant differences in any parameters demonstrated between in the G-2 and G-3. Level of HAQ-DI, and PS-VAS after Baseline in the G-1 was lower than in the G-3, whereas no significant difference of these parameters after Baseline demonstrated between in the G-2 and G-3. TJC, SJC, PGA, and EGA demonstrated significant less level in the G-1 than in the other two groups. The mean SDAI score at the time of first achievement of Boolean remission in the G-1 and G-2 were 1.08 and 2.57, respectively. The mean value of SDAI score after remission in the G-1 and G-2 were 3.35 and 6.44, respectively. These values and PS-VAS including change of the SDAI score demonstrated significant difference between the two groups (p<0.01), whereas HAQ-DI in the two groups demonstrated no significant difference.Conclusion:These results suggested that setting PGA as no more than 10mm should be reasonable for the evaluation of clinical remission with the Boolean criteria.Disclosure of Interests:None declared


2021 ◽  
Vol 9 (2) ◽  
pp. 3780-3784
Author(s):  
P.Vani ◽  
◽  
Sharan B Singh M ◽  

Introduction: Cigarette smoking is a prime risk factor for cardiovascular morbidity and mortality. Chronic smoking results in autonomic dysfunction leading to increased cardiovascular risk in smokers. The present study was planned to study the effect of smoking on the Cardiovascular Autonomic Functions among smokers. Materials and Methods: Fifty male subjects who were in the age group of 25 to 45 years. They were grouped into 25 smokers and 25 non-smokers. The participant subjects were selected among the staff members, residents and the patients from the routine OPD in SVIMS. Prior to study, they were informed about the procedure and the purpose of the study tests and written consents were obtained from them. The Cardiovascular Autonomic Function Tests were assessed by using a POLYGRAPH which was available in the department. Results and Conclusion: After applying the ‘t’-test for the difference between the two sample means, it was observed that there was a highly significant difference between the mean values of the BMI(i.e.p<0.01) and the para-sympathetic function tests among the smokers and the non – smokers(i.e.p<0.00). The Resting Heart Rate had significantly increased and the Deep breathing difference, the postural tachycardial index (Response to standing) and the Valsalva Ratio had significantly decreased in the smokers as compared to those in the non – smokers. After applying the ‘t’-test for the difference between the two sample means, it was observed that there was no significant difference between the mean values of the Postural hypotension test (i.e. p>0.05) and that there was a highly significant difference between the mean values of the Sustained handgrip test in the smokers and the non – smokers (i.e. p<0.00). KEY WORDS: Cardiovascular autonomic function tests, Smoking, Resting heart rate.


2016 ◽  
Vol 8 (2) ◽  
Author(s):  
Jimmy Koan ◽  
Laurens T. B. Kalesaran ◽  
Heber B. Sapan

Abstract: Available laboratory markers in the early stage of injury are very helpful for the clinicians to predict the diturbances in cellular level concerning prevention of early decompensation, therefore, vital condition of the patient can improve faster. Lactate and leucocyte levels are assumed as sensitive markers of metabolic changes that occur at the time of injury. This study aimed to obtain the changes of lactate and leukocyte levels in multitraumatic patients after resusitation at Prof. Dr. R. D. Kandou Hospital Manado from August to September 2015. This was an observational analytical study. The results showed that there were 36 multitraumatic patients in this study, consisted of 27 males and 9 females. One patient died during this study. The mean decrease of blood lactate was 1.4611 mmol/L, meanwhile, of leukocytes was 5582.2000/mm3. The paired T test showed very significant changes of blood lactate and leukocyte levels (P < 0.001) after resusitation. Conclusion: Achievement of resusitation and improvement in cellular level could be monitored by using lactate and leukocyte levels after resusitation of multitraumatic patients although the definitive aim of the trauma was not final yet.Kata kunci: lactate, leukocyte, multitraumatic patientsAbstrak: Tersedianya penanda laboratorik pada fase awal cedera dapat memudahkan klinisi memrediksi kelainan yang terjadi di tingkat sel untuk mencegah terjadinya fase dekompensasi secara dini sehingga dapat memperbaiki kondisi vital pasien dengan segera. Kadar laktat dan jumlah leukosit telah lama dianggap sebagai salah satu penanda yang sensitif terhadap perubahan metabolisme yang terjadi saat cedera. Penelitian ini bertujuan untuk mengetahui perubahan nilai serum laktat dan leukosit darah yang terjadi pada pasien multitrauma setelah penanganan di RSUP Prof. Dr. R. D. Kandou Manado sejak bulan Agustus sampai dengan September 2015. Jenis penelitian ini observasional analitik dengan desain potong lintang. Hasil penelitian memperlihatkan terdapat 36 pasien multitrauma, terdiri dari 27 laki-laki dan 9 perempuan. Selama penelitian didapatkan 1 pasien meninggal saat penanganan. Pada pasca penanganan, rerata penurunan nilai asam laktat darah sebesar 1,4611 mmol/L dan nilai leukosit sebesar 5582,2000/mm3. Hasil uji T berpasangan memperlihatkan perubahan nilai laktat darah dan leukosit pasca penanganan yang sangat bermakna (P < 0,001). Simpulan: Tercapainya resusitasi dan perbaikan di tingkat sel dapat dimonitor dari nilai laktat dan leukosit darah pasca penanganan pasien multitrauma walaupun penanganan belum sampai pada tujuan definitif trauma.Kata kunci: asam laktat, leukosit, multitrauma


2019 ◽  
Vol 10 (2) ◽  
Author(s):  
Nurul Afifah

This present study was quasi experiment research. This study aimed to find out whether or not there is any the improvement of the students’ reading comprehension by using buzz group technique. The population of the study was all the eighth grade students of SMP SENTOSA BAKTI BATURAJA in Academic Year 2019/ 2020. The sample was taken by using cluster random sampling. The sample is divided by two experimental class and control group. The try-out was done at VIII. C with 22 respondents. The data was collected by using test. The reliability of the data was taken through Alpha Cronbach. The data were analyzed by using paired T-test of control class and paired t-test of experimental class and independent t-test too. The result showed that from the mean score was 71 improved to be 84, 6 and based on independent T-test the value of T obtained was 8,122 as significant level of 0.05 for 2 tailed testing and degree of freedom (df) was 48 the critical value of T table 3, 425. The value was higher than T table (8,122>3,425) and the value sig, (2 tailed)= 0.000 less than the value of significant level (0.05).  It mean that there was significant improvement the students who was taught by using buzz group technique and those who was not at SMP SENTOSA BAKTI Baturaja. It concluded that Buzz group technique was effective to promote students’ reading comprehension at the Eighth Grade students of SMP SENTOSA BAKTI BATURAJA.


2018 ◽  
Vol 51 (4) ◽  
pp. 173
Author(s):  
Vita Previa Indirayana ◽  
Gita Gayatri ◽  
N. R. Yuliawati Zenab

Background: Model analysis constitutes an essential aspect of orthodontic diagnostic practice. Pavan has developed an application to simplify the mathematical calculations employed in orthodontic model analysis. Purpose: This study was conducted to obtain the differences in results and time periods of model analysis using conventional means and iModelAnalysis. Methods: The research represented a comparative analytic study. The populations comprised dental casts dating from 2014 in the Orthodontics Laboratory of Padjadjaran University. The samples comprised 31 dental casts which were subjected to a total sampling method consisting of two treatments; a conventional method calculation and one using iModelAnalysis. A normality test was conducted and processed using a paired t-test with α=0.05. Results: The means of arch length discrepancies were 1.64±2.63 mm and 1.37±3.07 mm for the conventional methods and 1.65±2.43mm and 1.42±3.04mm for iModelAnalysis. The results of a Bolton analysis for conventional methods were 78.05±2.69% and 91.93±1.29%, while those for iModelAnalysis were 77.91±2.70% and 91.96±2.13%. A Howes analysis of conventional methods produced a result of 45.56±2.83%, while for an iModelAnalysis one of 45.56±2.85%. Pont analysis for conventional methods was 39.35±0.04 mm and 49.17±2.55 mm, while for iModelAnalysis it was 39.35±0.07 mm and 49.19±2.57mm. The mean of the duration of analysis using conventional methods was 1703.81±56.46 seconds, while for iModelAnalysis it was 990.06±34.87 seconds. A normality test confirmed that the data was normally distributed (p>0.05). The results of a paired sample t-test with p>0.05 showed that there was no significant difference between the results of each analysis, while there was significant difference in the time period of analysis. Conclusion: There was no difference in the analysis results. However, there was difference in the time period of analysis between conventional methods and that of iModelAnalysis.


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