scholarly journals Prevalence of thyroid dysfunction in women with abnormal uterine bleeding in reproductive age

Author(s):  
Hema K. R. ◽  
Girish B. L. ◽  
Dhananjaya B. S. ◽  
Riyaj Ahmad Kalaburgi

Background: Abnormal uterine bleeding (AUB) is one of the commonest presentations encountered in gynecological outpatient department. Menstruation is also regulated by many mechanisms, including thyroid hormone. So, for definitive management of AUB, it becomes imperative to assess thyroid status in those with abnormal uterine bleeding.Methods: Cross sectional study was conducted on all woman attending to OPD at Sri Siddhartha Medical College, Tumukuru, with complaints of abnormal uterine bleeding (AUB). Thyroid test was done for those who were eligible under inclusion criteria. Incidence of thyroid disorders among AUB and type of abnormal menstrual pattern associated with specific type of thyroid dysfunction were noted in this study.Results: Total of 522 presented with AUB. AUB was most common among woman age >40 years at 49.23% (257 of total 522 cases). AUB was more common in Multipara at 61.49% (321 of 522 cases). Menorrhagia was commonest pattern in AUB accounting for 51.34% (268 of 522cases). Thyroid dysfunction was present in 12.27% (64 of 522) of cases with AUB. Among them hypothyroid was most common accounting for 8.81% (46 of 522 cases). Hyperthyroidism was present in 3.44% (18 of 522 cases). Menorrhagia was most common pattern in Hypothyroidism at 65.21% (30 of 46 cases, followed by polymenorrhea at 17.39% (8 of 46 cases). Oligomenorrhea was most common in hyperthyroid group at 55.54% (10 of 18 cases) closely followed by hypomenorrhea at 44.44% (8 of 18 cases).Conclusions: Abnormal uterine bleeding (AUB) is one of the commonest gynecological complaint at gynecological OPD.  Thyroid dysfunction is noted consistently in cases of AUB. So, evaluation of thyroid profile should be part of evaluation of AUB, especially during perimenopause.

2020 ◽  
Vol 58 (225) ◽  
Author(s):  
Minaxi Thakur ◽  
Meenu Maharjan ◽  
Heera Tuladhar ◽  
Yam Dwa ◽  
Sunita Bhandari ◽  
...  

Introduction: Abnormal uterine bleeding is a common gynecological presentation, accounting forat least 20% of all new outpatient visits. It has been recognized that thyroid dysfunction may haveprofound effects on the female reproductive system. Both hypothyroidism and hyperthyroidism areassociated with a variety of changes, including delayed onset of puberty, anovulatory cycles, andabnormally high fetal wastage. Hence, this study was conducted to know the thyroid status of thepatient with abnormal uterine bleeding. Methods: A descriptive cross-sectional study was conducted in all the patients with abnormaluterine bleeding in a tertiary care hospital from 2 August 2019 to 2 February 2020. Ethical clearancewas received from the institutional review committee of KIST Medical College. Convenient samplingwas done. Data was collected using a questionnaire which includes patients profile, the pattern ofabnormal uterine bleeding, and thyroid profile. Statistical analysis was done using Statistical Packagefor the Social Sciences version 23. Results: Out of 79 patients, it was found that 67 (84.8%) were euthyroid, 11 (13.9%) were hypothyroid,and 1 (1.2%) was hyperthyroidism. The most common type of abnormal uterine bleeding wasmenorrhagia 34 (43%), followed by polymenorrhoea 23 (29%), oligomenorrhoea 13 (16.5%),menometrorrhagia 6 (7.6%), metrorrhagia 2 (2.5%), and hypomenorrhea 1 (1.3%). The maximumnumber of patients was between 20-25 years with the mean age of 31 years. Among hypothyroid, 7(8.8%) had subclinical hypothyroidism and 4 (5%) had frank hypothyroidism. Conclusions: Most females with abnormal uterine bleeding were euthyroid. Menorrhagia was themost common pattern of abnormal uterine bleeding.


Author(s):  
Prachi Singh ◽  
Prashant Dubey ◽  
Shweta Yadav ◽  
Sachin Singh Yadav

Background: Abnormal Uterine Bleeding (AUB) is one of the commonest gynecological complain in reproductive age group. Menstrual abnormalities are commonly seen when there is any alteration in thyroid function. Objective of present study was to investigate the prevalence of AUB and to determine the menstrual pattern in cases with thyroid dysfunction.Methods: The present cross sectional observational study was conducted Teerthankar Mahaveer Medical College and Research Center Moradabad. Total 400 cases presenting with AUB were included in the study. Routine blood test, ultrasonography and thyroid function tests were done in these cases.Results: Among all the cases presenting with menstrual abnormalities 26% had hypothyroidism and 9% have hyperthyroidism and rest had euthyroid status. Menorrhagia (45.2%) and polymenorrhoea (37.5%) were commonest menstrual abnormality seen in cases with hypothyroidism. Most cases with hyperthyroidism presented with hypomenorrhoea (27.8%).Conclusions: Thyroid function abnormality is common in cases presenting with AUB and it gets relieved in correcting hormonal imbalance.


Author(s):  
Fatemeh Moradi ◽  
Fatemeh Alizadeh ◽  
Nafiseh Zafarghandi ◽  
Farhad Jafari ◽  
Mahdi Alizadeh Vaghasloo ◽  
...  

Abnormal Uterine Bleeding (AUB) is the most common reason for women’s medical referral in the reproductive age. In Persian Medicine, one of the major causes of this disorder is known as uterine dystemperament (Su-e-Mizaj). AUB is known as “Kesrat-e Tams” in this medical school. We aimed to investigate the frequency of positive symptoms of uterine dystemperament in patients with AUB from the perspective of Persian Medicine. This cross-sectional study was conducted from October 2009 to September 2010 in Tehran, Iran. It comprised 70 patients with abnormal uterine bleeding who were 15-45 years old. Data were collected by a questionnaire prepared based on the textbooks of Persian Medicine. The frequency of each symptom of uterine dystemperament was obtained. Among the four uterine dystemperaments, the “dry” and “warm” uterine types had the highest rankings. In patients with excess uterine hemorrhage, the symptoms of warm uterine is more frequent than cold uterine. Meanwhile, the warm uterine dystemperament interference was also observed in excess uterine hemorrhage.


Author(s):  
Rini Ezhil ◽  
Nivedita K. ◽  
Fatima Shanthini N.

Background: The most common complaint with which women present for gynecological consultation is abnormal uterine bleeding which may be due to varied etiology. Among non-structural causes for AUB, endocrinological disorders like thyroid dysfunction is very common. Thyroid dysfunction is often overlooked, and unnecessary hormonal or surgical interventions are performed in patients with AUB.Methods: This is a hospital based cross sectional study carried out in Sri Manakula Vinayagar Medical College and Hospital, Puducherry between January 2017 to June 2017 for a period of 6 months and the participants were 200 women attending gynecological OPD with complaints of abnormal uterine bleeding. After obtaining a written informed consent from the participants a detailed history and complete examination including a thorough gynecological examination was performed. A transvaginal ultrasound examination to note for any structural causes for AUB was performed. Thyroid function test (FT3, FT4, TSH) was performed in all study participants and they were then categorized into euthyroid, hypothyroid, hyperthyroid, subclinical hypo or hyperthyroid based on the results. After preliminary preparation all participants were subjected for an endometrial biopsy in the outpatient department and the tissue obtained was sent for histopathological analysis. All the information was tabulated and analyzed using SPSS 22 version with descriptive and inferential statistics (chi square test). A p value of < 0.05 was considered as statistically significant.Results: Heavy menstrual bleeding was the most common menstrual abnormality found in 85% of the study participants.77% had structural causes for AUB whereas 23% had non-structural causes. 79.5% of the patients with AUB were euthyroid whereas 20.5% had some form of thyroid dysfunction. Subclinical hypothyroidism was the most common thyroid dysfunction (15.5%) in this study followed by hypothyroidism (3.5%). Only 1.5% of patients had hyperthyroidism. In the present study no, significant association was found between any particular thyroid dysfunction and specific menstrual pattern or endometrial pattern in histopathology.Conclusions: Testing and treating for thyroid disorder would prove to be cost effective in patients with AUB particularly with nonstructural causes as it would avoid many costly interventions done for AUB.


Author(s):  
Zahra Tavoli ◽  
Melika Agha Mohammad Ali Kermani ◽  
Somayeh Moradpanah ◽  
Ali Montazeri

Introduction: The most common causes of Abnormal Uterine Bleeding (AUB) in women of reproductive age are uterine polyps. Operative hysteroscopy is the management of choice to remove polyp. However, the certainty of the treatment remains to be examined. Aim: To investigate the outcome of hysteroscopy polypectomy in women with AUB. Materials and Methods: This was a cross-sectional study on the samples of women with AUB who underwent a hysteroscopy polypectomy. Patients were assessed pre and postoperatively and were asked to respond to a number of outcome measures including duration of monthly cycle, menstruation cycle, heavy menstrual bleeding, the number of pads used in day and night and improvement of inter-menstrual bleeding, postcoital bleeding, and limited activity. Pre-and postsurgery data were compared using Wilcoxon and McNemar tests. Results: In all, 83 patients were entered into the study. The mean age of participants was 41.8 (±8.37) years. The most common preoperative complaint was heavy menstrual bleeding (n=63, 76%) followed by intermenstrual bleeding (n=40, 48%). There were significant differences between preoperative and postoperative symptoms (p-values <0.05). Perceived complete recovery (n=54, 65%), partial recovery (n=13, 15.7%) and satisfaction (n=66, 79.5%) were high after hysteroscopy. Conclusion: AUB due to polyp might be improved with hysteroscopy. Further investigations are needed to confirm the results and to study on co-existence of other causes of AUB after hysteroscopy polypectomy.


Author(s):  
Sarala V. ◽  
Ushadevi Gopalan

Background: Abnormal uterine bleeding (AUB) is a very common debilitating gynecological condition among women of the reproductive age group. This diagnosis is given to women in whom no clear etiology is identified. It can occur in ovulatory and anovulatory cycle. It influences the physical, emotional, sexual and professional life of a woman. This study was carried out to evaluate the clinical profile of abnormal uterine bleeding.Methods: This cross-sectional study was carried out among 350 patients who were clinically diagnosed with AUB for a period of one year from April 2018 to March 2019. Patients with uterine polyp, adenomyosis, Leiomyoma, malignancies and with various coagulopathies were excluded from the study by physical examination, ultrasound, histopathology and blood test. The remaining 280 patients between the ages 20-60 years were selected for clinical classification of AUB.Results: Majority of the participants were in the age group of 41-50 years (60%). AUB is most commonly seen in multiparous women (48.92%). The prominent bleeding pattern seen was menorrhagia (52.2%).Conclusions: Menorrhagia is the most common form of AUB and there is a need to prevent the consequences of menorrhagia by way of creating awareness among the women, and by early diagnosis and clinical management of complications.


2020 ◽  
Author(s):  
Godfrey Shichenje Mutakha ◽  
Emily Mwaliko ◽  
Philip Kirwa

ABSTRACTBackgroundAbnormal uterine bleeding (AUB) affects 30% of reproductive age women globally. However, there are limited local studies evaluating the management of these women. The diagnostic guideline using structural and functional causes of AUB adopts the PALM-COEIN criteria, namely: Polyp; Adenomyosis; Leiomyoma; Malignancy and Hyperplasia; Coagulopathy; Ovulatory dysfunction; Endometrial; Iatrogenic; and Not yet classified. This study aimed to determine the clinical bleeding patterns and management of AUB among women in their reproductive age.MethodsA cross-sectional study among 108 women with AUB aged 18-45 years was conducted at the gynaecology department of Moi Teaching and Referral Hospital in Western Kenya between April 2018 and April 2019. Their sociodemographic and clinical characteristics were collected using interviewer administered structured questionnaire and chart reviews. Adherence to diagnosis recommendations was assessed using PALM COEIN classification. Descriptive and inferential data analysis was conducted at 95% confidence interval.ResultsThe median age was 30 (IQR: 22, 41) years with prolonged bleeding as the most predominant pattern at 41.7%. Bleeding patterns were significantly associated with age (p = 0.04). Only 16.7% were diagnosed as per the PALM-COEIN criteria with PALM and COEIN accounting for 60% and 40% respectively. Leiomyoma (44.5%) was the common cause of AUB. Laboratory evaluation included: pregnancy tests, full Haemogram, hormonal profile and biopsy. Most (79.6%) of the women had abdominopelvic ultrasound done. Medical management was provided for 78.7% of women.ConclusionProlonged bleeding was the most common pattern with medical management preferred. There is need for in-hospital algorithms to ensure adherence to PALM-COEIN guidelines.


2021 ◽  
pp. 9-10
Author(s):  
Madhuri Rani ◽  
Kumudini Jha ◽  
Debarshi Jana

Background:. AUB is any abnormal uterine bleeding in the absence of any palpable pelvic pathology and demonstrable extra genital causes. AUB is responsible for 10% of gynaecological complaints.Hypothyroidism and Hyperthyroidism leads to menstrual irregularities. Females with thyroid gland abnormality have chances of reproductive abnormalities ranging from abnormal sexual development, menstrual irregularities, infertility and premature menopause.The objective of this study is to estimate the prevalence of thyroid disorders in women with abnormal uterine bleeding and to assess the menstrul pattern in women with thyroid disorder Methods: The present study was conducted in the Department of Obstetrics and Gynecology, Darbhanga Medical College and Hospital, Laheriasarai, Bihar. Total100 women of reproductive age group between 15-45 years women with abnormal bleeding were studied.Quantitative determination of T3, T4, and TSH by CLIAestimated in autoanlyser. Results: About 100 women participated in the study in which Most of the subjects belong to 26-30 years of age group(30%)followed by20-25 yrs(22%).13% in age group36-40.menorrhagia was the most common presenting symptom(66%)followed by oligomenorrhoea(21%) Thyroid disorders were prevalent in 22%.hypothyroid in 20%and hyperthyroidism in 2%.Majority had menorrhagia 66%followed by oligomenorrhea21%.among thyroid dysfunction 63.3%had menorrhagia and 36.36% had oligomenorrhea. Conclusions: So, biochemical evaluation of thyroid functioning should be made mandatory in all provisionally diagnosed cases of AUB to detect thyroid dysfunction.


2019 ◽  
Vol 34 (1) ◽  
pp. 22-27
Author(s):  
Kamrun Nahar ◽  
Suraiya Apsara ◽  
Luna Farhana Hoque ◽  
Hosne Ara Baby

Abnormal uterine bleeding(AUB) is one of the most common gynaecological problems encountered in clinical practice. The PALM-COEIN classification for causes of AUB was proposed by the International Federation of Gynaecology and Obstetrics (FIGO) in 2011, which has gradually been applied in Bangladesh for the diagnosis of AUB. Objective: the objective of this study was to evaluate the prevalence of chronic AUB according to FIGO classification in reproductive age women , carry out histopathological study and analyze it,s clinicopathological pattern. Material and methods: this descriptive cross sectional study was carried out among 100 women of reproductive age (20-49 years) who presented with abnormal uterine bleeding (AUB) in the department of obstetrics and gynaecology of Dhaka Medical College Hospital during the period of January 2012 to December 2012. Clinical diagnosis was made according to PALM-COEIN classification on the basis of history, examination and necessary investigations. Endometrial sample and hysterectomy specimen were assessed by histopathology. Result: Thirty five (35%) percent patients were 41-45 years. Ninety two (92%) patients were married ,2(2%) were unmarried and 6(6%) were widow. Among married women 98% were fertile and 2% were subfertile. Most common presenting symptom was menorrhagia (48%), followed by metrorrhagia (25%) and polymenorrhoea was observed in 22% cases. Ovulatory dysfunction (AUB-O) was the most common cause of abnormal uterine bleeding among the non structural causes and it was 44% . AUB-L were the most common (30%) among the structural causes, followed by AUB-A(10%) and AUB-P(5%). Regarding histopathological findings most of the patients( 34%) revealed unremarkable histopathological findings. Other findings were leiomyoma 27(27%), adenomyosis 13(13%) and fibroid uterus with adenomyosis in 5(5%) cases. Conclusion: AUB –O was the leading cause of abnormal uterine bleeding and histopathological evaluation correlated well with the clinical diagnosis. Bangladesh J Obstet Gynaecol, 2019; Vol. 34(1): 22-27


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