scholarly journals A mimic of nasopharynx carcinoma turned out to be primary nasopharynx tuberculosis

2018 ◽  
Vol 7 (1) ◽  
pp. 294
Author(s):  
Sivanes Chandrashekaran ◽  
Mohd Syukra bin Abd Ghani
Keyword(s):  
Hearing Loss ◽  
Extrapulmonary Tuberculosis ◽  
Systemic Infection ◽  
Neck Mass ◽  
Tuberculosis Patient ◽  
Active Pulmonary Tuberculosis ◽  
Antituberculosis Therapy ◽  
Rare Manifestation ◽  
Rule Out ◽  
Do So

Nasopharyngeal tuberculosis is indeed a rare manifestation of extrapulmonary tuberculosis. The general symptoms of nasopharyngeal tuberculosis are nasal obstruction, neck mass, epitaxis, rhinorrhoea, otalgia and hearing loss. Constitutional symptoms may present in almost 12-30% of nasopharyngeal tuberculosis cases, hence it often disguise as nasopharyngeal carcinoma in patients. Apart from that, most cases of nasopharyngeal tuberculosis usually occur with combined active pulmonary tuberculosis or systemic infection. Hereby presenting a case of nasopharyngeal tuberculosis in a lady who is otherwise healthy presented with neck mass for duration of two months with no obstructive symptoms. Upon proceeding with rigid nasal endoscopy, obliteration of fossa of rossenmuller was noted and biopsy confirmed tuberculosis. Patient was immediately started on antituberculosis therapy. Upon subsequent follow ups, resolution of the neck mass was noted. Hence, it is crucial to have a high index of suspiciousness to rule out nasopharyngeal tuberculosis as this is a curable disease and failure to do so can pave way for the deathly pathogen to disseminate in its host and cause mortality.

scholarly journals INCIDENCE OF ORONASOPHARYNGEAL & LARYNGEAL TUBERCULOSIS CASES IN PULMONARY TUBERCULOSIS CASES

2020 ◽  
Vol VOLUME 8 (ISSUE 2) ◽  
pp. 28-32
Author(s):  
Mohd Aftab
Keyword(s):  
Hearing Loss ◽  
Global Health ◽  
Pulmonary Tuberculosis ◽  
Health Problem ◽  
Extrapulmonary Tuberculosis ◽  
Cervical Lymphadenopathy ◽  
Neck Mass ◽  
Common Symptom ◽  
Global Health Problem ◽  
Laryngeal Tuberculosis

ABSTRACT Background: Tuberculosis is a major global health problem. Tuberculosis may be Pulmonary or Extrapulmonary. Oro-nasopharyngeal and L a r yngea l tuberculosis a re a form of Extrapulmonary Tuberculosis. Nasopharyngeal tuberculosis presents with neck mass, nasal obstruction, rhinorrhoea, epistaxis, Otalgia, hearing loss and cervical Lymphadenopathy. Common symptom of Laryngeal tuberculosis is hoarseness of voice. This study will increase awareness regarding Oro-nasopharyngeal / Laryngeal tuberculosis and will help in differentiating it from Oro-nasopharyngeal / Laryngeal carcinoma.

scholarly journals Non-specific biological markers as a screening test for diagnostic of extrapulmonary tuberculosis

2012 ◽  
Vol 64 (2) ◽  
pp. 489-495 ◽  
Author(s):  
G. Stevanovic ◽  
M. Pelemis ◽  
S. Pelemis ◽  
M. Pavlovic
Keyword(s):  
Adenosine Deaminase ◽  
Immunoglobulin G ◽  
Clinical Investigation ◽  
Extrapulmonary Tuberculosis ◽  
Unknown Origin ◽  
High Sensitivity ◽  
Serum Levels ◽  
Serum Concentrations ◽  
Extra Pulmonary Tuberculosis ◽  
Antituberculosis Therapy

Serum concentrations of adenosine deaminase were determined in 223 febrile patients. In 62, we discovered extrapulmonary tuberculosis. Serum levels of immunoglobulin G were monitored in 287 febrile patients, and 68 had extra-pulmonary tuberculosis. Serum concentrations of adenosine deaminase were significantly higher in patients with tuberculosis compared to other patients with fever of unknown origin. Serum concentrations declined during antituberculosis therapy. A correlation with the localization of infection was not found. Levels of immunoglobulin G were higher in patients with tuberculosis. Both tests had high sensitivity and specificity and could therefore be used for screening extrapulmonary tuberculosis; however, they can only be interpreted adequately following a full clinical investigation.

scholarly journals Isolated Pancreatic Tuberculosis Mimicking Pancreatic Cancer: A Diagnostic Challenge

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Abhishek Bhurwal ◽  
Muhammad Masoodul Haq ◽  
Sunil Sapru ◽  
Matthew Tortora ◽  
Dhanasekaran Ramasamy
Keyword(s):  
Pancreatic Tumor ◽  
Extrapulmonary Tuberculosis ◽  
Rare Condition ◽  
Abdominal Tuberculosis ◽  
Needle Aspiration ◽  
Diagnostic Challenge ◽  
Prognostic Implication ◽  
Pancreatic Tuberculosis ◽  
Antituberculosis Therapy ◽  
Persistent Abdominal Pain

Isolated pancreatic tuberculosis is an exceedingly rare condition, even in areas of the world where the disease is highly prevalent. Abdominal tuberculosis is a common form of extrapulmonary tuberculosis but involvement of the pancreas is very rare. We report a case of isolated pancreatic tuberculosis presenting as a pancreatic mass in a patient with persistent abdominal pain and jaundice. Clinically and radiologically, the mass mimicked a malignant pancreatic tumor with a vastly different prognostic implication and therapeutic approach. Endoscopic ultrasound with fine-needle aspiration (EUS-FNA) can provide valuable diagnostic information in this scenario. After the tissue showed evidence of acid-fast bacilli and the cultures showed growth of Mycobacterium tuberculosis, antituberculosis therapy was initiated. Conservative management is usually successful in alleviating symptoms and leading to a cure. The excellent response to ATT makes it imperative that these patients are diagnosed early and managed appropriately to avoid unnecessary surgery and associated morbidity.

A Case of Poncet’s Disease Masquerading Rheumatoid Arthritis

2013 ◽  
Vol 3 (1) ◽  
pp. 64-67
Author(s):  
Gopal Chandra Ghosh
Keyword(s):  
Rheumatoid Arthritis ◽  
Pulmonary Tuberculosis ◽  
Clinical Condition ◽  
Extrapulmonary Tuberculosis ◽  
Active Pulmonary Tuberculosis ◽  
Direct Invasion ◽  
Poncet’S Disease

Poncet’s disease is a rare clinical condition, occurs in in the setting of active pulmonary and extrapulmonary tuberculosis. It typically manifestated by arthritis of large joints, without direct invasion of joints by tubercle bacilli. Rarely it involves small joints thus sometimes mimic rheumatoid arthritis The author is reporting a case of a 17 year old female with evidence of active pulmonary tuberculosis presented with additive evidence of polyarthritis of large as well as small joints. On further investigation joint aspirate did not reveal any direct invasion by tubercle bacilli and patients symptoms responded completely to anti tuberculous therapy. The diagnosis of Poncet’s disease was established.

scholarly journals Two cases of tuberculous spondylodiscitis: a rare manifestation of extrapulmonary tuberculosis

2017 ◽  
Vol 7 (1) ◽  
pp. 132-137
Author(s):  
José Antonio de Jesús Batún-Garrido ◽  
Marisol Salas-Magaña ◽  
Oscar Alejandro García-Padrón ◽  
Nicolás Valencia-Serrano
Keyword(s):  
Extrapulmonary Tuberculosis ◽  
Rare Manifestation ◽  
Tuberculous Spondylodiscitis

Systemic infection causes antibiotic-induced hearing loss

2015 ◽  
Vol 8 (388) ◽  
pp. ec216-ec216
Author(s):  
Leslie Ferrarelli
Keyword(s):  
Hearing Loss ◽  
Systemic Infection

Does actin produce the force that moves a chromosome to the pole during anaphase?

1985 ◽  
Vol 63 (6) ◽  
pp. 585-598 ◽  
Author(s):  
Arthur Forer
Keyword(s):  
Spindle Fibre ◽  
Apparent Contradiction ◽  
Spindle Poles ◽  
Ultraviolet Microbeam ◽  
The Face ◽  
Spindle Fibres ◽  
Rule Out ◽  
Do So

Chromosomes move towards spindle poles because of force produced by chromosomal spindle fibres. I argue that actin is involved in producing this force. Actin is present in chromosomal spindle fibres, with consistent polarity. Physiological experiments using ultraviolet microbeam irradiations suggest that the force is due to an actin and myosin (or myosin-equivalent) system. Other physiological experiments (using inhibitors in "leaky" cells or antibodies injected into cells) that on the face of it would seem to rule out actin and myosin on closer scrutiny do not really do so at all. I argue that in vivo the "on" ends of chromosomal spindle fibre microtubules are at the kinetochores; I discuss the apparent contradiction between this conclusion and those from experiments on microtubules in vitro. From what we know of treadmilling in microtubules in vitro, the poleward movements of irradiation-induced areas of reduced birefringence (arb) can not be explained as treadmilling of microtubules: additional assumptions need to be made for arb movements toward the pole to be due to treadmilling. If arb movement does indeed represent treadmilling along chromosomal spindle fibre microtubules, treadmilling continues throughout anaphase. Thus I suggest that chromosomal spindle fibres shorten in anaphase not because polymerization is stopped at the kinetochore (the on end), as previously assumed, but rather because there is increased depolymerization at the pole (the "off" end).

Ukraine leaders delay reforms and consider tactics

2018 ◽  
Keyword(s):  
Electoral Reform ◽  
Domestic Currency ◽  
Currency Markets ◽  
Legislative Elections ◽  
Content Type ◽  
Rule Out ◽  
Do So ◽  
The Imf

Significance The Rada is dragging its feet on legislation on the special court and electoral reform, despite pressure from the IMF and EU. The two months remaining before parliament goes into recess are the last window for President Petro Poroshenko's team to call early legislative elections, if he is minded to do so. Impacts The uncertainty created by early elections would effectively rule out further IMF tranche disbursements for that period. Election campaigning, whenever it happens, may have a destabilising effect on the economy and domestic currency markets. There is talk of an Armenia-style reform shifting power from president to parliament, but little time remains to engineer this.

scholarly journals Ancient Schwannoma of Ansa Cervicalis: A Rare Clinical Entity and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Satyajit Rath ◽  
Prakash K. Sasmal ◽  
Kaushik Saha ◽  
N. Deep ◽  
Pritinanda Mishra ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
English Literature ◽  
Preoperative Evaluation ◽  
Neck Mass ◽  
Cervical Region ◽  
Ansa Cervicalis ◽  
S 100 ◽  
Mitotic Figures ◽  
Diffuse Positivity ◽  
Rule Out

Ancient schwannoma is an uncommon variant of schwannoma, a benign tumor arising from the nerve sheath. It is reported to arise from any nerves except optic and olfactory. However, only six cases of ancient schwannomas arising from ansa cervicalis nerve have been reported to date in English literature. Proper preoperative evaluation is necessary to rule out other causes of neck mass such as thyroid lesions, lymphadenopathy, and carotid body tumor. We report a case of ancient schwannoma arising from the ansa cervicalis nerve. The origin of the lesion from ansa cervicalis was confirmed by intraoperative finding. Postoperative histopathological examination revealed degenerative changes including pleomorphism, cellular atypia, large nuclei with prominent nucleoli, and paucity of mitotic figures. Periphery of the mass showed nuclear palisading with characteristic verocay bodies. Immunohistochemical evaluation for S-100 showed diffuse positivity of the tumor cells, thereby confirming the diagnosis of schwannoma. We consider that schwannoma of cervical region can have origin from any nerve and should try to identify the origin pre- and intraoperatively. The postoperative complications depend on the nerve of origin and the precision of the surgery performed.

scholarly journals Primary Gastroduodenal Tuberculosis Complicated With Acute Pancreatitis: A Rare Case Report and Literature Review

2020 ◽  
Author(s):  
Yuanhua Li ◽  
Suhuan Liao ◽  
Haijun Zuo ◽  
Wei Yang ◽  
Di Jiang
Keyword(s):  
Acute Pancreatitis ◽  
Extrapulmonary Tuberculosis ◽  
Interesting Case ◽  
Major Health Problem ◽  
Guided Biopsy ◽  
Middle Aged Person ◽  
Aged Person ◽  
Rare Manifestation ◽  
Rare Case Report ◽  
Gastroduodenal Tuberculosis

Abstract Background: Tuberculosis (TB) is a major health problem worldwide. Even in highly prevalent countries, primary gastroduodenal tuberculosis is a rare manifestation of extrapulmonary tuberculosis. In recent years, as the incidence of tuberculosis has increased year by year, the occur of gastroduodenal tuberculosis has also increased. Endoscopy is an important tool for diagnosing gastroduodenal tuberculosis. The performance of gastroduodenal tuberculosis under endoscopy is often non-specific, which may imitate other benign or malignant gastroduodenal diseases. Diagnosis of gastroduodenal tuberculosis relies on a combination of endoscopy and guided biopsy. Case presentation: Here, we report a rare and interesting case of gastroduodenal tuberculosis with acute pancreatitis. The case initially mimicked gastroduodenal ulcers in morphology and appeared in a middle-aged person with normal immunity but with prolonged fever and abdominal pain. The disease was diagnosed through endoscopy and guided biopsy, and it responded well to antituberculosis drugs. Conclusions: Clinicians must remember that even in the absence of immunodeficiency, as in this case, tuberculosis can affect any part of the gastrointestinal tract.

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