The effect of vitamin D3 supplements on the 25(OH)D levels in the II and III trimester of pregnant women in Sleman, Indonesia: randomized controlled trial

Background: Pregnant women are among the groups at high risk of vitamin D3 deficiency due to the increased need for micro and macro nutrients during pregnancy. Vitamin D3 deficiency is associated with pregnancy complications, namely preterm birth, pre-eclampsia, gestational diabetes, and babies born small according to their gestational age.Methods: The study involved a randomized pretest-posttest control group design. Subjects selected include 80 pregnant women in second trimester. Data were collected in June 2020 to September 2020. The respondents were then randomly divided into 2 groups, comprising 40 each, where the first received 400 IU/day vitamin D3 supplementation for 12 weeks, and the second served as a control. Furthermore, 25 (OH) D were measured by using the ELISA method.Results: The mean value of the 25(OH)D levels after D3 supplementation and statistically showed a significant difference with a significance value of p<0.05 (0.01), compared to the control group. Furthermore, the mean value of the 25(OH)D levels in the control group actually decreased by 2.7 ng/ml which was statistically significant with a p value of 0.00, compared to the control group. Furthermore, the mean value of the 25(OH)D levels in the control group actually decreased by 2.7 ng/ml which was statistically significant with a p value of 0.00.Conclusions: Vitamin D3 supplement of 400 IU per day can increase the levels of 25(OH)D in the II and III trimester of pregnant women in antenatal care (ANC), Sleman Regency, Yogyakarta.

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Chicory Aroma Water for Neonatal Jaundice: A Randomized Clinical Trial

Galen Medical Journal ◽

10.31661/gmj.v6i4.973 ◽

2017 ◽

Vol 6 (4) ◽

pp. 312-318

Author(s):

Mohsen Manouchehrian ◽

Mehrdad Shakiba ◽

Mamak Shariat ◽

Mohammad Kamalinejad ◽

Mehdi Pasalar ◽

...

Keyword(s):

Pregnant Women ◽

Neonatal Jaundice ◽

Controlled Trial ◽

Mean Value ◽

Control Group ◽

Term Infants ◽

Randomized Controlled ◽

Significant Difference ◽

The Mean ◽

Single Blind

Background: Although neonatal jaundice occurs in 60% of term infants, very little evidence is available on how to prevent it. Given the ethno-medical use of chicory aroma water (CAW) for the management of jaundice by Iranian pregnant women, the aim of this study was to evaluate whether the frequent CAW consumption was associated with fewer jaundice symptoms after 40 days. Materials and Methods: A single blind randomized controlled trial was designed to enroll participants from Lolagar Hospital, Tehran, Iran. Pregnant women (n=80) were randomly divided into two groups. The trial group was provided with common diet and an instruction to consume CAW. The control group was maintained on common diet. The proportion of phototherapy and mean value of bilirubin were measured and compared between the two groups. (IRCT registry number: IRCT2017041633475N1) Results: There was no statistically significant difference in the mean value of bilirubin between the women with frequent CAW consumption compared with the control. Also, the intake of CAW was not associated with a marked improvement in the need for phototherapy (P > 0.05). Conclusion: The findings of this study highlighted that the intake of CAW by pregnant women failed to ameliorate neonatal jaundice.[GMJ.2017;6(4):312-8] DOI: 10.22086/gmj.v6i4.973

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Assessment of the Tissue Response to Modification of the Surface of Dental Implants with Carboxyethylphosphonic Acid and Basic Fibroblastic Growth Factor Immobilization (Fgf-2): An Experimental Study on Minipigs

Biology ◽

10.3390/biology10050358 ◽

2021 ◽

Vol 10 (5) ◽

pp. 358

Author(s):

Javier Aragoneses ◽

Ana Suárez ◽

Nansi López-Valverde ◽

Francisco Martínez-Martínez ◽

Juan Manuel Aragoneses

Keyword(s):

Surface Treatment ◽

Test Group ◽

Mean Value ◽

Control Group ◽

P Value ◽

Implant Surface ◽

Bone Contact ◽

Bone Implant ◽

Significant Difference ◽

The Mean

The aim of this study was to evaluate the effect of implant surface treatment with carboxyethylphosphonic acid and fibroblast growth factor 2 on the bone–implant interface during the osseointegration period in vivo using an animal model. The present research was carried out in six minipigs, in whose left tibia implants were inserted as follows: eight implants with a standard surface treatment, for the control group, and eight implants with a surface treatment of carboxyethylphosphonic acid and immobilization of FGF-2, for the test group. At 4 weeks after the insertion of the implants, the animals were sacrificed for the histomorphometric analysis of the samples. The means of the results for the implant–bone contact variable (BIC) were 46.39 ± 17.49% for the test group and 34.00 ± 9.92% for the control group; the difference was not statistically significant. For the corrected implant–bone contact variable (BICc), the mean value of the test group was 60.48 ± 18.11%, and that for the control group, 43.08 ± 10.77%; the difference was statistically significant (p-value = 0.035). The new bone formation (BV/TV) showed average results of 27.28 ± 3.88% for the test group and 26.63 ± 7.90% for the control group, meaning that the differences were not statistically significant (p-value = 0.839). Regarding the bone density at the interthread level (BAI/TA), the mean value of the test group was 32.27 ± 6.70%, and that of the control group was 32.91 ± 7.76%, with a p-value of 0.863, while for the peri-implant density (BAP/TA), the mean value of the test group was 44.96 ± 7.55%, and that for the control group was 44.80 ± 8.68%, without a significant difference between the groups. The current research only found a significant difference for the bone–implant contact at the cortical level; therefore, it could be considered that FGF-2 acts on the mineralization of bone tissue. The application of carboxyethylphosphonic acid on the surface of implants can be considered a promising alternative as a biomimetic coating for the immobilization of FGF-2. Despite no differences in the new bone formation around the implants or in the interthread or peri-implant bone density being detected, the biofunctionalization of the implant surface with FGF-2 accelerates the mineralization of the bone–implant interface at the cortical level, thereby reducing the osseointegration period.

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THE COMPARISON OF THE EFFECT OF HONEY AND CHLORHEXIDINE IN PREVENTING VENTILATOR ASSOCIATED PNEUMONIA IN PATIENTS ON MECHANICAL VENTILATON

Belitung Nursing Journal ◽

10.33546/bnj.355 ◽

2018 ◽

Vol 4 (2) ◽

pp. 161-167

Author(s):

Syaukia Adini ◽

Bedjo Santoso ◽

Sarkum Sarkum ◽

Sudirman Sudirman

Keyword(s):

Oral Hygiene ◽

Control Group ◽

P Value ◽

Ventilator Associated Pneumonia ◽

Control Group Design ◽

Group Design ◽

Significant Difference ◽

Quasi Experimental ◽

The Mean ◽

Honey Solution

Background: Ventilator Associated Pneumonia (VAP) is one of the causes of infection in the hospital and the main cause of death due to nosocomial infection. The strategy to prevent VAP is by oral hygiene. Honey may be a good solution for oral hygiene.Objective: This study aims to compare the effect of the use of 20% honey solution and 0.2% chlorhexidine as oral hygiene on VAP prevention in patients on mechanical ventilation.Methods: This was a quasi-experimental study with posttest only control group design in an incentive care unit of a general hospital in Indonesia. Thirty respondents were selected using consecutive sampling, which 15 respondents assigned in a 20% honey group and 0.2% chlorhexidine group. Clinical Pulmonary Infection Score (CPIS) was used to measure Ventilator Associated Pneumonia. Data were analyzed using Independent t-test.Results: The mean of CPIS in the honey group was 3.33 and the chlorhexidine group was 3.53. Independent t-test showed p-value 0.618 (>0.05), which indicated that there was no significant difference of the effect of honey and chlorhexidine on VAP event.Conclusions: The 20% honey solution has the same effect with 0.2% chlorhexidine in preventing VAP events in patients on mechanical ventilation.

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The Impact of Strengthening Exercise on Dynamic Balance in Patients with Knee Osteoarthritis

10.53350/pjmhs2115103429 ◽

2021 ◽

Vol 15 (10) ◽

pp. 3429-3431

Author(s):

Shenbaga Subramanian Sundaram ◽

Makesh Babu Subramanian ◽

Riziq Allah Mustafa Gaowgeh ◽

Mikhled Falah Maayah ◽

Ziyad Neamatallah ◽

...

Keyword(s):

Knee Osteoarthritis ◽

Dynamic Balance ◽

Mean Value ◽

Control Group ◽

P Value ◽

Strengthening Exercise ◽

Significant Difference ◽

The Mean ◽

The Impact ◽

Experimental Group

Background: Knee osteoarthritis is characterised clinically by usage-related pain and/or functional limitation. OA that is associated with physical dysfunction and decline in health-related quality of life caused the main disability worldwide and is expected to increase due to aging and obesity rates and further load on the population and health system. The strengthening exercises that normally used is knee flexion and extensions, isometric quadriceps exercise, isometric hamstring exercise, and sit to stand to improve the balance. Objectives: is to find out the impact of Strengthening exercise on Balance in patients with knee Osteoarthritis Study Design: Quasi experimental study Methods: Fifty-six (n=56) of knee OA patients were involved in this study by judgemental sampling design. Researcher will first demonstrate and explain the Y-balance tools testing procedure based on Plisky and colleagues study. Participants are given to practice six trials before the formal testing, stated that SEBT have a significant learning effect and found that the reaching distances reached the longest distance after six trials and then will be constant. Results: Independent t-test shows significant difference in only anterior direction. In the experimental group the mean value is 69.83 with a SD of 11.62 while in the control group the mean value is 63.51 with a SD of 11.36; p-value of .045 and t-value of 2.056. In postero-lateral directions result shows there is no significant difference, experimental group the mean value is 91.10 with a SD of 9.74 while in control group mean value is 90.88 with SD value of 12.68; p-value of .947 and t-value of .067. Result of postero-medial shows no significant difference too, in experimental group the mean value of 95.16 with SD of 10.92 while in control group the mean value is 93.40 with SD of 8.20; p=value of .501 and t-value of .678. Conclusion: This study has proven strengthening exercise using YBT improved only anterior direction of YBT but no significant difference in postero-lateral and postero-medial direction. Key Words: Knee Osteoarthritis, Strengthening exercise, Dynamic Balance, Star excursion test

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JUMLAH PLATELET PADA PENDERITA PRE-EKLAMPSIA

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v20i1.441 ◽

2016 ◽

Vol 20 (1) ◽

pp. 43

Author(s):

M. Arif Muchlis ◽

Suci Aprianti ◽

Hj. Darmawati ER

Keyword(s):

Platelet Count ◽

Pregnant Women ◽

Secondary Data ◽

Large Cell ◽

Endothelial Damage ◽

Control Group ◽

P Value ◽

Distribution Width ◽

Significant Difference ◽

The Mean

In pregnant women who previously did not have hypertension pre-eclampsia is a pregnancy complication, which characterized by the increased of blood pressure, proteinuria and/or oedema. One of theory about aetiology of pre-eclampsia suggests that this is caused by endothelial damage that can lead to adhesion and platelet aggregation. The aim of this study was to know the platelet count and indices by analyzing, such as mean platelet volume (MPV), its distribution width (PDW) and the large cell ratio (P-LCR) for diagnostic confirmation in pre-eclampsia patients. This research was a retrospective study using secondary data of routine blood test from medical records of pre eclampsia patients who were treated at Dr. Wahidin Sudirohusodo Hospital during the period of January to December 2011 and the normal pregnant women data that were taken as control. The data obtained were platelet count, MPV, PDW, P-LCR and analyzed using independent T test. The results showed that the mean platelet count in pre-eclampsia patients was lower than the control but had no statistically significant difference (p=0.325) whereas the mean of MPV, PDW and P-LCR in pre-eclampsia patients increased compared to the control group and was statistically significant with p value of MPV (p=0.003), PDW (p=0.002) and P-LCR (p=0.010). In conclusion, platelet indices can be used as diagnostic confirmation markers in pre-eclampsia patients.

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Meningkatkan Hemoglobin pada Ibu Hamil Trimester III dengan Rebusan Bunga Rosella

Jurnal Bidan Cerdas (JBC) ◽

10.33860/jbc.v2i3.95 ◽

2020 ◽

Vol 2 (3) ◽

pp. 163-169

Author(s):

Rifi Wulandari

Keyword(s):

Pregnant Women ◽

T Test ◽

Control Group ◽

P Value ◽

Third Trimester ◽

Control Group Design ◽

Anemia During Pregnancy ◽

The Mean ◽

And Control ◽

Pregnant Mothers

Anemia during pregnancy is one of the most common disorders in pregnant women in Indonesia. Rosella (Hibiscus sabdariffa) is considered able to increase the hemoglobin levels in pregnant mothers. To analyze the effect of Rosella flower on the increase of Hemoglobin level in pregnant women receiving Fe tablet. This study was a quasi-experiment with a pretest-posttest control group design. 32 participants were selected using accidental sampling, which assigned in the experiment and control group. All samples were pregnant women in the third trimester and receiving iron tablets. Independent t-test and paired t-test were used for data analysis. The result indicated that there was an increase in hemoglobin levels in both the experiment and the control group. The mean increase of hemoglobin levels in the control group was 0.59gr and in the experiment group was 1.11. The hemoglobin levels in the experiment group were higher than the levels in the control group. Independent t-test obtained a p-value of 0.241 indicating that there wasn’t a significant mean difference of hemoglobin levels between the control group and the treatment group. The consumption of rosella combined with Fe tablet showed a significant increase of hemoglobin levels compared to pregnant women. Therefore, it is suggested for midwives to use the result of this research as evidence-practice through counseling for pregnant mothers about the utilization of rosella that can increase hemoglobin levels in pregnant.

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EFFECT OF ROSELLE (HIBISCUS SABDARIFFA) ON CHANGES IN HEMOGLOBIN LEVELS IN PREGNANT WOMEN WITH ANEMIA TAKING IRON SUPPLEMENT

Belitung Nursing Journal ◽

10.33546/bnj.305 ◽

2017 ◽

Vol 3 (6) ◽

pp. 771-777

Author(s):

Rif’atun Nisa ◽

Ariawan Soejoenoes ◽

Sri Wahyuni

Keyword(s):

Pregnant Women ◽

Hemoglobin Level ◽

T Test ◽

Control Group ◽

P Value ◽

Hibiscus Sabdariffa ◽

Control Group Design ◽

Significant Difference ◽

And Control ◽

Paired T Test

Background: Anemia during pregnancy is one of the most common disorders in pregnant women in Indonesia. The Government has made efforts to overcome this problem, however, the rate of anemic mothers remains high. Rosella (Hibiscus Sabdariffa) is considered able to increase the hemoglobin levels in pregnant mothers.Objective: To analyze the effect of Rosella flower extract (Hibiscus Sabdariffa) on the increase of Hemoglobin level in pregnant women with anemia receiving Fe tablet.Methods: This study was a quasy experiment with pretest-posttest control group design conducted in November - December 2016 in the working area of Tlogosari Wetan Community Health Center. Forty-two participants were selected using accidental sampling, which 21 assigned in the experiment and control group. All samples were pregnant women in the second trimester suffering from anemia and receiving iron tablets. Hemoglobin levels were measured using hematology analyzer in laboratory. Independent t-test and paired t-test were used for data analysis.Results: Paired t-test obtained p-value 0.00 (<0.05), indicated that there was an increase of hemoglobin levels in both experiment and control group. The mean increase of hemoglobin levels in the control group was 0.61 gr and in the experiment group was 1.08. The hemoglobin levels in the experiment group were higher than the levels in the control group. Independent t-test obtained p-value 0.000 (<0.05) indicating that there was a significant difference of mean of hemoglobin levels between the control group and the treatment group.Conclusion: The consumption of rosella extract combined with Fe tablet showed a significant increase of hemoglobin levels compared with the consumption of Fe tablet alone. Therefore, it is suggested for midwife to use the result of this research as a evidence practice through counseling for pregnant mother about utilization of rosella extract that can increase hemoglobin level in pregnant woman with anemia.

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Efek Paket “Tabahanmil” terhadap Pengetahuan, Sikap dan Ketrampilan Ibu Hamil dalam Mencegah Perdarahan

Journal of Telenursing (JOTING) ◽

10.31539/joting.v1i2.965 ◽

2019 ◽

Vol 1 (2) ◽

pp. 314-323

Author(s):

Eko Riyanti ◽

Irna Nursanti ◽

Natsir Hugroho

Keyword(s):

Pregnant Women ◽

Quantitative Research ◽

Intervention Group ◽

Warning Signs ◽

Bivariate Analysis ◽

Control Group ◽

P Value ◽

Control Group Design ◽

Average Value ◽

Significant Difference

The purpose of this study was to determine the effect of the package of warning signs of bleeding pregnant women (tabahanmil) on the knowledge, attitudes and skills of pregnant women in preventing bleeding in Bayan District, Purworejo Regency. The type of quantitative research with Quasi experimental research design, pretest-posttest with control group design. The results of bivariate analysis found that the intervention group after being given a tabahanmil package significantly affected compared to the control group that was not given a tabahanmil package on knowledge, attitudes, and skills, each of which has a p value = 0,000 less than 0.05. Conclusion, there is a significant difference from the average value of knowledge, attitudes, and skills of pregnant women in preventing bleeding in the intervention group and the control group. Keywords: Pregnant Women, Skills, Preventing Bleeding, Knowledge, Attitudes

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EFEKTIVITAS PEPPERMINT DAN POMELO DALAM MENURUNKAN INTENSITAS MUAL DAN MUNTAH PADA IBU HAMIL

Jurnal Kebidanan Malahayati ◽

10.33024/jkm.v6i4.3005 ◽

2020 ◽

Vol 6 (4) ◽

pp. 435-441

Author(s):

Nora Veri ◽

Nila Suci Ramadhani ◽

Alchalidi Alchalidi

Keyword(s):

Pregnant Women ◽

The Body ◽

Nausea And Vomiting ◽

Control Group ◽

P Value ◽

Average Intensity ◽

Control Group Design ◽

Group Design ◽

Significant Difference ◽

Quasi Experimental

ABSTRACT Background: Emesis gravidarum can get worse into hyperemesis gravidarum which causes the body to become weaker, paler, and the frequency of urination decreases. As a result, decreased body fluids and hemoconcentration of blood can cause tissue damage. Non pharmacological treatment is very important because it reduces the pharmacological effects that appear in pregnant women. The herbal therapy that has been proven to be beneficial is the administration of peppermint, but research on the effects of Pamelo fruit related to nausea and vomiting in pregnant women is still rare.Objective: To determine the comparison of the effectiveness of peppermint and Pomelo orange on the intensity of nausea and vomiting in pregnant womenMethods: The research design was a quasi experimental study with a pretest posttest control group design approach. The number of samples was 24 pregnant women who were grouped into 3 groups.Results: The average intensity of nausea and vomiting in the peppermint group at pretest was 2.38 and decreased at posttest to 1 with P-value 0.004. The intensity of nausea and vomiting in the Pomelo group at pretest was 6.38, falling to 1.75 at posttest with P-value 0.000. The result of further test showed that there was no significant difference in the intensity of nausea and vomiting between the two groups with Sig. 0.428.Conclusion: Peppermint and pomelo are effective in reducing the intensity of nausea and vomiting in trimester I pregnant women.Suggestion : This research needs to be refined by enlarging the research sample and measuring the intensity of nausea and vomiting can be done every day during the study considering that this study only measured twice the number of 24 respondents. Keywords : Nausea, Vomiting, Pregnancy, Peppermint, Pomelo ABSTRAK Latar Belakang : Emesis gravidarum dapat bertambah berat menjadi hiperemesis gravidarum yang mengakibatkan tubuh semakin lemah, pucat, dan frekuensi buang air kecil menurun. Akibatnya cairan tubuh berkurang dan hemokonsentrasi darah yang dapat menimbulkan kerusakan jaringan. Pengobatan non farmakolgis sangat penting karena mengurangi efek farmakologis yang muncul pada ibu hamil. Terapi herbal yang sudah terbukti bermanfaat adalah pemberian peppermint, namun penelitian efek buah Pamelo yang berkaitan dengan mual muntah pada ibu hamil masih jarang.Tujuan Penelitian : Untuk mengetahui perbandingan efektifitas pemberian peppermint dan Jeruk Pomelo terhadap intensitas mual dan muntah pada ibu hamilMetode Penelitian : Rancangan penelitian ini adalah quasi experimental dengan pendekatan pretest posttest control group design. Jumlah sampel adalah sebanyak 24 orang ibu hamil yang dikelompokkan kedalam 3 kelompok.Hasil Penelitian : Rata-rata intensitas mual muntah pada kelompok peppermint saat pretest adalah 2,38 dan menurun pada saat posttest menjadi 1 dengan P-value 0,004. Intensitas mual muntah kelompok Pomelo pada pretest adalah 6.38 turun menjadi 1,75 pada saat posttest dengan P-value 0,000. Hasil uji lanjut didapatkan tidak ada perbedaan bermakna intensitas mual muntah antara kedua kelompok dengan Sig. 0,428.Kesimpulan : Pemberian Peppermint dan pomelo efektif dalam menurunkan intensitas mual dan muntah pada ibu hamil trimester I.Saran : Penelitian ini perlu disempurnakan dengan memperbesar sampel penelitian dan pengukuran intensitas mual muntah dapat dilakukan setiap hari selama penelitian mengingat penelitian ini hanya mengukur sebanyak dua kali pada 24 responden. Kata kunci : Mual, Muntah, Kehamilan, Peppermint, Pomelo

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EFEKTIVITAS INTERVENSI PSIKOEDUKASI TERHADAP KEPATUHAN BEROBAT PASIEN SKIZOFRENIA

Real in Nursing Journal ◽

10.32883/rnj.v1i1.226 ◽

2018 ◽

Vol 1 (1) ◽

pp. 1

Author(s):

Neila Sulung ◽

Nice Foresa

Keyword(s):

Health Education ◽

Treatment Compliance ◽

Control Group ◽

P Value ◽

Control Group Design ◽

Psychosocial Therapy ◽

Significant Difference ◽

The Mean ◽

And Control ◽

Experimental Group

Psychoeducation is one form of intervention, both for families and clients who are part of the psychosocial therapy. Psychoeducation aims to increase knowledge about schizophrenia patients and families and to improve treatment compliance. This study aims to determine the effectiveness of psychoeducation intervention for treatment compliance of schizophrenia patient. The kind of this research is quasiexperimentalwith control group design with 16 samples that was selected by pusposive sampling, consist of 8 people was the experimental group that was given psychoeducation intervention and 8 people was the control group that was given health education. The datawas collected by filled the observation sheet as much as 12 statements. The Test that used was T-Test Independent with p value <0.05. The result of this research is the mean of treatment compliance on experimental group is 11,00 and control group 6,88. In statistic test showed that there is the significant difference between treatment compliance of schizopheria patient on experimental group and control group with p value 0,0005 (p < 0,05).Based of the result above can be concluded than psychoeducation intervention more effective to increase the treatment compliance of schizophrenia patients than health education. It is recomended to the nurse in health center to implements this psychoeducation regularly in gives nursing care to schizophrenia patients. Keywords : psychoeducation, treatment compliance, schizophrenia

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