scholarly journals Histopathological spectrum of chronic skin ulcers in a tertiary care hospital

2019 ◽  
Vol 6 (3) ◽  
pp. 101
Author(s):  
Imza Feroz ◽  
Abdul Haseeb Wani ◽  
Mir Wajahat Un Nazir ◽  
Mohammad Iqbal Lone ◽  
Arshed Hussain Parry
Keyword(s):  
Skin Biopsy ◽  
Bacterial Infections ◽  
Tertiary Care Hospital ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
The Body ◽  
Care Hospital ◽  
Diabetic Ulcer ◽  
Skin Ulcers ◽  
Wide Range

<p class="abstract"><strong>Background:</strong> The skin is the largest organ of the body, comprising of epidermis, dermis and hypodermis. Thus, a wide range of diseases can develop from the skin ranging from infectious diseases to malignancy, some of which may present as non-healing ulcers. Skin biopsy forms the fundamental basis for differentiation of similar looking lesions, thus helping the pathologists to make a definitive diagnosis and more so to the clinician for better management of patients. The objective was to study the histopathological spectrum of chronic non healing ulcers of skin for proper management and treatment.</p><p class="abstract"><strong>Methods:</strong> This was a hospital-based study which was conducted in SKIMS, Soura, a tertiary care hospital of Kashmir valley for a period of 1 year extending from January 2018 to December 2018. All the patients who presented with the complaint of non-healing ulcer for more than 4 to 6 weeks were subjected to skin biopsy and histopathological examination.</p><p class="abstract"><strong>Results:</strong> A total of 260 biopsies were examined. Out of 260 patients 146 were males and 114 were females. Ninety out of 260 cases (34.61%) and 170 (65.39%) were diagnosed as malignant and benign ulcers respectively.</p><p class="abstract">Diabetic ulcer was the second most common cause of non-healing ulcers followed by bacterial infections and tuberculosis. Squamous cell carcinoma was the most common neoplastic pathology.</p><p class="abstract"><strong>Conclusions: </strong>It was concluded from the study that non-healing skin ulcers can be encountered at any age in daily medical practice.</p>

scholarly journals Clinicopathological study of bacterial lesions in a tertiary care hospital

2021 ◽  
Vol 9 (7) ◽  
pp. 2072
Author(s):  
Sonti Sulochana ◽  
Jalavadi Rahul Siddartha
Keyword(s):  
Bacterial Infections ◽  
Tertiary Care Hospital ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Granulomatous Inflammation ◽  
The Body ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
H Pylori ◽  
One Year

Background: The incidence of bacterial lesions has been on the rise over the decades. In our study, we assessed and studied the spectrum of bacterial lesions retrospectively for one year and their clinicopathological correlation which was diagnosed on histopathological examination in a tertiary health care center.Methods: The present study (retrospective) has been done to analyse the incidence of bacterial infections obtained in the histopathology laboratory and study its clinical correlation and significance. Clinical details of the cases were accessed from biopsy requisition forms and included tissues from various sites in the body. Special stains were done which included acid fast bacilli (AFB), Fite Farraco (FF) stain and gram stain for the identification of bacteria.Results: A total of 318 cases including 288 H. pylori infections, granulomatous inflammation 18, Hansen disease 9 and 3 actinomycosis infections.Conclusions: The histopathological diagnosis of bacterial lesions are of utmost importance as it is more reliable than culture in circumstances of reduced tissue availability. Early reporting is extremely necessary to reduce complications related to bacterial lesions.

scholarly journals HISTOPATHOLOGICAL STUDY OF UTERINE LESIONS IN HYSTERECTOMY SPECIMENS IN A TERTIARY CARE HOSPITAL.

2020 ◽  
pp. 1-2
Author(s):  
Reddythota Sujeeva Swapna ◽  
V Siva Sankar Naik ◽  
C Bhavani ◽  
M Neeraja
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Female Genital Tract ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
The Body ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Wide Range

Background: The Female Genital Tract is a hormone-responsive system to a degree unmatched by any other system in the body. The gross configuration of the uterus changes dramatically throughout life. It is a kind of 'Puppet on a string", thus manipulated throughout life by altering levels of ovarian hormones. Objective of the study: The present study is aimed at detailed histopathological evaluation of uterine lesions of hysterectomy specimens. Methodology: A total of 448 cases of hysterectomy specimens were received in the department of pathology GGH Ananthapur, for two years, were reviewed. The specimens were processed, and the histopathological diagnosis was studied. Result: Peak age group of hysterectomy was 40-49 years with 186 (41.51%) cases. The youngest patient was 21 years old, and the oldest was 75 years old. The most frequent type of hysterectomy done was total abdominal hysterectomy in 293 (65.4%) cases. Conclusion: Hysterectomy is the most common surgery performed in gynecological practice. A wide range of lesions were noted when hysterectomy specimens are subjected to histopathological examination.

A 3 YEARS HISTOPATHOLOGICAL STUDY OF GALLBLADDER AFTER CHOLECYSTECTOMY IN A TERTIARY CARE HOSPITAL

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
M. Reeta Devi ◽  
L. Nabina ◽  
R.K. Ronal
Keyword(s):  
Tertiary Care Hospital ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Chronic Cholecystitis ◽  
Common Disease ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Xanthogranulomatous Cholecystitis ◽  
Incidental Diagnosis ◽  
Wide Range

Background: Diseases of the gallbladder are pretty common. Most of the cases admitted in hospitals required surgical intervention and removal. Histopathological routine examination of the resected gallbladder shows a wide range of changes, from inflammatory to different variants and from premalignant to malignancy. This study is undertaken to find the changes in the cholecystectomy specimen along with their gender and age distribution. Methods: The present retrospective study was conducted in the cholecystectomy specimen received in the department of Pathology, Regional Institute of Medical Sciences (RIMS), a tertiary care hospital during the period of January 2014 to December 2016. The corresponding blocks are retrieved from the archives of the department, sections are cut and slides are stained with Hematoxylin and Eosin stain,Three representative slides of each specimen are examined. The aim of this study is to analyse the different histopathological changes of the gallbladder and their distribution in different age groups and as well as  in gender. Results: A total of 1506 cholecystectomy specimen were received in the histopathology section of the department. Out of which, 1282 cases (85.12%) were females while 224 cases (14.88%) were male patients. Female to male ratio is 6:1. The most common histopathological diagnosis of cholecystectomy specimen was chronic cholecystitis followed by chronic cholecystitis with focal evidence of cholesterolosis and xanthogranulomatous cholecystitis. There were 3 cases of incidental diagnosis of adenocarcinoma gallbladder. Conclusion: Chronic cholecystitis is the most common disease affecting the gallbladder which with a high rate of occurance all over the world. The study firmly recommends thorough histopathological examination of all resected gallbladder. Incidental diagnosis of adenocarcinoma further warrents the need for thorough histopathological examination to help in treatment and prognosis. Keywords: Chronic cholecystitis, cholesterolosis, xanthogranulomatous cholecystitis,  incidental adenocarcinoma.

Homelessness among an inpatient HIV-positive cohort at a tertiary care hospital in central London

2020 ◽  
Vol 31 (7) ◽  
pp. 705-707
Author(s):  
Venkateshwaran Sivaraj ◽  
Rudiger Pittrof ◽  
Olubanke Davies ◽  
Ranjababu Kulasegaram
Keyword(s):  
Bacterial Infections ◽  
Substance Misuse ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Hiv Positive ◽  
Care Hospital ◽  
Hiv Viral Load ◽  
Cd4 Cell Count ◽  
Cell Counts ◽  
Cd4 Cell

A cohort review was conducted at a central London tertiary care hospital trust on the prevalence of homelessness among human immunodeficiency virus (HIV)-positive inpatients over a year. Data were collected on the duration of inpatient stay, co-morbidities including acquired immune deficiency syndrome (AIDS)-defining illnesses, co-infections, initiation of antiretroviral therapy, CD4 cell count, HIV viral load and substance misuse. Homeless people were found to be at high risk for hepatitis C, mental health illness, substance misuse including injecting drug use, recurrent bacterial infections, AIDS-associated illnesses, lower CD4 cell counts and HIV viremia. They also had more missed HIV outpatient appointments. It was highlighted that a multidisciplinary approach in their care was necessary to address their needs and reduce the morbidity burden in this cohort.

A CLINICOEPIDEMIOLOGICAL STUDY ON PAEDERUS DERMATITIS IN A TERTIARY CARE CENTRE, CHENNAI

2021 ◽  
pp. 25-27
Author(s):  
P. Mohan ◽  
P. Revathi Guru ◽  
V. Sudha ◽  
L. Balamurugan ◽  
Pavithra Gunasekaran ◽  
...  
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Sudden Onset ◽  
The Body ◽  
Care Hospital ◽  
Age Group ◽  
Common Condition ◽  
Tertiary Care Centre ◽  
Linear Lesions ◽  
Paederus Dermatitis

Paederus dermatitis is a form of irritant contact dermatitis due to contact with certain insects of the genus Paederus presenting with mostly erythematous linear lesions of sudden onset on exposed parts of the body. To study the clinico epi Aim: demiological features in patients with Paederus dermatitis. A retrospective analysis of clinicoepidemiological Materials & Methods: features of patients affected with Paederus dermatitis who had attended the Dermatology OPD, in a tertiary care hospital between January 2018 to December 2019 was done. All the required data had been collected from the OPD records and details were tabulated and analysed. A total of 56 patients had been affected with Result: Paederus dermatitis during the study period, of which 32 were males and 24 were females. 41out of 56 (73.21%) of patients presented between the months of August and December. Most common age group affected were between 11 to 30 yrs, with front and back of neck being the most common affected sites. In 42 out of the 56 patients the lesions resolved with post inammatory hyperpigmentation. Conclusion: Paederus dermatitis is a common condition that is often misdiagnosed and hence awareness is required for the clinicians and the general public to prevent it.

scholarly journals Nasomaxillary swellings: our experience at tertiary care hospital

2021 ◽  
Vol 7 (3) ◽  
pp. 469
Author(s):  
Mukesh Rawat ◽  
Archana Lall ◽  
Kavita Sachdeva
Keyword(s):  
Tertiary Care Hospital ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Final Diagnosis ◽  
Inverted Papilloma ◽  
Nasal Endoscopy ◽  
Common Symptom ◽  
Fungal Sinusitis ◽  
Care Hospital ◽  
Malignant Lesions

<p class="abstract"><strong>Background:  </strong>A wide spectrum of lesions may present as nasomaxillary swellings ranges from benign to malignant lesions including fungal sinusitis and fibro vascular lesions example: JNA (Juvenile nasopharyngeal angiofibroma) and Inverted papilloma. Many Pathologies ranging from benign to malignant tumors may mimic a simple Nasomaxillary mass. It is diagnostic challenge to determine pathology behind it. A detailed clinical evaluation with nasal endoscopy and relevant pre-operative investigations including radiological imaging and histopathological examination is essential to reach up to final diagnosis. The aim of the study was to do clinicopathological evaluation of patients presenting with nasomaxillary swelling and correlation of clinical, radiological and Histopathological findings.</p><p class="abstract"><strong>Methods: </strong>This was a prospective observational study on 50 nasomaxillary swelling patients who are presented in the Department of ENT and Head and Neck Surgery of N.S.C.B. MCH Jabalpur, a tertiary care Hospital, between March 2018 to August 2019. A detailed history taking and clinical examination with nasal endoscopy and relevant preoperative investigations including CECT Nose and PNS and histopathological examination was done in all patients.</p><p class="abstract"><strong>Results: </strong>50 Nasomaxillary swelling patients were selected for this study. 30 patients were male and 20 were females. Ages of patients were varied from 12 years to 72 years. 23 patients (46%) were malignant and 27 (54%) were benign. Histopathological examination results shows benign lesions like JNA (6 cases), fungal sinusitis (6 cases), dermoid cyst (1 case), inverted papilloma (3 cases), sebaceous cyst (1 case), jaw lesions (10 cases), (odontogenic like radicular/ infected cyst, dentigerous cyst, cystic ameloblastoma and non-odontogenic like fibrous dysplasia) and malignant lesions like SCC (squamous cell carcinoma) (12 cases), spindle cell sarcoma (2 cases), undifferentiated carcinoma (3 cases), adenocarcinoma (3 cases), adenoid cystic carcinoma (1 case), Invasive pleomorphic sarcoma (1 case) and malignant melanoma (1 case). SCC was most common lesion f/b JNA and fungal sinusitis. Well differentiated SCC was most common histological type (10 out of 12 cases of SCC). Most common symptom was nasal obstruction (66% cases) f/b epistaxis (52% cases) but epitasis was most common symptom among malignant and JNA cases. In 6 cases (3 JNA, 1 inverted papilloma, 1 malignancy and 1 radicular cyst) radiological diagnosis were not correlated with histological findings.</p><p class="abstract"><strong>Conclusions: </strong>Most our cases were malignant nasomaxillary lesions followed by fungal sinusitis and JNA. Most patients presented in advanced stage of disease so rapidly evaluation including nasal endoscopy should be done. CECT scan is essential to determine tumors extent and bony lesions. All patients should undergo hisotopatholigical examination. The final diagnosis should be made on the basis of clinical, radiological and histopathological findings.</p>

scholarly journals Prevalence of carbapenemase-producing Klebsiella pneumoniae at a tertiary care hospital in Kathmandu, Nepal

2021 ◽  
Vol 49 (1) ◽  
Author(s):  
Susil Pyakurel ◽  
Mehraj Ansari ◽  
Smriti Kattel ◽  
Ganesh Rai ◽  
Prasha Shrestha ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Diffusion Method ◽  
Clinical Samples ◽  
Resistant Bacteria ◽  
Growth Media ◽  
Care Hospital ◽  
Drug Resistant ◽  
Biochemical Tests

Abstract Aim Although carbapenem is the last-resort drug for treating drug-resistant Gram-negative bacterial infections, prevalence of carbapenem-resistant bacteria has substantially increased worldwide owing to irrational use of antibiotics particularly in developing countries like Nepal.  Therefore, this study was aimed to determine the prevalence of carbapenemase-producing K. pneumoniae and to detect the carbapenemase genes (blaNDM-2 and blaOXA-48) in at a tertiary care hospital in Nepal. Materials and methods A hospital-based cross-sectional study was carried out from June 2018 to January 2019 at the Microbiology Laboratory of Annapurna Neurological Institute and Allied Sciences, Kathmandu, Nepal. Different clinical samples were collected and cultured in appropriate growth media. Biochemical tests were performed for the identification of K. pneumoniae. Antibiotic susceptibility testing (AST) was performed by the Kirby–Bauer disc diffusion method. The modified Hodge test (MHT) was performed to detect carbapenemase producers. The plasmid was extracted by the modified alkaline hydrolysis method. Carbapenemase-producing K. pneumoniae were further confirmed by detecting blaNDM-2 and blaOXA-48 genes by PCR using specific forward and reverse primers followed by gel electrophoresis. Results Out of the total 720 samples, 38.9% (280/720) were culture positive. K. pneumoniae was the most predominant isolate 31.4% (88/280). Of 88 K. pneumoniae isolates, 56.8% (50/88) were multi-drug resistant (MDR), and 51.1% (45/88) were MHT positive. Colistin showed the highest sensitivity (100%; 88/88), followed by tigecycline (86.4%; 76/88). blaNDM-2 and blaOXA-48 genes were detected in 24.4% (11/45) and 15.5% (7/45) of carbapenemase-producing K. pneumoniae isolates, respectively. Conclusion The rate of MDR and carbapenemase production was high in the K. pneumoniae isolates. Colistin and tigecycline could be the drug of choice for the empirical treatments of MDR and carbapenemase-producing K. pneumoniae. Our study provides a better understanding of antibiotic resistance threat and enables physicians to select the most appropriate antibiotics.

scholarly journals Study of prescription pattern of antimicrobials used in post-operative surgical patients in tertiary care hospital

2021 ◽  
Vol 10 (6) ◽  
pp. 627
Author(s):  
Jitendra H. Hotwani ◽  
Nishikant H. Madkholkar
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Total Duration ◽  
Hospital Setting ◽  
Surgical Site Infections ◽  
The Body ◽  
Brand Names ◽  
Surgical Patients ◽  
Care Hospital ◽  
Prescription Pattern

Background: Antimicrobials are used for prophylaxis and treatment of infections which occur following surgical procedures, to reduce the morbidity and mortality associated with surgical site infections (SSIs). A surgical site infection is an infection that occurs after surgery in the part of the body where the surgery took place. These are infections of the tissues, organs, or spaces exposed by surgeons during performance of an invasive procedure.Methods: A prospective, non-interventional, observational study in tertiary care hospital for duration of 9 months. Sample size was 330.Results: The prescription pattern shows that nitroimidazoles were the most commonly prescribed group of antimicrobials in 72% of patients followed by penicillins (58%) and cephalosporins (42%). Metronidazole (72%), amoxicillin and clavulanic acid (51.21%) ceftriaxone (20.90%) were most commonly prescribed antimicrobials in these groups. Two antimicrobials were prescribed in 47% patients with nitroimidazole and penicillins being the most commonly prescribed combination of antimicrobial. Three antimicrobials were prescribed in 25% patients and four antimicrobials in 8% patients. This shows trend towards polypharmacy. About 82% of antimicrobials were prescribed by brand names and 64% of total antimicrobials prescribed from outside the hospital pharmacy source. About 12.42% of patients changed antimicrobial therapy after culture and sensitivity report.Conclusions: Total duration, number of anti-microbial used was more in clean-contaminated, contaminated, dirty wound surgeries as compare to clean wound surgeries. Our study provides a framework for continuous prescription audit of antimicrobials in a hospital setting and thus can help in rational use of antimicrobials in post-operative surgical patients.

scholarly journals Cervical Cancer Screening On 1000 Healthy Asymptomatic Women Residing In Slum of Rajshahi City of Bangladesh

2017 ◽  
Vol 7 (1) ◽  
pp. 14-17
Author(s):  
Munira Ferdausi ◽  
Fatema Ashraf ◽  
Nourin Rahman ◽  
Zara Rahman ◽  
Fahima Mustanzid
Keyword(s):  
Tertiary Care Hospital ◽  
Histopathological Examination ◽  
Cervical Screening ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
Study Population ◽  
Asymptomatic Women ◽  
Rajshahi City

Background: Cervical carcinoma is an important cause of mortality among adult women.Objective: The purpose of the present study was to detect the pre-cancerous condition of cervix in women.Methodology: This cross sectional study was carried out in the OPD of a tertiary care hospital of Rajshahi City in Bangladesh during the year June 2010 to August 2011. Healthy asymptomatic women residing in slum of Rajshahi city with a marital age of 8 years and above were included as study population. VIA test was performed in all women. The VIA positive cases were invited for colposcopy and directed biopsies were obtained from women who were colposcopically positive.Result: A total number of 1000 women were studied. Among them 80(8%) women were VIA positive. These positive cases were also referred for colposcopy. Out of the 80 cases, 26 (32%) were colposcopically normal and 50(63%) were CIN-1 and 4(5%) women were CIN II. Directed biopsy was done among colposcopically positive group. Histopathological examination shows 44 (82%) were CIN-1 and 4(7%) were CIN- II and 6(11%) were chronic cervicities.Conclusion: Cervical screening of the slum area women shows an important number of women suffering from precancerous condition of which CIN-l is the most common.J Shaheed Suhrawardy Med Coll, 2015; 7(1):14-17

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