Antibiotics in children with bronchial asthma

Background: This study was conducted to determine if oral antibiotics started at presentation reduce the duration of acute exacerbations of bronchial asthma by comparing the durations of mild to moderate exacerbations of asthma managed with or without antibiotics in children below 12 years.Methods:In this systematic trial, we allocated the eligible children to antibiotic group (who also received standard of care and control (the standard of care) group (n=40 in each group) and compared the duration of acute asthma exacerbation between the two groups.Results: The mean difference of duration of mild and moderate exacerbations between the antibiotic and control group was 4.76 hours (95% Confidence Interval (CI) of -36.76 to 28.84) which was found not to be statistically significant (p value- 0.482).Conclusions:There was no significant reduction in the duration of mild to moderate exacerbations of asthma in children below 12 years by the administration of empirical antibiotics.

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O3 DIRECT ORAL FEEDING FOLLOWING MINIMALLY INVASIVE ESOPHAGECTOMY (NUTRIENT II TRIAL): AN INTERNATIONAL, MULTICENTER, OPEN-LABEL RANDOMIZED CONTROLLED TRIAL

Diseases of the Esophagus ◽

10.1093/dote/doz092.03 ◽

2019 ◽

Vol 32 (Supplement_2) ◽

Cited By ~ 1

Author(s):

Gijs H K Berkelmans ◽

Laura F C Fransen ◽

Annemarie C P Dolmans-Zwartjes ◽

Ewout A Kouwenhoven ◽

Marc J van Det ◽

...

Keyword(s):

Anastomotic Leakage ◽

Functional Recovery ◽

Controlled Trial ◽

Minimally Invasive Esophagectomy ◽

Standard Of Care ◽

Oral Feeding ◽

Control Group ◽

P Value ◽

Invasive Esophagectomy ◽

And Control

Abstract Aim Patients undergoing an esophagectomy are often kept nil-by-mouth postoperatively out of fear for increasing anastomotic leakage and pulmonary complications. This study investigates the effect of direct start of oral feeding following minimally invasive esophagectomy (MIE) compared to standard of care. Background & Methods Elements of enhanced recovery after surgery (ERAS) protocols have been successfully introduced in patients undergoing an esophagectomy. However, start of oral intake, which is an essential part of the ERAS protocols, remains a matter of debate. Patients in this multicenter, international randomized controlled trial were randomized to directly start oral feeding (intervention) after a MIE with intrathoracic anastomosis or to receive nil-by-mouth and tube feeding for five days postoperative (control group). Primary outcome was time to functional recovery. Secondary outcome parameters included anastomotic leakage, pneumonia rate and other surgical complications scored by predefined definitions. Results Baseline characteristics were similar in the intervention (n=65) and control (n=67) group. Functional recovery was seven days for patients receiving direct oral feeding compared to eight days in the control group (p-value 0.436). Anastomotic leakage rate did not differ in the intervention (18.5%) and control group (16.4%, p-value 0.757). Pneumonia rates were comparable between the intervention (24.6%) and control group (34.3%, p-value 0.221). Other morbidity rates were similar, except for chyle leakage which was more prevalent in the standard of care group (p-value 0.032). Conclusions Direct oral feeding after an esophagectomy does not affect functional recovery and did not increase incidence or severity of postoperative complications.

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Early treatment with inhaled GM-CSF improves oxygenation and anti-viral immunity in COVID-19 induced lung injury – a randomized clinical trial

10.21203/rs.3.rs-959220/v1 ◽

2021 ◽

Author(s):

Bart Lambrecht ◽

Karel Van Damme ◽

Elisabeth De Leeuw ◽

Jozefien Declercq ◽

Bastiaan Maes ◽

...

Keyword(s):

Group Treatment ◽

Standard Of Care ◽

Care Group ◽

Control Group ◽

Viral Immunity ◽

Open Label ◽

Hypoxemic Respiratory Failure ◽

Gm Csf ◽

Macrophage Colony ◽

And Control

Abstract Granulocyte-macrophage colony-stimulating factor (GM-CSF) instructs monocytes to differentiate into alveolar macrophages (AM) that preserve lung homeostasis. By comparing AM development in mouse and human, we discovered that COVID-19 patients showed marked defects in GM-CSF-dependent AM instruction. The multi-center, open-label, randomized, controlled SARPAC-trial evaluated the efficacy and safety of 5 days of inhalation of rhu-GM-CSF (sargramostim, Leukine®) in 81 non-ventilated patients with COVID-19 and hypoxemic respiratory failure identified by PaO2/FiO2 ratio < 350mmHg. At day 6, more patients in the sargramostim group experienced at least 25% improvement in oxygenation compared with the standard of care group. Higher numbers of circulating class-switched B cells and effector virus-specific CD8 lymphocytes were found in the sargramostim group. Treatment adverse events, including signs of cytokine storm, were not different between active and control group. This proof-of-concept study demonstrates the feasibility and safety of inhaled GM-CSF in restoring alveolar gas exchange, while simultaneously boosting anti-COVID-19 immunity. ClinicalTrials.gov (NCT04326920).

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Moderate Bronchial Asthma

MicroRNA ◽

10.2174/2211536609666201221122715 ◽

2020 ◽

Vol 09 ◽

Author(s):

Akmaral Aripova ◽

Almira Akparova ◽

Rakhmetkazhy Bersimbaev

Keyword(s):

Blood Plasma ◽

Bronchial Asthma ◽

Control Group ◽

P Value ◽

Small Nuclear Rna ◽

Circulating Micrornas ◽

Chronic Respiratory Diseases ◽

Asthmatic Patients ◽

Nuclear Rna ◽

And Control

Background: Bronchial asthma (BA) is a complex of heterogeneous disease with a number of molecular immunopathological mechanisms underlying airway inflammation, hyperreactivity, and bronchial remodeling. MicroRNAs are important regulators in the pathogenesis and progression of chronic respiratory diseases, including BA. Objective: The aim of the study is to investigate the level of expression of cell-free circulating miR-19b-3p and miR-320c in the blood plasma by comparing their plasma levels with IL-4 in moderate BA and control group. Methods: The level of expression miR-19b-3p and miR-320c were evaluated by qRT-PCR by using the comparative threshold cycle (Ct) method. U6 small nuclear RNA was taken as endogenous control. The content of IL - 4 in blood plasma was determined by using ELISA. Results: miR-19b-3p and miR-320c were significantly dysregulated in moderate asthmatic patients in comparison with control group. The area under the ROC curve of miR-19b-3p and miR-320c showed 0.8088 (95% CI 0.6925 to 0.9251, P value =0.0001) and 0,9048 (95% CI 0,7792 to 1,000, P value <0,0001), respectively. BA patients showed a considerably positive correlation between the expression level of microRNA-320c and IL-4 levels. Conclusion: These cell-free circulating microRNAs are probably deregulated in others inflammatory/pathological diseases, so they could be useful to understand the molecular pathogenesis of BA or to investigate the "inflammatory reaction" in this disease.

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The Estimation of prostate specific antigen (PSA) concentrations in patients with prostatitis by fully automated ELISA technique.

Journal of Medical Research and Health Sciences ◽

10.15520/jmrhs.v3i11.279 ◽

2020 ◽

Vol 3 (11) ◽

pp. 1100-1104

Author(s):

Hussein Naeem Aldhaheri ◽

Ihsan Edan AlSaimary ◽

Murtadha Mohammed ALMusafer

Keyword(s):

Personal Information ◽

Receptor Gene ◽

Specific Antigen ◽

Gene Clusters ◽

Control Group ◽

P Value ◽

Group Data ◽

Elisa Technique ◽

And Control

The Aim of this study was to determine Immunogenetic expression of Toll-like receptor gene clusters related to prostatitis, to give acknowledge about Role of TLR in prostatitis immunity in men from Basrah and Maysan provinces. A case–control study included 135 confirmed prostatitis patients And 50 persons as a control group. Data about age, marital status, working, infertility, family history and personal information like (Infection, Allergy, Steroid therapy, Residency, Smoking, Alcohol Drinking, Blood group, Body max index (BMI) and the clinical finding for all patients of Prostatitis were collected. This study shows the effect of PSA level in patients with prostatitis and control group, with P-value <0.0001 therefore the study shows a positive significant between elevated PSA levels and Prostatitis.

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PENGGUNAAN SELAPUT AMNION SEGAR PADA INSISI LUKA OPERASI SEKSIO SESAREA

JOURNAL OBGIN EMAS ◽

10.25077/aoj.1.2.47-55.2017 ◽

2019 ◽

Vol 1 (2) ◽

pp. 47-55

Author(s):

Syahredi Syaiful Adnani ◽

Hafni Bachtiar

Keyword(s):

Wound Healing ◽

Caesarean Section ◽

Amniotic Membrane ◽

Healing Time ◽

Cost Of Care ◽

Control Group ◽

P Value ◽

Control Groups ◽

And Control ◽

Wound Healing Time

In the last few decades, the incidence of caesarean section is increasing in the world, especially in Indonesia. One of the way to treat tissue scar is through biologic and synthetic dressing where nowadays, amnion has been used as biologic dressing frequently. This study was conducted to determine the effect of the use of fresh amniotic membrane on wound incision Caesarean section compared with Caesarean section incision wound covered using regular gauze bandages and fixated with plaster in RS. Dr. Reksodiwiryo Padang. The design of this study is an experimen-tal study with Post test design with control group design. Sampling was done using a formula consecutive sampling two different test samples obtained an average of 72 people for each group. The analysis used include univariate and bivariate analyzes. The average wound healing time the difference was statistically significant (p value <0.05) in the treatment and control groups. There was highly significant difference in the proportion of local infection on day 3 between the treatment and control groups (p value <0.05). There were very significant differences in the proportion of local allergic reactions at day 3, and 5 between the treatment and control group (p <0.05). There are significant differences in terms of the cost of care per day between treatment and control groups (p <0.05). From this study, the average wound healing time has a very significant difference.Keywords: Fresh Amniotic Membrane, Wound Cesarean Section, Wound Healing

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Convalescent Plasma for COVID-19: A multicenter, randomized clinical trial

10.1101/2020.08.26.20182444 ◽

2020 ◽

Cited By ~ 7

Author(s):

Cristina Avendano-Sola ◽

Antonio Ramos-Martinez ◽

Elena Munez-Rubio ◽

Belen Ruiz-Antoran ◽

Rosa Malo de Molina ◽

...

Keyword(s):

Clinical Trial ◽

Mechanical Ventilation ◽

Randomized Clinical Trial ◽

Strong Dependence ◽

Standard Of Care ◽

Ordinal Scale ◽

Control Group ◽

Standard Of Care Treatment ◽

And Control ◽

To Receive

Background: Passive immunotherapy with convalescent plasma (CP) is a potential treatment for COVID-19 for which evidence from controlled clinical trials is lacking. Methods: We conducted a multi-center, randomized clinical trial in patients hospitalized for COVID-19. All patients received standard of care treatment, including off-label use of marketed medicines, and were randomized 1:1 to receive one dose (250-300 mL) of CP from donors with IgG anti-SARS-CoV-2. The primary endpoint was the proportion of patients in categories 5, 6 or 7 of the COVID-19 ordinal scale at day 15. Results: The trial was stopped after first interim analysis due to the fall in recruitment related to pandemic control. With 81 patients randomized, there were no patients progressing to mechanical ventilation or death among the 38 patients assigned to receive plasma (0%) versus 6 out of 43 patients (14%) progressing in control arm. Mortality rates were 0% vs 9.3% at days 15 and 29 for the active and control groups, respectively. No significant differences were found in secondary endpoints. At inclusion, patients had a median time of 8 days (IQR, 6-9) of symptoms and 49,4% of them were positive for anti-SARS-CoV-2 IgG antibodies. Conclusions: Convalescent plasma could be superior to standard of care in avoiding progression to mechanical ventilation or death in hospitalized patients with COVID-19. The strong dependence of results on a limited number of events in the control group prevents drawing firm conclusions about CP efficacy from this trial. (Funded by Instituto de Salud Carlos III; NCT04345523).

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E MUSCULOSKELETAL DISORDERS (MS PENGARUH WORKPLACE STRETCHING EXERCISE TERHADAP PENURUNAN KELUHAN MUSCULOSKELETAL DISORDERS(MSDs) PADA PEKERJA BATIK TULIS DI KECAMATAN SOKARAJA

Kesmas Indonesia ◽

10.20884/1.ki.2017.9.02.158 ◽

2017 ◽

Vol 9 (02) ◽

pp. 49

Author(s):

Siti Harwanti ◽

Nur Ulfah ◽

Budi Aji

Keyword(s):

Musculoskeletal Disorders ◽

Wilcoxon Test ◽

Control Group ◽

P Value ◽

Control Group Design ◽

Test Analysis ◽

Result Show ◽

Post Test ◽

Equivalent Control ◽

And Control

Batik maked process especially �mbironi�, is done in sit position. If this position maintained for a long period, that could be cause muscle strain which may lead into musculoskeletal disorders. The research was aim to know the effect of Workplace Stretching Exercise (WSE) to reduced MSDs in hand-made batik workers. The research was quasy experimental by non-equivalent control group design. Subjects were 37 female handmade batik workers used purposive sampling. Data analysis used Friedman test and Wilcoxon test, then for two independent sample used Independent t Test and Mann Whitney test with significancy level at 5% or a = 0,05. Analysis result show that there is no difference in MSDs on experiment and control group after pre-test which had p-value = 0,371 (>0,05). The result of middle-test and post-test p value = 0,000 (<0,05) that there is significant mean difference of MSDs between experiment and control group. Based on the middle-test and post-test analysis result, it could be conclude that there is an effect of WSE to reduce MSDs of handmade batik workers.

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Android-Based Education toward the Role of Postpartum Primipara Mothers in Fulfilling the Independent Perinium Care

Women, Midwives and Midwifery ◽

10.36749/wmm.1.2.55-67.2021 ◽

2021 ◽

Vol 1 (2) ◽

pp. 55-67

Author(s):

Werna Nontji ◽

Dwi Kartika Sari ◽

Sitti Maria Ulfa ◽

Syafruddin Syarif ◽

Inez Vravty Lestari ◽

...

Keyword(s):

Treatment Group ◽

Intervention Group ◽

Wilcoxon Test ◽

Control Group ◽

P Value ◽

Control Groups ◽

Post Test ◽

Android App ◽

And Control ◽

Perineal Care

Background: Educating mothers during their postpartum period could potentially help them to overcome some important phases after giving birth. The process of education is evaluated based on the mothers’ knowledge about their independent self-care. Independency is an activity that is started individually and is done based on self-capability. The independency in the postpartum care is not only important to decrease the mother’s mortality and morbidity rate, but it is also crucial to strengthen and improve the post-partum mother’s healthy behavior during the perineal care. Providing education using Android-based application called BUBI Care could be potential to facilitate a more dynamic transfer of knowledge to the postpartum mothers.Aims: To analyze the knowledge, skills, and independence of primipara postpartum mothers in independent perineal care before and after accessing BUBI Care app. Research Method: employing quasi experimental research with pre-test and post-test design with control group design. The sample for this research were 19 pregnant mothers TM III (pregnancy age of ? 38 weeks) on each group. The treatment group was educated using BUBI Care Android app that was conducted at one of Public Health Center. The control group was educated without BUBI Care that was conducted at a Midwife Practice Clinic. The research was conducted on September to October 2020. Study Result: According to the Wilcoxon test, there was a difference in the pre-test knowledge of the treatment and control groups with the similar median of 53 and p-value of 0.666, the treatment group showed their scores improved to 80 on the post-test while the control group stayed at 53 with the p-value of 0.000. It means that BUBI Care app education influences the post-test. On the other hand, the perineal care skill saw a difference between the intervention and control groups. The intervention group had a mean of 70.05 and 56.68 for the control group with the p-value of 0.002 which means that there was an influence from the BUBI Care app education. Additionally, Mann Whitney test showed that the intervention group had a mean score of 78.95, but the control group only had 49.26, the total difference between the two are 29.69 with the p-value of 0.000. It can be concluded that there is a significance in difference in the independency rate from the provision of BUBI Care Android app education.Conclusion: there is a significance effect on the intervention group in terms of Android based usage.

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A prospective, open label, randomized-controlled study to evaluate the efficacy and safety of Herbovir syrup in mildly symptomatic COVID-19 patients

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20205548 ◽

2020 ◽

Vol 10 (1) ◽

pp. 106

Author(s):

A. Gopal Rao ◽

Shankar Achar Somashekar ◽

Poorna Prasad ◽

Manjunath Reddy Lekkala ◽

Sreenivasa Hanumanthaiah ◽

...

Keyword(s):

Clinical Symptoms ◽

Standard Of Care ◽

Pulmonary Complications ◽

Controlled Study ◽

Control Group ◽

P Value ◽

Immune Markers ◽

Open Label ◽

Early Recovery ◽

D Dimer

Background: COVID-19 patients experience cytokine storm which cause pulmonary and extra-pulmonary complications. Effective antiviral and immune boosters are need of hour to treat COVID-19 as well as post COVID complications.Methods: In this study involving mild COVID-19 we randomized 40 patients to receive a Herbovir syrup along with standard of care (SOC) or SOC alone in 1:1 ratio. We evaluated the benefits of Herbovir syrup by assessing clinical outcomes and improvement in immune markers (LDH, CRP, D-dimer).Results: At the end of the study the immune markers in Herbovir group improved significant compared to control group. In patients who received Herbovir, LDH decreased from 334 U/l at baseline to 254 U/l at the end of treatment (p value <0.009), CRP decreased from 7.4 mg/l to 3.1 mg/l (p value=0.0171) and D-dimer decreased from 0.610 mg/l at baseline to 318 mg/l at the end of study (p value=0.001). TLC values did not go below normal range in Herbovir group whereas 8 patients in control group had low TLC at the end of study. Early recovery from COVID 19 symptoms was observed in >75% patients in Herbovir treated group.Conclusions: Herbovir accelerated recovery of COVID-19 patients by early improvement in clinical symptoms and immune markers in this study and results clearly indicates that Herbovir syrup has antiviral, immune booster activity and has definitive role in the management of mild COVID-19 patients along with standard of care. (Funded by Venkat pharma. CTRI no. CTRI/2020/08/027041).

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EFFECT OF AUDIO THERAPY USING AL-QUR'AN MURROTAL ON BEHAVIOR DEVELOPMENT IN CHILDREN WITH AUTISM

Belitung Nursing Journal ◽

10.33546/bnj.189 ◽

2017 ◽

Vol 3 (5) ◽

pp. 470-477

Author(s):

Anjar Astuti ◽

Suryono Suryono ◽

Melyana Nurul Widyawati ◽

Ari Suwondo ◽

Mardiyono Mardiyono

Keyword(s):

Neurodevelopmental Disorder ◽

Alternative Therapy ◽

Children With Autism ◽

Simple Random Sampling ◽

Behavioral Development ◽

Control Group ◽

P Value ◽

Significant Difference ◽

The Mean ◽

And Control

Background: Autism is a neurodevelopmental disorder. Audio therapy is considered as one of the complementary therapies to improve the behavior of children with autism.Objective: This study was to analysis the effectiveness of the Al-Qur'an murrotal audio therapy on behavioral development in children with autism.Methods: This study was a true-experimental research using pretest and posttest approach with control group. This research was conducted on November 2016 in the Autism Foundation of Semarang City. There were 30 samples were selected using simple random sampling, with 15 samples assigned in the experiment and control group. Mann Whitney and Wilcoxon tests were used for data analysis in this study.Results: Results showed that there was a significant difference in the mean of behavioral development after given intervention between the experiment group and control group with p-value 0.034 (<0.05). The mean of behavioral development in the experiment group (4.53) was higher than the mean in the control group (3.47).Conclusion: The Al-Qur'an murrotal audio therapy is effective to develop behavior of children with autism. Therefore, it is expected that this audio therapy can be applied an alternative therapy for children with autism.

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