scholarly journals Clinical profile of congenital limb anomalies in neonates

2018 ◽  
Vol 5 (2) ◽  
pp. 299 ◽  
Author(s):  
Yogesh N. Parikh ◽  
Mitul B. Kalathia ◽  
Dhanya Soodhana
Keyword(s):  
Prospective Observational Study ◽  
Demographic Data ◽  
Epidemiological Studies ◽  
Birth Prevalence ◽  
Limb Anomalies ◽  
History Of ◽  
Limb Malformations ◽  
Congenital Limb ◽  
The Mean ◽  
Insight Into

Background: Reported birth prevalence of congenital limb defects vary from country to country. Epidemiological studies permit the timely detection of trends in congenital limb anomalies and the associations with other birth defects. The objective of this study was to know the prevalence and the variety of congenital limb anomalies and their association with other anomalies.Methods: A prospective observational study in which all newborns reported to the neonatal department were surveyed to find out the incidence, diversity and association of limb anomalies. Age of the mother, risk factors and other demographic data of the newborns was analyzed. Babies born less than 28 weeks were excluded from the study.Results: The prevalence was 6.34 per thousand live births. The majority of the neonates were term babies and female. 28 % of the babies were born out of consanguineous marriage. The mean age of the mother was 25. Median parity was 1. 9.52 % of the babies had a history of anomaly in the sibling. 4.76 % had a history of still birth. The most common congenital anomaly was congenital talipo equino varus. The other congenital limb anomalies observed were polydactyly, syndactyly, bifid thumb and absence of the radius. There were multiple congenital anomalies in 28.57 % of the babies.Conclusions: The study has given us an insight into the variety of congenital limb malformations and also into the possible etiological factors. A study done on a larger population would probably help us assess the incidence and pattern of occurrence of limb anomalies and help us counsel the parents. 

scholarly journals Determinants of anemia among pregnant women: A hospital based cross sectional study

2019 ◽  
Vol 8 (9) ◽  
pp. 3609
Author(s):  
P. Kalpana ◽  
A. Kavitha
Keyword(s):  
Pregnant Women ◽  
Demographic Data ◽  
Cross Sectional Study ◽  
Hemoglobin Level ◽  
Sectional Study ◽  
Cross Sectional ◽  
Lower Segment Cesarean Section ◽  
Menstrual History ◽  
History Of ◽  
The Mean

Background: The objective was to study the determinants of anemia among pregnant women. There is a negative effect on the health of the mother and as well as that of the child due to anemia in women with pregnancy. Death rate is more in women who are pregnant and having anemia. The objective of this study was to study the determinants of anemia among pregnant women.Methods: A hospital based cross sectional study was carried out among 40 pregnant women over a period of six months. Demographic data like age, residence, occupation etc was recorded. Obstetric data like gravida, parity, previous LSCS was also recorded. The data was presented as means and student’s t test was applied.Results: The mean age was 23.43±3.4 years. Majority were young between the ages of 19-22 years. Majority belonged to urban residents i.e. 57.5%. 20% of the subjects were found to be illiterate. Majority of the mothers were housewives i.e. 82.5%. Majority were multi-gravida i.e. 60%. Majority had no history of abortions in the past i.e. 75%. Out of total 19 repeat pregnancies, majority i.e. 84.2% had lower segment cesarean section. Majority reported that they had normal menstrual history. The mean hemoglobin level was found out to be 7.94 gm/dl. It was found that the mean hemoglobin level did not differ significantly across age, residence, education, occupation, gravidity, history of abortions, type of delivery but differed significantly by abnormal menstrual cycle.Conclusions: Mean hemoglobin level was more in women with normal menstrual history compared to those women with abnormal menstrual history and this difference was found out to be statistically significant. Hence abnormal menses should be promptly treated, hemoglobin assessed.

scholarly journals Early Airway Pathological Changes in Children: New Insights into the Natural History of Wheezing

2019 ◽  
Vol 8 (8) ◽  
pp. 1180 ◽  
Author(s):  
Matteo Bonato ◽  
Mariaenrica Tiné ◽  
Erica Bazzan ◽  
Davide Biondini ◽  
Marina Saetta ◽  
...  
Keyword(s):  
Natural History ◽  
Genetic Background ◽  
Current Knowledge ◽  
Persistent Asthma ◽  
Epidemiological Studies ◽  
Airflow Limitation ◽  
Clinical Expression ◽  
Heterogeneous Condition ◽  
History Of ◽  
Insight Into

Asthma is a heterogeneous condition characterized by reversible airflow limitation, with different phenotypes and clinical expressions. Although it is known that asthma is influenced by age, gender, genetic background, and environmental exposure, the natural history of the disease is still incompletely understood. Our current knowledge of the factors determining the evolution from wheezing in early childhood to persistent asthma later in life originates mainly from epidemiological studies. The underlying pathophysiological mechanisms are still poorly understood. The aim of this review is to converge epidemiological and pathological evidence early in the natural history of asthma to gain insight into the mechanisms of disease and their clinical expression.

scholarly journals Childhood asthma and risk factors

2010 ◽  
Vol 63 (7-8) ◽  
pp. 516-521 ◽  
Author(s):  
Radmila Ljustina-Pribic ◽  
Slobodanka Petrovic ◽  
Jelena Tomic
Keyword(s):  
Risk Factors ◽  
Childhood Asthma ◽  
Epidemiological Studies ◽  
Supporting Evidence ◽  
Prognosis Factors ◽  
History Of Disease ◽  
Heterogeneous Nature ◽  
Causes Of Disease ◽  
History Of ◽  
Insight Into

Introduction. This article summarizes the contribution of epidemiology to the understanding of childhood asthma. The first task in epidemiology is to determine prevalence and incidence of any disease. Prevalence. Epidemiological investigations are aimed at evaluating hypotheses about causes of disease by defining demographic characteristics of a certain population as well as by determining possible effects of environmental factors. In spite of some limitations, data obtained by epidemiological investigations have been valuable in confirming both the increasing incidence of asthma and the differences in prevalence in certain population groups. The observance of this phenomenon has led to much speculation and a lot of attempts to identify the reasons behind the rising prevalence. Risk factors. Epidemiological studies have identified risk factors for the development of childhood asthma and provided insight into natural history of disease and prognosis. Factors ranging from increased numbers of immunizations to increased air pollution have been suggested, but subsequent analysis has failed to provide the supporting evidence to implicate most of these possibilities. The concept known as the hygiene hypothesis has gained some support from epidemiological studies. Conclusion. The development of asthma as well as its severity are affected by numerous factors and their interactions can be explained by the heterogeneous nature of this disease.

scholarly journals Comorbid non-alcohol substance misuse among people with schizophrenia

2001 ◽  
Vol 179 (6) ◽  
pp. 509-513 ◽  
Author(s):  
Peter J. Duke ◽  
Christos Pantelis ◽  
Michael A. McPhillips ◽  
Thomas R. E. Barnes
Keyword(s):  
Substance Misuse ◽  
Alcohol Misuse ◽  
Demographic Data ◽  
Epidemiological Studies ◽  
Lifetime History ◽  
The Usa ◽  
History Of ◽  
And Gender ◽  
The Uk ◽  
Drug And Alcohol

BackgroundFew epidemiological studies have assessed the extent and nature of comorbid non-alcohol substance misuse in people with schizophrenia in the community in the UK.AimsTo study the extent and nature of comorbid non-alcohol substance misuse in people with schizophrenia in central London.MethodSubjects were identified in an epidemiological census survey of South Westminster. Standardised assessment of each subject included demographic data, ratings of mental state and movement disorder and questioning about drug and alcohol misuse.ResultsIndividuals with schizophrenia or related psychoses were identified (n=352) and 57 (16%) reported a lifetime history of non-alcohol substance misuse. Age and gender were the main variables relevant to the extent and pattern of misuse. Self-reported non-alcohol substance misuse showed no significant relationship with a range of outcome measures.ConclusionsThe high proportion of subjects reporting non-alcohol substance misuse is comparable with figures from the USA. The reports of lifetime misuse most commonly referred to cannabis, psychostimulants, LSD, opiates and anticholinergics. Misuse was concentrated in those younger than 36 years and was reported more often by males.

scholarly journals A clinical and experimental overview of sirenomelia: insight into the mechanisms of congenital limb malformations

2011 ◽  
Vol 4 (3) ◽  
pp. 289-299 ◽  
Author(s):  
C. Garrido-Allepuz ◽  
E. Haro ◽  
D. Gonzalez-Lamuno ◽  
M. L. Martinez-Frias ◽  
F. Bertocchini ◽  
...  
Keyword(s):  
Limb Malformations ◽  
Congenital Limb ◽  
Insight Into

scholarly journals Prevalence of chronic kidney disease in Bhuj district: a cross sectional study

2017 ◽  
Vol 4 (5) ◽  
pp. 1412
Author(s):  
Vinayak Chauhan ◽  
Kashyap Buch
Keyword(s):  
Blood Test ◽  
Serum Uric Acid Level ◽  
Demographic Data ◽  
Simple Random Sampling ◽  
Cross Sectional Study ◽  
Basic Knowledge ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of ◽  
The Mean

Background: In order to control any disease basic knowledge about the prevalence and risk factors of the particular disease is required.Methods: In this cross-sectional study, 2600 individuals aged between 25 and 70 years old were recruited. Participants were selected from the general population residing in Bhuj, Gujarat, India via simple random sampling. Demographic data were collected. Urine and blood test were performed, and the glomerular filtration rate was estimated.Results: One hundred and thirty participants (10%) had CKD. The mean age was significantly higher in the CKD group. Hypertension and diabetes mellitus were significantly more prevalent among the participants with CKD than those without CKD (P < 0.001 for both). Proteinuria was significantly associated with CKD, whereas a history of urinary tract infection, a history of nephrolithiasis, smoking, serum uric acid level, lipid profile, and blood glucose level were not.Conclusions: Overall, it seems that CKD is a common health problem in Gujarat, but further studies in other parts of this country is recommended for the better estimation of CKD prevalence. This study shows the importance of screening for CKD.

scholarly journals MicroRNAs as Potential Indicators of the Development and Progression of Uterine Leiomyoma

2021 ◽  
Author(s):  
Myungshin Kim ◽  
Mi Yeon Kwon ◽  
HeeJeong Lee ◽  
Min Jeong Kim
Keyword(s):  
Extracellular Matrix ◽  
Uterine Leiomyoma ◽  
Cellular Proliferation ◽  
Expression Profiles ◽  
Mass Effect ◽  
History Of ◽  
Target Molecules ◽  
The Mean ◽  
Insight Into

Abstract Recent studies demonstrated a significant role of several microRNAs (miRs) in the development of leiomyoma. Here, we investigated miR expression profiles using microarray and found a significantly higher expression of miRs in leiomyoma than in adjacent myometrium. We also confirmed the upregulation of five selected miRs including miR-181a-5p, 127-3p, 28-3p, 30b-5p and let-7c-5p in cellular proliferation, extracellular matrix turnover, and angiogenesis by RT-qPCR. Interestingly, the miRs showed a higher expression in cases of large leiomyoma or in patients with a history of transfusion due to anemia. We then analyzed the expression of the miR target molecules including TGFBR2 and IGF2BP1 via immunohistochemistry. TGFBR2 and IGF2BP1 were positively stained in 81% and 62.5% of leiomyoma tissues but not in adjacent myometrium. Both were more frequently positive in patients with ≥ 6 cm leiomyoma and mass effect. The mean expression levels of miR-181a-5p, 127-3p, 28-3p, 30b-3p and let-7c-5p were higher in cases with TGFBR2 and IGF2BP1 positive leiomyoma. These results provide insight into the role of miRs in the development and progression of leiomyoma and underscore the need to validate their utility as diagnostic or therapeutic targets.

Attitude Examination Related to Breast Cancer Among Women in Bács-Kiskun County, Hungary

2016 ◽  
Vol 11 (3) ◽  
pp. 223-232
Author(s):  
Annamária Pakai ◽  
András Oláh ◽  
Gabriella Farkasné-Buzánczky ◽  
Mónika Sélleyné-Gyúró ◽  
Éva Brantmüller
Keyword(s):  
Breast Cancer ◽  
Health Status ◽  
Demographic Data ◽  
Principal Component ◽  
Its Region ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
History Of ◽  
The Mean ◽  
Population Mortality

AbstractBreast cancer is the most commonly diagnosed type of cancer and a leading cause of mortality among women both in developed and developing countries all over the world. Our research questions were the following: 1. What is the ratio of women participating in mammography screening? 2. What factors influence the attendance of the screening? A quantitative, cross-sectional, and descriptive study (2013) examined women aged 35-65 without a history of breast cancer from Kecskemét City and its region. Non-random, convenience sampling method was applied in the study. The self-edited and self-administered questionnaire included the following groups of questions: socio-demographic data, attitude examination related to screening, reasons for absence. Besides SPSS Statistics, 20.00 test, x2 test, t-test, and ANOVA were used (p<0.05). During the Principal Component Analysis, 23 variables of the motivational scale were grouped into six theoretical subgroups, and the Cronbach-alpha value was 0.758. The mean age of the participants was 49.96±8.91 years.71% of the interviewees never attended breast cancer screening. Regarding the sample, the mean age of women participating in the screening for the first time was 39.66±12.21 years. Women with college/university degree attained high scores on the knowledge test (p<0.05). A significant part of women went to the screening because they feel responsibility for their health status or due to the family history of breast cancer. Fear, shame, or inconveniencies during examination did not affect participation in screening. Prevention programs play a significant role in the improvement of the health status of the Hungarian population. Mortality and morbidity indicators can be reduced by regularly organized, preventive activities based on appropriate knowledge. Thus, the number of healthy years can be increased.

scholarly journals The Outcome of Agitation in Poisoned Patients in an Iranian Tertiary Care University Hospital

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
Ali Mohammad Sabzghabaee ◽  
Ahmad Yaraghi ◽  
Elham Khalilidehkordi ◽  
Seyyed Mohammad Mahdy Mirhosseini ◽  
Elham Beheshtian ◽  
...  
Keyword(s):  
Prospective Observational Study ◽  
Demographic Data ◽  
Tertiary Care ◽  
Previous History ◽  
University Hospital ◽  
Richmond Agitation Sedation Scale ◽  
Alcohol Abusers ◽  
History Of ◽  
Acute Agitation ◽  
Time Of Admission

Introduction. This study was conducted to evaluate and document the frequency and causes of agitation, the symptoms accompanying this condition in intoxications, relationship between agitation score on admission and different variables, and the outcome of therapy in a tertiary care referral poisoning center in Iran.Methods. In this prospective observational study which was done in 2012, 3010 patients were screened for agitation at the time of admission using the Richmond Agitation Sedation Scale. Demographic data including age, gender, and the drug ingested were also recorded. The patients’ outcome was categorized as recovery without complications, recovery with complications (hyperthermia, renal failure, and other causes), and death.Results. Agitation was observed in 56 patients (males,n=41), mostly aged 19–40 years (n=38) and more frequently in illegal substance (stimulants, opioids and also alcohol) abusers. Agitation score was not significantly related to the age, gender, and previous history of psychiatric disorders. Forty nine patients had recovery without any complication. The need for mechanical ventilation was the most frequent complication. None of the patients died.Conclusion. Drug abuse seems to be a must-to-consider etiology for patients presenting with acute agitation and its morbidity and mortality could be low in agitated poisoning cases if prompt supportive care is performed.

Natural History of 321 Flatfoot Reconstructions in Adult Acquired Flatfoot Deformity Over a 14-Year Period

2020 ◽  
pp. 193864002091285
Author(s):  
Madison Goss ◽  
Christopher Stauch ◽  
Joseph Lewcun ◽  
Ryan Ridenour ◽  
Jesse King ◽  
...  
Keyword(s):  
Natural History ◽  
Smoking Status ◽  
Demographic Data ◽  
Treatment Options ◽  
Female Gender ◽  
Additional Surgery ◽  
Increased Risk ◽  
History Of ◽  
Adult Acquired Flatfoot Deformity ◽  
Insight Into

The purpose of this study was to report the natural history, demographics, and mechanisms of requirement for additional surgery in patients undergoing flatfoot reconstruction for adult acquired flatfoot. A total of 321 consecutive patients undergoing flatfoot reconstruction over a 14-year period were included (2002-2016). All procedures were performed by a senior orthopaedic foot and ankle surgeon at our institution. Demographic data, operative reports, clinic notes, and radiographs were available for review. Statistical analysis included calculation of relative risk (RR) ratios. The majority of patients were female (83.2%,) and most patients were overweight with a body mass index greater than 25 kg/m2 (56.4%). Patient comorbidities included diabetes (13.7%) and rheumatoid arthritis (3.7%). Additional surgery was required for 54 patients (16.8%). The most common reasons for additional surgery were the following: painful calcaneal hardware (57.4%), conversion to triple arthrodesis (16.7%), and wound healing complications (9.1%). An increased risk of need for additional surgery was associated with female gender (RR = 3.4; P = .0005), smoking status (RR = 1.9; P = .0081), and age (<60 years of age; RR = 1.8; P = .042). Although retrospective, the results provide insight into the natural history of this procedure. Clinicians may use these data to appropriately counsel patients who are at increased risk of requirement for additional surgery, such as smokers, women, and patients <60 years old, regarding treatment options. Levels of Evidence: Level IV

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