scholarly journals A study on clinical correlation of EEG in neonates with perinatal asphyxia

2019 ◽  
Vol 6 (2) ◽  
pp. 390
Author(s):  
Rajendra Shinde ◽  
Kiran Haridas ◽  
Madhavi Shelke ◽  
L. S. Deshmukh ◽  
P. S. Patil
Keyword(s):  
Prospective Observational Study ◽  
Neonatal Period ◽  
Background Activity ◽  
Perinatal Asphyxia ◽  
Cerebral Injury ◽  
Eeg Analysis ◽  
Clinical Correlation ◽  
Term Neonates ◽  
Duration Of Hospitalization ◽  
Eeg Changes

Background: Perinatal asphyxia is the most common and important cause of preventable cerebral injury occurring in the neonatal period. The WHO has estimated that 4 million babies die during the neonatal period every year. According to WHO, perinatal asphyxia is defined as the failure to initiate and sustain breathing at birth. The objective is to study the electroencephalographic changes and correlation between severity of Perinatal asphyxia with EEG changes.Methods: It is prospective observational study, which includes 40 term neonates admitted in NICU with perinatal asphyxia in GMCH Aurangabad. EEG analysis focused on background activity and classified into four categories.Results: The EEG was normal in 45%, mild abnormal in 25%, intermediate in 15%, and severely abnormal in 15%.  Outcome at discharge was normal in 19(47.5%) and abnormal in 21(52.5%) including 1 death. Abnormal outcome was seen in 27% of newborns with normal EEG and 72% of abnormal EEG.Conclusions: Severity of perinatal asphyxia correlated well with abnormality of EEG. EEG changes and severity showed good correlation with immediate outcome of newborn in terms of duration of hospitalization and normal neurological examination.

"COMPARATIVE STUDY OF EARLY NEONATAL MORBIDITIES OF LATE PRETERM AND TERM NEONATES"

2021 ◽  
pp. 23-25
Author(s):  
Jatin Manocha ◽  
Kusum Mahajan ◽  
Anuj Kumar
Keyword(s):  
Preterm Infants ◽  
Prospective Observational Study ◽  
Neonatal Period ◽  
Newborn Infants ◽  
Late Preterm ◽  
Preterm Neonates ◽  
Feeding Problems ◽  
Term Neonates ◽  
Late Preterm Infants ◽  
Study Results

Background- Newborn infants are unique in their physiology and the health problems that they experience. Neonatal period is dened from birth to under four weeks of age. Late preterm infants may physiologically and physically appear like infants born at term, but most late preterm infants may undergo complications like respiratory distress, apnea, hypothermia, feeding problems, hypoglycemia, hyperbilirubinemia, sepsis, and mortality. AIM-To compare the clinical prole of late preterm neonates with term neonates. MATERIALAND METHODS: This prospective observational study was carried out in neonatal division of department of pediatrics MMIMSR, Mullana. Eligible neonates delivered at MMIMSR, Mullana born from 34 weeks up to 42 weeks gestation were included. All infants enrolled in the study was followed daily till rst 7 days of life for any morbidity by clinical evaluation and review of hospital records.104 preterms included in the study and 226 term neonates were included in the study. Results- Preterms born via LSCS and NVD were(58%vs.42%).Morbidities in late preterms were Hypoglycemia (21.2% vs. 9.3%), Hypothermia (15.4%vs5.7%), hypocalcaemia (38.4% vs. 5.3%), neonatal hyperbilirubinemia(67.3% vs. 30.5%), feeding difculties(44.2% vs. 14.6%), sepsis(40.4% vs. 19.5%), respiratory support(53% vs. 47%)

scholarly journals Clinico-etiological profile of neonatal seizures in term neonates

2017 ◽  
Vol 4 (5) ◽  
pp. 1626
Author(s):  
K. Venkataramana Reddy ◽  
C. Soren ◽  
Snigdha Jagtap ◽  
Y. Pardhasaradhi ◽  
S. Satish
Keyword(s):  
Neonatal Period ◽  
Perinatal Asphyxia ◽  
Neonatal Seizure ◽  
Neonatal Seizures ◽  
Metabolic Disturbances ◽  
Term Neonates ◽  
Medical College ◽  
Neurological Problem ◽  
Neonatal Convulsions ◽  
Epileptic Fits

Background: Neonatal seizures or neonatal convulsions are epileptic fits occurring from birth to the end of the neonatal period. Neonatal seizures are a common neurological problem with a frequency of 1.5-14/1000 neonates. Neonatal seizure is common in this part of the Telangana and there was paucity of data from this area. Identification of etiology will help in management there by reducing morbidity and mortality.Methods: This prospective study was done in NICU of S.V.S. Medical College and Hospital, Mahabubnagar, from Jan 2016 to Jan 2017. Term neonates with clinically identifiable seizure were included in the present study. This study was approved by institutional ethical committee and written consent was obtained from parents of the studied neonates.Results: Of 84 studied neonates, 46 were males and 38 were females. 29 neonates had seizures within first 24 hours and 22 neonates had seizures on day 2. Perinatal asphyxia was seen in 28 neonates and septicemia was seen in 21 neonates.Conclusions: Perinatal asphyxia was the most common cause for neonatal seizures in term neonates, followed by septicaemia and metabolic disturbances. 

scholarly journals Rodent EEG: Expanding the Spectrum of Analysis

2020 ◽  
Vol 20 (3) ◽  
pp. 149-153 ◽  
Author(s):  
Atul Maheshwari
Keyword(s):  
Background Activity ◽  
Great Promise ◽  
Rodent Models ◽  
Eeg Analysis ◽  
Computational Power ◽  
Epilepsy Research ◽  
Eeg Changes ◽  
Software Platforms ◽  
Electroencephalogram Eeg ◽  
Models Of Epilepsy

In epilepsy research, the analysis of rodent electroencephalogram (EEG) has been performed by many laboratories with a variety of techniques. However, the acquisition and basic analysis of rodent EEG have only recently been standardized. Since a number of software platforms and increased computational power have become widely available, advanced rodent EEG analysis is now more accessible to investigators working with rodent models of epilepsy. In this review, the approach to the analysis of rodent EEG will be examined, including the evaluation of both epileptiform and background activity. Major caveats when employing these analyses, cellular and circuit-level correlates of EEG changes, and important differences between rodent and human EEG are also reviewed. The currently available techniques show great promise in gaining a deeper understanding of the complexities hidden within the EEG in rodent models of epilepsy.

Study of Myocardial Dysfunction in Perinatal Asphyxia Field

2018 ◽  
Vol 2 (S1) ◽  
pp. e000127
Author(s):  
Kushali Tanna ◽  
K M Mehariya ◽  
Suchita Munsi ◽  
Charul Pujani
Keyword(s):  
Troponin I ◽  
Heart Diseases ◽  
Perinatal Asphyxia ◽  
Myocardial Dysfunction ◽  
Birth Asphyxia ◽  
Serum Levels ◽  
Spontaneous Respiration ◽  
Term Neonates ◽  
Myocardial Involvement ◽  
Ischemic Encephalopathy

Aims and Objectives: To study an incidence of myocardial dysfunction in neonates admitted with perinatal asphyxia, to find out its correlation with severity of birth asphyxia and its outcome. Methods: This prospective study was conducted among 40 term neonates admitted in NICU of Civil Hospital Ahmedabad who had suffered with perinatal asphyxia (defined by WHO ), resuscitated as per NRP guidelines-2015 including both intramural and extramural admissions and who developed to hypoxic ischemic encephalopathy as defined by Levene staging. Neonates with congenital heart diseases, major central nervous system malformations and neonatal sepsis were excluded. Myocardial involvement was assessed by clinical evaluation, ECG, Creatinine Kinase Total (25-200IU/L), CK-MB (0-25IU/L) and Troponin I (0-0.03ug/L) measurements. Results: Among 40 cases, 10(25%) neonates had moderate birth asphyxia while 30(75%) had severe birth asphyxia. Respiratory distress was observed in 34(77.5%), poor spontaneous respiration 4(10%),shock in 14(35%),CCF 19(47.5%) while ECG was abnormal in 30(76.7%). Serum levels of CPK Total, CPK- MB and Troponin I were raised in 34(85%), 32(80%) and 28 (70%) neonates, respectively.  Conclusion: There was a direct correlation between ECG changes and enzymatic levels which showed increasing abnormalities with increasing with severity of HIE.  

scholarly journals Respiratory distress in Full and Post term neonates: Prevalence, Etiologies and Outcomes in a Tertiary Health Center in Yaoundé

2020 ◽  
Author(s):  
Didi Stanine Mefo Kue ◽  
Aude Sabine Nanfack ◽  
ANNE ESTHER NJOM NLEND
Keyword(s):  
Mortality Rate ◽  
Respiratory Distress ◽  
Health Center ◽  
Perinatal Asphyxia ◽  
Clinical Signs ◽  
Respiratory Control ◽  
Neonatal Infection ◽  
Full Term ◽  
Cross Sectional ◽  
Term Neonates

Abstract Introduction Respiratory distress (RD) is a common condition for admission of newborns in neonatal care unit (NCU), in both preterm and full-term neonates. Our objective was to describe the clinical features, causes and treatment of RD in full term neonates in a tertiary health center in Yaoundé, the Essos Hospital Centre (EHC). Patients and Method We conducted a cross sectional retrospective study. Full term neonates with RD at EHC from January 2017 to December 2018 were included, assuming clinical signs of RD prior to 48 hours following admission. Factors evaluated: incidence of RD, main etiologies, short term outcomes and risk factors for severity. Data were collected using a chart, then analyzed using software Stata Version 13.Results 186 full term neonates out of 2312 newborn babies admitted in NCU, met the inclusion criteria giving a prevalence rate of RD of 8%. Sex ratio of 2.15 was favoring males; median age at admission was 7.25 hours and 89.2 % were born at a median gestational age of 38 weeks. Clinical signs of RD were dominated by signs of respiratory control with a Silverman score above 4/10 in 64%. The most common etiologies were neonatal infection / pneumonia (45.9%), followed by transient tachypnea. Clinical management was performed using nasal cannula oxygen and antibiotics. Perinatal asphyxia, cyanosis and caesarian section were found to be associated with severe RD in this setting. Mortality rate was 10.4%.Conclusion RD in full term neonates is common in this setting, with neonatal infection as preeminent etiology; the mortality rate is high and the management still inappropriate.

scholarly journals Role of Human Recombinant Erythropoietin (rHuEPO) in Perinatal Asphyxia-a randomized controlled trial

2018 ◽  
Vol 10 (1) ◽  
pp. 330-334
Author(s):  
Syeda Mehnaz ◽  
MAK Azad Chowdhury ◽  
BH Nazma Yasmeen ◽  
Md Masudur Rahman ◽  
Rowshan Jahan Akter ◽  
...  
Keyword(s):  
Neurological Outcome ◽  
Seizure Control ◽  
Standard Treatment ◽  
Perinatal Asphyxia ◽  
Intervention Group ◽  
Treatment Protocol ◽  
Oral Feeding ◽  
Control Group ◽  
Term Neonates ◽  
And Control

Background : Perinatal asphyxia is an insult to the fetus or newborn infant due to lack of oxygen (hypoxia) and/or a lack of perfusion (ischemia) to various organs, which will manifest as difficulty in establishing spontaneous respiration evident by delayed cry after birth, at least after one minute. World-wide, perinatal asphyxia accounts for about 900,000 deaths each year. In Bangladesh it is a major cause of neonatal death. A substantial proportion of the children that survive suffer late effects such as cerebral palsy and epilepsy. Objective : To determine the efficacy of erythropoietin in improving the neurological outcome of term neonates with perinatal asphyxia (HIE stage II and III). Materials and methods : A Randomized Controll Trial was carried out in the Neonatal ward and NICU of Dhaka Shishu Hospital from 1st April 2014 to 30th Sep 2015. A total 68 neonates with perinatal asphyxia (both HIE stage II and III) who fulfill the inclusion criteria were enrolled and randomly assigned to intervention group (n=35) and control group (n=33). Intervention group received rHuEPO 300- 500 U/kg/dose daily subcutaneously for 5 days within first 48 hours of birth along with the standard treatment protocol and control group received standard treatment protocol only. Results : Baseline clinical characteristics, USG of brain during hospital stay were almost similar in both groups. Statistically significant effect was noted in seizure control, tolerance of oral feeding, hospital stay and neurological outcome at 3 months of age (p=008). USG of brain at 3 months of age also improved significantly (p=0.027). Conclusion : This study demonstrates the effectiveness of early administration of rHuEPO to term neonates with moderate to severe asphyxia, beneficial effect on short term outcomes like seizure control, tolerance of oral feeding and neurological outcome at 3 months of age. A large multicenter study would be done for further evaluation of these findings. Northern International Medical College Journal Vol.10(1) Jul 2018: 330-334

Predicting Severity of Acute Kidney Injury in Term Neonates with Perinatal Asphyxia Using Urinary Neutrophil Gelatinase Associated Lipocalin

2016 ◽  
Vol 83 (12-13) ◽  
pp. 1374-1378 ◽  
Author(s):  
Vasanthan Tanigasalam ◽  
Ballambattu Vishnu Bhat ◽  
Bethou Adhisivam ◽  
Magadi Gopalakrishna Sridhar ◽  
Kottyen Thazath Harichandrakumar
Keyword(s):  
Acute Kidney Injury ◽  
Perinatal Asphyxia ◽  
Kidney Injury ◽  
Term Neonates ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

Serum Creatine Kinase Muscle-Brain Fraction (CK-MB) and Lactate Dehydrogenase (LDH) as Markers of Perinatal Asphyxia in Term Neonates

2020 ◽  
Vol 17 (2) ◽  
pp. 2-6
Author(s):  
Piush Kanodia ◽  
Sudesh Shrestha ◽  
Santosh Gautam ◽  
Sachin Chawla
Keyword(s):  
Analytical Study ◽  
Operating Characteristic ◽  
Perinatal Asphyxia ◽  
Significant Rise ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Roc Curve Analysis ◽  
Cross Sectional ◽  
Term Neonates

Background: The enzymes CK-MB & LDH are used as potential predictors of timing and grade of HIE in newborns with perinatal asphyxia. Objectives: To differentiate HIE neonates from non-HIE ones on the basis of significant rise of LDH & CK-MB. Methodology: Prospective cross-sectional analytical study. Among 164 newborns, 82 comprising the cases and 82 neonates comprising the controls met the inclusion and exclusion criteria. The umbilical cord blood samples for CK-MB and LDH was drawn and sent for analysis. A serum CK-MB value >92.6 U/L and LDH value >580 U/L was taken as the cut-off level. Descriptive statistical analyses were done to find the significance between two groups. ROC Curve analysis was performed to find the diagnostic performance of CK-MB and LDH. Results: Out of total 164 neonates studied, 18.3% had moderate HIE & 11%had severe HIE while 56.1%had No HIE. Seventy-two newborns were found to have LDH levels >580 U/L out of which 71 were in case group and 1 was in control group. Among the 164 neonates studied, 7.9% from case group were found to have CK-MB levels >92.6 U/L. Both the results of LDH & CK-MB levels were very significant with P value <0.001. Area under ROC (Receiving operating Characteristic) value of LDH when compared to CK-MB is (0.978 vs. 0.731). Conclusion: Estimation of CK-MB and LDH enzymes can help to distinguish asphyxiated from non-asphyxiated term neonates when correlating with their history and clinical features.

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