scholarly journals Serum testosterone levels and clinical signs of hypogonadism in men with type 2 diabetes

2021 ◽  
Vol 8 (8) ◽  
pp. 3777
Author(s):  
Manouchehr Iranparvar ◽  
Firouz Amani ◽  
Md. Javad Naghizadeh
Keyword(s):  
Clinical Signs ◽  
Serum Testosterone ◽  
Free Testosterone ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Testosterone Levels ◽  
Drug History ◽  
Male Patients ◽  
Age Range

Background: Diabetes mellitus is a common metabolic disease that its association with low level of testosterone has already been shown in many studies. Considering the role of testosterone hormone in impotency, fatigue, and bone mass deficiency this study aimed to evaluate the total and free testosterone levels and clinical signs of hypogonadism in male patients with type 2 diabetes.Methods: In this descriptive-cross sectional study, sixty-five diabetic male patients aged 35-70 years were randomly selected and enrolled to the study. The necessary information such as patient demographics, BMI, past medical history, drug history, and history of smoking, education level and employment were completed by a checklist. Then, the patients were evaluated for total and free testosterone levels and symptoms related to decreased testosterone, hypogonadism symptoms by ADAM questionnaire. Finally, the data were statistical analyzed by spss version 21.Results: The mean age of patients was 57.12±4.7 years with age range of 38-69 years. According to the ADAM questionnaire, 51 (78.4%) of the patients were positive and 14 (21.6%) were negative. 16 (24.6%) of all patients had hypogonadism. Among ADAM positive patients, 46 (90.1%) had erectile dysfunction and 33 (64.7%) had decreased libido. Most people (75%) with hypogonadism had BMI more than 30.Conclusions: Testosterone levels are commonly found low in diabetic men, most of whom have symptoms of hypogonadism. Body mass index is known as an independent risk factor for hypogonadism in T2D men. There was also a significant correlation between free testosterone levels and hypogonadism. 

scholarly journals Profile of Osteomyelitis Patients Visiting the Orthopedic Clinic of Dr. Hasan Sadikin General Hospital, Indonesia, in 2017–2018

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Aditya Nugraha ◽  
Hermawan Nagar Rasyid ◽  
Hadyana Sukandar
Keyword(s):  
Staphylococcus Aureus ◽  
General Hospital ◽  
Sampling Method ◽  
Operative Procedure ◽  
Bone Destruction ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Male Patients ◽  
The Common ◽  
Age Range

Background: Osteomyelitis is an inflammatory process caused by microorganism infection that leads to bone destruction. Osteomyelitis may affect all bones, particularly long bones, and infects all ages. This disease is hard to diagnose and the treatment is complex due to the disease’s heterogenicity, pathophysiology, clinical presentation, and management. This study aimed to determine the profile of osteomyelitis inpatients and outpatients presented to the Orthopedic Clinic of Dr. Hasan Sadikin General Hospital Bandung, IndonesiaMethods: This was a descriptive cross-sectional study conducted from July to October 2019 using the total sampling method. Data were collected from the medical records of osteomyelitis inpatients and outpatients presented to the Orthopedic Clinic of Dr. Hasan Sadikin General Hospital Bandung, Indonesia from 2017–2018. Data were then analyzed descriptively and the results were presented in frequencies.Result: In total, 90 data were retrieved. Most of data presented male patients (n= 69, 76.7%) with the age range of 20–29 years old (24.4%). The majority of these patients experienced chronic onset of disease (94.4%) located on the tibia (51.1%), which was caused by a post-operative procedure (61.1%). The most common treatment was operative procedure without antibiotic beads (51.1%). Staphylococcus aureus was the common pathogens identified in these patients (22.2%).Conclusion: The majority of osteomyelitis patients are males in productive age with chronic onset of disease located on the tibia caused by a post-operative procedure. Staphylococcus aureus is the common pathogen involved and the most common treatment is an operative procedure without antibiotic beads.

scholarly journals Hypoactive sexual desire in transsexual women: prevalence and association with testosterone levels

2008 ◽  
Vol 158 (3) ◽  
pp. 393-399 ◽  
Author(s):  
Els Elaut ◽  
Griet De Cuypere ◽  
Petra De Sutter ◽  
Luk Gijs ◽  
Michael Van Trotsenburg ◽  
...  
Keyword(s):  
Sexual Desire ◽  
Free Testosterone ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Sex Hormone Binding Globulin ◽  
Control Group ◽  
Total Testosterone ◽  
Cross Sectional ◽  
Oestrogen Treatment ◽  
Testosterone Levels

ObjectiveAn unknown proportion of transsexual women (defined as post-operative male-to-female transsexuals on oestrogen replacement) experience hypoactive sexual desire disorder (HSDD). It has been suggested that the absence of ovarian androgen production together with oestrogen treatment-related increase in sex hormone-binding globulin (SHBG) levels could be leading to HSDD, due to low levels of biologically available testosterone. This study wishes to document the HSDD prevalence among transsexual women and the possible association to androgen levels.DesignCross-sectional study.MethodsTranssexual women (n=62) and a control group of ovulating women (n=30) participated in this study. Questionnaires measuring sexual desire (sexual desire inventory) and relationship and sexual satisfaction (Maudsley Marital Questionnaire) were completed. Serum levels of total testosterone, LH and SHBG were measured in blood samples obtained at random in transsexual women and in the early follicular phase in ovulating women.ResultsThe transsexual group had lower levels of total and calculated free testosterone (both P<0.001) than the ovulating women. HSDD was reported in 34% of the transsexual and 23% of the ovulating women (P=0.30). Both groups reported similar levels of sexual desire (P=0.97). For transsexual women, no significant correlation was found between sexual desire and total (P=0.64) or free testosterone (P=0.82). In ovulating women, these correlations were significant (P=0.006, resp. P=0.003).ConclusionsHSDD is reported in one-third of transsexual women. This prevalence is not substantially different from controls, despite markedly lower (free) testosterone levels, which argues against a major role of testosterone in this specific group.

scholarly journals Reduction of Testosterone Levels in Schistosoma Haematobium or Schistosoma Mansoni Infected Men: A Cross-Sectional Study in Two Schistosomiasis-Endemic Areas of the Adamawa Region of Cameroon

2021 ◽  
Author(s):  
Hermine BOUKENG JATSA ◽  
Ulrich MEMBE FEMOE ◽  
Calvine NOUMEDEM DONGMO ◽  
Romuald Issiaka NGASSAM KAMWA ◽  
Betrand NONO FESUH ◽  
...  
Keyword(s):  
Genital Tract ◽  
Reproductive Function ◽  
Serum Testosterone ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Serum Testosterone Level ◽  
Cross Sectional ◽  
Endemic Areas ◽  
Age Range ◽  
The Impact

Abstract Background: The incidence of schistosomiasis‐induced male reproductive dysfunction and infertility is probably underestimated comparing to female genital schistosomiasis. This study aimed to investigate the impact of S. haematobium or S. mansoni infection on the reproductive function of adult men in Tibati and Wouldé, two schistosomiasis endemic areas in the Adamawa region of Cameroon.Methods: A total of 89 men in the reproductive age (range: 14 – 56 years) from two localities were enrolled in the study with 51 in Tibati and 38 in Wouldé. Each participant was submitted to a questionnaire to document data on sociodemographic and stream contact behaviors. A medical examination was performed to measure the circumference of the testes and to evaluate genital tract pathologies. Stool and urine samples were collected and screened for the presence of S. haematobium or S. mansoni ova. Blood serum was use to evaluate the level of transaminases and testosterone.Results: S. haematobium was present only in Tibati with a prevalence of 31.37%. S. mansoni prevalence was 3.92% at Tibati and 44.71% in Wouldé. The intensity of infection was 22.12 ± 9.57 eggs/10 mL for S. haematobium and 128.10 ± 3.76 epg for S. mansoni. Serum transaminases activity and the mean testicular circumference of Schistosoma-positive individuals were close to those of negative ones. The testes size was however higher in S. mansoni-positive individuals than in S. haematobium-positive ones (P < 0.05). The serum testosterone level of S. haematobium and S. mansoni-positive men was significantly reduced by 56.07% (P < 0.001) and 51.94% (P < 0.01) respectively in comparison to that of Schistosoma-negative ones. A significant and negative correlation was established between schistosomiasis and the low level of serum testosterone. Male genital tract pathologies such as scrotal abnormalities, varicocele, nodular epididymis, inguinal hernia and hydrocele were recorded in both Schistosoma-positive and Schistosoma-negative men. However, no significant link was established between schistosomiasis infection and these pathologies.Conclusion: These results demonstrated that infection with S. haematobium or S. mansoni is associated with a low production of the reproductive hormone testosterone, and may be a major cause of male infertility.

Abstract 660: Prevalence of Hypertension Among Children with Diabetes Mellitus.

Hypertension ◽  
2014 ◽  
Vol 64 (suppl_1) ◽  
Author(s):  
Robert O Drutel ◽  
Remberto Paulo
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Age Groups ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cross Sectional ◽  
Study Population ◽  
Standard Of Practice ◽  
Age Range

This study aims to determine the prevalence of hypertension among children with diabetes mellitus, and describe adherence to the standard of practice regarding early diagnosis and treatment of hypertension in this population. Diabetes renders higher susceptibility to cardiovascular disease in affected patients and thus early detection of hypertension can be beneficial for future quality of life. We hypothesize that a number of diabetic children with hypertension are not promptly diagnosed and treated due to the difficult process preceding diagnosis. This cross-sectional study in an out-patient clinic of a university hospital was based on a group of 263 children (both females and males, age range between 3-18) diagnosed with type 2 diabetes. At the visit, the child's weight and height were recorded, BMI was calculated, systolic and diastolic blood pressure (BP) was taken, and blood sample drawn for hemoglobin A1C (HbA1C) readings. Within the study population we have identified a group of 73 children with hypertension. Comparing the two groups: the normotensive with the hypertensive, we have observed that the normotensive patients have significantly lower average BMI (26.7), p=0.000012 and slightly reduced HbA1C (8.9%), p=0.28 levels compared to the hypertensive group: BMI (32.5) and HbA1C (9.3%), respectively. We investigated the same parameters within every age group starting from age 10, and recorded that HbA1C was only significantly different for the group of 14 year-olds (8.7%; 11.7%, p=0.039). We also found that a significantly higher BMI is linked with hypertension for groups: age 13: BMI (29.2; 33.9, p=0.047), age 14: BMI (24.1; 35.6, p=0.00007) and age 18: BMI (31.8; 45.6, p=0.045). Within the different age groups there were differences between normotensive and hypertensive patients in BMI and HbA1C measurements, but they were not statistically significant and we assume that an increased sample size would be needed to confirm the data. We are currently working on identifying other risk factors including sex, race, height, urine creatinine, urine microalbumin, serum creatinine, lipid profile and thyroid function, that might be responsible for hypertension in pediatric patients with type 2 diabetes.

scholarly journals The Role of CorrugateDrain In Decreasing Postoperative Complication Of Penile Fracture Surgery

2017 ◽  
Vol 26 (2) ◽  
pp. 220-232
Author(s):  
Salam Abd El-Ameer Almosawi ◽  
Ahmed Turki Obaid
Keyword(s):  
Teaching Hospital ◽  
Age Distribution ◽  
Cross Sectional Study ◽  
Penile Fracture ◽  
Cross Sectional ◽  
Penile Pain ◽  
Male Patients ◽  
Age Range ◽  
Fracture Surgery

Objective:tostudy the role of corrugate drain (which is used by some urosurgeons) followed surgical correction of fractured penis in decreasing post operative complications such as penile swelling, pain and curvature. Patient and method:comparative cross sectional study was carried out at the urological department of Al-Hilla teaching hospital from March 2008 to April 2011. Twenty male patients (age between 21-40 years) admitted to the urological department in Al-Hila teaching hospital suffering from penile fracture from March 2008 to April 2011 were included in this study. Immediate surgical repair done to all those patients ,corrugate drain put post operatively for 10 patients while the remaining 10 patients without drains. All patients are fallowed for at least 3 months regarding postoperative penile swelling, deformity, pain and sexual function. Result:regarding age distribution of patients suffering from fracture penis, from twenty patients included in this study 11 patients their agerange from (20-30)years, 7 patients their age group range from (31-45)years and only 2 patients their age range from (46-60)years. Fifteen patients are married and only 5 patients are unmarried. No one develop postoperative penile swelling in patients with corrugate drain and only one patient develops swelling in patients without corrugate drain. Regarding postoperative pain, in patients surgically corrected with drain, 6 patients develop pain and only 2 patients surgically corrected without drain develops pain. Conclusion:No beneficial effect of corrugate drain in decreasing postoperative penile swelling or curvature and on the other hand it increase post operative penile pain.

scholarly journals Estimation of serum testosterone concentration in type 2 diabetic males

2020 ◽  
Vol 7 (2) ◽  
pp. 226
Author(s):  
Satya Bhushan Nayyar ◽  
Karamvir Singh ◽  
Neha .
Keyword(s):  
Serum Testosterone ◽  
Free Testosterone ◽  
Significant Negative Correlation ◽  
Total Testosterone ◽  
Control Groups ◽  
Testosterone Levels ◽  
High Incidence ◽  
And Control ◽  
Type 2 Diabetic

Background: A high incidence of hypogonadism in men with Type 2 Diabetes Mellitus has been globally reported. The present study was aimed at determining the frequency of hypogonadism in T2DM males. Screening and management of hypogonadism in Diabetic males should be done.Methods: In this case control study conducted from January 2018 to August 2019 at SGRDIMSR Sri Amritsar 100 Type 2 Diabetic males were taken as cases. 50 age matched nondiabetic males were taken as controls. Apart from BMI and waist hip ratio routine investigations, HbA1C, serum total and free testosterone levels were done. All the subjects were subjected to ADAM questionnaire to evaluate for hypogonadism.Results: Majority of subjects were in the age of 40-50 years. Mean Serum Total Testosterone levels in Study and Control Groups were 4.94±5.32 nmol/L and 6.63±4.54 nmol/L respectively (p=0.045). Mean Serum Free Testosterone levels in Study and Control Groups were 4.12±3.43 pg/ml and 6.05±3.24 pg/ml respectively (p=0.001). A statistically highly significant negative correlation was found between BMI and Serum Testosterone levels in both groups. Prevalence of hypogonadism (Total Testosterone <4.56 nmol/L) in Study and Control Groups was 73% and 58% respectively. Sensitivity and specificity of ADAM questionnaire was found to be 78.46% and 94.29 % respectively.Conclusions: Prevalence of hypogonadism among T2DM males is high. So, screening for hypogonadism should be done. ADAM questionnaire can be used as a screening tool, results must be confirmed with Serum Total Testosterone levels.

scholarly journals Peripheral and Autonomic Neuropathy in South Asians and White Caucasians with Type 2 Diabetes Mellitus: Possible Explanations for Epidemiological Differences

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Abd A. Tahrani ◽  
Q. A. Altaf ◽  
Milan K. Piya ◽  
Anthony H. Barnett
Keyword(s):  
Type 2 Diabetes ◽  
Autonomic Neuropathy ◽  
South Asians ◽  
Clinical Signs ◽  
Cross Sectional Study ◽  
Cardiac Autonomic Neuropathy ◽  
Diabetes Clinic ◽  
Cross Sectional ◽  
The Impact

Objectives.To compare the prevalence of diabetic peripheral neuropathy (DPN) and that of cardiac autonomic neuropathy (CAN) between South Asians and White Caucasians with type 2 diabetes and to explore reasons for observed differences.Methods.A cross-sectional study of casually selected South Asian and White Caucasian adults attending a hospital-based diabetes clinic in the UK. DPN and CAN were assessed using the Michigan Neuropathy Screening Instrument (MNSI) and heart rate variability testing, respectively.Results.Patients (n=266) were recruited (47.4% South Asians). DPN was more common in White Caucasians compared to South Asians (54.3% versus 38.1%,p=0.008). Foot insensitivity as assessed by 10 g monofilament perception was more common in White Caucasians (43.9% versus 23.8%,p=0.001). After adjustment for confounders, White Caucasians remained twice as likely to have DPN as South Asians, but the impact of ethnicity became nonsignificant after adjusting for adiposity measures or height. No difference in prevalence of standardized CAN test abnormalities was detected between ethnicities. Skin microvascular assessment demonstrated that South Asians had reduced heating flux but preserved acetylcholine response.Conclusions.South Asians with type 2 diabetes have fewer clinical signs of DPN compared to White Caucasians. Differences in adiposity (and its distribution) and height appear to explain these differences.

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