scholarly journals A cross-sectional descriptive clinical study of dermatological manifestations in obesity

2017 ◽  
Vol 3 (3) ◽  
pp. 337 ◽  
Author(s):  
Sivakumar S. ◽  
Banupriya K.
Keyword(s):  
Metabolic Syndrome ◽  
Acanthosis Nigricans ◽  
Varicose Veins ◽  
Western World ◽  
Obese Patients ◽  
Cross Sectional ◽  
Insulin Levels ◽  
Skin Tags ◽  
Skin Conditions ◽  
Morbid Conditions

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Obesity is major health hazard in the western world, however studies on skin manifestations in obese patients are limited. Most common co-morbid conditions associated with obesity are hypertension, Type 2 Diabetes Mellitus, dyslipidaemia, degenerative joint diseases etc. Skin conditions such as acrochordons, acanthosis Nigricans can be easily made out on inspection and seen most commonly with obesity. It is important for the clinicians to routinely screen patients for obesity and co-morbid conditions.</span>The aims were t<span lang="EN-IN">o study the prevalence of various skin disorders in obese patients and the frequency of skin changes in various obesity classes and to study the presence of metabolic syndrome and its association with leptin and insulin levels in those patients with acanthosis Nigricans and skin tags.</span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">Cross-sectional descriptive study done on 100 patients with a BMI &gt;30 and waist circumference &gt;90 cm (in males) and &gt;80 cm (in females).</span><strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Acanthosis Nigricans was the most prevalent skin condition (65%) and the association statistically was significant (p=0.012). Association of Skin tags (second commonest, in 42%) with p=0.012. Acanthosis Nigricans and skin tags among the various skin conditions studied like psoriasis, striae-distensae, fissure-feet, pyoderma, intertrigo, varicose veins, seborrheic dermatitis, Hand-feet eczema, osteoarthritis, candiasis was significantly associated with obesity. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Acanthosis Nigricans and skin tags among the various skin conditions studied had a strong correlation with obesity and metabolic syndrome which may be a marker for atherosclerosis and cardiovascular risk. It was also noted that in patients with Acanthosis Nigricans and skin tags, who had metabolic syndrome, there was an elevation of the plasma leptin levels and fasting plasma insulin levels but not significant with a p=0.25.</span></p>

scholarly journals Cutaneous manifestations in obese patients and non-obese controls in a tertiary care centre: a case-control study

2019 ◽  
Vol 5 (4) ◽  
pp. 695
Author(s):  
Raghuveer Chekuri ◽  
Thameena Mohamed
Keyword(s):  
Acanthosis Nigricans ◽  
Tertiary Care ◽  
Control Group ◽  
Obese Patients ◽  
Striae Distensae ◽  
Tertiary Care Centre ◽  
Cutaneous Manifestations ◽  
High Prevalence ◽  
Skin Conditions ◽  
And Function

<p class="abstract"><strong>Background:</strong> Obesity has emerged as one of the most serious public health concerns in the 21<sup>st</sup> century. It is responsible for varied changes in structure and function of different components of skin. Skin care of obese patients deserves particular attention, not only because of high prevalence of cutaneous alteration but mainly because many of these disorders are preventable and could be treated, improving patient’s quality of life.</p><p class="abstract"><strong>Methods:</strong> Two hundred patients with BMI ≥30 kg/m<sup>2</sup> and two hundred age and sex matched controls (BMI: 18.5-24.9 kg/m<sup>2</sup>) were included in this study.<strong></strong></p><p class="abstract"><strong>Results:</strong> Compared to the control group, obese patients were having higher prevalence of various skin conditions of which most common were acanthosis nigricans, acrochordons, striae distensae, frictional hyperpigmentation and infections.</p><p class="abstract"><strong>Conclusions:</strong> There is increased incidence and severity of cutaneous manifestations like acanthosis nigricans, acrochordons, striae distensae, frictional hyperpigmentation and infections in obese patients than control subjects. These can be used as markers for the early detection of various components of metabolic syndrome.</p>

scholarly journals Increased Level of Serum Ceramides Correlate with Liver Steatosis, Hba1c and Cholesterol in Obese Patients

2020 ◽  
Vol 4 (1) ◽  
Keyword(s):  
Metabolic Syndrome ◽  
Metabolic Diseases ◽  
Glycosylated Hemoglobin ◽  
Liver Steatosis ◽  
Metabolic Parameters ◽  
Control Group ◽  
Obese Patients ◽  
Active Components ◽  
Cross Sectional ◽  
Nonalcoholic Fatty Liver

Objective: Sphingolipids including ceramides are biological active components of all cell membranes. They play a great role in cell interconnections in the process of proliferation, maturation, cell apoptosis and any fluctuations of their level can lead to development of metabolic diseases such as type 2 diabetes (T2D) and nonalcoholic fatty liver disease. Nevertheless, there is lack of information about what type of ceramides play a role in aforementioned diseases. Here we investigated the relationship between the serum level of some type of ceramides and parameters of metabolic syndrome that is commonly present in obese patients. Design: We performed cross-sectional study in two groups. One of them was control group – lean healthy people (n=10, body mass index, BMI 21, 2±1, 89) and the second group included patients with the obesity (n=24, BMI 33, 9±3, 1). We quantified the levels of serum ceramide by liquid chromatography-mass spectrometry, analyzed the parameters for insulin resistance, liver function and lipid metabolism by biochemical blood test. Results: The subjects with obesity had elevated level of ceramide C16:0, C18:0, C24:0 comparing with control group (p<0,001). As results of our study, we found correlation of the level ceramide C16:0, C18:0, C24:0 with the results of steatometry and some metabolic parameters (glycosylated hemoglobin (Hb A1C), cholesterol). Conclusion: These results demonstrate that obese subjects had increased level of ceramide C16:0, C18:0, C24:0 that correlated with some metabolic parameters supposedly recognizing them as new biomarkers of metabolic syndrome.

Association between multiple skin tags and metabolic syndrome: A multicentre cross-sectional study in primary care

2016 ◽  
Vol 42 (2) ◽  
pp. 126-129 ◽  
Author(s):  
E.S.Y. Hui ◽  
B.H.K. Yip ◽  
K.W. Tsang ◽  
F.T.T. Lai ◽  
K. Kung ◽  
...  
Keyword(s):  
Primary Care ◽  
Metabolic Syndrome ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Skin Tags

scholarly journals Systemic Inflammation and Lung Function Impairment in Morbidly Obese Subjects with the Metabolic Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Astrid van Huisstede ◽  
Manuel Castro Cabezas ◽  
Erwin Birnie ◽  
Gert-Jan M. van de Geijn ◽  
Arjan Rudolphus ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Lung Function ◽  
Cross Sectional Study ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
Function Impairment ◽  
Lung Function Impairment

Background. Obesity and asthma are associated. There is a relationship between lung function impairment and the metabolic syndrome. Whether this relationship also exists in the morbidly obese patients is still unknown.Hypothesis. Low-grade systemic inflammation associated with the metabolic syndrome causes inflammation in the lungs and, hence, lung function impairment.Methods. This is cross-sectional study of morbidly obese patients undergoing preoperative screening for bariatric surgery. Metabolic syndrome was assessed according to the revised NCEP-ATP III criteria.Results. A total of 452 patients were included. Patients with the metabolic syndrome (n=293) had significantly higher blood monocyte (mean 5.3 versus 4.9,P=0.044) and eosinophil percentages (median 1.0 versus 0.8,P=0.002), while the total leukocyte count did not differ between the groups. The FEV1/FVC ratio was significantly lower in patients with the metabolic syndrome (76.7% versus 78.2%,P=0.032). Blood eosinophils were associated with FEV1/FVC ratio (adj. B −0.113,P=0.018).Conclusion. Although the difference in FEV1/FVC ratio between the groups is relatively small, in this cross-sectional study, and its clinical relevance may be limited, these data indicate that the presence of the metabolic syndrome may influence lung function impairment, through the induction of relative eosinophilia.

scholarly journals Metabolic syndrome in skin tags: a hospital based observational study

2021 ◽  
Vol 7 (5) ◽  
pp. 708
Author(s):  
Subrata Kumar Das ◽  
Saptadipa Das
Keyword(s):  
Metabolic Syndrome ◽  
Observational Study ◽  
Care Center ◽  
Tertiary Care ◽  
Age Group ◽  
Adult Treatment Panel ◽  
Cross Sectional ◽  
Laboratory Parameters ◽  
Number Of Patients ◽  
Skin Tags

<p class="abstract"><strong>Background: </strong>The aim was to evaluate the parameters of metabolic syndrome in patients of skin tags and to investigate the possibility of an existing relationship between metabolic syndrome and skin tags.</p><p class="abstract"><strong>Methods: </strong>This cross-sectional observational study included 47 patients with skin tags attended Outpatient department (OPD) of Department of Dermatology at a tertiary care center during a period of 1 year. Clinical and laboratory parameters were noted in each patient.</p><p class="abstract"><strong>Results: </strong>This study included 47 patients with skin tags (28 males and 19 females). In the present study maximum number of patients belonged to the age group &gt;40 years with 19 patients, followed by 30-40 years with 13 patient. In this study no. of students were 15, and no of employee were 11. Most patients had skin tags in more than one area, neck and axilla were involved in 9 patients each. In this study out of 47 patients. 11 patients had derangement of clinical and laboratory parameters of metabolic syndrome based on NCEP adult treatment panel III.</p><p class="abstract"><strong>Conclusions:</strong> In the present study we observed significant derangement of clinical and laboratory parameters of metabolic syndrome in patients of skin tags.  </p>

scholarly journals The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Cuiling Zhu ◽  
Ran Cui ◽  
Mingming Gao ◽  
Sharvan Rampersad ◽  
Hui You ◽  
...  
Keyword(s):  
Acanthosis Nigricans ◽  
Cross Sectional Study ◽  
Serum Glucose ◽  
High Serum ◽  
Oral Glucose ◽  
Obese Patients ◽  
Cross Sectional ◽  
Metabolic Indices

Objective. Recent studies have shown that hyperuricemia (HUA) is associated with hypertension, dyslipidemia, insulin resistance, and metabolic syndrome (MetS). We aimed to examine the relationship of serum UA with Acanthosis nigricans (AN) and related metabolic indices in obese patients. Methods. A cross-sectional study with 411 obese patients recruited from our department was analyzed in this study. Weight, body mass index (BMI), UA, lipid profile, liver function, and renal function were measured in all participants. Oral glucose tolerance tests were performed, and serum glucose, insulin, and C peptide were measured at 0, 30, 60, 120, and 180 min. Results. AN group had higher serum UA levels than OB group. Circulating UA levels were associated with BMI, dyslipidemia, hypertension, IR, and AN. In logistic regression analyses (multivariable‐adjusted), a high serum UA level was associated with high odds ratios (ORs) (95% confidence interval [CI]) for AN in females (ORs = 3.00 and 95% CI [1.02–8.84]) and males (ORs = 6.07 and 95% CI [2.16–17.06]) in the highest quartile (Q4) of serum UA. Conclusions. Serum UA levels were positively associated with multiple metabolic abnormalities including obesity, hypertension, hyperglycemia, hyperlipidemia, and AN and may be an important risk factor in the development of AN; further evidences in vitro and in vivo are needed to investigate the direct or indirect relationship.

scholarly journals Increased Level of Serum Ceramides Correlate with Liver Steatosis, Hba1c and Cholesterol in Obese Patients

2020 ◽  
Vol 4 (1) ◽  
Keyword(s):  
Metabolic Syndrome ◽  
Metabolic Diseases ◽  
Glycosylated Hemoglobin ◽  
Liver Steatosis ◽  
Metabolic Parameters ◽  
Control Group ◽  
Obese Patients ◽  
Active Components ◽  
Cross Sectional ◽  
Nonalcoholic Fatty Liver

Objective: Sphingolipids including ceramides are biological active components of all cell membranes. They play a great role in cell interconnections in the process of proliferation, maturation, cell apoptosis and any fluctuations of their level can lead to development of metabolic diseases such as type 2 diabetes (T2D) and nonalcoholic fatty liver disease. Nevertheless, there is lack of information about what type of ceramides play a role in aforementioned diseases. Here we investigated the relationship between the serum level of some type of ceramides and parameters of metabolic syndrome that is commonly present in obese patients. Design: We performed cross-sectional study in two groups. One of them was control group – lean healthy people (n=10, body mass index, BMI 21, 2±1, 89) and the second group included patients with the obesity (n=24, BMI 33, 9±3, 1). We quantified the levels of serum ceramide by liquid chromatography-mass spectrometry, analyzed the parameters for insulin resistance, liver function and lipid metabolism by biochemical blood test. Results: The subjects with obesity had elevated level of ceramide C16:0, C18:0, C24:0 comparing with control group (p<0,001). As results of our study, we found correlation of the level ceramide C16:0, C18:0, C24:0 with the results of steatometry and some metabolic parameters (glycosylated hemoglobin (Hb A1C), cholesterol). Conclusion: These results demonstrate that obese subjects had increased level of ceramide C16:0, C18:0, C24:0 that correlated with some metabolic parameters supposedly recognizing them as new biomarkers of metabolic syndrome.

scholarly journals Acanthosis Nigricans – A Two-Sided Coin: Consider Metabolic Syndrome and Malignancies!

2019 ◽  
Vol 7 (18) ◽  
pp. 3081-3084 ◽  
Author(s):  
Uwe Wollina ◽  
Gesina Hansel ◽  
Torello Lotti ◽  
Georgi Tchernev ◽  
Aleksandra Vojvodic ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Acanthosis Nigricans ◽  
Variable Amount ◽  
Case Presentation ◽  
Clinical Appearance ◽  
The Third ◽  
The Metabolic Syndrome ◽  
Body Regions ◽  
Skin Tags ◽  
Red Flag

BACKGROUND: Acanthosis nigricans (AN) is acquired hyperpigmentation of the intertriginous body regions. Histologically, AN is characterised by a thickened stratum corneum and a variable amount of acanthosis. Although benign and rarely symptomatic, AN may be a red flag for underlying pathologies. CASE PRESENTATION: We analysed our patients with AN and could differentiate three different patterns, that are illustrated by one case report each. The is the benign AN associated with metabolic syndrome including obesity. The second type is the paraneoplastic AN malignancy which is associated with a wider range of malignancies. This type may occur before, after or with the clinical appearance of the malignancy. The third type is relapsing AN after complete remission. We present a patient who had a malignant AN and was treated successfully for his cancer. Years later, however, AN relapsed. In that case in association with the appearance of skin tags. Cancer restaging excluded a tumour relapse. His BMI was 31.2 kg/m2, and the diagnosis of benign AN was confirmed. CONCLUSIONS: The diagnosis of AN remains incomplete without screening for metabolic syndrome and/ or cancer. The combination of AN and skin tags is more often associated with metabolic syndrome. AN may be considered as a red flag for malignancies and the metabolic syndrome.

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