scholarly journals A histopathological study of unusual findings in appendectomy specimens in a tertiary care hospital of Andhra Pradesh

2021 ◽  
Vol 6 (4) ◽  
pp. 291-294
Author(s):  
Suneetha Kona ◽  
Srinivasulu Kande ◽  
Boddu Penchala Prasanna ◽  
Sushma Chandulee Kancharla
Keyword(s):  
Acute Appendicitis ◽  
Andhra Pradesh ◽  
Carcinoid Tumour ◽  
Tertiary Care ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Medical College ◽  
Retrospective Assessment ◽  
Inflammatory Bowel

Acute appendicitis is sudden inflammation of the appendix, usually initiated by obstruction of the lumen. This results in invasion of the appendix wall by gut flora, and it becomes inflamed and infected.: To investigate retrospectivelythe prevalence and implications of unusual histopathological findings in appendectomy specimens from patients with suspected acute appendicitis.This is retrospective assessment of hospital records of 150 patients who were diagnosed as acute appendicitis and underwent appendicectomy during March 2018 to February 2020 at Government Medical College, Bhagya Nagar, Ongole, Andhra Pradesh .Data of the patients were assessed based on age, sex, histopathological diagnosis, coexisting pathologies and uncommon findings on histology. According to histopathology report, negative for acute appendicitis were noted in 82 cases (55%), whereas positive for acute appendicitis in 68 cases (45.3%) . Rare findings were foundin 38 (55.8%) cases out of 68 cases. Parasites were found in 7 (18.4%) (Enterobius Vermicularis, Balantidum Coli, Schistosoma Haematobium), Mucocele in 12 (32%), carcinoid tumour in 8(21%), B cell malignant lymphoma in 2 (5%), leiomyoma in 2 (5%), Primary appendiceal adenocarcinoma in 3 (8%), Acute appendicitis with dysplastic changes in 2 (5%) and inflammatory bowel polyp was reported in remaining two cases(5%).: Even though unusualpathologies can be seen rarely during appendectomy, this should be kept in mind for further evaluation of each cases.

scholarly journals Histopathological Study of Pathological Specimens of Various Organs in a Tertiary Care Hospital in Bangladesh

2021 ◽  
Vol 34 (1) ◽  
pp. 16-25
Author(s):  
Monira Parveen ◽  
SM Asafudullah ◽  
Md Nowshad Ali ◽  
M Rokeya Khatun ◽  
Khadiza Khanom ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Tertiary Care ◽  
Transitional Cell ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Screening Programs ◽  
Medical College ◽  
Wide Range ◽  
Bladder Pathology

This retrospective study of histopathological specimens was done at the Department of Pathology of Rajshahi Medical College, Bangladesh, from July 2019 to June 2020, emphasizing challenges and diagnosis outcomes. Data obtained from their case notes included age at admission, the site from where the specimens were collected, and histopathological diagnosis.  Out of the 2026 histopathology samples, chronic cervicitis constitutes about 50% of the cases. Serous cystadenoma (about 1/4th cases) was common among ovarian pathology. 54.16% of the breast pathology exhibited Invasive ductal carcinoma. Reactive follicular hyperplasia and lymphoma constitute 49.44% of the lymph node pathology. About 80% of the gall bladder pathology was chronic cholecystitis, and metastatic adenocarcinoma was the commonest pathology involving the liver. Squamous cell carcinoma constitutes about 40% of the skin pathology. Osteosarcoma, osteochondroma, and giant cell tumor were the common pathologies involved in bones. Transitional cell carcinoma constitutes about 45% of urinary bladder pathology, and renal cell carcinomas were the commonest pathology of the kidney. Adenocarcinoma constitutes about 45 % of stomach pathology, 28% of small intestine pathology, and 14% of large intestine pathology.  Histopathological specimens at the pathology Rajshahi Medical College department with a wide range of pathologies are a major problem. From this study necessity of screening programs for early cancer detection appeared as a time-demanding issue. TAJ 2021; 34: No-1: 16-25

scholarly journals Comparison of early appendectomy versus conservative management for appendicular lump at Tertiary Care Hospital.

2020 ◽  
Vol 27 (09) ◽  
pp. 1818-1822
Author(s):  
Zulfiqar Ali Imtiaz Memon ◽  
Mashooque Ali Khowaja ◽  
Inayat Ali Zardari ◽  
Altaf Hussain Ghumro ◽  
Farkhanda Jabeen Dahri ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Wound Dehiscence ◽  
Cross Sectional Study ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Negative Results ◽  
Clinical Presentations

Objectives: The purpose is to compare two options of management of appendicular lump in order to sort out the better one for the benefit and betterment of populace. Study Design: Cross Sectional study. Setting: Peoples Medical College Hospital Nawabshah. Period: 2016 August to August 2018. Material & Methods: Total 50 patients of appendicular lump were included in this research. All patients were divided into 2 groups. Group 1 included those patients undergoing emergency appendectomy. They were admitted, optimized and the required treatment was initiated. Results: Of total 50, 30(60%) were male and 20(40%) were females. Age was between 14 to 51 years. All patients presented with different clinical presentations. Pain in RIF was in 42(84%) patients whereas 47(94%) patients presented with lump in RIF. 20(40%) patients were operated for appendectomy in emergency and 5(10%) patients for right hemi-colectomy. Histopathological diagnosis was inflammation in 24(48%) patients and 1(2%) resulted in cecal tumor. Infected wound was found in 15 (30%) patients, hematoma in 3 (6%), wound dehiscence in 1(2%) and also cecal fistula in 1 (2%). Conclusion: Conservative treatment is better option to treat appendicular lump with least negative results.

scholarly journals HISTOPATHOLOGICAL STUDY OF BENIGN AND MALIGNANT LESIONS OF UTERUS AND CERVIX IN HYSTERECTOMY SPECIMENS

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Shikha Raghuwanshi ◽  
Dharmendra Singh Bhadouria ◽  
Surendra Raghuwanshi ◽  
Arun Saxena ◽  
S.K. Nema
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Common Finding ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Fibroid Uterus ◽  
Malignant Lesions ◽  
Chronic Cervicitis ◽  
Insight Into

Background: The present study was aimed to obtain insight into the varied histopathological patterns of lesions of uterus and cervix in hysterectomy specimens and their age-wise distribution in Index MedicalCollege, Hospital and Research Center. Methodology: This was anobservational study conducted on 100 cases of hysterectomy specimens received at tertiary care hospital Indore. All the specimen was subjected to detailed gross and histopathological examination. Results: Mean age of patients was 44.78±8.64 years. The most common age group was 41-50yrs (42%). Maximum cases were diagnosed as AUB/ DUB/Menorrhagia (31%) followed by fibroid uterus (28%). Uterus was bulky in 70%, cut sections revealed single fibroid in majority i.e. 39% cases and endometrium was in proliferative phase (early 12%, mid 30%, late 19%). Most common histopathological diagnosis of uterus was leiomyoma in 39% cases whereas chronic nonspecific cervicitis (47%) was most common histological diagnosis of cervix. Intramural leiomyoma were most common and were associated with degenerative changes in 33 cases. Hyaline degeneration was observed in maximum cases. Conclusion: The most common indication for hysterectomies in our institution is excessive uterine bleeding. Fibroid uterus as the cause of bleeding is the most common pathology for which hysterectomy is performed. Chronic cervicitis is the most common finding and Adenomyosis continued to be missed preoperatively and diagnosed postoperatively on histopathological examination. Every hysterectomy specimen should be subjected to histopathological examination to confirm various pathological lesions. Keywords: Leiomyoma, histopathology, spectrum, uterus, cervix, hysterectomy

scholarly journals HISTOPATHOLOGICAL STUDY OF UTERINE LESIONS IN HYSTERECTOMY SPECIMENS IN A TERTIARY CARE HOSPITAL.

2020 ◽  
pp. 1-2
Author(s):  
Reddythota Sujeeva Swapna ◽  
V Siva Sankar Naik ◽  
C Bhavani ◽  
M Neeraja
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Female Genital Tract ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
The Body ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Wide Range

Background: The Female Genital Tract is a hormone-responsive system to a degree unmatched by any other system in the body. The gross configuration of the uterus changes dramatically throughout life. It is a kind of 'Puppet on a string", thus manipulated throughout life by altering levels of ovarian hormones. Objective of the study: The present study is aimed at detailed histopathological evaluation of uterine lesions of hysterectomy specimens. Methodology: A total of 448 cases of hysterectomy specimens were received in the department of pathology GGH Ananthapur, for two years, were reviewed. The specimens were processed, and the histopathological diagnosis was studied. Result: Peak age group of hysterectomy was 40-49 years with 186 (41.51%) cases. The youngest patient was 21 years old, and the oldest was 75 years old. The most frequent type of hysterectomy done was total abdominal hysterectomy in 293 (65.4%) cases. Conclusion: Hysterectomy is the most common surgery performed in gynecological practice. A wide range of lesions were noted when hysterectomy specimens are subjected to histopathological examination.

scholarly journals A pattern of serious adverse drug reactions reported in a tertiary care hospital, Rangaraya Medical College, Kakinada, Andhra Pradesh

2020 ◽  
Vol 9 (4) ◽  
pp. 566
Author(s):  
Sweta Bindu Mendu ◽  
K. V. Siva Prasad
Keyword(s):  
Adverse Drug Reactions ◽  
Andhra Pradesh ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Kidney Injury ◽  
Close Monitoring ◽  
Care Hospital ◽  
Social Inhibition ◽  
Drug Reactions ◽  
Medical College

Background: Serious adverse drug reactions (ADRs) constitute a major limitation in clinical development of a drug thus necessitating close monitoring. Studies regarding the pattern of serious ADRs are limited in southern India. The present study was conducted in tertiary care hospital in Andhra Pradesh with an objective to evaluate the pattern of severe cutaneous and non-cutaneous ADRs in our hospital and to assess the causality, severity, and preventability of these reactions.Methods: A retrospective observational study was conducted over two years, from January 2016 till January 2018 in our ADR monitoring center. The pattern of serious adverse drug reactions, the nature of ADR, suspected drug, the outcome and preventability were analyzed using Modified Hartwig and Siegel scale, and modified Schumock and Thorton scale.Results: Out of 734 ADRs reported, 42 were serious, while 692 were non-serious. Out of 42, 22 were dermatological in origin while the others were acute kidney injury, acute psychosis, febrile neutropenia, gynecomastia, and lipodystrophy. According to WHO causality assessment scale, 27 were probable while 15 were possible. The majority were reported in the age group of 16 to 65 years with female (34) preponderance. The most common drug category responsible was antimicrobials, followed by antiretrovirals, anti-epileptics, and analgesics.Conclusions: Antimicrobial, anti-epileptics, and analgesics contributed to serious ADRs. Although non-cutaneous ADRs did not result in hospitalization, they caused social inhibition and mental stress in the patient.

scholarly journals Histopathological study of endoscopic biopsies of large intestine

2021 ◽  
Vol 8 (3) ◽  
pp. 340-344
Author(s):  
Manjiri N Karandikar ◽  
Purva Kulkarni ◽  
Smita Mulay ◽  
R C Nimbergi ◽  
N S Mani
Keyword(s):  
Large Intestine ◽  
Tertiary Care ◽  
Bowel Habit ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Safe Procedure ◽  
Care Hospital ◽  
Colonoscopic Examination ◽  
Endoscopic Biopsies ◽  
Intestinal Pathology

The large intestine is a site of a variety of diseases. The lesions tend to occur affecting different age groups ranging from early childhood to late adulthood. Patients may present with very vague clinical symptoms ranging from abdominal pain, loose stools, vomiting, diarrhoea, bleeding per rectum, and change in bowel habit. Patients presenting with repeated symptoms related to lower intestinal pathology are advised to undergo colonoscopic examination.To study clinico-pathological correlation of endoscopic biopsies of large intestine and to study spectrum of large intestinal lesions.The study was conducted at a tertiary care hospital from August 2018 to July 2020. All endoscopic biopsy samples were included in this study. All endoscopic biopsies were performed by high definition colonoscope. Clinical and endoscopic correlation with histopathological diagnosis was performed and results were generated.Total 133 cases were included in this study, out of 133 patients 86 were males and 47 were females. Patients showed wide age range from 11 years to 80 years. There were 25 patients each in age group of 31-40 years and 61-70 years. The most common presenting complaint was loose stools in 66 cases. The most common endoscopic finding was erythema in 82 cases. Out of 133 cases, 105 cases were non neoplastic, 08 cases were benign neoplastic and 20 cases were malignant neoplastic on histopathology.Colonoscopy is very high yielding and safe procedure to perform.Colonoscopic biopsies are proven to be of great importance. Clinical, endoscopic and histopathological correlation is always advisable in large intestinal pathology for early diagnosis and treatment.

Histopathological Study of Placenta in COVID-19 Positive Mothers in a Tertiary Care Hospital, South Kerala

2021 ◽  
Vol 8 (35) ◽  
pp. 3236-3240
Author(s):  
Krishna Govindan ◽  
Jithesh Girijakumar ◽  
Sreekumari Radha ◽  
Priyasree Jayasimham ◽  
Reshma Pallikara Kunjunny
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Tertiary Care ◽  
Case Series ◽  
Clinical Information ◽  
Histopathological Study ◽  
Low Grade ◽  
Care Hospital ◽  
Global Public Health ◽  
Medical College ◽  
Routine Clinical Examination

BACKGROUND The coronavirus disease 2019 (Covid-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), is a global public health emergency. Data on the effect of coronavirus disease 2019 in pregnancy is limited to few case series. The purpose of this study was to describe the histopathological findings in the placentas of women with Covid-19 during pregnancy. METHODS Pregnant women with Covid-19 who delivered between August 1, 2020 and May 10, 2021, at Government Medical College, Trivandrum were considered for the study. Handling of specimens were carried out using Indian council of medical research (ICMR) guidelines for Covid-19 specimens. Placentas underwent routine clinical examination and processing. Clinical information was retrieved from the medical records. Histological examination was performed and features classified into maternal vascular malperfusion (MVM) and fetal vascular malperfusion (FVM). RESULTS 50 placentas from patients with severe acute respiratory syndrome coronavirus 2 were examined [33 patients delivered at term, 12 patients were preterm, 4 cases were intrauterine fetal demise and 1 case was medical termination of pregnancy (MTP)]. Patients with risk factors for maternal and fetal vascular malperfusion were excluded. 8 cases showed features of maternal vascular malperfusion and 11 cases showed features of fetal vascular malperfusion. Among intra uterine fetal death (IUFD) cases, 2 cases showed features of vascular malperfusion, 7 cases showed low grade acute inflammatory pathology which needs further studies with a greater number of cases to establish relationship with Covid-19 virus. CONCLUSIONS Covid-19 placentas showed increased rates of maternal and fetal vascular malperfusion. These changes may reflect a hypercoagulable state influencing placental pathology and hence an increased antenatal surveillance for women diagnosed with SARS–CoV-2 infection may be warranted. Further studies with control groups are necessary to determine the reproducibility and significance of these initial findings. KEYWORDS Covid-19, Pregnancy, Maternal Vascular Malperfusion, Fetal Vascular Malperfusion.

HISTOPATHOLOGICAL STUDY OF COLPOSCOPIC BIOPSY OF CERVICES IN A TERTIARY CARE HOSPITAL (RAJSHAHI MEDICAL COLLEGE) IN BANGLADESH

2021 ◽  
pp. 166-168
Author(s):  
Monira Parveen ◽  
SM Asafudullah ◽  
M. Rokeya Khatun ◽  
Md. Nowshad Ali ◽  
Khadiza Khanom ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care ◽  
Histopathological Study ◽  
Invasive Squamous Cell Carcinoma ◽  
Care Hospital ◽  
Medical College ◽  
Chronic Cervicitis

Introduction: Colposcopy is done to detect cervical cancer and changes that may lead to cervical cancer. We aimed our study to observe the incidence of different pathologies of the cervix in Colposcopic specimens in Rajshahi Medical College of Bangladesh. Materials and Methods: Retrospective data were collected from the routine histopathological laboratory in the department of pathology Rajshahi Medical College and were recorded during a study period of 1 year (July 2019 to June 2020). Observations: Colposcopic biopsy is one of the commonest diagnostic procedures for assessing cervical Pathosis. Out of 641 specimens more than half, 365 specimens (56.50%) were Chronic Cervicitis. In present study, Chronic Cervicitis with squamous metaplasia and Invasive squamous cell carcinoma became the 2nd, 16.39% (105 specimens), and 3rd, 13.42% (86 specimens) most pathology involving the cervix. Cervical polyp, Endocervical and Leiomyomatous constitute 6.39% and 1.57% of the specimens respectively. 4.36% (28 specimens) of the study sample were the Intraepithelial neoplasia (CIN I, CIN II, CIN III). Adenocarcinoma and Clear cell carcinoma constitute 0.79% and 0.16% of the study specimens. 50 % of the cervical squamous cell carcinoma was moderately differentiated and well-differentiated and poorly differentiated squamous cell carcinoma constitutes 30.23% and 19.77% respectively. Conclusions: Colposcopic examination of cervical biopsy specimens helps to detect the exact causes and underlined pathology

scholarly journals A histopathological study of sebaceous neoplasms and related lesions at a tertiary care centre

2019 ◽  
Vol 7 (5) ◽  
pp. 1894
Author(s):  
Swagata Dowerah ◽  
Munmun Harlalka
Keyword(s):  
Tertiary Care ◽  
Sebaceous Carcinoma ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Tertiary Care Centre ◽  
Sebaceous Adenoma ◽  
Nevus Sebaceous ◽  
Adnexal Tumors ◽  
Nevus Sebaceus

Background: Sebaceous lesions have intrigued pathologists and dermatologist alike causing a great deal of diagnostic confusion. Tumors and tumor like conditions of the sebaceous glands include sebaceous hyperplasia, Nevus sebaceus of Jadassohn, sebaceous adenoma, sebaceoma and sebaceous carcinoma.Methods: A three-year study of all lesions with sebaceous differentiation was carried out in the histopathology section of a tertiary care hospital to study the spectrum of lesions showing sebaceous differentiation. Patient records were noted, and paraffin embedded sections stained with haematoxylin and eosin were examined for histopathological diagnosis. Clinical correlation was done in all the cases.Results: The spectrum of lesions encountered included sebaceous carcinoma, Nevus sebaceous, sebaceous hyperplasia, sebaceous adenoma among others. Eyelid was the most common site followed by scalp. Clinicopathological correlation was found to be poor in these lesions with clinical examination failing to correctly identify most of the cases.Conclusions: Sebaceous neoplasms were seen to be rarer in our population as compared to other adnexal tumors. Histopathology, in the presence of typical features, is the mainstay of diagnosis with immunohistochemistry aiding in certain doubtful cases.

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