Histopathological Study of Placenta in COVID-19 Positive Mothers in a Tertiary Care Hospital, South Kerala

2021 ◽  
Vol 8 (35) ◽  
pp. 3236-3240
Author(s):  
Krishna Govindan ◽  
Jithesh Girijakumar ◽  
Sreekumari Radha ◽  
Priyasree Jayasimham ◽  
Reshma Pallikara Kunjunny
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Tertiary Care ◽  
Case Series ◽  
Clinical Information ◽  
Histopathological Study ◽  
Low Grade ◽  
Care Hospital ◽  
Global Public Health ◽  
Medical College ◽  
Routine Clinical Examination

BACKGROUND The coronavirus disease 2019 (Covid-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), is a global public health emergency. Data on the effect of coronavirus disease 2019 in pregnancy is limited to few case series. The purpose of this study was to describe the histopathological findings in the placentas of women with Covid-19 during pregnancy. METHODS Pregnant women with Covid-19 who delivered between August 1, 2020 and May 10, 2021, at Government Medical College, Trivandrum were considered for the study. Handling of specimens were carried out using Indian council of medical research (ICMR) guidelines for Covid-19 specimens. Placentas underwent routine clinical examination and processing. Clinical information was retrieved from the medical records. Histological examination was performed and features classified into maternal vascular malperfusion (MVM) and fetal vascular malperfusion (FVM). RESULTS 50 placentas from patients with severe acute respiratory syndrome coronavirus 2 were examined [33 patients delivered at term, 12 patients were preterm, 4 cases were intrauterine fetal demise and 1 case was medical termination of pregnancy (MTP)]. Patients with risk factors for maternal and fetal vascular malperfusion were excluded. 8 cases showed features of maternal vascular malperfusion and 11 cases showed features of fetal vascular malperfusion. Among intra uterine fetal death (IUFD) cases, 2 cases showed features of vascular malperfusion, 7 cases showed low grade acute inflammatory pathology which needs further studies with a greater number of cases to establish relationship with Covid-19 virus. CONCLUSIONS Covid-19 placentas showed increased rates of maternal and fetal vascular malperfusion. These changes may reflect a hypercoagulable state influencing placental pathology and hence an increased antenatal surveillance for women diagnosed with SARS–CoV-2 infection may be warranted. Further studies with control groups are necessary to determine the reproducibility and significance of these initial findings. KEYWORDS Covid-19, Pregnancy, Maternal Vascular Malperfusion, Fetal Vascular Malperfusion.

scholarly journals Overview of exanthems: a case series in a tertiary care hospital

2020 ◽  
Vol 6 (4) ◽  
pp. 484
Author(s):  
Ramesh A. ◽  
Thamizhinian K.
Keyword(s):  
Medical Records ◽  
Analytical Study ◽  
Viral Infections ◽  
Tertiary Care ◽  
Case Series ◽  
Maculopapular Rash ◽  
Care Physician ◽  
Care Hospital ◽  
Medical College ◽  
Madras Medical College

<p class="abstract"><strong>Background:</strong> Generalized rashes are the most common conditions seen by primary care physician and the most common reason for new patient visit to dermatologists. There is often difficulty in diagnosing a generalized rash because many conditions produce similar rashes and a single condition can result in rashes with varied appearance. Accurate diagnosis is important because treatment varies depending on the cause. Hence, we decided to undertake a steady on the various presentations of exanthems in Madras medical college Chennai. To find out the incidence of exanthems in the OPD of Department of Dermatology, Venerology and Leprosy (DVL) in Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai to help in early diagnosis and treatment of the diseases.  </p><p class="abstract"><strong>Methods:</strong> The study included all the newly diagnosed cases attending to the OPD of DVL, Madras Medical College, Chennai for a period of three months. Diagnosis was done based on clinical grounds and lab investigations were done whenever required.<strong></strong></p><p class="abstract"><strong>Results:</strong> An analytical study of the medical records of patients attending the OPD of DVL, Madras Medical College, Chennai shows that maculopapular rash is the most common presentation of exanthems followed by papules, vesiculobullous, pustular, nodules, verrucous lesions.</p><p class="abstract"><strong>Conclusions:</strong> The present study includes exanthems as a whole on contrary to many such studies performed in other parts of India which included rashes caused by viral infections and drugs. Our study included generalized skin eruptions due to infections, drugs, specific dermatoses, allergy.   </p>

scholarly journals TO STUDY THE CLINICAL PROFILE OF SUSPECTED CASES OF COVID 19 PRESENTED TO EMERGENCY IN TERTIARY CARE HOSPITAL.

2021 ◽  
pp. 1-3
Author(s):  
Rajvi Dave ◽  
Bhavesh Jarwani ◽  
Sanket Nandani ◽  
Tirth Patel
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Clinical Features ◽  
Tertiary Care ◽  
World Health ◽  
Disease Spread ◽  
Care Hospital ◽  
Global Public Health ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Spread Of Infection

BACKGROUND : Coronavirus disease 2019(COVID 19) is an illness which is associated with the novel coronavirus known as severe acute respiratory syndrome coronavirus 2(SARS-CoV -2).On December 2019, Wuhan City in China, became the epicenter of this pandemic. On March 17 2020 Ahmedabad reported its first positive case. On January 2020, Chinese scientists identified this as a novel coronavirus, temporarily labelled as, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1]. Its name was then changed to coronavirus disease 2019 (COVID-19) by the World Health Organization in February 2020 as the disease spread worldwide [2]. COVID 19 pandemic has posed a huge threat to global public health .The clinical features of COVID-19 are very diverse, ranging from asymptomatic state to acute respiratory distress syndrome and multi organ dysfunction. The common clinical features include fever, cough, sore throat, headache, fatigue, headache, myalgia and breathlessness. Emergency workers carry a huge responsibility in this pandemic. We have to provide early triage and management of patients with suspected or confirmed infection in which inflammatory markers play an important role. More importantly we have to try to prevent the spread of infection and also be prepared to tackle such large footfalls in ED

scholarly journals A histopathological study of unusual findings in appendectomy specimens in a tertiary care hospital of Andhra Pradesh

2021 ◽  
Vol 6 (4) ◽  
pp. 291-294
Author(s):  
Suneetha Kona ◽  
Srinivasulu Kande ◽  
Boddu Penchala Prasanna ◽  
Sushma Chandulee Kancharla
Keyword(s):  
Acute Appendicitis ◽  
Andhra Pradesh ◽  
Carcinoid Tumour ◽  
Tertiary Care ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Medical College ◽  
Retrospective Assessment ◽  
Inflammatory Bowel

Acute appendicitis is sudden inflammation of the appendix, usually initiated by obstruction of the lumen. This results in invasion of the appendix wall by gut flora, and it becomes inflamed and infected.: To investigate retrospectivelythe prevalence and implications of unusual histopathological findings in appendectomy specimens from patients with suspected acute appendicitis.This is retrospective assessment of hospital records of 150 patients who were diagnosed as acute appendicitis and underwent appendicectomy during March 2018 to February 2020 at Government Medical College, Bhagya Nagar, Ongole, Andhra Pradesh .Data of the patients were assessed based on age, sex, histopathological diagnosis, coexisting pathologies and uncommon findings on histology. According to histopathology report, negative for acute appendicitis were noted in 82 cases (55%), whereas positive for acute appendicitis in 68 cases (45.3%) . Rare findings were foundin 38 (55.8%) cases out of 68 cases. Parasites were found in 7 (18.4%) (Enterobius Vermicularis, Balantidum Coli, Schistosoma Haematobium), Mucocele in 12 (32%), carcinoid tumour in 8(21%), B cell malignant lymphoma in 2 (5%), leiomyoma in 2 (5%), Primary appendiceal adenocarcinoma in 3 (8%), Acute appendicitis with dysplastic changes in 2 (5%) and inflammatory bowel polyp was reported in remaining two cases(5%).: Even though unusualpathologies can be seen rarely during appendectomy, this should be kept in mind for further evaluation of each cases.

scholarly journals Histopathological Study of Pathological Specimens of Various Organs in a Tertiary Care Hospital in Bangladesh

2021 ◽  
Vol 34 (1) ◽  
pp. 16-25
Author(s):  
Monira Parveen ◽  
SM Asafudullah ◽  
Md Nowshad Ali ◽  
M Rokeya Khatun ◽  
Khadiza Khanom ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Tertiary Care ◽  
Transitional Cell ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Screening Programs ◽  
Medical College ◽  
Wide Range ◽  
Bladder Pathology

This retrospective study of histopathological specimens was done at the Department of Pathology of Rajshahi Medical College, Bangladesh, from July 2019 to June 2020, emphasizing challenges and diagnosis outcomes. Data obtained from their case notes included age at admission, the site from where the specimens were collected, and histopathological diagnosis.  Out of the 2026 histopathology samples, chronic cervicitis constitutes about 50% of the cases. Serous cystadenoma (about 1/4th cases) was common among ovarian pathology. 54.16% of the breast pathology exhibited Invasive ductal carcinoma. Reactive follicular hyperplasia and lymphoma constitute 49.44% of the lymph node pathology. About 80% of the gall bladder pathology was chronic cholecystitis, and metastatic adenocarcinoma was the commonest pathology involving the liver. Squamous cell carcinoma constitutes about 40% of the skin pathology. Osteosarcoma, osteochondroma, and giant cell tumor were the common pathologies involved in bones. Transitional cell carcinoma constitutes about 45% of urinary bladder pathology, and renal cell carcinomas were the commonest pathology of the kidney. Adenocarcinoma constitutes about 45 % of stomach pathology, 28% of small intestine pathology, and 14% of large intestine pathology.  Histopathological specimens at the pathology Rajshahi Medical College department with a wide range of pathologies are a major problem. From this study necessity of screening programs for early cancer detection appeared as a time-demanding issue. TAJ 2021; 34: No-1: 16-25

HISTOPATHOLOGICAL STUDY OF COLPOSCOPIC BIOPSY OF CERVICES IN A TERTIARY CARE HOSPITAL (RAJSHAHI MEDICAL COLLEGE) IN BANGLADESH

2021 ◽  
pp. 166-168
Author(s):  
Monira Parveen ◽  
SM Asafudullah ◽  
M. Rokeya Khatun ◽  
Md. Nowshad Ali ◽  
Khadiza Khanom ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care ◽  
Histopathological Study ◽  
Invasive Squamous Cell Carcinoma ◽  
Care Hospital ◽  
Medical College ◽  
Chronic Cervicitis

Introduction: Colposcopy is done to detect cervical cancer and changes that may lead to cervical cancer. We aimed our study to observe the incidence of different pathologies of the cervix in Colposcopic specimens in Rajshahi Medical College of Bangladesh. Materials and Methods: Retrospective data were collected from the routine histopathological laboratory in the department of pathology Rajshahi Medical College and were recorded during a study period of 1 year (July 2019 to June 2020). Observations: Colposcopic biopsy is one of the commonest diagnostic procedures for assessing cervical Pathosis. Out of 641 specimens more than half, 365 specimens (56.50%) were Chronic Cervicitis. In present study, Chronic Cervicitis with squamous metaplasia and Invasive squamous cell carcinoma became the 2nd, 16.39% (105 specimens), and 3rd, 13.42% (86 specimens) most pathology involving the cervix. Cervical polyp, Endocervical and Leiomyomatous constitute 6.39% and 1.57% of the specimens respectively. 4.36% (28 specimens) of the study sample were the Intraepithelial neoplasia (CIN I, CIN II, CIN III). Adenocarcinoma and Clear cell carcinoma constitute 0.79% and 0.16% of the study specimens. 50 % of the cervical squamous cell carcinoma was moderately differentiated and well-differentiated and poorly differentiated squamous cell carcinoma constitutes 30.23% and 19.77% respectively. Conclusions: Colposcopic examination of cervical biopsy specimens helps to detect the exact causes and underlined pathology

scholarly journals Spectrum of Etiology among Adult Intussusception Patients: Study of 11 Cases at a Tertiary Care Hospital in Bangladesh

2016 ◽  
Vol 14 (1) ◽  
pp. 3-7
Author(s):  
SM Quamrul Akhter ◽  
Md. Mamunur Rahman ◽  
Syed Masud Reza ◽  
Md. Mozammel Hoque ◽  
Syeda Nishat Marium ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Case Series ◽  
Stromal Tumour ◽  
Adult Intussusception ◽  
Resected Specimen ◽  
Care Hospital ◽  
Medical College ◽  
Common Etiology ◽  
Study Population ◽  
One Year

Background: Intussusception in adult patients is occurred in different reasons. Objectives: The purpose of the present study was to see the spectrum of etiology among adult intussusception patients. Methodology: This case series was performed in the Department of Surgery at Shaheed Suhrawardy Medical College, Dhaka from July 2014 to June 2015 for a period of 1(one) year. All the patients presented with intussusceptions were selected as study population. A detailed history was obtained from each patient. Patients with the age of ?18 years, regardless the symptoms like onset, duration, intensity, progression were included for this study. Per-operative diagnosis was further confirmed by histopathology of the resected specimen. Result: A total number of 11 cases were recruited after fulfilling the inclusion and exclusion criteria. Gastro intestinal stromal tumour (GIST) was the most common etiology of intussusceptions which was 5(45.5%) cases followed by adenocarcinoma which was 2(18.2%) cases. Meckel’s diverticulum, Intestinal TB, Lipoma and Leiyomyomatous polyp were also found in 1 case each. Conclusion: Adult intussusception is most commonly occurred due to gastro intestinal stromal tumour followed by adenocarcinoma. Journal of Science Foundation, January 2016;14(1):3-7

scholarly journals ADRENAL GLAND TUMOURS: A 2-YEAR TERTIARY CARE HOSPITAL BASED CASE SERIES

2021 ◽  
pp. 1-3
Author(s):  
Muktanjalee Deka ◽  
Asreen Suhana ◽  
Surajit Roy ◽  
Birinchi Kumar Saikia
Keyword(s):  
Adrenal Gland ◽  
Tertiary Care ◽  
Age Distribution ◽  
Case Series ◽  
Adrenal Tumors ◽  
Low Grade ◽  
Adrenocortical Adenoma ◽  
Care Hospital ◽  
Pathologic Classification ◽  
Adrenal Gland Tumors

Introduction: Adrenal gland tumors are rare. Asymptomatic adrenal tumours are found in 2-10% of the population worldwide, out of which, adrenocortical carcinomas(ACC) have an incidence of 0.5-2 cases/million population/year. ACC accounts for 0.05% -0.2% of all malignancies with a bimodal age distribution, in the first two decades and then in the fifth decade. They can be asymptomatic and diagnosed as Incidentalomas or present with signs and symptoms of hormone imbalance. Materials and methods: In this 2 year hospital-based retrospective case series from June,2018 to May,2020 , 5 cases of adrenal gland tumors diagnosed in the Department of Pathology , GMCH, were retrieved from the archives and reviewed. Each case was analyzed with respect to age , sex, site and tumor characteristics. Results: In this 2-year period, 5 cases of adrenal tumors were found. The age range of the patients was 8-54 years. Out of 5 cases,2 cases were male and 3 cases were female. Out of 5 cases of , 4 were on the left side and 1 was on the right side.2 out of the 5 cases were diagnosed as Adrenocortical carcinoma(low grade), 1 as Phaeochromocytoma and 2 as Adrenocortical Adenoma. Conclusion: Adrenal gland tumors are rare, so the pathologic classification and determination of prognosis are very challenging.

SEROPREVALENCE OF HIV AND HBsAg AMONGST BLOOD DONORS IN A TERTIARY CARE HOSPITAL, CHHATTISGARH.

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Anusha P ◽  
Bankar Nandkishor J ◽  
Karan Jain ◽  
Ramdas Brahmane ◽  
Dhrubha Hari Chandi
Keyword(s):  
Hepatitis B ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Tertiary Care ◽  
Laboratory Diagnosis ◽  
Blood Bank ◽  
Care Hospital ◽  
Medical College ◽  
The World ◽  
First Time

INTRODUCTION: India being the second highly populated nation in the world. HIV/AIDS has acquired pandemic proportion in the world. Estimate by WHO for current infection rate in Asia. India has the third largest HIV epidemic in the world. HIV prevalence in the age group 15-49 yrs was an estimate of 0.2%. India has been classified as an intermediate in the Hepatitis B Virus (HBV) endemic (HBsAg carriage 2-7%) zone with the second largest global pool of chronic HBV infections. Safety assessment of the blood supply, the quality of screening measures and the risk of transfusion transmitted infectious diseases (TTIs) in any country can be estimated by scrutinizing the files of blood donors. After the introduction of the blood banks and improved storage facilities, it became more extensively used. Blood is one of the major sources of TTIs like hepatitis B, hepatitis C, HIV, syphilis, and many other blood borne diseases. Disclosure of these threats brought a dramatic change in attitude of physicians and patients about blood transfusion. The objective of this study is to determine the seroprevalence of transfusion transmitted infections amidst voluntary blood donors at a rural tertiary healthcare teaching hospital in Chhattisgarh. MATERIAL AND METHODS: This retrospective study was carried out in Chandulal Chandrakar Memorial Medical College, Kachandur, Durg. Blood donors were volunteers, or and commercial donors who donated the blood and paid by patients, their families, or friends to replace blood used or expected to be used for patients from the blood bank of the hospital. After proper donation of blood routine screening of blood was carried out according to standard protocol. Laboratory diagnosis of HIV 1 and HIV 2 was carried out by ELISA test. Hepatitis B surface antigen was screened by using ELISA. RESULTS: A total of 1915 consecutive blood donors’ sera were screened at Chandulal Chandrakar Memorial Medical College, blood bank during study period. Of these 1914 were male and 1 female. The mean age of patients was found to be 29.34 years with standard deviation (SD) of 11.65 Years. Among all blood donors in present study, 759(39.63%) were first time donors and 1156(60.37%) were repeated donors. 1 patient was HIV positive in first donation group while 3 (75%) were positive in repeat donation group. 7 (38.9%) were HBsAg positive in in first donation group while 11(61.1%) were positive in repeat donation group. Two patients in first donation group had dual infection of HIV and HBsAg. CONCLUSION: Seropositivity was high in repeated donors as compared to first time donors. The incidence of HIV is observed to be 0.2% and that of HBsAg is 0.94%. Strict selection of blood donors should be done to avoid transfusion-transmissible infections during the window period.

scholarly journals Peripartum hysterectomy: a five year review at a tertiary care centre

2017 ◽  
Vol 6 (8) ◽  
pp. 3590
Author(s):  
Deepak A. V. ◽  
K. J. Jacob ◽  
Sumi P. Maria
Keyword(s):  
Tertiary Care ◽  
Case Series ◽  
Case Fatality ◽  
Tertiary Care Centre ◽  
Retrospective Case ◽  
College Hospital ◽  
Peripartum Hysterectomy ◽  
Medical College ◽  
Obstetric Haemorrhage ◽  
Suboptimal Care

Background: Peripartum hysterectomy is a life-saving procedure resorted to when conservative measures fail to control obstetric haemorrhage. Several predisposing factors, suboptimal care and lack of infrastructure may lead to this emergency procedure. We wanted to find out factors associated with peripartum hysterectomy and the adverse maternal outcomes at our centre.Methods: A retrospective case series analysis of 40 cases of peripartum hysterectomy performed over a period of 5 years from January 2010 to December 2014 at Government Medical College Hospital, Thrissur, Kerala was done.Results: The incidence of peripartum hysterectomy was 0.29%. The most common indication for peripartum hysterectomy was hysterectomy was uterine atony (50%). Thirty-five women (88%) were between 20 and 35 years. Most of the subjects were unbooked. There were two maternal deaths (case fatality rate of 5%) following peripartum hysterectomy during this period. All the subjects required blood transfusion.Conclusions: Prompt performance hysterectomy before the patient’s clinical condition deteriorates is the key to success. The incidence of adherent placenta is increasing, so every effort should be taken to reduce the caesarean section rates globally. 

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