scholarly journals Screening of chromosomal region 21q22.3 for mutations in genes associated with neuronal Ca2+ signalling in bipolar affective disorder.

2006 ◽  
Vol 53 (2) ◽  
pp. 317-320 ◽  
Author(s):  
Andrzej Kostyrko ◽  
Joanna Hauser ◽  
Janusz K Rybakowski ◽  
Wiesław H Trzeciak
Keyword(s):  
Affective Disorder ◽  
Chromosomal Region ◽  
Bipolar Affective Disorder ◽  
Single Strand Conformation Polymorphism ◽  
Rapid Screening ◽  
Control Group ◽  
Polymorphism Analysis ◽  
Coding Sequence ◽  
Large Gene ◽  
Intracellular Ca

The therapeutic effect of lithium in bipolar affective disorder may be connected with decreasing intracellular Ca(2+) concentrations. Several linkage studies have identified a potential bipolar affective disorder susceptibility locus within chromosomal region 21q22.3. This locus contains two genes expressed in the brain - ADARB1 and TRPM2 - involved in regulating intracellular Ca(2+) concentrations. The aim of this study was an identification of mutations in the coding sequences of ADARB1 and TRPM2 and their association with bipolar affective disorder. For that purpose we screened 60 patients with bipolar affective disorder and a control group of 66 subjects using single strand conformation polymorphism and sequence analysis. For rapid screening we performed restriction fragment length polymorphism analysis. Screening of bipolar affective disorder patients for mutations in TRPM2 led to identification of three novel and four known transitions. Two transitions resulted in the substitutions: R755C and A890V. Screening of the coding sequence of ADARB1 did not reveal any mutations except one already known transition. A comparison of the transition frequency in patients and controls does not support association of the detected mutations with bipolar affective disorder. According to our results, bipolar affective disorder may not be caused by mutations in ADARB1. However, this study does not exclude TRPM2 as a candidate gene since we have screened only about 30 per cent of the entire coding sequence of this large gene.

scholarly journals A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25–q26

2001 ◽  
Vol 6 (3) ◽  
pp. 342-349 ◽  
Author(s):  
S Cichon ◽  
G Schmidt-Wolf ◽  
J Schumacher ◽  
D J Müller ◽  
M Hürter ◽  
...  
Keyword(s):  
Affective Disorder ◽  
Chromosomal Region ◽  
Bipolar Affective Disorder ◽  
Susceptibility Locus

scholarly journals Cognitive errors assessed by observer ratings in bipolar affective disorder: relationship with symptoms and therapeutic alliance

2009 ◽  
Vol 2 (2) ◽  
pp. 92-105 ◽  
Author(s):  
Ueli Kramer ◽  
Guy Bodenmann ◽  
Martin Drapeau
Keyword(s):  
Cognitive Therapy ◽  
Affective Disorder ◽  
Mood Disorders ◽  
Bipolar Affective Disorder ◽  
Cognitive Model ◽  
Control Group ◽  
Cognitive Errors ◽  
Manic Symptoms ◽  
Observer Ratings ◽  
Depressive Patients

AbstractThe construct of cognitive errors is clinically relevant for cognitive therapy of mood disorders. Beck's universality hypothesis postulates the relevance of negative cognitions in all subtypes of mood disorders, as well as positive cognitions for manic states. This hypothesis has rarely been empirically addressed for patients presenting bipolar affective disorder (BD). In-patients (n= 30) presenting with BD were interviewed, as were 30 participants of a matched control group. Valid and reliable observer-rater methodology for cognitive errors was applied to the session transcripts. Overall, patients make more cognitive errors than controls. When manic and depressive patients were compared, parts of the universality hypothesis were confirmed. Manic symptoms are related to positive and negative cognitive errors. These results are discussed with regard to the main assumptions of the cognitive model for depression; thus adding an argument for extending it to the BD diagnostic group, taking into consideration specificities in terms of cognitive errors. Clinical implications for cognitive therapy of BD are suggested.

scholarly journals Altered Magnetic Resonance White-Matter T1 Values in Patients with Affective Disorder

1990 ◽  
Vol 157 (1) ◽  
pp. 107-110 ◽  
Author(s):  
R. J. Dolan ◽  
A. M. Poynton ◽  
P. K. Bridges ◽  
M. R. Trimble
Keyword(s):  
White Matter ◽  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Normal Control Group ◽  
Proton Relaxation ◽  
Control Group ◽  
Frontal Lobe Dysfunction ◽  
Unipolar Disorder ◽  
Frontal White Matter ◽  
Bipolar Patients

The MRI T1 proton relaxation values were assessed in 14 patients with bipolar affective disorder and 10 with a unipolar disorder and a matched normal control group. The T1 values in the frontal white matter of patients significantly exceeded those of the controls. This difference was accounted for by an increase in T1 values in the frontal white matter of unipolar patients: the values for bipolar patients alone did not differ from those for controls. These preliminary findings support a hypothesis of frontal lobe dysfunction mediating pathological changes in mood.

Postpartum Mania

1979 ◽  
Vol 135 (6) ◽  
pp. 551-554 ◽  
Author(s):  
Arnold Kadrmas ◽  
George Winokur ◽  
Raymond Crowe
Keyword(s):  
Affective Disorder ◽  
Depressive Episode ◽  
Postpartum Period ◽  
Matched Control ◽  
Bipolar Affective Disorder ◽  
Practical Significance ◽  
Control Group ◽  
Matched Control Group ◽  
Theoretical Significance ◽  
Unselected Group

SummaryTwenty-one patients with bipolar affective disorder (20 manic episodes, one depressive episode) during the postpartum period were evaluated. They were compared to an unselected group of women with bipolar histories, as well as to a matched control group. The postpartum group had significantly more Schneiderian symptoms and fewer recurrences of illness within the three-year period after the index admission. There was a notable trend toward postpartum patients having fewer affectively ill relatives than the controls. The practical significance of these findings with regards to lithium therapy is discussed, as is the theoretical significance in terms of heterogeneity of the bipolar syndrome.

Are patients with bipolar affective disorder socially disadvantaged? A comparison with a control group

2002 ◽  
Vol 4 (4) ◽  
pp. 243-248 ◽  
Author(s):  
Zainab Abood ◽  
Alison Sharkey ◽  
Marcus Webb ◽  
Alan Kelly ◽  
Michael Gill
Keyword(s):  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Control Group ◽  
Socially Disadvantaged

Shoplifting in the Mentally Ill: The role of bipolar affective disorder and mental retardation

2005 ◽  
Vol 45 (4) ◽  
pp. 317-320 ◽  
Author(s):  
Rachel S Y Cheng ◽  
Candy Lin ◽  
Marcella L Y Fok ◽  
Chi-Ming Leung
Keyword(s):  
Mental Retardation ◽  
Affective Disorder ◽  
Mentally Ill ◽  
Matched Control ◽  
Psychiatric Patients ◽  
Bipolar Affective Disorder ◽  
Mental Illnesses ◽  
Control Group ◽  
University Department

This study explores shoplifting behaviour in mentally ill patients, and evaluates the association between shoplifting and different mental illnesses in a local Chinese population. A comparison is made between shoplifting offenders and a matched control group of non-offenders among the psychiatric patients registered at a university department of psychiatry. Major depression, bipolar affective disorder (BAD) and mental retardation (MR) are the most common diagnoses among mentally ill shoplifters, while patients with a diagnosis of BAD or MR are at higher risk of committing an offence than patients with other diagnoses. Bipolar affective disorder has not been described as a risk factor for shoplifting behaviour in the psychiatric literature. Such a possibility should be seriously considered in the psychiatric assessment of shoplifting cases.

scholarly journals A Comparative Personality Profile Study Between Bipolar-affective disorders (Mania) and Normal control group

2017 ◽  
Vol 5 (1) ◽  
pp. 37-42
Author(s):  
R. Kumar ◽  
A.R. Singh
Keyword(s):  
Affective Disorder ◽  
Normal Control ◽  
Rating Scale ◽  
Bipolar Affective Disorder ◽  
Normal Control Group ◽  
Personality Factor ◽  
Control Group ◽  
Normal Male ◽  
Personality Profile ◽  
Bipolar Affective Disorders

Introduction: Personality is the important core feature and identification of an individual. Some factors in personality may be vulnerable for psychiatric illness.Objective: To compare Personality profile of Bipolar Affective Dirosder with Normal control group.Method: 30 male patients diagnosed as Bipolar affective disorder (mania) and 30 normal male were included in the study, with the aim to determine the comparison of personality characteristic of Bipolar affective disorder (Mania) and Normal control group. Each individual was given the inform consent response than collected Socio demographic and Clinical data sheet after that Young mania rating scale and 16 personality factor was applied for data collection.Result: Present study explore that the Manic (BAD) groups of subject differ significantly on all the factors except Q4 from normal controls. Higher mean scores on factor Q4 means that manic (BAD) are tense, restless, fretful & driven, extremely high tension level was disrupt school and work performance.Conclusion: Both the groups differentiated significantly on all the factors except Q4. The mean score obtained by normal control has higher in comparison of BAD-manic category.

scholarly journals Use of Dermatoglyphic Parameters as Possible Markers in Bipolar Affective Disorder

2021 ◽  
Vol 11 (7) ◽  
pp. 385-393
Author(s):  
Amit Kumar Pal ◽  
Sagarika Ray ◽  
Jishnu Bhattacharya
Keyword(s):  
Bipolar Disorder ◽  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Control Group ◽  
Healthy Controls ◽  
Ridge Count ◽  
Primordial Prevention ◽  
And Gender ◽  
The Individual ◽  
Bipolar Patients

Background: Bipolar affective disorder is an episodic illness characterized by fluctuating mood states. Association of dermatoglyphic traits with bipolar affective disorder has been observed in various studies. This study was undertaken to evaluate epidermal ridge patterns in bipolar patients as compared to healthy controls attending a super speciality district hospital in West Bengal. Context and purpose of study: Establishing dermatoglyphic parameters as biomarkers for early diagnosis and consequently, prompt intervention in bipolar affective disorder will ensure a greater scope of recovery, and thus promote a better quality of life for the individual as well as lower the burden of disease for the society. Methods: Quantitative dermatoglyphic parameters namely, Total Finger Ridge Count (TFRC), Total A-B Ridge Count (TABRC), and ATD Angle of 100 bipolar patients were compared to 100 age and gender matched healthy controls. Results: Statistically significant differences were found on comparing the dermatoglyphic parameters between cases and controls. TFRC was found to be decreased while ATD angle was increased in bipolar cases, as compared to the control group. However, no significant change was observed in TABRC between the two groups. Conclusions: This study found a significant association between dermatoglyphic pattern anomalies and the development of bipolarity. This may offer a scope of primordial prevention of bipolar disorder in future. Key words: Dermatoglyphics, ridge pattern, bipolar disorder, Total Finger Ridge Count (TFRC), Total A-B Ridge Count (TABRC), ATD angle.

A Mutation in the Thrombomodulin Gene, 127G to A Coding for Ala25Thr, and the Risk of Myocardial Infarction in Men

1998 ◽  
Vol 80 (11) ◽  
pp. 743-748 ◽  
Author(s):  
Carine Doggen ◽  
Gabriella Kunz ◽  
Frits Rosendaal ◽  
Hans Vos ◽  
Peter Stubbs ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Risk Factor ◽  
Single Strand Conformation Polymorphism ◽  
Cell Surface Receptor ◽  
Control Group ◽  
Metabolic Risk Factor ◽  
Polymorphism Analysis ◽  
Additional Risk ◽  
Predicted Risk

SummaryThrombomodulin is an endothelial cell surface receptor that transforms the procoagulant thrombin into an anticoagulant. A mutation in the thrombomodulin gene is a potential risk factor for venous and arterial thrombosis.We screened a region within the coding sequence of the thrombomodulin gene by single-strand conformation polymorphism analysis (SSCP) in a pilot study of 104 patients with myocardial infarction and 104 age, sex and race matched controls. We identified a 127G to A mutation in the gene, which predicts an Ala25Thr substitution, in 2 out of 104 patients (1 man and 1 woman) with myocardial infarction but in no controls. We assessed the risk of myocardial infarction associated with the mutation in a larger “Study of Myocardial Infarctions Leiden” (SMILE). Among 560 men with a first myocardial infarction before the age of 70, 12 were carriers of the Ala25Thr substitution. In a control group of 646 men, frequency-matched for age, seven were carriers of the Ala25Thr substitution. The allelic frequencies were 1.07% among patients and 0.54% among controls suggesting risk associated with the mutation [odds ratio (OR) 2.0, 95% confidence interval (CI) 0.8-5.1]. In patients aged below 50, the predicted risk was almost seven times increased (OR 6.5, CI 0.8-54.2). In the presence of additional risk factors, such as smoking and a metabolic risk factor, the predicted risk increased to 9-fold (OR 8.8, CI 1.8-42.2) and 4-fold (OR 4.4, CI 0.9-21.3), respectively.While not conclusive, these results strongly suggest that the Ala25Thr substitution is a risk factor for myocardial infarction, especially in young men, and when in the presence of additional risk factors.

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