scholarly journals The Effects of Continuous and High Intensity Interval Trainings on Plasma Betatrophin Level in Diabetic Rats Treated with Metformin

2020 ◽  
Author(s):  
Yadollah Mahmoudi ◽  
Mandana Gholami ◽  
Hojatolah Nikbakht ◽  
Khosrow Ebrahim ◽  
Salar Bakhtiyari
Keyword(s):  
Blood Glucose ◽  
High Intensity ◽  
Training Session ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Moderate Intensity ◽  
Control Group ◽  
P Value ◽  
Continuous Training ◽  
High Intensity Interval

Objective: The study aimed to determine the effect of eight weeks high intensity interval (HIIT) and sub-maximal continuous trainings on plasma betatrophin level in diabetic rats treated with metformin. Materials and Methods: In this experimental study, 42 diabeticwistar rats were divided into six groups (n=7): diabetic control (C), diabetic control + metformin consumption(C+M), diabetic HIIT, diabetic HIIT + metformin (HIIT+M), diabetic sub-maximal continuous training (SMCT), and diabetic sub-maximal continuous training + metformin (SMCT+M). Metformin was given 150 mg/kg/day by gavage every day, 48 hours after the end of the last training session, the rats were sacrificed. Then blood glucose and glycated hemoglobin (HbA1c) levels were measured. One-way ANOVA test was used for statistical analysis of data. Results: The level of plasma betatrophin was significantly different in the HIIT ( P -value= 0.01) and C+M ( P -value= 0.001) groups compared to C group. Blood glucose was significantly decreased in all training groups with or without betatrophin compared with the diabetic control group ( P -value= 0.001). However, there were no significant changes between glucose levels in HIIT, HIIT+M, SMCT, and SMCT+M groups but SMCT showed most reduction in blood glucose. Conclusion: Treatment with metformin did not change blood glucose but two types of exercise training with high and moderate intensity reduced blood glucose thus exercise can be a good alternative modality rather than taking medicine.

High-intensity interval training has a greater effect on reverse cholesterol transport elements compared with moderate-intensity continuous training in obese male rats

2019 ◽  
pp. 204748731988782 ◽  
Author(s):  
Saleh Rahmati-Ahmadabad ◽  
Mohammad-Ali Azarbayjani ◽  
Parvin Farzanegi ◽  
Lida Moradi
Keyword(s):  
High Intensity ◽  
Reverse Cholesterol Transport ◽  
Training Session ◽  
Interval Training ◽  
Male Rats ◽  
Moderate Intensity ◽  
Cholesterol Transport ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
High Intensity Interval

Objectives The present study compares the effect of high-intensity interval training (HIIT; 18 min) and moderate-intensity continuous training (MIT; 1 h) on reverse cholesterol transport (RCT) elements in obese subjects. Methods Thirty adult male rats were induced high-fat diet (HFD) for 12 weeks. After four weeks, the rats were randomly divided into three groups while simultaneously continuing the HFD for the remaining eight weeks. Group specificities were HFD–control, HFD–MIT and HFD–HIIT. The rats were sacrificed 48 h after the last training session and the samples were collected. Analysis of variance and Pearson’s correlation test were used for the statistical analyses (significance level: p ≤ 0.05). Results The results showed that both HIIT and MIT improved heart ABCA1, ABCG1, ABCG4, ABCG5, ABCG8, LXR-α and PPARγ gene expression as well as plasma Apo A1, LCAT, lipids and lipoproteins ( p ≤ 0.05). Moreover, higher cardiac ABCA1, ABCG1, ABCG4, ABCG5, ABCG8 and PPARγ expression and plasma high-density lipoprotein cholesterol ( p ≤ 0.05) concentrations were found in the HFD–HIIT group compared with the HFD–MIT group. Conclusion HIIT may have more cardioprotective effects than MIT against atherosclerosis, along with saving time, as supported by the changes observed in the main factors involved in the RCT process.

scholarly journals Effects of High Intensity Interval versus Moderate Continuous Training on Markers of Ventilatory and Cardiac Efficiency in Coronary Heart Disease Patients

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Gustavo G. Cardozo ◽  
Ricardo B. Oliveira ◽  
Paulo T. V. Farinatti
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
High Intensity ◽  
Interval Training ◽  
Carbon Dioxide Production ◽  
Moderate Intensity ◽  
Control Group ◽  
Maximal Heart Rate ◽  
Continuous Training ◽  
High Intensity Interval

Background. We tested the hypothesis that high intensity interval training (HIIT) would be more effective than moderate intensity continuous training (MIT) to improve newly emerged markers of cardiorespiratory fitness in coronary heart disease (CHD) patients, as the relationship between ventilation and carbon dioxide production (VE/VCO2slope), oxygen uptake efficiency slope (OUES), and oxygen pulse (O2P).Methods. Seventy-one patients with optimized treatment were randomly assigned into HIIT (n=23, age = 56 ± 12 years), MIT (n=24, age = 62 ± 12 years), or nonexercise control group (CG) (n=24, age = 64 ± 12 years). MIT performed 30 min of continuous aerobic exercise at 70–75% of maximal heart rate (HRmax), and HIIT performed 30 min sessions split in 2 min alternate bouts at 60%/90% HRmax (3 times/week for 16 weeks).Results. No differences among groups (before versus after) were found for VE/VCO2slope or OUES (P>0.05). After training the O2P slope increased in HIIT (22%,P<0.05) but not in MIT (2%,P>0.05), while decreased in CG (−20%,P<0.05) becoming lower versus HIIT (P=0.03).Conclusion. HIIT was more effective than MIT for improving O2P slope in CHD patients, while VE/VCO2slope and OUES were similarly improved by aerobic training regimens versus controls.

High-intensity interval training improves interventricular synchrony and strain under hypoxic stress in sedentary males

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
Y.C Huang ◽  
J.S Wang
Keyword(s):  
High Intensity ◽  
Interval Training ◽  
Moderate Intensity ◽  
Control Group ◽  
Funding Source ◽  
Peak Strain ◽  
High Intensity Interval Training ◽  
The Difference ◽  
High Intensity Interval ◽  
Longitudinal Strains

Abstract Background Interventricular interactions in increased RV afterload such as hypoxia stress, which affects both synchrony and function in an in-series effect as well as a parallel effect arising from leftward septal shift. Improved myocardial contractility is a critical circulatory adaptation to exercise training, however, the types of exercise that can improve interventricular synchrony under hypoxic environment have not yet been established. Purpose This study investigates how high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) influence on the interventricular synchrony in response to normobaric hypoxia in sedentary men. Methods Fifty-four sedentary males were randomized to perform HIIT (3-minute intervals at 40% and 80% VO2peak, n=18), MICT (sustained 60% VO2peak, n=18) for 30 minutes/day, 5 days/week for 6 weeks and the control group (CTL, n=18). Synchrony measurements at apical 4-chamber view including (1) intra-delay, the difference in time to peak strain (TS) between segmental septal-to-lateral ventricular or atrial walls, and (2) inter-delay, the difference in TS between RV or RA free wall and LV or LA lateral wall. The data were acquired by 2-dimensional speckle tracking echocardiography at rest under hypoxic condition (12% FIO2, simulated an altitude of 4,500 m) before and after the interventions. Results HIIT had significantly elevated radial and longitudinal strains in both LA and LV (p&lt;0.05). As the results showed, HIIT was superior than MICT in improvement of longitudinal intra-delay of LV; furthermore, only HIIT simultaneously ameliorated both radial and longitudinal synchrony at apex. Although the HIIT enhanced intraventricular synchrony in both motions, whereas the interventricular synchrony deteriorated at radial motion. In atrium synchrony, although both groups augmented the intra-LA synchrony, however, only HIIT reduced the inter-delay between LA and RA at the roof motion. LV end-systolic volume (ESV) significantly correlated with the longitudinal inter-delay of ventricle (r=−0.53, p&lt;0.05), whereas the LV end-diastolic volume (EDV) correlated with the inter-delay of atrium in roof motion (r=0.40, p&lt;0.05). Conclusion We found differences between HIIT and MICT in segmental intra- and inter- synchrony. HIIT enhanced both ventricular or atrial synchrony, and further increased the EDV coupled with decreased ESV. These findings give new insight into cardiac adaptation to difference endurance training and the long-term impact of such changes warrants future study in cardiac diseases. Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): National Science Council of Taiwan

Moderate-intensity continuous training and high-intensity interval training improve cognition, and BDNF levels of middle-aged overweight men

2021 ◽  
Author(s):  
Neumir Sales de Lima ◽  
Ricardo Augusto Leoni De Sousa ◽  
Fabiano Trigueiro Amorim ◽  
Fernando Gripp ◽  
Caíque Olegário Diniz e Magalhães ◽  
...  
Keyword(s):  
High Intensity ◽  
Interval Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Middle Aged ◽  
Continuous Training ◽  
High Intensity Interval

scholarly journals The Effects of High-Intensity Interval Training vs. Moderate-Intensity Continuous Training on Heart Rate Variability in Physically Inactive Adults

2018 ◽  
Vol 15 (7) ◽  
pp. 1508 ◽  
Author(s):  
Abdullah Alansare ◽  
Ken Alford ◽  
Sukho Lee ◽  
Tommie Church ◽  
Hyun Jung
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
High Intensity ◽  
Interval Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
Significant Interaction Effect ◽  
High Intensity Interval ◽  
Physically Inactive

Physically inactive adults are prevalent worldwide. This study compared the effects of short-term high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) on heart rate variability (HRV) in physically inactive adults as a preliminary study. Thirteen physically inactive male adults (27.5 ± 3.80 years) were randomly assigned to HIIT (N = 7) or MICT (N = 6). The HIIT program consisted of 20 min of interval training with cycling to rest ratio of 10/50 s at ≥90% HRpeak, while the MICT program consisted of 40 min of continuous cycling at 60–75% HRpeak. Both groups completed eight sessions of training within two weeks. Time and frequency domains of HRV were measured for 20 min with Actiwave-Cardio monitor (CamNtech, UK). The number of R-R interval and inter-beat interval (IBI) were significantly improved (p < 0.05) in both HIIT and MICT programs following eight sessions of training. A significant interaction effect for group by time was found in the lnLF/HF ratio (p < 0.05) where it was only improved in the HIIT group from pre- to post-test. The HIIT program is superior to MICT in improving HRV in physically inactive adults. The HIIT program can be applied as a time-efficient program for improving cardiac-autoregulation.

scholarly journals Short-Term High-Intensity Interval Training on Body Composition and Blood Glucose in Overweight and Obese Young Women

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Zhaowei Kong ◽  
Shengyan Sun ◽  
Min Liu ◽  
Qingde Shi
Keyword(s):  
Body Composition ◽  
Blood Glucose ◽  
Cardiorespiratory Fitness ◽  
Young Women ◽  
High Intensity ◽  
Interval Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Short Term ◽  
High Intensity Interval

This study was to determine the effects of five-week high-intensity interval training (HIIT) on cardiorespiratory fitness, body composition, blood glucose, and relevant systemic hormones when compared to moderate-intensity continuous training (MICT) in overweight and obese young women.Methods. Eighteen subjects completed 20 sessions of HIIT or MICT for five weeks. HIIT involved 60 × 8 s cycling at ~90% of peak oxygen consumption (V˙O2peak) interspersed with 12 s recovery, whereas MICT involved 40-minute continuous cycling at 65% ofV˙O2peak.V˙O2peak, body composition, blood glucose, and fasting serum hormones, including leptin, growth hormone, testosterone, cortisol, and fibroblast growth factor 21, were measured before and after training.Results. Both exercise groups achieved significant improvements inV˙O2peak(+7.9% in HIIT versus +11.7% in MICT) and peak power output (+13.8% in HIIT versus +21.9% in MICT) despite no training effects on body composition or the relevant systemic hormones. Blood glucose tended to be decreased after the intervention (p=0.062). The rating of perceived exertion in MICT was higher than that in HIIT (p=0.042).Conclusion. Compared with MICT, short-term HIIT is more time-efficient and is perceived as being easier for improving cardiorespiratory fitness and fasting blood glucose for overweight and obese young women.

scholarly journals Hypoglycemic Potential of Dietary Supplementation of Protein Isolate from Fermented Cucumeropsis manii in Streptozotocin Induced Hyperglycemic in Male Wistar Albino Rats

2021 ◽  
pp. 31-42
Author(s):  
A. O. Abiola ◽  
A. O. Iyoribhe ◽  
S. A. Adeniyi ◽  
O. B. Adu ◽  
A. S. Ogunbowale ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Concentration ◽  
Diabetic Control ◽  
Protein Isolate ◽  
Diabetic Rats ◽  
Control Group ◽  
Albino Rats ◽  
Antioxidant Enzyme Activities ◽  
Cvd Risk ◽  
Streptozotocin Induced Diabetes

The effect of Protein isolate from fermented melon seeds (Ogiri Protei Isolates; OPI) of Cucumeropsis manii on blood glucose, lipid profile, and antioxidant enzyme activities in streptozotocin (STZ)-induced diabetic rats was investigated. Thirty Male Wistar rats were divided into five equal groups. GThe first control group with no exposure. The second group of rats with Streptozotocin-induced non-treated diabetes. The 3rd and 4th groups of rats with Streptozotocin-induced diabetes supplemented with Ogiri protein isolates (200, 600 mg/kg in diet). And the 5th group of rats with Streptozotocin-induced diabetes administered glibenclamide in a dose 500 ug/kg in diet [17]. The OPI was administered for 6 weeks. The administration of OPI reduced the blood glucose concentration of the STZ-induced diabetic rats. Sera and hepatic superoxide dismutase, activities of the STZ-induced diabetic rats were significantly (P< 0.05) increased in comparison with the diabetic control rats. Lipid peroxidation of the supplemented OPI diabetic rats was significantly (P< 0.05) decreased in comparison with the diabetic control rats as the administration of OPI to the STZ-induced diabetic rats significantly increased the enzymes’ activities. The concentration of low-density lipoproteins in the OPI supplemented rats was significantly elevated. These data demonstrate that OPI supplements might be beneficial for correcting hyperglycemia but the consumption of OPI can modulate some tissue lipids in a direction not beneficial for CVD risk in patients with diabetes.

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