Seasonal Variations of Serum Zinc Concentration in Adult Population: Tehran Lipid and Glucose Study

2020 ◽  
Author(s):  
Sahar ASKARI ◽  
Golaleh ASGHARI ◽  
Hossein FARHADNEJAD ◽  
Arash GHANBARIAN ◽  
Parvin MIRMIRAN ◽  
...  
Keyword(s):  
Seasonal Variations ◽  
Zinc Concentration ◽  
Adult Population ◽  
Geometric Mean ◽  
Serum Zinc ◽  
Seasonal Fluctuation ◽  
Serum Zinc Concentration ◽  
Four Seasons ◽  
Zinc Concentrations ◽  
General Populations

Background: Zinc, an essential trace element, plays a key role in many biological human body functions. Serum zinc concentration is the most widely used indicator of zinc status for general populations. Considering the limited data available on seasonal fluctuation of serum zinc concentration, we aimed at determining seasonal variations in serum zinc concentrations of Tehranian adults. Methods: The current study was conducted within the framework of the Tehran Lipid and Glucose Study, on 4698 subjects, aged ≥20 years. Serum zinc samples of subjects were obtained from all four seasons over three years (from 2009 to 2011); samples of similar seasons over three years were placed in one group and the geometric means of serum zinc concentration of four seasons were compared to determine possible seasonal variations. Results: Participants with mean age 46.3 yr and geometric mean of serum zinc concentration 116.3 µg/dl, were studied for almost three years through four seasons. Serum zinc concentrations in spring and summer were significantly higher than those in autumn and winter (112.2 and 114.4 vs. 106.7 and 104.8 µg/dl; P<0.001, respectively). Moreover, monthly serum zinc concentration of all subjects differed, with the lowest and highest levels found in October and August (98.5 vs. 122.7; P<0.001). Conclusion: This study demonstrates the difference in serum zinc concentration in Iranian adults of both genders in different months and seasons during the year.

scholarly journals Albendazole therapy reduces serum zinc in elementary school children with Ascaris lumbricoides infections

2016 ◽  
Vol 35 (3) ◽  
pp. 206
Author(s):  
Ria Buana ◽  
Jane Florida Kalumpiu ◽  
Yenny Djuardi ◽  
Taniawati Supali
Keyword(s):  
Elementary School ◽  
School Children ◽  
Ascaris Lumbricoides ◽  
Elementary School Children ◽  
Zinc Concentration ◽  
Serum Zinc ◽  
Absorption Spectrometry ◽  
Lower Serum ◽  
Serum Zinc Concentration ◽  
Zinc Concentrations

Background<br />Soil-transmitted helminth (STH) infection can cause malnutrition and vice versa, and decrease serum zinc concentrations. No previous studies were found on the effect of STH treatment on serum zinc concentrations in elementary school children. The objective of this study was to evalaute the effect of STH treatment on serum zinc concentration in elementary school children in Jakarta. <br /><br />Methods<br />A pre-experimental study (one group pre and post) was conducted on 3rd - 5th grade students in one elementary school in North Jakarta. FLOTAC examination was used to determine infection status and STH intensity, while serum zinc concentrations were measured by atomic absorption spectrometry. All children were given albendazole 400 mg for three consecutive days. Stool and blood samples were collected before and three weeks after treatment with albendazole. A paired t test was used to analyze the data. <br /><br />Results<br />The STH prevalence was 63.4%; these were mainly Ascaris lumbricoides and Trichuris trichiura infections. Before treatment, children infected with A.lumbricoides and T.trichiura had significantly higher serum zinc concentrations (p=0.028; p=0.014). After treatment, children with A.lumbricoides had significantly lower serum zinc concentrations (p=0.039), while children with T.trichiura had slightly lower serum zinc concentrations (p=0.659) than before treatment. <br /><br />Conclusions<br />Albendazole treatment produces lower serum zinc concentration in elementary school children with A.lumbricoides infections. A profound understanding of the interaction between helminth infections and zinc may assist in guiding integrated and sustainable intervention strategies among affected children throughout the world.

scholarly journals High Prevalence of Zinc Deficiency in Rural Nigerian Preschool Children: A Community-Based Cross-Sectional Study

2017 ◽  
Vol 24 (1) ◽  
pp. 31-39
Author(s):  
Amarabia N.E. Ibeawuchi ◽  
Alphonsus N. Onyiriuka ◽  
Philip O. Abiodun
Keyword(s):  
Zinc Deficiency ◽  
Rural Community ◽  
Zinc Concentration ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Community Based ◽  
Cross Sectional ◽  
Serum Zinc Concentration ◽  
High Prevalence ◽  
Zinc Concentrations

AbstractBackground and Aims: In Nigeria, community-based epidemiological data related to the prevalence of zinc deficiency in preschool children are scarce. We assessed the prevalence of zinc deficiency and the associated socio-demographic variables in children aged between 6 and 60 months, living in a Nigerian rural community.Materials and Methods: In this cross-sectional study, the serum zinc concentrations of 252 children aged between 6 and 60 months in a rural community in Nigeria were assessed, using atomic absorption spectrophotometry. The study population was selected by multistage random sampling and at least two children were selected from every household which had children in the study age group. The socio-demographic characteristics of the subjects were obtained, using an interviewer-administered questionnaire.Results: A total of 252 children were studied, 134 (53.2%) males and 118 (46.8%) females. The mean age was 32.7±17.0 months, similar for both sexes. Overall, 220 (87.3%) had low serum zinc concentrations (less than 7.65µmol/L). According to age, the highest mean serum zinc concentration was 5.43±3.52µmol/L in children aged between 6 and 12 months. Correlation between serum zinc concentration and family size or socio-economic status (SES) showed that the smaller the family size and the higher the SES, the higher the serum zinc concentration.Conclusions: The high prevalence of low serum zinc concentration indicates that zinc deficiency is a public health problem in our rural communities, requiring public health intervention.

scholarly journals Comparative study of serum zinc concentrations in benign and malignant prostate disease: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Jiang Zhao ◽  
Qingjian Wu ◽  
Xiaoyan Hu ◽  
Xingyou Dong ◽  
Liang Wang ◽  
...  
Keyword(s):  
Zinc Concentration ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Cochrane Library ◽  
Prostatic Disease ◽  
Serum Zinc Concentration ◽  
Prostate Disease ◽  
Zinc Concentrations ◽  
The Relationship ◽  
Normal Controls

Abstract Many studies have investigated the relationship between serum zinc concentration and prostatic disease, but have shown inconsistent results. Hence, we performed a systematic literature review and meta-analysis to assess the correlation between serum zinc concentration and prostate disease. Systematic literature searches were conducted with PubMed, EMBASE, Science Direct/Elsevier, MEDLINE, CNKI and the Cochrane Library up to June 2015 for studies that involved the relationship between serum zinc concentration and prostate disease. Fourteen studies were identified from the databases. Our results illustrated that the serum zinc concentrations in prostate cancer patients were significantly lower than those in Benign prostatic hyperplasia (BPH) patients and normal controls (SMD (95% CI), −0.94 [−1.57, −0.32]; −1.18 [−1.90, −0.45]). However, the serum zinc concentrations in BPH patients were significantly higher than those in normal controls (SMD (95% CI) 1.77 [0.15, 3.39]). The present study showed that different levels of serum zinc concentrations are correlated with different prostatic disease. Serum zinc concentration may be used as a tool for the diagnosis and screening of prostate disease. But, further studies with well-designed larger sample studies are needed in this field to further clarify the correlation between serum zinc concentration and prostate disease.

scholarly journals Administration of zinc to preterm infants with hypozincemia does not reduce serum copper concentrations in most cases: a single-center retrospective observational study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Toshikazu Ito ◽  
Kazuya Uenoyama ◽  
Kazuhiro Kobayashi ◽  
Mikio Kakumoto ◽  
Hiroshi Mizumoto ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Zinc Acetate ◽  
Zinc Concentration ◽  
Zinc Acetate Dihydrate ◽  
Serum Zinc ◽  
Serum Copper ◽  
Acetate Dihydrate ◽  
Serum Zinc Concentration ◽  
Postmenstrual Age ◽  
Zinc Concentrations

Abstract Background Zinc is an essential trace element involved in various physiological functions. In Japan, zinc acetate dihydrate is administered to neonates and infants with hypozincemia. Since serum copper concentrations are reduced by the administration of zinc, we retrospectively investigated changes in serum zinc and copper concentrations in preterm infants with hypozincemia receiving zinc acetate dihydrate. Methods Sixty-three preterm infants were included in the present study. Serum zinc and copper concentrations, doses, and other clinical characteristics were retrieved from electronic medical records. Results The medians and interquartile ranges of the dosage and duration of zinc acetate dihydrate were 2.1 (1.8–2.5) mg/kg/day and 12.0 (10.0–13.0) days, respectively. Its administration increased serum zinc concentrations in 39 patients (61.9%) and to more than 70 μg/dL in 16 patients (25.4%). The group with a serum zinc concentration of 70 μg/dL or higher after administration had a significantly higher zinc dose of 2.5 mg/kg/day than the group with a serum zinc concentration of less than 70 μg/dL. Serum copper concentrations did not decrease in 44 patients (69.8%). In the group with a decreased serum copper concentration, postmenstrual age and body weight were significantly lower, while serum zinc concentrations were significantly higher at the start of administration. Conclusion The present results showed that when zinc acetate dihydrate was administered to preterm infants with hypozincemia, it was possible to increase serum zinc concentrations without decreasing serum copper concentrations in many cases. However, caution may be required when administering zinc to preterm infants with a lower postmenstrual age or milder hypozincemia because serum copper concentrations may decrease.

Use of Serum Zinc Concentration as an Indicator of Population Zinc Status

2007 ◽  
Vol 28 (3_suppl3) ◽  
pp. S403-S429 ◽  
Author(s):  
Sonja Y. Hess ◽  
Janet M. Peerson ◽  
Janet C. King ◽  
Kenneth H. Brown
Keyword(s):  
Zinc Deficiency ◽  
Zinc Concentration ◽  
Zinc Supplementation ◽  
Serum Zinc ◽  
Interindividual Variation ◽  
Zinc Status ◽  
Dietary Zinc ◽  
Serum Zinc Concentration ◽  
Zinc Concentrations ◽  
Intervention Trials

Assessing the prevalence and severity of zinc deficiency in populations is critical to determine the need for and appropriate targeting of zinc intervention programs and to assess their effectiveness for improving the health and well-being of high-risk populations. However, there is very little information on the zinc status of populations worldwide due to the lack of consensus on appropriate biochemical indicators of zinc status. The objective of this review was to evaluate the use of serum zinc concentration as an indicator of population zinc status. We have reviewed the response of serum zinc concentration to dietary zinc restriction and zinc supplementation. In addition, we completed pooled analyses of nine zinc intervention trials in young children to assess the relations between serum zinc concentration of individuals before treatment and their responses to zinc supplementation. Also, in updated combined analyses of previously published data, we investigated the relation between the mean initial serum zinc concentration of a study population and their mean growth responses to zinc supplementation in randomized intervention trials among children. The results from depletion/repletion studies indicate that serum zinc concentrations respond appreciably to severe dietary zinc restriction, although there is considerable interindividual variation in these responses. There is also clear evidence that both individual and population mean serum zinc concentrations increase consistently during zinc supplementation, regardless of the initial level of serum zinc concentration. By contrast, an individual's serum zinc concentration does not reliably predict that person's response to zinc supplementation. Serum zinc concentration can be considered a useful biomarker of a population's risk of zinc deficiency and response to zinc interventions, although it may not be a reliable indicator of individual zinc status.

A positive association between maternal serum zinc concentration and birth weight

1990 ◽  
Vol 51 (4) ◽  
pp. 678-684 ◽  
Author(s):  
Y H Neggers ◽  
G R Cutter ◽  
R T Acton ◽  
J O Alvarez ◽  
J L Bonner ◽  
...  
Keyword(s):  
Birth Weight ◽  
Zinc Concentration ◽  
Serum Zinc ◽  
Positive Association ◽  
Maternal Serum ◽  
Serum Zinc Concentration

Reduced Serum Zinc Concentration During Pregnancy

1983 ◽  
Vol 62 (3) ◽  
pp. 313-318 ◽  
Author(s):  
C. A. SWANSON ◽  
J. C. KING
Keyword(s):  
Zinc Concentration ◽  
Serum Zinc ◽  
Serum Zinc Concentration

Serum Zinc Level in Pre-eclamptic Pregnancies: Association with Clinical Complication

1970 ◽  
Vol 39 (1) ◽  
pp. 7-10
Author(s):  
Touhida Ahsan ◽  
Razia Sultana Begum ◽  
Sheikh Naznul Islam
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Zinc Concentration ◽  
Serum Zinc ◽  
Zinc Level ◽  
Contributory Factor ◽  
Serum Zinc Concentration ◽  
Correlative Analysis ◽  
Blood Pressures ◽  
In Pregnancy

Pre-eclampsia is one of the fatal complications in pregnancy. Zinc plays an important role in the course and eventual outcome of human pregnancy, and is essential for normal embryogenesis and fetal growth. Zinc deficiency in pregnancy is thought to be associated with pre-eclampsia. The aim of this study was, therefore, to investigate the scum zinc level in pre-eclampsia and to examine its association (if any) with pre-eclampsia. A case control study was done among 45 pre-eclamptic and 35 normotensive pregnants at their third trimester. Serum zinc concentration was determined by Atomic Absorption Flame Spectrophotometric method. Correlative analysis was made to find any correlation, of serum zinc with blood Pressure. Results showed identical Maternal and gestational age, and different gravida distribution for the patients and controls, and significantly (P<0.005) higher blood pressures (systolic and diastolic) for pre-eclampsia. Serum zinc concentration were estimated 0.65±0.09mg/L in pre-eclamsia and 0.60±0.08mg/L in pregnant controls, difference of which was insignificant (p=0.284). Correlative analysis wowed that there was a linear correlation between serum level and diastolic blood pressure, but it was found to be insignificant (r=0.158, p=0.330). It was suggested that changes in zinc status may not be an etiological or contributory factor in pre-eclamsia. Key words: Serum zinc; pre-eclampsia; diastolic blood pressure DOI: 10.3329/bmj.v39i1.6226 Bangladesh Medical Journal 2010; 39(1): 7-10

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