The Success Rate and Factors Affecting the Outcome of Assisted Reproductive Treatment in Subfertile Men

2020 ◽  
Author(s):  
Alireza ZARINARA ◽  
Hojjat ZERAATI ◽  
Koorosh KAMALI ◽  
Kazem MOHAMMAD ◽  
Maryam RAHMATI ◽  
...  
Keyword(s):  
Success Rate ◽  
Live Birth ◽  
Treatment Success ◽  
Previous History ◽  
Infertility Treatment ◽  
Continuous Treatment ◽  
Male Factor ◽  
Historical Cohort ◽  
Factors Affecting ◽  
Treatment Type

Background: This study was conducted to evaluate the success rate of male infertility treatment and the factors affecting its outcome. Methods: In a historical cohort study, from Mar 2013 to Mar 2014, 323 couples with male factor were investigated. Couples had treated with IUI or/and ICSI were included randomly. Assisted reproduction technology (ART) outcome (treatment success) was defined as a live birth. Age, duration of infertility, type of infertility, treatment history and clinical examination results were investigated. The logistic regression and survival analysis were applied. Results: The average of men age, duration of infertility and BMI were 33.5, 4.7 (yr) and 26.6 (kg/m2 ) respectively. 87.9% of men have primary infertility and average duration of treatment was 14.1(month). Previous treatment, type of infertility, treatment method, man's BMI, normality of sperm and sperm head were important variable that affecting outcome. The rate of live birth in the first attempt was 29.7%, and 44.9% of the couples succeeded to give live birth after several treatment cycles. Couples who had no previous history of treatment were 8.5 times more successful in live birth. The Cox analysis showed that "BMI of man" and percentage of "Sperm with normal head" are predictors that had a significant effect on live birth. Conclusion: Live birth in the first treatment cycles was influenced by four variables but two other variable were affecting several treatment cycles outcome. The chances of successful treatment were higher with taking into account the length of time and having live birth was determined as 78% for five years of continuous treatment.

scholarly journals Estimation Methods for Infertility Treatment Success: Comparison of Four Methods

2021 ◽  
Author(s):  
Alireza Zarinara ◽  
Koorosh Kamali ◽  
Mohammad Mahdi Akhondi
Keyword(s):  
Survival Analysis ◽  
Success Rate ◽  
Life Table ◽  
Conditional Probability ◽  
Live Birth ◽  
Treatment Cycle ◽  
Treatment Success ◽  
Infertility Treatment ◽  
Estimation Methods ◽  
Infertile Couples

Objective: To analyze and compare four methods for estimating the chance of treatment success in infertile couples. Materials and methods: In a retrospective cohort study, information on demographic and clinical features, including age, body mass index (BMI), duration of infertility, semen analysis, previous history of treatment and clinical examination of infertile couples were analyzed. Treatment success (childbearing) was calculated with four methods as live birth ratio, conditional probability and survival analysis (life table and Kaplan-Meyer method) and results are compared. Results: The fertility ratio for the first treatment cycle was 29.72% which decreased to 23.13% by total treatment cycles. The success rate was 75.4%. With conditional probability calculation at the end of the five treatment cycles. With the life table method in a five-year period, the probability for live birth was 78% and by Kaplan-Meyer method 73.1% and the median of treatment time was 562 days. Conclusion: Calculation of infertility treatment success rate by only simple live birth ratio of childbearing couples is associated with underestimation. Using the conditional probability method reduces that underestimation, but it is not considered the censored cases in the treatments. It seems life table (as a proxy of survival analysis) presents the closest estimation to clinical facts with considering the repetition of the treatment cycle and the duration of treatment.

P–310 Women with endometriosis achieve live birth after a similar number of embryo transfers independent of the endometriosis subtype

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
A Koh. Schwartz ◽  
A Vidal ◽  
L Fritsche ◽  
K Nirgianakis ◽  
M Vo. Wolff ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Live Birth ◽  
Comparison Group ◽  
Treatment Success ◽  
University Hospital ◽  
Control Group ◽  
Deep Infiltrating Endometriosis ◽  
Male Factor ◽  
Ovarian Endometriosis ◽  
Infiltrating Endometriosis

Abstract Study question How many embryo transfers are needed to achieve the first live birth in women with endometriosis depending on disease localisation? Summary answer The number of transfers needed to achieve live birth in women with endometriosis is independent from the disease’s subtype. What is known already Infertility is one of the leading symptoms in women with endometriosis. Endometriosis is also known to negatively impact in-vitro fertilization (IVF) outcome. A reduction of oocyte yield, especially of mature oocytes in women with endometrioma (OMA) and deep infiltrating endometriosis (DIE) has been shown. Inflammatory processes possibly affect folliculogenesis and oocyte development, maybe impeding embryo development and implantation. In contrast, even with fewer retrieved oocytes per cycle live birth rate was not affected. However, it is currently unknown if specific endometriosis subtypes could differentially affect IVF success. This would be relevant for a more targeted counseling regarding the treatment success. Study design, size, duration This is a single-center cohort study including women (N = 229) with embryo transfer cycles leading to live birth at the Bern University Hospital between 2010 and 2017. We only included women until they achieved the first live birth at our center. Participants/materials, setting, methods: We included 86 women with endometriosis and 143 women with male factor infertility serving as comparison group. We collected patient characteristics, details from the endometriosis surgery and reproductive treatment and outcomes from medical reports. We hierarchically classified the dominant endometriosis localizations as follows: deep infiltrating endometriosis (DIE, N = 21) > ovarian endometriosis (OMA, N = 35) > superficial peritoneal endometriosis (SUP, N = 30). We compared the number of embryo transfers needed to achieve a live birth. Main results and the role of chance Women with endometriosis were older (34.5 ± 3.9 years) than women from the control group (33.4 ± 3.9), p = 0.03. Body-mass-index, previous parity or Anti-Mullerian hormone level did not differ between the groups SUP, OMA, DIE or the comparison group. The number of necessary embryo transfer cycles to achieve a live birth did not differ between women with SUP (3.4 ± 2.6 embryo transfers), OMA (2.9 ± 2.0), DIE (3.0 ± 2.4) and the comparison group (2.9 ± 2.2), p = 0.59. IVF is beneficial in women with endometriosis, especially when OMA and/or DIE affect mobility of tubes and ovaries and spontaneous pregnancy is unlikely or impossible. This could account for the equal number of transfer cycles needed to achieve a live birth in women with OMA compared to the comparison group, even though the women with endometriosis were of older age. This is reassuring when counseling women with endometriosis. Limitations, reasons for caution We did not calculate cumulative pregnancy rate per cycle, because in Switzerland IVF treatment is at the patient’s own cost and therefore biased. We wanted to include all women with endometriosis, so fresh and thawing cycles were included. Women from the comparison group had no surgical exclusion of endometriosis. Wider implications of the findings: Our study suggests that the endometriosis subtype does not determine the embryo transfer success rate after IVF and therefore is less relevant for counseling. Individualized anti-inflammatory treatment before embryo transfer might positively affect the cycles’ outcome. Studies with a larger sample are required to be more conclusive on this issue. Trial registration number BASEC 2015–00235

scholarly journals Trends of Tuberculosis Treatment Outcomes of Notified Cases in Three Refugee Camps in Sudan: A Four-year Retrospective Analysis, 2014–2017

2021 ◽  
Author(s):  
Tsegay Legesse ◽  
Mohammed Hussein Elduma ◽  
Nagi Masoud Awad ◽  
Mousab Siddig Elhag ◽  
Israa Abushama ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Success Rate ◽  
Treatment Outcomes ◽  
Treatment Success ◽  
Treatment Success Rate ◽  
Refugee Camps ◽  
Historical Cohort ◽  
Tb Treatment ◽  
Unsuccessful Treatment ◽  
Lost To Follow Up

Background: Refugees are vulnerable to tuberculosis (TB) infection. Tracking of program performance is needed to improve TB care and prevention. The objective of this study was to assess the trends of TB treatment outcomes of notified cases in three refugee camps in Sudan from 2014 to 2017. Methods: This study was a historical cohort study. Sex, age, type of TB, TB patient category, and treatment outcome of all TB cases registered in three refugee camps (Al Kashafa, Shagarab, Wadsherify) from January 1, 2014 to December 31, 2017 were collected from the TB register. Multivariable logistic regression was performed to explore factors for unsuccessful TB treatment. Results: A total of 710 TB cases of which 53.4% were men, 22.1% children (<15 years), and 36.2% extrapulmonary TB (EPTB) were registered. Overall, the TB treatment success rate was 75.7% with a declining trend from 86.2% in 2015 to 63.5% in 2017. On average, 11.4% were lost to follow-up (LTFU), 6.6% died, 5.9% were not evaluated, and in 0.3% the treatment failed. Being 15–24 years old and having EPTB were significantly associated with unsuccessful treatment outcome. Conclusion: The treatment success rate in the refugee camp in 2017 (63.5%) was far lower than the national treatment success rate (78%) and the End TB global target (≥90%) that needs to be improved. LTFU, died, and not evaluated outcomes were high which indicated the necessity to improve the TB treatment program.

scholarly journals Comparison of ICSI and Conventional IVF in Non-Male Factor Patients with Less Than Four Oocytes

2022 ◽  
Author(s):  
Mete Isikoglu ◽  
Ayşe Kendirci Kendirci Ceviren ◽  
Tuğba K Çetin ◽  
Ayşenur Avci ◽  
Batu K Aydınuraz ◽  
...  
Keyword(s):  
Live Birth ◽  
Semen Quality ◽  
Previous History ◽  
Implantation Rate ◽  
Factor Group ◽  
Semen Parameters ◽  
Study Patient ◽  
Male Factor ◽  
Fertilisation Rate ◽  
Group 1

Abstract Background: We aimed to analyse our clinical results for a particular subgroup of patients with poor ovarian response (POR) in order to clarify if lower number of oocytes is a drawback for proceeding to C-IVFMaterials and methods: In this retrospective study, patient files of all couples (#1733) who underwent oocyte retrieval between January 2017 and December 2019 were reviewed and 191 cases diagnosed with non-male factor infertility in which ≤3 cumulus-oocyte-complexes available for fertilisation were analysed. Exclusion criteria were: woman age>42, patients with a history of previous ART trial, prenatal genetic testing cycles and couples undergoing total cryopreservation for any indication. Three groups were constructed depending on the method of fertilisation and on semen quality as follows: IVF non-male factor (Group 1,n=77); ICSI non-male factor (Group 2, n=65); ICSI male factor- ICSI/MF n=49 according to WHO reference values. Main outcome parameters were: fertilisation rate, implantation rate and live birth rate. Results: Fertilisation rate per collected COC was significantly higher in group 1 compared to the other two groups (85,68%, 72,58%, 73,33% respectively, p=0,004). FR per inseminated oocyte also tended to be higher in group 1 but not reaching a statistically significant level. Both techniques yielded similar implantation rates (20,42%, 28,49%, 23,33% respectively, p=0,407) and live birth rates (26,8%, 30,6%, 31,1% respectively, p=0.643).Conclusions: In the presence of normal semen parameters, low egg number is not an indication to perform ICSI. The choice of fertilisation method should be based primarily on semen quality, in combination with the patient’s previous history regardless of the ovarian reserve.

scholarly journals Single versus double intrauterine insemination to assess the relevance of double intrauterine insemination: a prospective, randomized multicentric study

2021 ◽  
Vol 10 (6) ◽  
pp. 2459
Author(s):  
Deepak Patil
Keyword(s):  
Success Rate ◽  
Intrauterine Insemination ◽  
Randomized Study ◽  
Tertiary Care ◽  
Armed Forces ◽  
Male Factor ◽  
Assisted Reproductive Technique ◽  
Multicentric Study ◽  
Factors Affecting ◽  
Tertiary Care Centers

Background: Intrauterine insemination (IUI) is a widely used tool as initial treatment option for infertile couples. Being a non-invasive, outpatient department (OPD) based procedure it serves as first modality of assisted reproductive technique. Overtime various modifications in stimulation protocol, sperm preparation techniques and variation in timing has been attempted to improve upon the success rates.Methods: We conducted a multicentric, prospective randomized study and assessment of data of double IUI at three tertiary care centers of armed forces. The data was evaluated to study the patient parameters and various factors affecting the success rate of IUI.Results: We found that duration of infertility, age of couple and body mass index (BMI) are inversely related to success of IUI cycles. Double IUI increases the success rate in borderline male factor infertility, ladies with normal BMI and in cases of secondary infertility with previous live issue. In donor IUI cycles there is a positive correlation with sperm parameters and benefit from double insemination.Conclusions: Double IUI can be offered to selected couples to improve upon the success rate of IUI cycle.

Accuracies of Computer versus Manual Linkages of Routine Health Records

1979 ◽  
Vol 18 (02) ◽  
pp. 89-97 ◽  
Author(s):  
Martha E. Smith ◽  
H. B. Newcombe
Keyword(s):  
Success Rate ◽  
Record Linkage ◽  
Central Processor ◽  
Processor Time ◽  
Health Records ◽  
Factors Affecting ◽  
Linkage Methods ◽  
Empirical Tests ◽  
Speed Accuracy ◽  
Computer Operation

Empirical tests of the application of computer record linkage methods versus the use of routine clerical searching, for bringing together various vital and ill-health records, have shown that the success rate for the computer operation was higher (98.3 versus 96.7 per cent) and the proportion of false linkages very much lower (0.1 versus 2.3 per cent). The rate at which the ill-health records were processed by the computer was approximately 14,000 per minute of central processor time, representing a cost of a half a cent apiece.Factors affecting the speed, accuracy and cost of computerized record linkage are discussed.

Application of Automated FIB for TEM Sample Preparation in Semiconductor Failure Analysis

2014 ◽  
Author(s):  
Jie Zhu ◽  
Soo Sien Seah ◽  
Irene Tee ◽  
Bing Hai Liu ◽  
Eddie Er ◽  
...  
Keyword(s):  
Sample Preparation ◽  
Success Rate ◽  
Protective Layer ◽  
Factors Affecting ◽  
Dual Beam ◽  
Lamella Thickness ◽  
Surface Patterns ◽  
Working Parameters ◽  
Practical Factors ◽  
High Flexibility

Abstract In this paper, we describe automated FIB for TEM sample preparation using iFast software on a Helios 450HP dual-beam system. A robust iFast automation recipe needs to consider as many variables as possible in order to ensure consistent sample quality and high success rate. Variations mainly come from samples of different materials, structures, surface patterns, surface topography and surface charging. The recipe also needs to be user-friendly and provide high flexibility by allowing users to choose preferable working parameters for specific types of samples, such as: grounding, protective layer coating, milling steps, and final TEM lamella thickness/width. In addition to the iFast recipe, other practical factors affecting automation success rate are also discussed and highlighted.

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