scholarly journals Single versus double intrauterine insemination to assess the relevance of double intrauterine insemination: a prospective, randomized multicentric study

2021 ◽  
Vol 10 (6) ◽  
pp. 2459
Author(s):  
Deepak Patil
Keyword(s):  
Success Rate ◽  
Intrauterine Insemination ◽  
Randomized Study ◽  
Tertiary Care ◽  
Armed Forces ◽  
Male Factor ◽  
Assisted Reproductive Technique ◽  
Multicentric Study ◽  
Factors Affecting ◽  
Tertiary Care Centers

Background: Intrauterine insemination (IUI) is a widely used tool as initial treatment option for infertile couples. Being a non-invasive, outpatient department (OPD) based procedure it serves as first modality of assisted reproductive technique. Overtime various modifications in stimulation protocol, sperm preparation techniques and variation in timing has been attempted to improve upon the success rates.Methods: We conducted a multicentric, prospective randomized study and assessment of data of double IUI at three tertiary care centers of armed forces. The data was evaluated to study the patient parameters and various factors affecting the success rate of IUI.Results: We found that duration of infertility, age of couple and body mass index (BMI) are inversely related to success of IUI cycles. Double IUI increases the success rate in borderline male factor infertility, ladies with normal BMI and in cases of secondary infertility with previous live issue. In donor IUI cycles there is a positive correlation with sperm parameters and benefit from double insemination.Conclusions: Double IUI can be offered to selected couples to improve upon the success rate of IUI cycle.

scholarly journals Determinant factors affecting the trends of permanent sterilization: a decadal analysis in a tertiary care institute

2017 ◽  
Vol 6 (12) ◽  
pp. 5348 ◽  
Author(s):  
Meenakshi K. Bharadwaj ◽  
Seema Patrikar ◽  
Sanjay Singh
Keyword(s):  
Confidence Interval ◽  
Tertiary Care ◽  
Male Involvement ◽  
Cost Effective ◽  
Armed Forces ◽  
Fertility Rate ◽  
Factors Affecting ◽  
Care Institute ◽  
Socio Demographic Factors ◽  
Male Sterilization

Background: Permanent sterilization is a preferred method of contraception worldwide. In spite of popularization of temporary methods, it is used by 2/3rd of married women using any contraception. It has a low incidence of complications and failure rate and is cost-effective. Various socio-demographic factors play a role in acceptability of this method. It has an important role in controlling the total fertility rate.Methods: A retrospective record based analysis was done in armed forces personnel undergoing permanent sterilization operation over 11 years between 2005-2015 in a tertiary care institute. Analysis of trends in method choices of surgery, and comparison of the variables determining these choices was done. Year wise total fertility rates was calculated and the trend over 11 years was analyzed.Results: Permanent sterilization operations were performed in 2121 couples over the 11 years period. Of total operations, 1823 (85.95% with 95% confidence interval = 84.42, 87.38) were done in females and 298 (14.05% with 95% confidence interval = 12.62, 15.58) in males. Female sterilization acceptance ranged between 71.6% to 91.6% and male sterilization between 8.4%-28.4% with an increasing trend towards male sterilization acceptance over the years. Total fertility rate declined from 2.3 to 2.09 in 11 years.Conclusions: Increase in literacy rate of both the partners can positively impact the male involvement in permanent sterilization and control of TFR. This would help to stabilize India’s population growth. Also, a decline in son preference can be beneficial for decline in fertility rate. 

scholarly journals Study on Pregnancy Outcomes in Intrauterine Insemination Cycles with Motile Spermatozoa Insemination

2020 ◽  
Vol 19 (2) ◽  
pp. 41-45
Author(s):  
Mafruha Khanam ◽  
Rokeya Begum ◽  
Aditi Banerjee ◽  
Jesmin Jerin ◽  
Mohamed Mazih Fazyl ◽  
...  
Keyword(s):  
Success Rate ◽  
Endometrial Thickness ◽  
Intrauterine Insemination ◽  
Semen Analysis ◽  
Male Partner ◽  
Male Factor ◽  
Minimum Thickness ◽  
Successful Pregnancy ◽  
Multiple Variables ◽  
A Prospective Study

Background: Intrauterine Insemination (IUI) is one of the most common assisted reproductive technology methods in the world to treat various forms of infertility. The influence of number of IUI applied with the percentage of motile spermatozoa during insemination is critical on the likelihood of a successful pregnancy. The aim of our study is to assess the results of IUI as a function of the number of IUI applied with motile spermatozoa inseminated during intrauterine insemination in couples with infertility. Materials and methods: This is a prospective study conducted in Surgiscope Fertility Centre, Chattogram, Bangladesh over 21 months on 596 couples who underwent IUI from 01/12/2017 to 30/09/2019. We performed semen analysis of the male partner from the couples who underwent IUI, calculated the sperm motility and the relationship between number of IUI applied with motile spermatozoa and the pregnancy rate of IUI. Multiple variables were selected such as, patient parameters like age of female, number of IUI, percentage of motile spermatozoa inseminated, endometrial thickness and ovulation induction protocol which were recorded and statistically analyzed. Results: Among the 596 patients, the overall success rate was 11%. The maximum number of successes were observed in patients with 3 IUI applications whereas the success rate was lower in comparison with decreasing IUI applications. The regression between the success and number of insemination and age indicate that there is a statistically significant positive relationship between number of inseminations completed and the rate of successful pregnancy, but no significant relationship between the number of prewash sperm and successful pregnancy. These could be due to lower population size. As an ovulation inducing agent, a 12.42% success rate was observed among the patients administered with FSH whereas 9.28% was observed for patients administered with GONAL F. The mean endometrial thickness was observed to be 8.914 mm with a minimum thickness of 4.5 mm and a maximum thickness of 19 mm. Conclusion: The rationale for the use of insemination is to increase gamete density at the site of fertilization. This revealed that intrauterine insemination should be a firstchoice treatment rather than more invasive and expensive techniques of assisted reproduction in cases of cervical, unexplained and moderate male factor subfertility. Chatt Maa Shi Hosp Med Coll J; Vol.19 (2); July 2020; Page 41-45

scholarly journals A snapshot of children with congenital anomalies of the kidneys and urinary tract at three tertiary care centers of the armed forces

2020 ◽  
Vol 22 (2) ◽  
pp. 156
Author(s):  
Suprita Kalra ◽  
Arundhati Biswas ◽  
Tathagata Bose ◽  
RahulRanjan Mandal ◽  
Toshi Kapoor
Keyword(s):  
Urinary Tract ◽  
Congenital Anomalies ◽  
Tertiary Care ◽  
Armed Forces ◽  
Tertiary Care Centers

scholarly journals Outcome of Intra Uterine Insemination in Sahara International Fertility Centre Pokhara, Nepal

2018 ◽  
Vol 1 (2) ◽  
pp. 105-109
Author(s):  
Gir Dhari Sharma ◽  
Rajesh Adhikari ◽  
Shyam Sundar Parajuly ◽  
Kalpana Gautam Adhikari
Keyword(s):  
Success Rate ◽  
Pregnancy Rate ◽  
Intrauterine Insemination ◽  
Unexplained Infertility ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Reproductive Age ◽  
Male Factor ◽  
Ovulatory Dysfunction ◽  
Ejaculatory Dysfunction

Introduction: The incidence of infertility is about 10 to 15 % among reproductive age group. The cause of infertility may be either due to male factor or female factor or both. The main aim of this study was to evaluate the success rate of intrauterine insemination (IUI) in a private centre of Pokhara. Materials and Methods: This was a centre based retrospective study done in private fertility centre. Sub-fertile couples who were treated from January 1st 2015 to December 31st 2016 were enrolled for the study. Couples with unexplained male factor, ovulatory dysfunction, unilateral tubal occlusion and ejaculatory dysfunction were included in this study. Three hundred and eighty IUI cases were retrospectively reviewed. Clinical pregnancy rate was the primary outcome. Result: The success rate of IUI was 15.7%. It was higher among unexplained infertility cases. Clinical pregnancy rate was directly associated with the age of the patients, indications of infertility and number of cycles. Conclusion: Success rate of IUI in infertile couples who had unexplained infertility, tubal factor, ovulatory dysfunction was higher than male factor infertility and ejaculatory dysfunction.

scholarly journals Does increasing the number of inseminations per cycle increase the probability of conception? a randomized trial comparing single versus double intrauterine insemination

2020 ◽  
Vol 9 (8) ◽  
pp. 3171
Author(s):  
Yasaswi Khandavalli ◽  
Seema Rai ◽  
Rama Singodiya Lodha
Keyword(s):  
Pregnancy Rate ◽  
Intrauterine Insemination ◽  
Randomized Study ◽  
Male Factor ◽  
Non Invasive ◽  
Significant Difference ◽  
The Difference ◽  
Infertility Patients ◽  
Larger Sample ◽  
Single Versus

Background: Intrauterine insemination (IUI) remains an inexpensive, non-invasive, and effective first-line artificial insemination technique. The technique of IUI has evolved through various innovations since the time Cohen published the first report of IUI in 1962, and the success rate increased from 5% to >20%. The success of IUI depends upon several factors; two such prognostic factors are the timing and frequency of insemination.  The objective of this study was to compare the effectiveness of single versus double intrauterine insemination.Methods: This prospective randomized study was carried out in 130 patients with male factor infertility, PCOS and unexplained infertility. Patients were randomly assigned into two groups. In the first group of 65 patients, single IUI was applied at 36 to 40 hours after HCG administration, to the other 65 patients in the second group, double IUIs were applied at 12 to 16 hours and 36 to 40 hours after HCG administration. The primary end-point of the study was to compare the clinical pregnancy rate between the two groups.Results: The overall pregnancy rate was 18.46% (12/65) for single IUI group and 30.76% (20/65) for double IUI group. There was a no statistically significant difference between single and double IUI groups (p=0.16).Conclusions: This study did find a higher pregnancy rate following double IUI; however, the difference was not statistically significant. Further, larger sample size studies are required to determine if double IUI increases the pregnancy rate.

scholarly journals Relationship between pregnancy rate and number of intrauterine insemination cycles during the study of comparative efficacy of letrozole and clomiphene citrate adjuvants to gonadotropin stimulation in controlled ovarian stimulation cycles combined with intrauterine insemination therapy

2021 ◽  
Vol 11 (1) ◽  
pp. 106
Author(s):  
Pankaj Sharma ◽  
Ashok Verma ◽  
Kritika Katoch
Keyword(s):  
Pregnancy Rate ◽  
Intrauterine Insemination ◽  
Clomiphene Citrate ◽  
Randomized Study ◽  
Good Alternative ◽  
Human Menopausal Gonadotropin ◽  
Male Factor ◽  
Medical College ◽  
Group A ◽  
Group B

Background: Infertility is commonly defined as the failure of conception after at least twelve months of unprotected intercourse. Factors contributing are both male and female in which unexplained etiology accounts for 51%, male factor 28%, endometriosis 17% and ovulatory disorders 4%.Methods: Prospective, randomized study was conducted at DRRPG medical college, Tanda, Kangra, Himachal Pradesh. In our study, patients were randomized into two groups of 30 each. Women in group A received clomiphene citrate 100mg/day and group B received letrozole 2.5 mg/day from day 3-7 of menstrual cycle. All the patients received human menopausal gonadotropin 75 U given every alternate day from day 5 until HCG administration. Ovulation was triggered with recombinant HCG (5000 IUIM) when the dominant follicles reached 18 mm in diameter. A single IUI was performed 36 hours later. A maximum of four cycles were given.Results: In our study, total number of induction cycles given in group A and B were 120 and 114 respectively. Out of these, 112 and 111 IUI cycles were done in group A and B respectively. A pregnancy rate of 1.66% and 7.87% per IUI cycle was observed in group A and B respectively.Thus it is concluded that the pregnancy rates were significantly higher in letrozole group (30%) in comparison to clomiphene citrate group (6.66%).Conclusions: Aromatase inhibitor letrozole appears to constitute a good alternative to clomiphene citrate in patients with unexplained infertility undergoing gonadotropin-stimulated COS cycles combined with IUI therapy.

The Success Rate and Factors Affecting the Outcome of Assisted Reproductive Treatment in Subfertile Men

2020 ◽  
Author(s):  
Alireza ZARINARA ◽  
Hojjat ZERAATI ◽  
Koorosh KAMALI ◽  
Kazem MOHAMMAD ◽  
Maryam RAHMATI ◽  
...  
Keyword(s):  
Success Rate ◽  
Live Birth ◽  
Treatment Success ◽  
Previous History ◽  
Infertility Treatment ◽  
Continuous Treatment ◽  
Male Factor ◽  
Historical Cohort ◽  
Factors Affecting ◽  
Treatment Type

Background: This study was conducted to evaluate the success rate of male infertility treatment and the factors affecting its outcome. Methods: In a historical cohort study, from Mar 2013 to Mar 2014, 323 couples with male factor were investigated. Couples had treated with IUI or/and ICSI were included randomly. Assisted reproduction technology (ART) outcome (treatment success) was defined as a live birth. Age, duration of infertility, type of infertility, treatment history and clinical examination results were investigated. The logistic regression and survival analysis were applied. Results: The average of men age, duration of infertility and BMI were 33.5, 4.7 (yr) and 26.6 (kg/m2 ) respectively. 87.9% of men have primary infertility and average duration of treatment was 14.1(month). Previous treatment, type of infertility, treatment method, man's BMI, normality of sperm and sperm head were important variable that affecting outcome. The rate of live birth in the first attempt was 29.7%, and 44.9% of the couples succeeded to give live birth after several treatment cycles. Couples who had no previous history of treatment were 8.5 times more successful in live birth. The Cox analysis showed that "BMI of man" and percentage of "Sperm with normal head" are predictors that had a significant effect on live birth. Conclusion: Live birth in the first treatment cycles was influenced by four variables but two other variable were affecting several treatment cycles outcome. The chances of successful treatment were higher with taking into account the length of time and having live birth was determined as 78% for five years of continuous treatment.

scholarly journals FACTORS AFFECTING VISUAL OUTCOME IN INDIRECT TRAUMATIC OPTIC NEUROPATHY – A RETROSPECTIVE NON-RANDOMIZED STUDY

2020 ◽  
pp. 1-2
Author(s):  
Tharini. S ◽  
Subashini Kaliaperumal ◽  
Ramesh Babu K
Keyword(s):  
Visual Acuity ◽  
Optic Neuropathy ◽  
Road Traffic ◽  
Randomized Study ◽  
Tertiary Care ◽  
Visual Outcome ◽  
Treatment Modalities ◽  
Traumatic Optic Neuropathy ◽  
Tertiary Care Centre ◽  
Factors Affecting

Purpose To study the demographic profile and factors associated with visual outcome in patients with indirect traumatic optic neuropathy. Methods A retrospective study of patients admitted with indirect traumatic optic neuropathy, in a tertiary care centre in South India, from February 2016 to February 2018 was conducted. Patients with bony impingement on the optic nerve were treated with endoscopic surgical decompression and the rest were treated with low dose steroids. Visual acuity was assessed at presentation, 2 weeks and 3 months. Results The mean age of the patients was 31.6 years (13-75 years). 19(90.4%) patients were male and road traffic accident (95.23%) was the most common cause of injury. Mean time of presentation was 3.6 hours ( 1-7 hours) Vision at presentation was perception of light and above in 8(3.1%) and no perception of Light in 13(61.9%) patients. Visual improvement was seen in 4 out of 18 patients (22.2%) in the steroid group and 1 out of 3 patients (33.3%) in the surgery group. Visual acuity at presentation was significantly associated with final visual outcome (P=0.047). Conclusion Our study demonstrated that visual acuity at presentation was the only factor associated with final vision, irrespective of associated injuries and treatment modalities.

Accuracies of Computer versus Manual Linkages of Routine Health Records

1979 ◽  
Vol 18 (02) ◽  
pp. 89-97 ◽  
Author(s):  
Martha E. Smith ◽  
H. B. Newcombe
Keyword(s):  
Success Rate ◽  
Record Linkage ◽  
Central Processor ◽  
Processor Time ◽  
Health Records ◽  
Factors Affecting ◽  
Linkage Methods ◽  
Empirical Tests ◽  
Speed Accuracy ◽  
Computer Operation

Empirical tests of the application of computer record linkage methods versus the use of routine clerical searching, for bringing together various vital and ill-health records, have shown that the success rate for the computer operation was higher (98.3 versus 96.7 per cent) and the proportion of false linkages very much lower (0.1 versus 2.3 per cent). The rate at which the ill-health records were processed by the computer was approximately 14,000 per minute of central processor time, representing a cost of a half a cent apiece.Factors affecting the speed, accuracy and cost of computerized record linkage are discussed.

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