scholarly journals Changes in Serum Iron, Total Iron Binding Capacity and Transferrin Saturation Percent in Sudanese Females Newly Diagnosed with Breast Cancer at Khartoum Oncology Hospital: A case- control study

2017 ◽  
Vol 12 (3) ◽  
pp. 119
Author(s):  
Rufaida Mustafa Ahmed Mustafa ◽  
Nazik Elmalaika Obaid Seid Ahmed Husain
Keyword(s):  
Breast Cancer ◽  
Serum Iron ◽  
Case Control Study ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
Case Control ◽  
Newly Diagnosed ◽  
The Mean ◽  
Iron Binding Capacity ◽  
Control Study

Background:Iron is a vital constituent of cells but in excess may be harmful and is associated with a raised risk for some malignant diseases including breast cancer. We aimed to study changes in iron profile in Sudanese females newly diagnosed with breast cancer.Methods: A case- control study in which serum iron, Total Iron Binding Capacity (TIBC), and transferrin saturation percent were measured for fifty females with breast cancer referred to Khartoum Oncology Hospital and seventy apparently healthy females, using manual method (IRON-FERROZINE).  Results: Mean age was 47years and 42years in cases and control, respectively and the mean of parity was 4 in both groups. Mean of serum iron ±SD in case group was 244.30 ± 151.598(µg/dL)and in control group was 57.59 ± 43.191(µg/dL) (P. value = 0.000). Mean of TIBC ±SD in cases was 412.98 ± 177.460(µg/dL)and in controls it was 403.71 ± 168.765(µg/dL) (P.value = 0.838). The mean of transferrin saturation percent ± SD in cases was 61.08 % ±41.523 and in controls was 223.23 % ±149.195 (P.value=0.000). The mean of TIBC in grade I 343.00(µg/dL), 467.10(µg/dL) in grade II and 321.25(µg/dL) in grade III (P.value 0.019).Conclusion: There is a statistically significant increase in the mean of serum iron and decrease in transferrin saturation percent in women with breast cancer. TIBC vary significantly according to histopathological grade. Serum iron and transferrin saturation percent may be helpful as biochemical risk markers for breast cancer and TIBC may act as a predictor of disease grade.

scholarly journals Evaluation of serum iron overload, AST:ALT ratio and log10ferritin:AST ratio among schizophrenia patients in the Kumasi Metropolis, Ghana: a case–control study

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
W. K. B. A. Owiredu ◽  
Peter Kojo Brenya ◽  
Yaw Osei ◽  
Edwin Ferguson Laing ◽  
Clement Opoku Okrah ◽  
...  
Keyword(s):  
Serum Iron ◽  
Case Control Study ◽  
Transferrin Saturation ◽  
Case Control ◽  
Treatment Groups ◽  
Naive Group ◽  
Treatment Naïve ◽  
The Mean ◽  
Psychiatric Department ◽  
Control Study

Abstract Objective The association between unbalanced iron indices and the conditions of schizophrenia are not well understood. Liver dysfunction which has been linked to iron metabolism might be a contributing factor. This case–control study evaluated serum iron indices and liver function in treatment-naïve schizophrenia patients and those already on treatment at the Psychiatric Department of the Komfo Anokye Teaching Hospital (KATH), Kumasi-Ghana. Results The mean age of the respondents was 39.6 ± 0.8 years. Increased levels of serum iron, TS, AST, ALT and AST:ALT ratio and lower levels of UIBC, TIBC, Transferrin, and log Ferritin:AST ratio levels were observed among the treatment-naïve group compared to the control. The treatment-naïve and treatment groups showed significantly higher serum AST:ALT ratio, and lower log10ferrtin:AST ratio than the healthy controls. There was a significant correlation between log10ferritin and AST, and log10ferritin and GGT in both treatments (r = 0.343; p = 0.003, and r = 0.502; p = 0.001 respectively) and treatment-naïve groups (r = 0.348; p = 0.002, and r = 0.614; p < 0.001 respectively). Percentage transferrin saturation correlated significantly with GGT only, in the treatment-naïve group (r = 0.667; p < 0.001), and ALT and GGT in the treatment group (r = 0.252; p = 0.030 and r = 0.646; p = 0.014 respectively).

scholarly journals Body Mass Index and Breast Cancer Risks Among Igbo Women in Imo and Abia States, Nigeria: A Case Control Study

2019 ◽  
Vol 3 (1) ◽  
pp. 31-37
Author(s):  
Christopher S. Oyamienlen ◽  
Charles A. Adisa ◽  
Ikechukwu N. S. Dozie ◽  
Evangeline T. Oparaocha ◽  
Angelica A. Anele ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Body Mass ◽  
Case Control Study ◽  
Case Control ◽  
Cancer Risks ◽  
Imo State ◽  
Increased Risk ◽  
The Mean ◽  
Control Study

Background: The association between body mass index (BMI) and breast cancer risk has been well recognized. The purpose of this study was to determine the association of BMI with breast cancer risks among women of Igbo origin in Imo and Abia states in South Eastern Nigeria. Methods: The study was conducted at three different locations: Abia State University Teaching Hospital Aba, Abia State; Federal Medical Centre, Owerri, Imo State; and the Maranatha Specialist Mission Hospital, Aba, Abia State. This was a prospective hospital-based case control study. Data were collected on socio-demographic characteristics and anthropometric measures using a structured questionnaire. Collected data were imported to SPSS version 23 for analysis. In all, 681 patients participated in the study of which 347 were cases and 334 were controls. The T-test was used to assess statistical differences of height, weight, and BMI in the studied groups. Logistic regressions were used to calculate the multivariate odds ratio (OR) using 95% confidence interval (CI) with significant level set at p>0.05. Results: Higher BMI is associated with increased risk of breast cancer. There was a significant statistical difference between the height of cases and controls in both pre-and post-menopausal women. The mean value of height was 161.14± 7.1cm among cases compared to controls which was 161.39 cm (p<0.05). The mean weight among cases was 66.34 ± 11.8kg compared to controls at 65.45 ± 9.2kg (p<0.05); the mean BMI was 25.6± 4.8kg/m2 among cases compared to controls 25.1± 4.6 kg/m2 (p<0.05). Conclusion and Implications For Translation: Primary prevention measures are important to modestly curtail the increasing burden of obesity and high BMI. By controlling the weight, through physical activities, changes in diet and modestly alcohol intake will reduce the risk of breast cancer. Key words: • Breast Cancer • Imo State • Abia State • South East Nigeria • Body Mass Index • Nigeria   Copyright © 2019 Oyamienlen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Dietary factors and breast cancer: A case control study from rural India

2014 ◽  
Vol 6 (1) ◽  
pp. 55-60
Author(s):  
VR Mohite ◽  
AK Pratinidhi ◽  
RV Mohite
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Case Control Study ◽  
Vegetarian Diet ◽  
Case Control ◽  
Newly Diagnosed ◽  
Dietary Risk Factors ◽  
Dietary Risk ◽  
Strength Of Association ◽  
Control Study

Background: Diet, a modifiable risk factor for breast cancer is estimated approximately one-third of cases could be prevented by dietary modification. Objectives: To identify possible dietary risk factors of breast cancer among newly diagnosed cases of breast cancer and to determine the strength of association of the risk factors and cancer of breast. Methods: A hospital based case- control study was conducted in Satara district, India during year 2009 to 2011 among newly diagnosed cases of breast cancer and matched controls. The total number of 217 breast cancer cases and equal number of controls age, religion and residence matched were enrolled by purposive sampling technique from selected hospitals of the study area. The data was collected individually by employing pre-tested questionnaire utilizing interview method. Descriptive statistics, Odd’s ratio and chi-square test was used to find out the strength of association and statistically significant differences. Results: Maximum, 31.80% breast cancer cases were in age group 40-49 yrs with lowest age at diagnosis of disease was 25 years. Max, 63.59%, 71.42% and 56.68% breast cancer cases were housewives, literate and from upper economic class respectively. The risk of developing breast cancer as indicated by odd’s ratio was 2.38 times higher in overweight women, 2.1 times in women consuming non-vegetarian diet, 3.9 times with women consuming extra fat in diet and 13.5 times in women with having excess salt in their diet. Conclusion: The dietary risk factors such as non-vegetarian diet, excess fat and salt in diet and overweight was strongly associated with breast cancer. DOI: http://dx.doi.org/10.3126/ajms.v6i1.10285 Asian Journal of Medical Sciences Vol.6(1) 2015 55-60

Serum Iron profile in Female patients of Melasma-A case control study

2017 ◽  
Vol 4 (2) ◽  
pp. 141-146 ◽  
Author(s):  
Iram Qazi ◽  
◽  
Naina Kala Dogra ◽  
Devraj Dogra ◽  
◽  
...  
Keyword(s):  
Serum Iron ◽  
Case Control Study ◽  
Case Control ◽  
Female Patients ◽  
Iron Profile ◽  
Control Study

Reproductive Factors and Risk of Breast Cancer by Tumour Subtypes Among Ghanaian Women: A Population-Based Case-Control Study

2019 ◽  
Author(s):  
Jonine Figueroa ◽  
Brittny C. Davis Lynn ◽  
Lawrence Edusei ◽  
Nicholas Titiloye ◽  
Ernest Adjei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Reproductive Factors ◽  
Population Based ◽  
Case Control ◽  
Ghanaian Women ◽  
Control Study

The J-shaped Association Between Alcohol Consumption and Breast Cancer: A Case-Control Study

2014 ◽  
Vol 10 (2) ◽  
pp. 120-127
Author(s):  
Niki Mourouti ◽  
Meropi Kontogianni ◽  
Christos Papavagelis ◽  
Theodora Psaltopoulou ◽  
Petrini Plytzanopoulou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Alcohol Consumption ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

Association of Serum Homocysteine Level and Interstitial Lung Disease in Systemic Sclerosis: A Case-control Study

2018 ◽  
Vol 15 (1) ◽  
pp. 74-78
Author(s):  
Mohammadali Nazarinia ◽  
Asghar Zare ◽  
Mohammad javad Fallahi ◽  
Mesbah Shams
Keyword(s):  
Systemic Sclerosis ◽  
Healthy Subjects ◽  
Case Control Study ◽  
Homocysteine Level ◽  
Case Control ◽  
Control Group ◽  
Lung Involvement ◽  
Serum Homocysteine ◽  
The Mean ◽  
Control Study

Background:Systemic sclerosis is a disorder of connective tissue with unknown cause, affecting the skin and internal organs, characterized by fibrotic changes.Objective:To determine the correlation between serum homocysteine level and interstitial lung involvement in systemic sclerosis. </P><P> Materials and Methods: In this case – control study, 59 patients who fulfilled the ACR/EULAR classification criteria for systemic sclerosis and were referred to Hafez Hospital of Shiraz, Iran, were included as the case group. Fifty nine healthy subjects were involved as the control group. Patients were divided into two groups based on interstitial lung involvement and two subtypes, diffuse and limited type. Serum homocysteine, vitamin B12, and folate levels compared between the controls, and cases groups.Results:Of 59 case and control group, 53 (%89.8) were female and the mean age did not differ in both groups (P=0.929). Thirty five (%59.3) patients had interstitial lung involvement and 38(%64.4) had diffuse cutaneous systemic sclerosis. The mean serum homocysteine level was 13.9±6.3 µmol/L in the case and 13.7±9.2 µmol/L in the control group (P=0.86). The mean serum homocysteine level did not differ between the patients with and without interstitial lung involvement (P=0.52). The patients with lung involvement was older than those without lung involvement (P=0.004). Lung disease was more common in diffuse type (P=0.014).Conclusion:In our study, serum homocysteine level did not differ between the patients and healthy subjects. Also, there was no correlation between serum homocysteine level and lung involvement, but lung involvement was more common in older patients and also diffuse subtype.

scholarly journals A case–control study in France showing that a pro-inflammatory diet is associated with a higher risk of breast cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mariem Hajji-Louati ◽  
Emilie Cordina-Duverger ◽  
Nasser Laouali ◽  
Francesca-Romana Mancini ◽  
Pascal Guénel
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Odds Ratio ◽  
Hormone Receptors ◽  
Case Control Study ◽  
Breast Cancer Subtype ◽  
Case Control ◽  
Tumor Subtype ◽  
Control Study

AbstractDietary regimens promoting inflammatory conditions have been implicated in breast cancer development, but studies on the association between pro-inflammatory diet and breast cancer risk have reported inconsistent results. We investigated the association between the inflammatory potential of diet and breast cancer risk in a case–control study in France including 872 breast cancer cases and 966 population controls. All women completed a food frequency questionnaire that was used to compute a Dietary Inflammatory Index (DII) based on the inflammatory weight of 33 dietary components. The DII ranged from a median of − 3.22 in the lowest quartile (anti-inflammatory) to + 2.96 in the highest quartile (pro-inflammatory). The odds ratio contrasting quartile 4 to quartile 1 was 1.31 (95% CI 1.00, 1.73; p-trend = 0.02). Slightly higher odds ratios were observed in post-menopausal women, particularly those with body mass index > 25 kg/m2 (odds ratio 1.62; 95% CI 0.92, 2.83; p-trend = 0.02), and among ever smokers (odds ratio 1.71; 95% CI 1.11, 2.65; p-trend 0.01). The analyses by breast cancer subtype showed that the DII was associated with breast tumors that expressed either the estrogen (ER) or progesterone (PR) hormone receptors or the Human Epidermal Growth Factor Receptor-2 (HER2), but no association was seen for the triple negative breast tumor subtype. Our results add further evidence that a pro-inflammatory diet is associated with breast cancer risk with possible effect variation according to tumor subtype.

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