scholarly journals Cistanche deserticola polysaccharides alleviate cognitive decline in aging model mice by restoring the gut microbiota-brain axis

Aging ◽  
2021 ◽  
Author(s):  
Yuan Gao ◽  
Bing Li ◽  
Hong Liu ◽  
Yajuan Tian ◽  
Chao Gu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Cognitive Decline ◽  
Aging Model ◽  
Cistanche Deserticola

Relationship between the Japanese-style diet, gut microbiota, and dementia: a cross-sectional study

2021 ◽  
Author(s):  
Naoki Saji ◽  
Tsuyoshi Tsuduki ◽  
Kenta Murotani ◽  
Takayoshi Hisada ◽  
Taiki Sugimoto ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Gut Microbiota ◽  
Cognitive Decline ◽  
Gut Microbiome ◽  
Cross Sectional Study ◽  
Dietary Composition ◽  
Microbial Metabolites ◽  
Cross Sectional ◽  
Fish And Shellfish ◽  
Japanese Diet

Abstract Background Previous studies have shown associations between the gut microbiota, microbial metabolites, and cognitive decline. However, the effect of the dietary composition on such associations has not been fully investigated. Methods We performed a cross-sectional sub-analysis of data from our prospective hospital-based cohort study (the Gimlet study) to evaluate the relationships between dietary composition, cognitive decline, and the gut microbiota. All the participants of the Gimlet study had been provided with information regarding this sub-study in 2018. Patients were excluded if they were unable to provide sufficient data in the questionnaire regarding their dietary composition. We assessed their demographics, dietary composition, risk factors, cognitive function, results of brain imaging, gut microbiome, and microbial metabolites. On the basis of previous studies, a nine-component traditional Japanese diet index (JDI9), a 12-component modern JDI (JDI12), and a 12-component revised JDI (rJDI12), were defined. Higher JDI scores indicated greater conformity to the traditional Japanese diet. We then evaluated the relationships between the JDI scores, cognitive function, and the gut microbiome and microbial metabolites using multivariable logistic regression analyses. Results We analyzed data from 85 eligible patients (61% women; mean age: 74.6 ± 7.4 years; mean Mini-Mental State Examination score: 24 ± 5). Compared with participants with dementia, those without dementia were more likely to consume foods in the JDI12, including fish and shellfish (64.5% vs. 39.1%, P = 0.048), mushrooms (61.3% vs. 30.4%, P = 0.015), soybeans and soybean-derived foods (62.9% vs. 30.4%, P = 0.013), and coffee (71.0% vs. 43.5%, P = 0.024). There were non-significant trends towards lower fecal concentrations of gut microbial metabolites in participants with a more traditional Japanese diet. Participants with dementia had lower JDI9, JDI12, and rJDI12 scores than participants without dementia (dementia vs. non-dementia, median JDI9 score: 5 vs. 7, P = 0.049; JDI12: 7 vs. 8, P = 0.017; and rJDI12: 7 vs. 9, P = 0.006, respectively). Conclusions Adherence to a traditional Japanese diet was found to be inversely associated with cognitive decline and tended to be associated with lower concentrations of gut microbial metabolites. Trial registration: UMIN000031851.

scholarly journals Intermittent Fasting Alleviates Diabetes-induced Cognitive Decline via Gut Microbiota-metabolites-brain Axis (OR32-04-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Zhigang Liu ◽  
Tian Yuan ◽  
Xiaoshuang Dai ◽  
Lin Shi ◽  
Xuebo Liu
Keyword(s):  
Cognitive Function ◽  
Gut Microbiota ◽  
Cognitive Decline ◽  
Critical Role ◽  
Development Program ◽  
Plasma Metabolites ◽  
Intermittent Fasting ◽  
Metabolic Function ◽  
Behavioral Tests ◽  
Omics Analysis

Abstract Objectives Cognitive decline is one of severe type 2 diabetes complications. Intermittent fasting (IF) is a promising dietary intervention for T2D risk reduction, but its protective effect and mechanism on diabetic cognitive dysfunction remain elusive. Gut microbiota plays a vital role interphasing diet and host physiology and pathology and highly affected by the dietary composition and patterns. It has been reported that the microbiota homeostasis is essential for maintenance of gut health and for modulating cognitive function. We hypothesized that gut microbiota might play a pivotal role in mediating protective effects of IF on diabetes-induced cognitive decline. Methods After a 28-day IF regimen treatment, cognitive behavioral tests and brain insulin signaling were assessed on db/db mice. The microbiota-metabolites-brain axis alterations were detected by multiple-omics analysis (transciptomics, 16S rRNA sequencing and metabolomics). A intergrade multi-omics analysis was performed to analyze the correlation among gut microbiota, plasma metabolites, and hippocampal gene expression. Results Here we found that a 28-day Intermittent fasting (IF) regimen improved cognitive deficits in db/db mice via a microbiota-metabolites-brain axis assessed by behavioral tests and multiple-omics analysis: IF activated AMPK/PGC1α signaling, enhanced mitochondrial biogenesis in hippocampus and elevated genes enriched in hippocampal metabolic function. Moreover, IF re-structured gut microbiota and improved plasma microbial metabolites in relation to diabetes and cognitive function, e.g., serotonin, 3-Indolepropionic acid, and bile acids. Integration of multi-omics data demonstrated strong links between IF-related genes, gut microbiome and metabolites. Furthermore, removal of gut microbiota with antibiotics partly abolished the observed benefits of IF on cognition and hippocampal metabolic function. Conclusions Taken together, the present study suggests a critical role of gut microbiota in connecting peripheral metabolism with brain function, which could lead to novel interventions against metabolism-implicated neurodegenerative pathophysiologies. Funding Sources This work was financially supported by the National Key Research and Development Program of China, National Natural Science Foundation of China.

scholarly journals ZiBuPiYin recipe improves cognitive decline by regulating gut microbiota in Zucker diabetic fatty rats

Oncotarget ◽  
2017 ◽  
Vol 8 (17) ◽  
pp. 27693-27703 ◽  
Author(s):  
Chunyan Gu ◽  
Wen Zhou ◽  
Wang Wang ◽  
Hong Xiang ◽  
Huiying Xu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Cognitive Decline ◽  
Zucker Diabetic Fatty Rats

scholarly journals Spatial Memory and Gut Microbiota Alterations Are Already Present in Early Adulthood in a Pre-clinical Transgenic Model of Alzheimer’s Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Paola C. Bello-Medina ◽  
Fernando Hernández-Quiroz ◽  
Marcel Pérez-Morales ◽  
Diego A. González-Franco ◽  
Guadalupe Cruz-Pauseno ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gut Microbiota ◽  
Motor Activity ◽  
Spatial Memory ◽  
Cognitive Decline ◽  
Beta Diversity ◽  
Object Localization ◽  
Amyloid Peptide ◽  
Model Of Alzheimer’S Disease

The irreversible and progressive neurodegenerative Alzheimer’s disease (AD) is characterized by cognitive decline, extracellular β-amyloid peptide accumulation, and tau neurofibrillary tangles in the cortex and hippocampus. The triple-transgenic (3xTg) mouse model of AD presents memory impairment in several behavioral paradigms and histopathological alterations from 6 to 16 months old. Additionally, it seems that dysbiotic gut microbiota is present in both mouse models and patients of AD at the cognitive symptomatic stage. The present study aimed to assess spatial learning, memory retention, and gut microbiota alterations in an early adult stage of the 3xTg-AD mice as well as to explore its sexual dimorphism. We evaluated motor activity, novel-object localization training, and retention test as well as collected fecal samples to characterize relative abundance, alpha- and beta-diversity, and linear discriminant analysis (LDA) effect size (LEfSe) analysis in gut microbiota in both female and male 3xTg-AD mice, and controls [non-transgenic mice (NoTg)], at 3 and 5 months old. We found spatial memory deficits in female and male 3xTg-AD but no alteration neither during training nor in motor activity. Importantly, already at 3 months old, we observed decreased relative abundances of Actinobacteria and TM7 in 3xTg-AD compared to NoTg mice, while the beta diversity of gut microbiota was different in female and male 3xTg-AD mice in comparison to NoTg. Our results suggest that gut microbiota modifications in 3xTg-AD mice anticipate and thus could be causally related to cognitive decline already at the early adult age of AD. We propose that microbiota alterations may be used as an early and non-invasive diagnostic biomarker of AD.

scholarly journals Supplement of microbiota-accessible carbohydrates prevents neuroinflammation and cognitive decline by improving the gut microbiota-brain axis in diet-induced obese mice

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Hongli Shi ◽  
Qiao Wang ◽  
Mingxuan Zheng ◽  
Shanshan Hao ◽  
Jeremy S. Lum ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Cognitive Decline ◽  
Obese Mice

Altered Gut Microbiota in Adults with Subjective Cognitive Decline: The SILCODE Study

2021 ◽  
pp. 1-14
Author(s):  
Can Sheng ◽  
Li Lin ◽  
Hua Lin ◽  
Xiaoni Wang ◽  
Ying Han ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Gut Microbiota ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Illumina Miseq ◽  
Subjective Cognitive Decline ◽  
Pathophysiological Mechanism ◽  
Progressive Decline ◽  
Amyloid Positron Emission Tomography ◽  
Positron Emission

Background: Subjective cognitive decline (SCD) is the earliest symptomatic manifestation of preclinical Alzheimer’s disease (AD). Gut microbiota may serve as a susceptibility factor for AD. Altered gut microbiota has been reported in patients with mild cognitive impairment (MCI) and AD dementia. However, whether gut microbial compositions changed in SCD remains largely unknown. Objective: To characterize the gut microbiota in SCD. Methods: In this study, a total of 105 participants including 38 normal controls (NC), 53 individuals with SCD, and 14 patients with cognitive impairment (CI) were recruited. Gut microbiota of all participants isolated from fecal samples were investigated using 16S ribosomal RNA (rRNA) Illumina Miseq sequencing technique. The gut microbial compositions were compared among the three groups, and the association between altered gut microbiota and cognitive performance was analyzed. To validate the alteration of gut microbiota in SCD, we conducted amyloid positron emission tomography (PET) in selected participants and further compared the gut microbiota among subgroups. Results: The abundance of phylum Firmicutes, class Clostridia, order Clostridiales, family Ruminococcaceae, and genus Faecalibacterium showed a trend toward a progressive decline from NC to SCD and CI. Specifically, the abundance of the anti-inflammatory genus Faecalibacterium was significantly decreased in SCD compared with NC. In addition, altered bacterial taxa among the three groups were associated with cognitive performance. The findings were validated in SCD participants with positive amyloid evidence. Conclusion: The composition of gut microbiota is altered in individuals with SCD. This preliminary study will provide novel insights into the pathophysiological mechanism of AD.

Abnormalities in gut microbiota and serum metabolites in hemodialysis patients with mild cognitive decline: a single-center observational study

2020 ◽  
Vol 237 (9) ◽  
pp. 2739-2752
Author(s):  
Bin Zhu ◽  
Jianqin Shen ◽  
Riyue Jiang ◽  
Lina Jin ◽  
Gaofeng Zhan ◽  
...  
Keyword(s):  
Observational Study ◽  
Gut Microbiota ◽  
Cognitive Decline ◽  
Hemodialysis Patients ◽  
Single Center ◽  
Serum Metabolites ◽  
Single Center Observational Study

scholarly journals Age-related shifts in gut microbiota contribute to cognitive decline in aged rats

Aging ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 7801-7817 ◽  
Author(s):  
Yanli Li ◽  
Li Ning ◽  
Yiru Yin ◽  
Rui Wang ◽  
Zhiyong Zhang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Cognitive Decline ◽  
Aged Rats ◽  
Age Related

scholarly journals ZiBuPiYin Recipe Prevented and Treated Cognitive Decline in ZDF Rats With Diabetes-Associated Cognitive Decline via Microbiota–Gut–Brain Axis Dialogue

2021 ◽  
Vol 9 ◽  
Author(s):  
Tingting Bi ◽  
Ruiqi Feng ◽  
Libin Zhan ◽  
Weiming Ren ◽  
Xiaoguang Lu
Keyword(s):  
Fatty Acid ◽  
Gut Microbiota ◽  
Cognitive Decline ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Neurological Diseases ◽  
Metabolic Changes ◽  
Protective Mechanisms ◽  
Prevention And Treatment ◽  
Zdf Rats

Gut microbiota is becoming one of the key determinants in human health and disease. Shifts in gut microbiota composition affect cognitive function and provide new insights for the prevention and treatment of neurological diseases. Diabetes-associated cognitive decline (DACD) is one of the central nervous system complications of type 2 diabetes mellitus (T2DM). ZiBuPiYin recipe (ZBPYR), a traditional Chinese medicine (TCM) formula, has long been used for the treatment of T2DM and prevention of DACD. However, the contribution of ZBPYR treatment to the interaction between the gut microbiota and metabolism for preventing and treating DACD remains to be clarified. Here, we investigate whether the gut microbiota plays a key role in ZBPYR-mediated prevention of DACD and treatment of T2DM via incorporating microbiomics and metabolomics, and investigate the links between the microbiota–gut–brain axis interaction and the efficacy of ZBPYR in ZDF rats. In the current study, we found that ZBPYR treatment produced lasting changes in gut microbiota community and metabolites and remotely affected hippocampus metabolic changes, thereby improving memory deficits and reversing β-amyloid deposition and insulin resistance in the brain of ZDF rats from T2DM to DACD. This may be related to a series of metabolic changes affected by gut microbiota, including alanine, aspartic acid, and glutamic acid metabolism; branched-chain amino acid metabolism; short-chain fatty acid metabolism; and linoleic acid/unsaturated fatty acid metabolism. In summary, this study demonstrates that prevention and treatment of DACD by ZBPYR partly depends on the gut microbiota, and the regulatory effects of bacteria-derived metabolites and microbiota–gut–brain axis are important protective mechanisms of ZBPYR.

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