THE ROLE OF VITAMIN D IN THE PATHOGENESIS OF THE ARTERIAL HYPERTENSION

2020 ◽  
Vol 65 (1) ◽  
pp. 5-10
Author(s):  
N. L. Lystsova ◽  
Tatiana Ivanovna Petelina ◽  
L. I. Gapon ◽  
K. S. Avdeeva ◽  
S. G. Bucova ◽  
...  
Keyword(s):  
Vitamin D ◽  
Arterial Hypertension ◽  
Vitamin D Deficiency ◽  
Calcium Metabolism ◽  
Hormonal Status ◽  
Age Changes ◽  
Numerous Data ◽  
Mechanisms Of Development ◽  
The Relationship

In recent years, accumulated numerous data on the pathogenetic links of the formation of arterial hypertension. A number of studies have shown that vitamin D deficiency, associated with age, changes in sex hormonal status, increased tone of the renin-angiotensin-aldosterone system, endothelial dysfunction, and calcium metabolism, can be one of the mechanisms of development and progression of arterial hypertension. The purpose of the review was to summarize the results of the original domestic and foreign studies, prospective observations and meta-analyzes on the relationship between vitamin D deficiency and arterial hypertension.

scholarly journals Assessment of vitamin D among Sudanese Patients with Hypothyroidism

2021 ◽  
Vol 1 (2) ◽  
pp. 057-061
Author(s):  
Hasna Osman Fadalla Mohamed ◽  
Omer Fadol Edris ◽  
Gad Allah Modawe ◽  
Suhair Abdelrahman Ahmed
Keyword(s):  
Vitamin D ◽  
Autoimmune Diseases ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Control Hospital ◽  
Study Population ◽  
Thyroid Profile ◽  
Methods Analytical ◽  
The Relationship

Background: Vitamin D deficiency is a worldwide health issue and its role as an immune modulator has recently been emphasized. Evidence increasingly indicates the important role of vitamin D in reducing the incidence of autoimmune diseases. However, at this time the search for its role in autoimmune diseases and thyroid is not critical. Objectives: The study aimed to assess the relationship between vitamin D deficiency in Sudanese patients with hypothyroidism. Methods: Analytical case control hospital based study, conducted in Fadil Hospital and Police Hospital, Khartoum city, Khartoum state. The study carried out from March 2018 to September 2018. A total of 100 subjects were enrolled in the study. Vitamin D deficiency was set at levels below 20 ng / ml. Thyroid hormones (TSH, T3 and T4) were assessed in all participants using auto analyzer TOSOH AIA 313,while vitamin D was estimated using ELIZA. The data were analyzed using SPSS version (21). Results: The study included 76(76%) females and 24(24%) males, no significance differences between thyroid profile among study population.75 (75%) deficiency of vitamin D and 25(25%) normal vitamin D. vitamin D deficiency was significantly lower in female than male with( p =0.001). Conclusion: The results indicated that patients with hypothyroidism suffer from vitamin D deficiency significantly associated with the degree and severity of hypothyroidism. This encourages the desirability of vitamin D supplementation and recommends the detection of vitamin D deficiency for all hypothyroidism patients.

The role of vitamin D dificiency in the development of pathology in women of perimenopausal age

2018 ◽  
pp. 76-79
Author(s):  
Kh.V. Kozak ◽  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Neurological Diseases ◽  
Research Direction ◽  
Literary Sources ◽  
Autoimmune Conditions ◽  
Calcium Phosphorus ◽  
The Relationship

The article presents an analysis of literary sources about contemporary views on the role of vitamin D deficiency in the health problems of women of the perimenopausal period. According to research data of recent years, vitamin D plays a role not only in the control of calcium-phosphorus metabolism, but also plays a role in the pathogenesis of cardiovascular and neurological diseases, insulin resistance and diabetes, in the development of cancer and autoimmune conditions, especially in women of perimenopausal age. It is important to continue the study of the relationship between vitamin D deficiency and menopausal and menopausal disorders. Currently, the existing principles and effectiveness of the correction of lack of vitamin D in improving the quality of life of women of perimenopausal age are ambiguously assessed, which determines the relevance of this research direction. Key words: perimenopausal period, insufficiency/deficiency of vitamin D.

scholarly journals Pathogenetic role of vitamin D deficiency and immune-inflammatory disorders in development of fetal distress in pregnant women with chronic hydramnion

2020 ◽  
pp. 14-20
Author(s):  
N. A. Gaistruk ◽  
L. G. Dubas ◽  
A. N. Gaistruk ◽  
A. V. Melnik ◽  
O. L. Liovkina
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Statistical Processing ◽  
Fetal Distress ◽  
Immune Disorders ◽  
Inflammatory Disorders ◽  
Mechanisms Of Development ◽  
Anti Inflammatory Cytokine

The role of vitamin D deficiency and immune-inflammatory disorders in the mechanisms of development of fetal distress in pregnant women with chronic polyhydramnios remains unexplored. Objective: to evaluate the role of vitamin D deficiency and associated immune inflammatory disorders in the development of fetal distress in pregnant women with chronic polyhydramnios. Materials and methods. Surveyed 30 women with a physiological course of pregnancy and 90 pregnant women with chronic polyhydramnios. In the serum, the level of the metabolite of vitamin D – 25(OH)D and the cytokines IL-10 and IL-6 were determined by enzyme immunoassay using standard kits. Statistical processing of the obtained results was performed using standard methods using the «MS Excel» and «Statistica SPSS 10.0 for Windows» application package. The results of the research. In pregnant women with chronic polyhydramnios, there is a significant decrease of the metabolite of vitamin D – 25(OH)D level by 21 % in the serum, a decrease of the level of the anti-inflammatory cytokine IL-10 by 26.4 % and an increase of the concentration of pro-inflammatory IL-6 by 17 % compared to women with physiological course of pregnancy. The occurrence of fetal distress against the background of chronic polyhydramnios is accompanied by a intensification of vitamin D deficiency and immune-inflammatory disorders: levels 25(OH)D and IL-10, respectively, by 18.5 % and 17.5 % less, and IL-6 by 13.3 %, than in women with chronic polyhydramnios without fetal distress. The expressiveness of immune disorders in the organism of pregnant women with chronic polyhydramnios is determined by the level of vitamin D in the organism. Thus, in women with a deficiency of 25(OH)D in the serum, a significant decrease in the IL-10 concentration by 47.8 % and a significant increase in the IL-6 level by 34.6 % were recorded in comparison with the indicators in women with vitamin D deficiency. Conclusions. Vitamin D deficiency and associated immune-inflammatory disorders play an important role in the development of fetal distress in pregnant women with chronic polyhydramnios.

scholarly journals Role Of Vitamin D And Adipose Tissue Hormones In Women With Reproductive Disorders

Folia Medica ◽  
2015 ◽  
Vol 57 (1) ◽  
pp. 5-10
Author(s):  
Presiyana V. Nyagolova ◽  
Mitko D. Mitkov ◽  
Maria M. Orbetsova
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Polycystic Ovary ◽  
Serum Vitamin ◽  
Reproductive Function ◽  
Reproductive Disorders ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Relationship

Abstract The role of vitamin D beyond that it plays in bone metabolism and calcium homeostasis has been lately quite emphasized. In this respect, vitamin D deficiency has been associated with higher risk of cardiovascular disease, metabolic syndrome, and reproductive disorders. Growing evidence has suggested that vitamin D deficiency is implicated in the pathogenesis of insulin resistance and the development of metabolic disorders in the polycystic ovary syndrome. The goal of the review is to present contemporary concepts of the relationship between hormones affecting the metabolic body status, serum vitamin D levels and the reproductive function.

scholarly journals Relationship of arterial hypertension, metabolic syndrome with vitamin D deficiency in women

2020 ◽  
Vol 43 (4) ◽  
pp. 549-559
Author(s):  
Lyudmila V. Vasilieva ◽  
◽  
Yuliya V. Tatarintseva ◽  
Elena V. Gosteva ◽  
Sergej Y. Popov ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Arterial Hypertension ◽  
Blood Serum ◽  
Vitamin D Deficiency ◽  
Postmenopausal Women ◽  
Blood Pressure Monitoring ◽  
Low Hdl ◽  
Relationship Of ◽  
The Relationship

Objective: To assess the relationship between vitamin D deficiency (VD) and risk factors for metabolic syndrome (MS) in postmenopausal women with arterial hypertension (AH). Materials and methods of research. The study included 46 women aged 45–65 years with amenorrhea > 12 months, having grade 1 hypertension and metabolic syndrome. Anthropometric, laboratory and instrumental data were studied. Biochemical parameters included total cholesterol (OH), HDL, triglycerides, glucose, insulin, and 25-hydroxyvitamin-D [25 (OH)D]. Daily blood pressure monitoring was performed according to the standard protocol. Levels of 25(OH)D in blood serum was classified as-adequate (≥ 30 ng/ml) and insufficient (20–29 ng/ml). Results: Level 25 (OH)D in blood serum was sufficient in 21 women (45.6 %), insufficient – in 25 (54.4 %). Women with insufficient levels of 25 (OH)D had higher levels of cholesterol, triglycerides, insulin, and HOMA-IR. Metabolic syndrome was detected in 64 % (16/25) of women with hypovitaminosis D and in 43 % (9/21) of women with sufficient VD (p < 0.01). The correlation analysis established the relationship of the low level of 25 (OH)D (< 30 ng / ml) with MS (r = 0.68), high triglycerides (r = 0.74) and low HDL (r = 0.71). The average concentration of 25 (OH) D decreased with an increase in the number of MS components (p = 0.016). Conclusions: VD deficiency in postmenopausal women was associated with a higher prevalence of MS. Women with HDL deficiency had a higher risk of MS, hypertriglyceridemia, and low HDL levels compared to those with adequate levels.

The role of vitamin D deficiency in the pathogenesis of falls and fractures

2013 ◽  
Vol 154 (19) ◽  
pp. 731-736 ◽  
Author(s):  
Antal Salamon ◽  
Csaba Biró ◽  
Erzsébet Toldy
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Vitamin D Deficiency ◽  
Human Body ◽  
Calcium Metabolism ◽  
The Elderly ◽  
Review Literature ◽  
Age Group ◽  
Elderly Age

The diverse effects of vitamin D in human body became known during the last years. Vitamin D deficiency causes many problems in medical care. Important roles of vitamin D are the regulation of calcium metabolism and the effect on bone metabolism. The authors review literature data on vitamin D deficiency recognized as an important risk factor in the pathogenesis of falls and fractures and they call attention of Hungarian physicians to the importance of vitamin D substitution. Supplementation of vitamin D deficiency is particularly important in the elderly age-group. Orv. Hetil., 2013, 154, 731–736.

scholarly journals Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1378
Author(s):  
Francesco Palmese ◽  
Rossella Del Toro ◽  
Giulia Di Marzio ◽  
Pierluigi Cataleta ◽  
Maria Giulia Sama ◽  
...  
Keyword(s):  
Vitamin D ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Nutrient Deficiencies ◽  
Pathological Conditions ◽  
High Prevalence ◽  
The Relationship

Sarcopenia is a prevalent condition in patients with Crohn’s disease (CD), representing an independent predictor factor for the development of major postoperative complications. Thus, a proper assessment of the muscle strength, by using different validated tools, should be deemed an important step of the clinical management of these patients. Patients with CD are frequently malnourished, presenting a high prevalence of different macro- and micro-nutrient deficiencies, including that of vitamin D. The available published studies indicate that vitamin D is involved in the regulation of proliferation, differentiation, and regeneration of muscle cells. The relationship between vitamin D deficiency and sarcopenia has been extensively studied in other populations, with interesting evidence in regards to a potential role of vitamin D supplementation as a means to prevent and treat sarcopenia. The aim of this review was to find studies that linked together these pathological conditions.

scholarly journals Vitamin D deficiency during late pregnancy mediates placenta-associated complications

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tiphaine Raia-Barjat ◽  
Camille Sarkis ◽  
Florence Rancon ◽  
Lise Thibaudin ◽  
Jean-Christophe Gris ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Late Onset ◽  
Late Pregnancy ◽  
Vitamin D Insufficiency ◽  
Multicenter Cohort Study ◽  
Vitamin D Levels ◽  
The One ◽  
The Relationship

AbstractDuring pregnancy, maternal vitamin D insufficiency could increase the risk of preeclampsia. Aim of the study was to evaluate the relationship between vitamin D status and the occurrence of placenta-mediated complications (PMCs) in a population at high risk. A prospective multicenter cohort study of 200 pregnant patients was conducted. The vitamin D level of patients with placenta-mediated complications was lower at 32 weeks compared to uncomplicated pregnancies (P = 0.001). At 32 weeks, the risk of occurrence of PMCs was five times higher in patients with vitamin D deficiency (RR: 5.14 95% CI (1.50–17.55)) compared to patients with normal vitamin D levels. There was a strong, inverse relationship between serum 25(OH)D levels at 32 weeks and the subsequent risk of PMCs (P = 0.001). At 32 weeks, the vitamin D level of patients with late-onset PMCs was lower than the one of patients with early-onset PMCs and of patients without PMCs (P < 0.0001). These results suggest a role of vitamin D in the maintenance of placental performance and therefore in the prevention of the onset of late PMC.

scholarly journals Vitamin D imbalance effects on dentoalveolar system: a review

2021 ◽  
Vol 24 (1) ◽  
pp. 19-25
Author(s):  
E. Y. Diachkova ◽  
D. O. Trifonova ◽  
M. O. Ibadulaeva ◽  
G. E. Runova ◽  
V. V. Fadeyev ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Remodeling ◽  
Human Body ◽  
Oral Diseases ◽  
Antiproliferative Effects ◽  
Dental Patients ◽  
System A ◽  
The Relationship

Vitamin D is a fat-soluble secosteroid that plays an important role in the human body. There are two main native forms – vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol). The regulation of calcium-phosphate metabolism and ensuring adequate bone remodeling are the most studied function of vitamin D. In recent years, researchers have found out the «extra-bone» effects of vitamin D and it allows us to be convinced of the great role of this compound. The participation of active forms of vitamin D in the processes of immunomodulation, anti-inflammatory, antimicrobial, antiproliferative effects and stimulation of cell differentiation are reflected in diseases of the maxillofacial region.In this article, we examined the main functions of vitamin D in the human body, the mechanisms of its action and influence on the occurrence and course of oral diseases. The discovery of the relationship between vitamin D deficiency and the processes of osseointegration, bone remodeling, the severity of chronic recurrent aphthous stomatitis, squamous cell carcinoma and periodontitis allow us to conclude that it is advisable to diagnose vitamin D deficiency in appropriate time and correction its serum level in dental patients.

Sign in / Sign up

Export Citation Format

Share Document