scholarly journals The Viability of Dietary Probiotics (Bactosac�) Influencing Growth Parameters, Cellular Alteration in Intestinal Wall and Immune Response of Broilers

2014 ◽  
Vol 6 (3) ◽  
pp. 128-133
Author(s):  
M. Aminul Islam ◽  
S.M. Lutful Kabir ◽  
M. Bahanur Rahman ◽  
Shonkor Kumar Das ◽  
K.M. Mahmud Hossain ◽  
...  
Keyword(s):  
Immune Response ◽  
Growth Parameters ◽  
Intestinal Wall ◽  
Cellular Alteration

scholarly journals Adding hepatoprotective plants to beverage water: an alternative to conventional drugs for broiler production

2020 ◽  
Vol 14 (6) ◽  
pp. 1928-1940
Author(s):  
Dieudonné Pascal Chuisseu Djamen ◽  
Roland Nankam Chimi ◽  
Arouna Njayou Ngapagna ◽  
Leonard Tedong ◽  
François-Marie Kanmangne ◽  
...  
Keyword(s):  
Immune Response ◽  
Growth Parameters ◽  
Blood Parameters ◽  
Average Weight ◽  
Broiler Chicks ◽  
Humoral Immune ◽  
Growth Performances ◽  
Bursal Disease ◽  
Consumption Index ◽  
Kinetics Of

The present work was to study the effects of Desmoduin adscendens, Khaya grandifoliola, Xylopia phloiodora extracts on growth parameters and selected blood parameters of broilers chickens. A total of 252 broiler chicks were randomly distributed into 4 groups. Chickens of control batch received commercial hepatoprotective (Hepaturyl 1 g/l) and the experimental groups received a formulation based on 3 extracts hepatoprotective plants at a concentration of 200, 100 and 50 mg/kg body weight. The mortality rate of control and experimental groups was 6.3% and 4.7% respectively. Average weight of batches at day 48 was, 2.6 for the control, 2.7 for the batch 2, 2.6 batch 3 and 2.5 kg batch 4 with an average consumption index ranging from 1.6 for the control and 1.7 for the experimental groups. Liver function in broilers was not altered (The values of alanine aminotransferase and aspartate aminotransferase were 5-25 IU/l and 50-350 IU/l respectively). Cholesterolemia, proteinemia and the triglyceridemia increased with the age of the animals (0.6- 4.1 mmol / l; 21-83 g / l; 0.3- 3.8 g / l respectively). The kinetics of the humoral immune response against infectious bursal disease was not influenced. This work has shown that the use of the formulation as hepatoprotective in chick drinking water shows results similar to those of commercial hepatoprotectors.Keywords: Broilers, hepatoprotective plants, hepatic functioning, growth performances, immune response

scholarly journals Prediction of Immunocompetence and Resistance to Disease by Using Molecular Markers of the Major Histocompatibility Complex

1994 ◽  
Author(s):  
Susan J. Lamont ◽  
E. Dan Heller ◽  
Avigdor Cahaner
Keyword(s):  
Immune Response ◽  
Molecular Markers ◽  
Disease Resistance ◽  
Antibody Response ◽  
Genetic Background ◽  
Growth Parameters ◽  
Response Level ◽  
Animal Populations ◽  
The Impact ◽  
Meat Type

This project utilized two live-animal populations in an integrated research program to identify molecular markers for immune response and disease resistance. The populations each had their foundation from meat-type commercial breeder chicken lines of their respective countries. Investigations effectively used unique availability of resources in each country to study commercial-type environments in Israel and line-crosses with diverse inbred lines in the US. Two bacterial systems were investigated to cover both respiratory and gastrointestinal, and primary and secondary, infections. Individual experimental groups of animals were evaluated for combinations of vaccine antibody levels, response to pathogen challenge, growth parameters, genetic background and molecular markers. The positive association of antibody level with resistance to disease was confirmed. Effectiveness of genetic selection for vaccine antibody response level was demonstrated. Molecular markers, both inside and outside the MHC region, were associated with antibody response and resistance to disease. Markers were shown to have a generalized effect, by association with multiple traits of immune response and disease resistance. The impact of genetic background on marker effect was shown to be important. The overall results demonstrate the effectiveness of selection on vaccine antibody response and the potential of molecular marker-assisted selection to improve efficiency of production of meat-type chickens by reducing genetic susceptibility to disease.

scholarly journals Intestinal Microbiota and Immunity: A Review

2018 ◽  
pp. 1-10
Author(s):  
C. F. Egwuonwu ◽  
E. C. Evans ◽  
A. L. Olokun
Keyword(s):  
Immune Response ◽  
Intestinal Microbiota ◽  
Anaerobic Fermentation ◽  
Short Chain Fatty Acids ◽  
Interleukin 10 ◽  
Intestinal Wall ◽  
Specific Pattern ◽  
The Body ◽  
Signalling Molecules ◽  
Immune Mediators

Microorganisms establish a symbiotic relationship at all stages of growth in man, beginning from birth to adulthood. They are found in every part of the body, and they participate in the immune system against pathogen-mediated immune responses. Their actions are elicited by secreting microorganism associated-molecular proteins (MAMPs) which they use as signalling molecules to activate a cascade of immunological responses within the host cell. They maintain the barrier function of the intestinal wall as well as prevent colonisation of the intestine by pathogens. Using their MAMPs, they bind to specific pattern recognition receptors (PRR) activating immune mediators in response to pro-inflammation by pathogens. These immune mediators are either induced or suppressed (in the case of overproduced immune response). Some of these symbionts elicit their action by anaerobic fermentation of dietary fibres into byproducts of short-chain fatty acids (SCFAs). These bacterial metabolites functions by binding to G-protein coupled reactions (GPCRs) on colonic macrophages and Dendritic cells (DCs) and contributed to the increased production of interleukin 10 (IL 10) in response to pathogen-mediated immune response. These unique immunological actions of intestinal microbiota, have shown that microorganisms are beneficial to the host as against the widespread belief that they are disease-causing agents.

scholarly journals Celiac Disease and Its Association with Organ-Specific Auto-Immune Diseases

2021 ◽  
Vol 6 (10) ◽  
pp. 687-697
Author(s):  
Sakshi Buchke ◽  
Anusuiya Bora ◽  
Bhavika Mehta ◽  
Maitrali Relekar ◽  
Piyush Varsha ◽  
...  
Keyword(s):  
Immune Response ◽  
Celiac Disease ◽  
Intestinal Wall ◽  
Clear Correlation ◽  
Protein Subunits ◽  
Bidirectional Association ◽  
Organ Specific ◽  
Inflammatory Bowel ◽  
Hla Dq2

Wheat is one of the most consumed foods in the world. Although it is extremely nutrient rich for us humans, some of us have great difficulties in completely digesting its protein subunits. This review aims to understand the onset of Celiac Disease and its association with several other auto-immune diseases. The gliadin molecule, undigested in the small intestine, over time, ruptures the villi lining of the intestinal wall and enters the bloodstream which in turn activates the body's immune response. In some patients with the presence of HLA DQ2/DQ8 genes, this immune response results in Celiac Disease. Notably, researchers over the past several decades have found several links between Celiac Disease and multiple auto-immune diseases. Diabetes is one such auto-immune disease which has shown multiple associations with Celiac Disease. Similarly, in this review paper, we are critically analyzing the association of Celiac Disease with some of the most common autoimmune diseases namely Type-1 Diabetes, Multiple Sclerosis, Autism and Inflammatory Bowel Disease. In this paper, we have shown a clear correlation of celiac disease with several other auto-immune diseases. Further study is needed to understand the bidirectional association of Celiac Disease with different auto-immune diseases.

Bacterial-Mucosal Cell Junctional Complexes

1974 ◽  
Vol 32 ◽  
pp. 144-145
Author(s):  
Roger C. Wagner
Keyword(s):  
Intestinal Wall ◽  
Rat Colon ◽  
Mucosal Cell ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Mucosal Cells ◽  
Mucosal Lining ◽  
Degenerative Alterations ◽  
Junctional Complexes ◽  
Intestinal Mucosal Cells

Bacteria exhibit the ability to adhere to the apical surfaces of intestinal mucosal cells. These attachments either precede invasion of the intestinal wall by the bacteria with accompanying inflammation and degeneration of the mucosa or represent permanent anchoring sites where the bacteria never totally penetrate the mucosal cells.Endemic gram negative bacteria were found attached to the surface of mucosal cells lining the walls of crypts in the rat colon. The bacteria did not intrude deeper than 0.5 urn into the mucosal cells and no degenerative alterations were detectable in the mucosal lining.

A Cytochemical Study of Glucose-6-Phosphatase (G-6-PASE) in Cells Participating in Atherogenesis of Rabbit Aorta

1975 ◽  
Vol 33 ◽  
pp. 460-461
Author(s):  
Sidney D. Kobernick ◽  
Edna A. Elfont ◽  
Neddra L. Brooks
Keyword(s):  
Lipid Metabolism ◽  
New Zealand ◽  
Aortic Wall ◽  
Rabbit Aorta ◽  
Plaque Formation ◽  
Metabolic Changes ◽  
Atherosclerotic Plaques ◽  
Cytochemical Study ◽  
Cellular Alteration ◽  
New Zealand White Rabbits

This cytochemical study was designed to investigate early metabolic changes in the aortic wall that might lead to or accompany development of atherosclerotic plaques in rabbits. The hypothesis that the primary cellular alteration leading to plaque formation might be due to changes in either carbohydrate or lipid metabolism led to histochemical studies that showed elevation of G-6-Pase in atherosclerotic plaques of rabbit aorta. This observation initiated the present investigation to determine how early in plaque formation and in which cells this change could be observed.Male New Zealand white rabbits of approximately 2000 kg consumed normal diets or diets containing 0.25 or 1.0 gm of cholesterol per day for 10, 50 and 90 days. Aortas were injected jin situ with glutaraldehyde fixative and dissected out. The plaques were identified, isolated, minced and fixed for not more than 10 minutes. Incubation and postfixation proceeded as described by Leskes and co-workers.

Studies of Ge/Si(100) and Observation of Atomic Steps on Si(100) using Biassed Secondary Electron Imaging in a UHV STEM

1990 ◽  
Vol 48 (1) ◽  
pp. 308-309
Author(s):  
Mohan Krishnamurthy ◽  
Jeff S. Drucker ◽  
John A. Venablest
Keyword(s):  
Secondary Electron ◽  
Critical Thickness ◽  
Surface Defects ◽  
Film Growth ◽  
Growth Parameters ◽  
High Vacuum ◽  
Ultra High Vacuum ◽  
Surface Steps ◽  
Epitaxial Crystal Growth ◽  
Electron Imaging

Secondary Electron Imaging (SEI) has become a useful mode of studying surfaces in SEM[1] and STEM[2,3] instruments. Samples have been biassed (b-SEI) to provide increased sensitivity to topographic and thin film deposits in ultra high vacuum (UHV)-SEM[1,4]; but this has not generally been done in previous STEM studies. The recently developed UHV-STEM ( codenamed MIDAS) at ASU has efficient collection of secondary electrons using a 'parallelizer' and full sample preparation system[5]. Here we report in-situ deposition and annealing studies on the Ge/Si(100) epitaxial system, and the observation of surface steps on vicinal Si(100) using b-SEI under UHV conditions in MIDAS.Epitaxial crystal growth has previously been studied using SEM and SAM based experiments [4]. The influence of surface defects such as steps on epitaxial growth requires study with high spatial resolution, which we report for the Ge/Si(100) system. Ge grows on Si(100) in the Stranski-Krastonov growth mode wherein it forms pseudomorphic layers for the first 3-4 ML (critical thickness) and beyond which it clusters into islands[6]. In the present experiment, Ge was deposited onto clean Si(100) substrates misoriented 1° and 5° toward <110>. This was done using a mini MBE Knudsen cell at base pressure ~ 5×10-11 mbar and at typical rates of 0.1ML/min (1ML =0.14nm). Depositions just above the critical thickness were done for substrates kept at room temperature, 375°C and 525°C. The R T deposits were annealed at 375°C and 525°C for various times. Detailed studies were done of the initial stages of clustering into very fine (∼1nm) Ge islands and their subsequent coarsening and facetting with longer anneals. From the particle size distributions as a function of time and temperature, useful film growth parameters have been obtained. Fig. 1 shows a b-SE image of Ge island size distribution for a R T deposit and anneal at 525°C. Fig.2(a) shows the distribution for a deposition at 375°C and Fig.2(b) shows at a higher magnification a large facetted island of Ge. Fig.3 shows a distribution of very fine islands from a 525°C deposition. A strong contrast is obtained from these islands which are at most a few ML thick and mottled structure can be seen in the background between the islands, especially in Fig.2(a) and Fig.3.

Humoral and cellular immune response to a crude exo-antigen and purified keratinase of Microsporum canis in experimentally infected guinea pigs

1999 ◽  
Vol 37 (2) ◽  
pp. 123-129 ◽  
Author(s):  
B. R. Mignon ◽  
T. Leclipteux ◽  
CH. Focant ◽  
A. J. Nikkels ◽  
G. E. PIErard ◽  
...  
Keyword(s):  
Immune Response ◽  
Cellular Immune Response ◽  
Guinea Pigs ◽  
Microsporum Canis ◽  
Cellular Immune
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