The use of mild viruses for control of plant pathogenic viruses

2021 ◽  
pp. 507-540
Author(s):  
Nelia Ortega-Parra ◽  
◽  
Zafeiro Zisi ◽  
Inge M. Hanssen ◽  
◽  
...  
Keyword(s):  
Viral Vectors ◽  
Management Strategies ◽  
Cross Protection ◽  
Commercial Application ◽  
Future Research ◽  
Viral Pathogens ◽  
Resistant Varieties ◽  
Rapid Control ◽  
Pathogenic Viruses ◽  
Emerging Viral Diseases

Plant virus management strategies have largely been limited to the application of hygiene protocols, the control of viral vectors such as insects and nematodes and the use of resistant varieties. However, these approaches are often insufficient to prevent infections. The rapid control of newly emerging viral diseases remains challenging. This chapter focuses on cross-protection using mild viruses as active substances in biocontrol. The chapter begins by describing the theoretical modes of action of cross-protection. It then goes on to discuss crucial elements in the development of a cross-protection strategy, taking into account new insights based on commercial application of cross-protection. The chapter also provides case studies in which cross-protection has been applied in commercial crops, in particular vaccination strategies to control Pepino mosaic virus (PepMV) in greenhouse tomato. Finally, developments that may impact future research into the control of emerging viral pathogens are discussed.

Understanding Limited Use of Amplification in Infants and Children Who Are Hard of Hearing

2015 ◽  
Vol 25 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Ryan W. McCreery ◽  
Elizabeth A. Walker ◽  
Meredith Spratford
Keyword(s):  
Hard Of Hearing ◽  
Hearing Aid ◽  
Management Strategies ◽  
Infants And Children ◽  
Future Research ◽  
Research Needs ◽  
Case Examples ◽  
Hearing Aid Use ◽  
Wide Range ◽  
In Infants And Children

The effectiveness of amplification for infants and children can be mediated by how much the child uses the device. Existing research suggests that establishing hearing aid use can be challenging. A wide range of factors can influence hearing aid use in children, including the child's age, degree of hearing loss, and socioeconomic status. Audiological interventions, including using validated prescriptive approaches and verification, performing on-going training and orientation, and communicating with caregivers about hearing aid use can also increase hearing aid use by infants and children. Case examples are used to highlight the factors that influence hearing aid use. Potential management strategies and future research needs are also discussed.

scholarly journals A qualitative investigation of LGBTQ+ young people’s experiences and perceptions of self-managing their mental health

2021 ◽  
Author(s):  
Rosa Town ◽  
Daniel Hayes ◽  
Peter Fonagy ◽  
Emily Stapley
Keyword(s):  
Mental Health ◽  
Young People ◽  
Management Strategies ◽  
Intervention Development ◽  
Community Support ◽  
Self Management ◽  
Future Research ◽  
Youth Groups ◽  
Coping Methods ◽  
Group A

AbstractThere is evidence that young people generally self-manage their mental health using self-care strategies, coping methods and other self-management techniques, which may better meet their needs or be preferable to attending specialist mental health services. LGBTQ+ young people are more likely than their peers to experience a mental health difficulty and may be less likely to draw on specialist support due to fears of discrimination. However, little is known about LGBTQ+ young people’s experiences and perceptions of self-managing their mental health. Using a multimodal qualitative design, 20 LGBTQ+ young people participated in a telephone interview or an online focus group. A semi-structured schedule was employed to address the research questions, which focussed on LGBTQ+ young people’s experiences and perceptions of self-managing their mental health, what they perceived to stop or help them to self-manage and any perceived challenges to self-management specifically relating to being LGBTQ+ . Reflexive thematic analysis yielded three key themes: (1) self-management strategies and process, (2) barriers to self-management and (3) facilitators to self-management. Participants’ most frequently mentioned self-management strategy was ‘speaking to or meeting up with friends or a partner’. Both barriers and facilitators to self-management were identified which participants perceived to relate to LGBTQ+ identity. Social support, LGBTQ+ youth groups and community support were identified as key facilitators to participants’ self-management of their mental health, which merits further investigation in future research. These findings also have important implications for policy and intervention development concerning LGBTQ+ young people’s mental health.

scholarly journals When the Day Goes Awry: Families Caring for Persons With Dementia

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 638-639
Author(s):  
Karen Roberto ◽  
Jyoti Savla ◽  
Steven Zarit
Keyword(s):  
Family Caregivers ◽  
Rural Areas ◽  
Service Use ◽  
Management Strategies ◽  
Care Quality ◽  
Future Research ◽  
Full Time ◽  
Daily Lives ◽  
Formal Service ◽  
Formal Services

Abstract The daily lives of family caregivers of persons with dementia (PwD) often require that they manage multiple competing demands in a context of unpredictability. Memory and behavior changes associated with dementia can cause PwD to act in random and irrational ways that create stress and influence all aspects of caregivers’ everyday life. Supportive others, including informal helpers and formal service professionals, should provide relief to primary caregivers; however, help may not alleviate caregiver stress and can sometimes compound the burden of care. This symposium draws on daily diary surveys and face-to-face interviews to focus on four aspects of managing everyday care of PwD among family caregivers in rural areas. Brandy Renee McCann explores how caregivers’ vigilance on behalf of PwD care quality interacts with service use. Karen Roberto examines the ways in which caregivers manage PwD resistance to help, including their use of forceful care strategies. Rosemary Blieszner focuses on competing caregiver roles and demands that may contribute to or alleviate caregiver stress. Tina Savla addresses the unexpected, and often hidden, challenges involved in using formal services. Collectively, the four presentations provide in-depth insight into the complicated daily lives of families coping with dementia and the ways in which they meet the demands of full-time caregiving under often difficult and challenging circumstances. Discussant Steve Zarit considers the efficacy of these management strategies for various aspects of everyday care and offers suggestions for future research and person-centered programs and interventions to reduce health disparities among caregivers in rural areas.

Linking Residential Parking to Automobile Transportation Impact Outcomes at a Development Level

2020 ◽  
pp. 036119812096479
Author(s):  
Kristina M. Currans ◽  
Gabriella Abou-Zeid ◽  
Nicole Iroz-Elardo
Keyword(s):  
Travel Behavior ◽  
Travel Demand ◽  
Demand Management ◽  
Management Strategies ◽  
Land Development ◽  
Future Research ◽  
Alternative Mode ◽  
Travel Demand Management ◽  
Development Level ◽  
Automobile Demand

Although there exists a well-studied relationship between parking policies and automobile demand, conventional practices evaluating the transportation impacts of new land development tend to ignore this. In this paper, we: (a) explore literature linking parking policies and vehicle use (including vehicle trip generation, vehicle miles traveled [VMT], and trip length) through the lens of development-level evaluations (e.g., transportation impact analyses [TIA]); (b) develop a conceptual map linking development-level parking characteristics and vehicle use outcomes based on previously supported theory and frameworks; and (c) evaluate and discuss the conventional approach to identify the steps needed to operationalize this link, specifically for residential development. Our findings indicate a significant and noteworthy dearth of studies incorporating parking constraints into travel behavior studies—including, but not limited to: parking supply, costs or pricing, and travel demand management strategies such as the impacts of (un)bundled parking in housing costs. Disregarding parking in TIAs ignores a significant indicator in automobile use. Further, unconstrained parking may encourage increases in car ownership, vehicle trips, and VMT in areas with robust alternative-mode networks and accessibility, thus creating greater demand for vehicle travel than would otherwise occur. The conceptual map offers a means for operationalizing the links between: the built environment; socio-economic and demographic characteristics; fixed and variable travel costs; and vehicle use. Implications for practice and future research are explored.

scholarly journals Tics in patients with encephalitis

2021 ◽  
Author(s):  
James Badenoch ◽  
Tamara Searle ◽  
Iona Watson ◽  
Andrea E. Cavanna
Keyword(s):  
Movement Disorders ◽  
Future Research ◽  
Viral Pathogens ◽  
Encephalitis Lethargica ◽  
Scientific Databases ◽  
Aspartate Receptor ◽  
Immune Mediated ◽  
Jakob Disease ◽  
Meta Analyses ◽  
Practical Implications

Abstract Background Movement disorders have been described in the context of different types of encephalitis. Among hyperkinetic manifestations, tics have sporadically been reported in cases of encephalitis resulting from a range of aetiologies. Objective This review aimed to assess the prevalence and characteristics of tics in patients with encephalitis. Methods We conducted a systematic literature review of original studies on the major scientific databases, according to the standards outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results In addition to the established association between tics and encephalitis lethargica, our literature search identified reports of tics in patients with immune-mediated pathologies (including autoimmune encephalitides affecting the N-methyl-d-aspartate receptor, voltage-gated potassium channels, and glycine receptors) and infective processes (ranging from relatively common viral pathogens, such as herpes simplex, to prions, as in Creutzfeldt-Jakob disease). Tics were most commonly reported in the post-encephalitic period and involvement of the basal ganglia was frequently observed. Discussion The association of new-onset tics and encephalitis, in the background of other neuropsychiatric abnormalities, has practical implications, potentially improving the detection of encephalitis based on clinical features. Future research should focus on the categorisation and treatment of hyperkinetic movement disorders associated with encephalitis.

Research Advances in Potyviruses: From the Laboratory Bench to the Field

2021 ◽  
Vol 59 (1) ◽  
Author(s):  
Xiuling Yang ◽  
Yinzi Li ◽  
Aiming Wang
Keyword(s):  
Control Strategies ◽  
Genetic Resistance ◽  
Plant Viruses ◽  
Infection Process ◽  
Future Research ◽  
Annual Review ◽  
Publication Date ◽  
Viral Pathogens ◽  
Genome Expression ◽  
Amount Of Knowledge

Potyviruses (viruses in the genus Potyvirus, family Potyviridae) constitute the largest group of known plant-infecting RNA viruses and include many agriculturally important viruses that cause devastating epidemics and significant yield losses in many crops worldwide. Several potyviruses are recognized as the most economically important viral pathogens. Therefore, potyviruses are more studied than other groups of plant viruses. In the past decade, a large amount of knowledge has been generated to better understand potyviruses and their infection process. In this review, we list the top 10 economically important potyviruses and present a brief profile of each. We highlight recent exciting findings on the novel genome expression strategy and the biological functions of potyviral proteins and discuss recent advances in molecular plant–potyvirus interactions, particularly regarding the coevolutionary arms race. Finally, we summarize current disease control strategies, with a focus on biotechnology-based genetic resistance, and point out future research directions. Expected final online publication date for the Annual Review of Phytopathology, Volume 59 is August 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Comprehensive Imaging Characterization of Colorectal Liver Metastases

2021 ◽  
Vol 11 ◽  
Author(s):  
Drew Maclean ◽  
Maria Tsakok ◽  
Fergus Gleeson ◽  
David J. Breen ◽  
Robert Goldin ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Imaging Techniques ◽  
Management Strategies ◽  
Disease Assessment ◽  
Future Research ◽  
Phenotypic Characterisation ◽  
Challenges And Opportunities ◽  
Advanced Analysis

Colorectal liver metastases (CRLM) have heterogenous histopathological and immunohistochemical phenotypes, which are associated with variable responses to treatment and outcomes. However, this information is usually only available after resection, and therefore of limited value in treatment planning. Improved techniques for in vivo disease assessment, which can characterise the variable tumour biology, would support further personalization of management strategies. Advanced imaging of CRLM including multiparametric MRI and functional imaging techniques have the potential to provide clinically-actionable phenotypic characterisation. This includes assessment of the tumour-liver interface, internal tumour components and treatment response. Advanced analysis techniques, including radiomics and machine learning now have a growing role in assessment of imaging, providing high-dimensional imaging feature extraction which can be linked to clinical relevant tumour phenotypes, such as a the Consensus Molecular Subtypes (CMS). In this review, we outline how imaging techniques could reproducibly characterize the histopathological features of CRLM, with several matched imaging and histology examples to illustrate these features, and discuss the oncological relevance of these features. Finally, we discuss the future challenges and opportunities of CRLM imaging, with a focus on the potential value of advanced analytics including radiomics and artificial intelligence, to help inform future research in this rapidly moving field.

scholarly journals Cell Line Platforms Support Research into Arthropod Immunity

Insects ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 738
Author(s):  
Cynthia L. Goodman ◽  
David S. Kang ◽  
David Stanley
Keyword(s):  
Immune Responses ◽  
Cell Line ◽  
Cell Lines ◽  
Cost Effective ◽  
Future Research ◽  
Innate Immune Responses ◽  
Pathogenic Viruses ◽  
Future Research Directions ◽  
Bacteria And Fungi ◽  
Robust Systems

Innate immune responses are essential to maintaining insect and tick health and are the primary defense against pathogenic viruses, bacteria, and fungi. Cell line research is a powerful method for understanding how invertebrates mount defenses against pathogenic organisms and testing hypotheses on how these responses occur. In particular, immortal arthropod cell lines are valuable tools, providing a tractable, high-throughput, cost-effective, and consistent platform to investigate the mechanisms underpinning insect and tick immune responses. The research results inform the controls of medically and agriculturally important insects and ticks. This review presents several examples of how cell lines have facilitated research into multiple aspects of the invertebrate immune response to pathogens and other foreign agents, as well as comments on possible future research directions in these robust systems.

scholarly journals Investigation of Various Diseases Occurred in Poultry and Management Strategies for Eradication

2018 ◽  
Vol 7 (3.1) ◽  
pp. 150
Author(s):  
Sunil Patil ◽  
Chhanwal I.L
Keyword(s):  
Family Income ◽  
Migratory Birds ◽  
Management Practice ◽  
Management Strategies ◽  
Farm Management ◽  
Poultry Meat ◽  
Highly Pathogenic ◽  
The World ◽  
Pathogenic Viruses ◽  
Poultry Disease

Poultry plays a significant role in the Indian economy. Around 60 billion chickens are raised per annum as a basis of food for both their eggs and meat. Poultry meat is in significant source of minerals, protein and various vitamins to balance the diet of human. Broiler farming is an important source of family income depending on size of the farm. Chicken farming in Commercial way is the most fruitful business in India and all around the world. Proper farm management practice and care of birds will result in decent profit in a short span of time. In this paper, we are discussing various diseases caused to poultry hen and their preventing or treating methods. Our results shows that some of disease cannot be cured and only it can be prevented. Spreading of disease with the help of contaminated equipment and infected poultry trade is measured as foremost means of spreading of poultry disease. In some countries migratory birds have also been foremost means of spreading of poultry disease like highly pathogenic viruses. 

scholarly journals Mangrove Forest Restoration by Fisheries Communities in Lampung Bay: A study based on perceptions, willingness to pay, and management strategy

2021 ◽  
pp. 224-244
Author(s):  
Maulana Firdaus ◽  
Katsumori Hatanaka ◽  
Ramadhona Saville
Keyword(s):  
Willingness To Pay ◽  
Scenario Analysis ◽  
Mangrove Forest ◽  
Forest Restoration ◽  
Local Community ◽  
Management Strategies ◽  
Primary Data ◽  
Future Research ◽  
Mangrove Forests ◽  
Policy Scenario

Mangroves provide benefits and various services to local communities living along coastal areas, particularly fishery communities. Fishery community perceptions are significant in determining attitudes towards improving mangrove conditions, which can also be addressed through restoration activities. This research was conducted to analyze fisheries communities perceptions, willingness to pay (WTP) for mangroves restoration, and mangrove forest management strategies. Field surveys were conducted from July-August 2019 and February-March 2020. Primary data were collected from respondents in four regions (Kalianda Regency, South Lampung Regency, Bandar Lampung City, and Pesawaran Regency) in Lampung Province, Indonesia, which consist of fishers, shrimp farmers, crab and wood seekers, and finfish farmers. The respondents were 193 people, and four experts were involved in the policy scenario analysis. Results revealed a gap in the value of WTP among fishery community groups, in which the average value for fishers is lower than shrimp farmers. The years of formal education significantly influenced the WTP for mangrove restoration. Based on the scenario analysis, scenario 01 become a priority strategy, where four policies (P1 = Mangrove ecotourism development in Lampung Bay; P2 = Mangrove knowledge education and training on processing mangrove based products; P3 = Restoration and conservation of mangrove forests; and P4 = Community-based management for mangrove forests utilization) show high likelihoods to be simultaneously implemented for mangroves management, with mangrove ecotourism policy as the most decisive policy. For future research, other explanatory variables can be added, such as information on family member characteristics, and to develop a bottom-up policy scenario by identifying and involving the role of the local community.

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