scholarly journals Influence of interferon types on COVID-19 prevention and treatment

2021 ◽  
Author(s):  
S. S. Saidov ◽  
S. N. Ionov ◽  
A. S. Saidov ◽  
L. V. Krasovskaya ◽  
A. V. Zabotnov
Keyword(s):  
Prevention And Treatment ◽  
Coronavirus Infection

This article discusses the properties of endogenous and exogenous interferon as the most effective element in the fight against a new coronavirus infection, analyzes the use of various groups of interferons, the time criteria for their use, and resistance to modified strains of coronavirus.

Heparin inhalation in patients with new coronavirus infection (review)

2020 ◽  
Author(s):  
Н.А. Воробьева ◽  
Е.В. Ройтман ◽  
Е.Ю. Мельничук
Keyword(s):  
Lipoprotein Lipase ◽  
Medical Staff ◽  
Systemic Effects ◽  
Microvascular Thrombosis ◽  
Prevention And Treatment ◽  
Individual Protection ◽  
Coronavirus Infection ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Гепарин используется в клинической практике преимущественно как антикоагулянт. Однако спектр его эффектов значительно шире: противовоспалительный, антипролиферативный, гиполипидемический (как прямой, так и посредством повышения активности липопротеинлипазы), антикоагулянтный, противоотечный и др. Именно на противовоспалительное действие гепарина сделан акцент при терапии COVID-19. Одним из патогенетически обоснованных методов профилактики и терапии микрососудистого тромбоза в тканях легких может быть использование ингаляций нефракционированного гепарина, что позволяет реализовать как местное, так и системное действие этого препарата. Терапия ингаляциями гепарина не будет значительно увеличивать риск контаминации вирусом SARS-CoV-2 медицинского персонала при неукоснительном соблюдении стандартов и рекомендуемых мер индивидуальной защиты. Heparin is considered traditionally as an anticoagulant although it has anti-inflammatory, antiproliferative, hypolipidemic (both direct and by increasing the activity of lipoprotein lipase), anticoagulative, anti-edema effects as well. The anti-inflammatory effect of heparin is in the focus of COVID-19 therapy. Inhaled (nebulized) heparin performs local and systemic effects. This way is pathogenetically justified for the prevention and treatment of microvascular thrombosis in lung tissues. Procedures of heparin inhalation should not significantly increase the risk for medical staff to become infected with SARS-CoV-2 when individual protection is fully observed.

Promising natural compounds as possible means of prevention and treatment of the novel coronavirus infection caused by the SARS-CoV-2 virus

2020 ◽  
pp. 95-101
Author(s):  
V.M. Nikolaev ◽  
N.K. Chirikova ◽  
S.I. Sofronova ◽  
E.K. Rumyancev ◽  
A.G. Vasileva ◽  
...  
Keyword(s):  
Natural Compounds ◽  
The Novel ◽  
Prevention And Treatment ◽  
Coronavirus Infection ◽  
Novel Coronavirus

scholarly journals Prevention and treatment system of novel coronavirus infection in medical and health institutions: experience in West China Hospital of Sichuan University

2020 ◽  
Vol 37 (10) ◽  
pp. 639-641
Author(s):  
Qiao Zhou ◽  
He Yu ◽  
Zong-An Liang ◽  
Rong Yao ◽  
Feng-Ming Luo ◽  
...  
Keyword(s):  
Treatment System ◽  
The Novel ◽  
West China Hospital ◽  
West China ◽  
Global Pandemic ◽  
Prevention And Treatment ◽  
Coronavirus Infection ◽  
Health Institutions ◽  
Novel Coronavirus

The novel coronavirus infection broke out in Wuhan, China, in December 2019, and progressed to a global pandemic. We describe the measures taken by West China Hospital of Sichuan University to address the diagnosis, prevention and treatment of the infection.

scholarly journals Pathogenesis, Diagnosis, and Treatment of Hemostatic Disorders in COVID-19 Patients

Acta Naturae ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 79-84
Author(s):  
Airat F. Khalirakhmanov ◽  
Kamilla F. Idrisova ◽  
Raushaniya F. Gajfullina ◽  
Sergey V. Zinchenko ◽  
Rustem I. Litvinov ◽  
...  
Keyword(s):  
Multiple Organ ◽  
Pulmonary Insufficiency ◽  
The Novel ◽  
Thromboembolic Complications ◽  
Short Period ◽  
Prevention And Treatment ◽  
Organ Failures ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Hemostatic Disorders

The novel coronavirus infection named COVID-19 was first detected in Wuhan, China, in December 2019, and it has been responsible for significant morbidity and mortality in scores of countries. At the time this article was being written, the number of infected and deceased patients continued to grow worldwide. Most patients with severe forms of the disease suffer from pneumonia and pulmonary insufficiency; in many cases, the disease is generalized and causes multiple organ failures and a dysfunction of physiological systems. One of the most serious and prognostically ominous complications from COVID-19 is coagulopathy, in particular, decompensated hypercoagulability with the risk of developing disseminated intravascular coagulation. In most cases, local and diffuse macro- and microthromboses are present, a condition which causes multiple-organ failure and thromboembolic complications. The causes and pathogenic mechanisms of coagulopathy in COVID-19 remain largely unclear, but they are associated with systemic inflammation, including the so-called cytokine storm. Despite the relatively short period of the ongoing pandemic, laboratory signs of serious hemostatic disorders have been identified and measures for specific prevention and correction of thrombosis have been developed. This review discusses the causes of COVID-19 coagulopathies and the associated complications, as well as possible approaches to their early diagnosis, prevention, and treatment.

scholarly journals Aminodihydrophthalazinedione sodium in prevention, therapy and rehabilitation of patients with respiratory diseases

2021 ◽  
Vol 23 (3) ◽  
pp. 296-303
Author(s):  
Dmitry I. Trukhan ◽  
◽  
Natalya V. Bagisheva ◽  
Anna V. Mordyk ◽  
Ekaterina Yu. Nebesnaya ◽  
...  
Keyword(s):  
Viral Infections ◽  
Laboratory Diagnostics ◽  
The Novel ◽  
Modern Approach ◽  
Prevention Therapy ◽  
Prevention And Treatment ◽  
Respiratory Pathology ◽  
Coronavirus Infection ◽  
Respiratory Viral Infections ◽  
Novel Coronavirus

The modern approach to the prevention and treatment of acute respiratory viral infections consists in the use of drugs that increase the body’s defenses, helping to create a barrier to the penetration of the virus. Immunomodulators exhibit a nonspecific effect in acute respiratory viral infections, which makes it possible to use them against various types of respiratory viruses without accurate laboratory diagnostics and expands clinical capabilities. In the first part of the review, the features of sodium aminodihydrophthalazinedione and the experience of its use in respiratory pathology are considered. The pandemic of the novel coronavirus infection (COVID-19), spread by the novel coronavirus SARS-CoV-2, has become a challenge to health systems around the world. The second part of the review reviews the results of the first studies on the use of sodium aminodihydrophthalazinedione for the prevention and treatment of new coronavirus infection. Recently, much attention has been paid to the long-term consequences of the postponed coronavirus infection. In the final part of the review, various aspects of the “post-COVID syndrome” are discussed and the possibilities of aminodihydrophthalazinedione sodium at the stage of rehabilitation after a coronavirus infection are discussed.

scholarly journals Experience in the prevention and effectiveness of treatment of coronavirus infection at the prehospital stage

2021 ◽  
pp. 3-7
Author(s):  
V. E. Kazmirchuk ◽  
N. V. Denderuk ◽  
V. F. Orlik
Keyword(s):  
Cardiovascular System ◽  
Oxygen Therapy ◽  
Human Immunoglobulin ◽  
Single Person ◽  
Mental Problems ◽  
Prevention And Treatment ◽  
Coronavirus Infection

The paper describes the experience of prevention and treatment of coronavirus infection at the pre-hospital stage. Preventive schemes for the use of intramuscular human immunoglobulin normal, schemes for the use of 10 % bioven, albumin, dexamethasone, bicillin are indicated. Examples of patients with various chronic comorbid pathologies are given. Of the 150 patients who received the above prophylaxis and treatment, there were no mental problems from the cardiovascular system and no postcoid syndrome was observed. Not a single person was admitted to the hospital for oxygen therapy, and no one died.

scholarly journals Genetic determinants of the response to coronavirus infection COVID-19

2020 ◽  
Author(s):  
SV Poyarkov ◽  
VV Makarov ◽  
SA Kraevoy ◽  
SM Yudin
Keyword(s):  
Life Cycle ◽  
Clinical Manifestation ◽  
Clinical Course ◽  
Viral Life Cycle ◽  
Genetic Determinants ◽  
Allelic Variants ◽  
Prevention And Treatment ◽  
Coronavirus Infection ◽  
Personalized Approach

The heterogeneity of the clinical manifestation of COVID-19 may be associated with the characteristics of the genome of both humans and the virus. A combination of allelic variants of genes associated with viral life cycle can determine susceptibility to SARS-CoV-2 infection. Allelic variants in genes ACE1, ACE2, TMPRSS2, IL6, SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6, and XCR1 can determine the severity of COVID-19. Analysis of the genomes of COVID-19 patients with different clinical course and development on their basis of model for stratification of people according to the degree of susceptibility and severity of manifestation will allow to develop a personalized approach for the prevention and treatment of COVID-19.

scholarly journals Cancer patients having COVID-19 in Primorsky region: Morbidity and mortality

2020 ◽  
pp. 5-9
Author(s):  
A. V. Fateeva ◽  
L. I. Gurina
Keyword(s):  
Medical Treatment ◽  
Cancer Patients ◽  
Causative Agent ◽  
International Committee ◽  
Intensive Study ◽  
Virus Taxonomy ◽  
Death Rates ◽  
Medical Specialists ◽  
Prevention And Treatment ◽  
Coronavirus Infection

In the end of the year 2019 there was an outbreak of the new coronavirus infection with the epicenter in China, Wuhan (Hubei province). On 11th of February WHO defined an official name of the infection generated by new coronavirus – COVID-19 (COronaVIrus Disease 2019). On the 11th of February the International Committee on Virus Taxonomy assigned the name to the causative agent – SARS-CoV-2. The emergence of the COVID-19 set the task to the medical specialists connected with the fast diagnostics and providing medical treatment to the patients. Currently the intensive study of the clinical and epidemiological peculiarities of the disease, the development of new ways of prevention and treatment is the ongoing process. In this article the results of the morbidity and death rates connected with COVID-19 of the patients having cancer in Primorskiy region from 31st of March to 31st of August 2020 are introduced.

Neurological disorders associated with Covid-19 (literature review)

2020 ◽  
Vol 21 (4) ◽  
pp. 140-144
Author(s):  
M. A. Ahmet’yanov ◽  
◽  
O. A. Kicherova ◽  
L. I. Reikhert ◽  
M. V. Deeva ◽  
...  
Keyword(s):  
Nervous System ◽  
Literature Review ◽  
Healthcare System ◽  
Neurological Disorders ◽  
Neurological Complications ◽  
Pathological Conditions ◽  
Prevention And Treatment ◽  
Coronavirus Infection ◽  
Human Nervous System

The pandemic of the new SARS-CoV2, that started at the beginning of 2020, caused a catastrophic increase in morbidity and mortality in early 2020 and posed a number of challenges for healthcare system. Primarily, this concerns the study of the effect on different organs and systems, that new virus can exhibit. This knowledge further can serve as a key to the development of effective methods for the prevention and treatment of COVID-19 associated pathological conditions. The objectives of this review include the analysis of neurological complications caused by the new coronavirus infection and the determination of the possible mechanisms of the virus’s effect on the human nervous system.

COVID-associated coagulopathy and its consequences

2021 ◽  
pp. 56-71
Author(s):  
Larisa Vladimirovna Bychkova ◽  
Pavel Evgen’evich Shmaevskii ◽  
\Mihail Grigor’evich Rodoman ◽  
Ekaterina Vasil’evna Mukovnikova ◽  
Dar’ya Andreevna Tsigura ◽  
...  
Keyword(s):  
Literature Review ◽  
Respiratory System ◽  
Organ Damage ◽  
Hematopoietic System ◽  
Treatment Methods ◽  
Comprehensive Literature Review ◽  
Target Organs ◽  
Prevention And Treatment ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Novel coronavirus disease has been known for about a year and a half. Medical scientists worldwide have been united to fight it. 2019 novel coronavirus infection, COVID-19, can harm the heart, kidneys, hematopoietic system, and brain, in addition to the respiratory system. At present, there is a large amount of data on the pathogenetic mechanisms of damage to target organs and systems. Both prevention and treatment methods are getting improved. Many countries started widespread COVID-19 vaccination. Still, there is a lot of problems to be solved by medical scientists and healthcare institutions. This article provides a comprehensive literature review on COVID related organ damage and its effect on multiple body systems.

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