scholarly journals Experience in the prevention and effectiveness of treatment of coronavirus infection at the prehospital stage

2021 ◽  
pp. 3-7
Author(s):  
V. E. Kazmirchuk ◽  
N. V. Denderuk ◽  
V. F. Orlik
Keyword(s):  
Cardiovascular System ◽  
Oxygen Therapy ◽  
Human Immunoglobulin ◽  
Single Person ◽  
Mental Problems ◽  
Prevention And Treatment ◽  
Coronavirus Infection

The paper describes the experience of prevention and treatment of coronavirus infection at the pre-hospital stage. Preventive schemes for the use of intramuscular human immunoglobulin normal, schemes for the use of 10 % bioven, albumin, dexamethasone, bicillin are indicated. Examples of patients with various chronic comorbid pathologies are given. Of the 150 patients who received the above prophylaxis and treatment, there were no mental problems from the cardiovascular system and no postcoid syndrome was observed. Not a single person was admitted to the hospital for oxygen therapy, and no one died.

Experience in Applying Hyperbaric Oxygen Therapy Using Portable Pressure Chambers for the Treatment of Patients with the Novel Coronavirus Infection COVID-19

Biomeditsina ◽  
2020 ◽  
pp. 39-46
Author(s):  
A. S. Samoilov ◽  
Yu. D. Udalov ◽  
M. V. Sheyanov ◽  
A. V. Gholinsky ◽  
A. B. Litvinenko
Keyword(s):  
Oxygen Saturation ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Capillary Blood ◽  
Blood Hemoglobin ◽  
Patient Groups ◽  
Radiological Changes ◽  
Coronavirus Infection ◽  
Novel Coronavirus

This communication presents the experience of using mobile pressure chambers in patients with the confi rmed novel coronavirus infection in hospital settings. The obtained preliminary results indicate positive antihypoxic effects of hyperbaric oxygen therapy (HBO) applied in the form of increased saturation. After a session of HBO, patients demonstrated an increase in the oxygen saturation of capillary blood hemoglobin at the average level of 3.71 points. Differences between SatO2 levels prior to and following HBO treatment were signifi cant in the CT2, CT3 and CT4 groups (p0.05). As expected, the effi cacy of HBO in terms of the oxygen saturation of capillary blood hemoglobin was the greatest in the patient groups showing pronounced clinical and radiological changes in the lungs.

IDENTIFICATION AND ASSESSMENT OF RISK FACTORS ROLE IN MYOCARDIAL INFARCTION DEVELOPMENT

2019 ◽  
Vol 72 (5) ◽  
pp. 779-783
Author(s):  
Victor A. Ognev ◽  
Anna A. Podpriadova ◽  
Anna V. Lisova
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Cardiovascular System ◽  
Control Group ◽  
Biological Factors ◽  
Prevention And Treatment ◽  
High Level ◽  
Social Importance ◽  
The Impact

Introduction:The high level of morbidity and mortality from cardiovascular disease is largely due toinsufficient influence on the main risk factors that contribute to the development of myocardial infarction.Therefore, a detailed study and assessment of risk factors is among the most important problems of medical and social importance. The aim: To study and evaluate the impact of biological, social and hygienic, social and economic, psychological, natural and climatic risk factors on the development of myocardial infarction. Materials and methods: A sociological survey was conducted in 500 people aged 34 to 85. They were divided into two groups. The main group consisted of 310 patients with myocardial infarction. The control group consisted of 190 practically healthy people, identical by age, gender and other parameters, without diseases of the cardiovascular system. Results: It was defined that 30 factors have a significant impact on the development of myocardial infarction.Data analysis revealed that the leading risk factors for myocardial infarction were biological and socio-hygienic. The main biological factors were: hypertension and hypercholesterolemia. The man socio-hygienic factor was smoking. Conclusions: Identification of risk factors provides new opportunities for the development of more effective approaches for the prevention and treatment of myocardial infarction.

scholarly journals ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis

2021 ◽  
Vol 22 (9) ◽  
pp. 4691
Author(s):  
Anastasia V. Poznyak ◽  
Evgeny E. Bezsonov ◽  
Ali H. Eid ◽  
Tatyana V. Popkova ◽  
Ludmila V. Nedosugova ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Renin Angiotensin System ◽  
Myocardial Damage ◽  
Angiotensin Converting Enzyme 2 ◽  
Adjacent Element ◽  
Chinese Province ◽  
Coronavirus Infection ◽  
First Time ◽  
The Relationship ◽  
Interspecies Barrier

COVID-19 is a highly contagious new infection caused by the single-stranded RNA Sars-CoV-2 virus. For the first time, this infection was recorded in December 2019 in the Chinese province of Wuhan. The virus presumably crossed the interspecies barrier and passed to humans from a bat. Initially, the disease was considered exclusively in the context of damage to the respiratory system, but it quickly became clear that the disease also entails serious consequences from various systems, including the cardiovascular system. Among these consequences are myocarditis, myocardial damage, subsequent heart failure, myocardial infarction, and Takotsubo syndrome. On the other hand, clinical data indicate that the presence of chronic diseases in a patient aggravates the course and outcome of coronavirus infection. In this context, the relationship between COVID-19 and atherosclerosis, a condition preceding cardiovascular disease and other disorders of the heart and blood vessels, is particularly interesting. The renin-angiotensin system is essential for the pathogenesis of both coronavirus disease and atherosclerosis. In particular, it has been shown that ACE2, an angiotensin-converting enzyme 2, plays a key role in Sars-CoV-2 infection due to its receptor activity. It is noteworthy that this enzyme is important for the normal functioning of the cardiovascular system. Disruptions in its production and functioning can lead to various disorders, including atherosclerosis.

SIGNIFICANCE OF PLATELETS IN INFLAMMATORY AND THROMBOTIC REACTIONS IN THE ELDERLY

2021 ◽  
pp. 76-83
Author(s):  
А. М. Осадчук ◽  
И. Л. Давыдкин ◽  
И. А. Золотовская
Keyword(s):  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
Antiplatelet Therapy ◽  
Plasma Levels ◽  
The Elderly ◽  
Wide Audience ◽  
Hemostatic System ◽  
Clinical Consequences ◽  
Coronavirus Infection ◽  
System Today

Развитие тромботических реакций, приводящих к нежелательным клиническим последствиям у лиц пожилого возраста, известно при многих заболеваниях, включая патологию сердечно-сосудистой системы. Сегодня идет накопление данных о степени выраженности изменений системы гемостаза у пациентов с новой коронавирусной инфекцией (COVID-19) и изучение тромбоцитарного и плазменного звена. Для понимания некоторых механизмов, связанных с патологией тромбоцитов, нами представлен обзор, в котором обобщены сведения о патофизиологических реакциях тромбоцитов в условиях их старения и возможных механизмах их патологической агрегации. Возможно, представленные фундаментальные и клинические данные будут интересны широкой аудитории специалистов для обсуждения ранней антитромбоцитарной терапии и ее обоснования не только у пациентов с сердечно-сосудистыми заболеваниями, но и с COVID-19. The development of thrombotic reactions that lead to undesirable clinical consequences in the elderly is known in many diseases, including pathology of the cardiovascular system. Today, data on the severity of changes in the hemostatic system in patients with a new coronavirus infection (COVID-19) and the study of platelet and plasma levels are being accumulated. In order to understand some of the mechanisms associated with platelet pathology, we present a review that summarizes information about the pathophysiological reactions of platelets in the conditions of their aging and possible mechanisms of their pathological aggregation. Perhaps the presented fundamental and clinical data will be of interest to a wide audience of specialists to discuss early antiplatelet therapy and its justification not only in patients with cardiovascular diseases, but also with COVID-19.

scholarly journals The impact of non-invasive respiratory support techniques on the lethal outcome frequency in adult with severe respiratory failure caused by the new coronavirus infection

2021 ◽  
Vol 18 (1) ◽  
pp. 47-56
Author(s):  
К. A. Tsygankov ◽  
I. N. Grachev ◽  
Vladimir I. Shatalov ◽  
А. V. Schegolev ◽  
D. A. Аveryanov ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Oxygen Therapy ◽  
High Flow ◽  
Severe Respiratory Failure ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
High Flow Oxygen ◽  
Coronavirus Infection ◽  
Group 2

The objective: to evaluate the effect of high-flow oxygen and non-invasive ventilation on the mortality rate in adults with severe respiratory failure caused by the new coronavirus infection in the intensive care unit (ICU).Subjects and methods. A one-center retrospective study was conducted. Electronic medical files of patients treated in the ICU from April 1 to May 25, 2020, were analyzed. Totally, 101 medical files were selected, further, they were divided into two groups. Group 1 (n = 49) included patients who received oxygen insufflation, and should it fail, they received traditional artificial ventilation. No non-invasive respiratory therapy was used in this group. Group 2 (n = 52) included patients who received high-flow oxygen therapy and non-invasive ventilation. The mortality rate in the groups made a primary endpoint for assessing the impact of high-flow oxygen therapy and non-invasive ventilation. The following parameters were also analyzed: drug therapy, the number of patients in whom non-invasive techniques were used taking into account the frequency of cases when these techniques failed, and the number of patients in whom artificial ventilation was initiated.Results. In Group 2, non-invasive methods of respiratory therapy were used in 31 (60%) cases. High-flow oxygen therapy was used in 19 (36%) of them; in 13 cases this method allowed weaning them from the high flow. Non-invasive ventilation was used in 18 cases, in 12 patients it was used due to progressing severe respiratory failure during humidified oxygen insufflation, in 6 patients – after the failed high-flow oxygen therapy. In Group 1, 25 (51%) patients were intubated and transferred to artificial ventilation, in Group 2, 10 (19.2%) underwent the same. The lethal outcome was registered in 23 (47%) cases in Group 1, and in 10 (19.2%) in Group 2 (p = 0.004). Analysis of drug therapy in the groups revealed the difference in the prescription of pathogenetic therapy. Logistic regression demonstrated the effectiveness of the combination of tocilizumab + a glucocorticoid in reducing the frequency of lethal cases (p = 0.001).Conclusion. The use of non-invasive respiratory support in adults with severe respiratory failure caused by the new coronavirus infection combined with therapy by tocilizumab + a glucocorticoid can reduce the incidence of lethal cases.

scholarly journals Influence of interferon types on COVID-19 prevention and treatment

2021 ◽  
Author(s):  
S. S. Saidov ◽  
S. N. Ionov ◽  
A. S. Saidov ◽  
L. V. Krasovskaya ◽  
A. V. Zabotnov
Keyword(s):  
Prevention And Treatment ◽  
Coronavirus Infection

This article discusses the properties of endogenous and exogenous interferon as the most effective element in the fight against a new coronavirus infection, analyzes the use of various groups of interferons, the time criteria for their use, and resistance to modified strains of coronavirus.

scholarly journals MiR-125 Family in Cardiovascular and Cerebrovascular Diseases

2021 ◽  
Vol 9 ◽  
Author(s):  
Yang Wang ◽  
Jing Tan ◽  
Lu Wang ◽  
Gaiqin Pei ◽  
Hongxin Cheng ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Ischemia Reperfusion Injury ◽  
Mirna Family ◽  
Ischemia Reperfusion ◽  
Cerebrovascular Diseases ◽  
Clinical Applications ◽  
Abnormal Development ◽  
Prevention And Treatment ◽  
Huge Challenge

Cardiovascular and cerebrovascular diseases are a serious threaten to the health of modern people. Understanding the mechanism of occurrence and development of cardiovascular and cerebrovascular diseases, as well as reasonable prevention and treatment of them, is a huge challenge that we are currently facing. The miR-125 family consists of hsa-miR-125a, hsa-miR-125b-1 and hsa-miR-125b-2. It is a kind of miRNA family that is highly conserved among different species. A large amount of literature shows that the lack of miR-125 can cause abnormal development of the cardiovascular system in the embryonic period. At the same time, the miR-125 family participates in the occurrence and development of a variety of cardiovascular and cerebrovascular diseases, including myocardial ischemia, atherosclerosis, ischemia-reperfusion injury, ischemic stroke, and heart failure directly or indirectly. In this article, we summarized the role of the miR-125 family in the development and maturation of cardiovascular system, the occurrence and development of cardiovascular and cerebrovascular diseases, and its important value in the current fiery stem cell therapy. In addition, we presented this in the form of table and diagrams. We also discussed the difficulties and challenges faced by the miR-125 family in clinical applications.

Heparin inhalation in patients with new coronavirus infection (review)

2020 ◽  
Author(s):  
Н.А. Воробьева ◽  
Е.В. Ройтман ◽  
Е.Ю. Мельничук
Keyword(s):  
Lipoprotein Lipase ◽  
Medical Staff ◽  
Systemic Effects ◽  
Microvascular Thrombosis ◽  
Prevention And Treatment ◽  
Individual Protection ◽  
Coronavirus Infection ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Гепарин используется в клинической практике преимущественно как антикоагулянт. Однако спектр его эффектов значительно шире: противовоспалительный, антипролиферативный, гиполипидемический (как прямой, так и посредством повышения активности липопротеинлипазы), антикоагулянтный, противоотечный и др. Именно на противовоспалительное действие гепарина сделан акцент при терапии COVID-19. Одним из патогенетически обоснованных методов профилактики и терапии микрососудистого тромбоза в тканях легких может быть использование ингаляций нефракционированного гепарина, что позволяет реализовать как местное, так и системное действие этого препарата. Терапия ингаляциями гепарина не будет значительно увеличивать риск контаминации вирусом SARS-CoV-2 медицинского персонала при неукоснительном соблюдении стандартов и рекомендуемых мер индивидуальной защиты. Heparin is considered traditionally as an anticoagulant although it has anti-inflammatory, antiproliferative, hypolipidemic (both direct and by increasing the activity of lipoprotein lipase), anticoagulative, anti-edema effects as well. The anti-inflammatory effect of heparin is in the focus of COVID-19 therapy. Inhaled (nebulized) heparin performs local and systemic effects. This way is pathogenetically justified for the prevention and treatment of microvascular thrombosis in lung tissues. Procedures of heparin inhalation should not significantly increase the risk for medical staff to become infected with SARS-CoV-2 when individual protection is fully observed.

Promising natural compounds as possible means of prevention and treatment of the novel coronavirus infection caused by the SARS-CoV-2 virus

2020 ◽  
pp. 95-101
Author(s):  
V.M. Nikolaev ◽  
N.K. Chirikova ◽  
S.I. Sofronova ◽  
E.K. Rumyancev ◽  
A.G. Vasileva ◽  
...  
Keyword(s):  
Natural Compounds ◽  
The Novel ◽  
Prevention And Treatment ◽  
Coronavirus Infection ◽  
Novel Coronavirus

scholarly journals Prevention and treatment system of novel coronavirus infection in medical and health institutions: experience in West China Hospital of Sichuan University

2020 ◽  
Vol 37 (10) ◽  
pp. 639-641
Author(s):  
Qiao Zhou ◽  
He Yu ◽  
Zong-An Liang ◽  
Rong Yao ◽  
Feng-Ming Luo ◽  
...  
Keyword(s):  
Treatment System ◽  
The Novel ◽  
West China Hospital ◽  
West China ◽  
Global Pandemic ◽  
Prevention And Treatment ◽  
Coronavirus Infection ◽  
Health Institutions ◽  
Novel Coronavirus

The novel coronavirus infection broke out in Wuhan, China, in December 2019, and progressed to a global pandemic. We describe the measures taken by West China Hospital of Sichuan University to address the diagnosis, prevention and treatment of the infection.

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