scholarly journals Sialotripsy as a treatment option for patients with salivary stone disease

2021 ◽  
Author(s):  
A. V. Ivachenco ◽  
A. E. Yablokov ◽  
Е. О. Filatova ◽  
V. A. Monakov
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Stone Disease ◽  
Submandibular Salivary Gland ◽  
Clinical Group ◽  
Preoperative Stage ◽  
Salivary Calculi ◽  
Medical University ◽  
Methods Of Treatment ◽  
Minimally Invasive Methods

Background. The pathologies of the salivary glands are very diverse. Salivary stone disease occupies a special place among diseases of the salivary glands of a non-neoplastic nature. The incidence of salivary stone disease is extremely extensive and accounts for up to 85% of all pathologies of the salivary glands.Objective. Improvement of minimally invasive methods of treatment of salivary stone disease, which does not lead to excision of the gland.Material and methods. On the basis of the Clinics of the Samara State Medical University of the Ministry of Health of Russia, in the period from 2010 to 2020, a clinical group was formed, consisting of 193 patients with salivary stone disease of various localization. The age of the patients ranged from 16 to 84 years. All patients were therapeutically examined at the preoperative stage, voluntary informed consent was signed. Shockwave sialotripsy was performed in 95 patients of the main group (in 64 patients the calculus was located in the submandibular salivary gland, in 31 patients – in the parotid salivary gland). For lithotripsy, we used a lithotripter apparatus "Edap" (France) and "Wolf" (Germany).Results. The analysis of the results obtained as a result of the study made it possible to draw a conclusion about reasonably better results of removal of calculi in the ducts of the salivary glands using the lithotripter "Swiss LithoClast® Master" (Switzerland). At the first visit and the therapeutic effect of the lithotripter, all patients suffering from bouts of salivary colic showed complete cessation.Conclusion. Thus our study, which was devoted to the study of the results of various methods of treating patients with salivary stone disease showed that sialolithotripsy using special narrowly targeted devices for crushing and subsequent excretion of salivary calculi allows to achieve the best results at present.

scholarly journals "The effectiveness of ultrasound and CT in the diagnosis of saliva stone disease. Conservative methods of treatment of salivary stone disease as an alternative to surgery.»

2018 ◽  
Vol 14 (4) ◽  
pp. 58-63
Author(s):  
Лариса Зюлькина ◽  
Larisa Zyul'kina ◽  
Екатерина Костригина ◽  
Ekaterina Kostrigina ◽  
Евгений Афанасьев ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Surgical Treatment ◽  
Salivary Glands ◽  
Stone Disease ◽  
Ct Diagnosis ◽  
Main Method ◽  
Surgical Methods ◽  
Modern Methods ◽  
Inflammatory Processes ◽  
Methods Of Treatment

Subject: Salivary stone disease is a disease that occurs as a result of inflammatory processes occurring in the salivary glands. More recently, salivary stone disease was considered a rare disease. Thanks to the available modern methods of diagnosis, the detection of salivary stone disease is significantly progressing. Purpose: In our work we aimed to figure out the most effective methods of diagnosis of salivary stone disease . Among the private methods of radiation diagnosis of salivary stone disease, we have identified ultrasound and CT examination of the salivary glands and ducts. Our task was also to determine how conservative treatment is competitive with the surgical method of treatment of this disease. Results: As a result of our studies , we concluded that the ultrasound method in the diagnosis of inflammation of the salivary glands and the presence of concretions in the glands and ducts is highly informative , safe and accessible to patients . Conservative methods of treatment used in patients who were diagnosed with the presence of concretions at the outlet of the salivary gland ducts are no less effective than surgical methods. Surgical treatment of salivary stone disease is advisable only in cases of block of the salivary gland and ducts concretions more than 0.5 cm in diameter. Conclusion: Salivary Stone disease in our medical institution is diagnosed quite often. The method of ultrasound diagnosis is the main method of examination of patients who came to us with symptoms of salivary stone disease. CT method is advisable to carry out patients in need of surgical treatment of the disease. The method of CT diagnosis allows to establish the exact coordinates and sizes of concretions located in the salivary glands and deep in the ducts.

scholarly journals The determination of specificity, sensitivity and accuracy of core needle biopsy in the diagnosis of parotid and submandibular salivary glands tumors

2019 ◽  
Vol 76 (9) ◽  
pp. 921-928
Author(s):  
Aleksandar Oroz ◽  
Zorana Bokun ◽  
Djordje Antonijevic ◽  
Jasna Jevdjic
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Tumor Tissue ◽  
Submandibular Salivary Gland ◽  
Histopathological Analysis ◽  
Core Needle ◽  
Parotid Salivary Gland ◽  
Submandibular Salivary Glands

Background/Aim. The diagnosis of tumors of salivary glands relies heavily on radiological examination and biopsy of pathological tissue. The aim of this study was to investigate the sensitivity, specificity and accuracy of core needle biopsy in diagnosis of tumors of parotid and submandibular glands. Methods. This study was designed as a crosssectional clinical trial performed between May 2008 and ?ay 2015 at the Department of Otorhinolaryngology and Maxillofacial Surgery, Clinical Center Zemun, Belgrade, Serbia. The examinations included 200 patients among which 100 were diagnosed with tumors of parotid salivary glands and 100 with tumors of submandibular salivary glands. The core needle biopsy was undertaken in all cases where tumor was smaller than 2 cm, far from blood vessels and far from the deep layer of parotid gland. The histopathological analysis was performed to identify histological type of the lesion. Upon performing the surgical procedure and consequently the tumor tissue extirpation, tissue samples obtained were investigated for the definitive diagnosis. Results. The sensitivity of the procedure was 90.9% for parotid salivary gland and 74% for submandibular salivary gland, the specificity was 95.9% for parotid salivary gland and 93% for submandibular salivary gland and the accuracy was 94.7% for parotid salivary gland and 87% for submandibular salivary gland. Based on the histopathological findings of the salivary glands obtained using core needle biopsy of the tumor tissue, it was possible to differentiate between malignant and benign lesions. Conclusion. Current investigation points to the advantages and efficiency of core needle biopsy in diagnosis of tumors of parotid and submandibular salivary glands.

scholarly journals Incidence of salivary gland tumors: A morphological study at Pathology Department of King Edward Medical University/Mayo Hospital, Lahore

2016 ◽  
Vol 12 (1) ◽  
Author(s):  
Ihteshamud Din ◽  
Mulazim Hussain Bukhari ◽  
Tahira Hamid ◽  
Samina Zaman ◽  
Qureshi G R ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Mucoepidermoid Carcinoma ◽  
Minor Salivary Glands ◽  
Pathology Department ◽  
Adenoid Cystic ◽  
Chronic Sialadenitis ◽  
Monomorphic Adenoma ◽  
Medical University ◽  
Age Range

This study was conducted to see the incidence of the lesions of Salivary Gland. All the cases of salivary tissues submitted to the Pathology Department of King Edward Medical University were taken at the end of year (Jan 2005-Dec2005) and reanalyzed. There were 42 cases of salivary glands, out of which 19(45%) were males and 23(55%) were females. Age range was 12-72 years. Major number of cases (17) were from parotid, whereas 15 were from submandibular, 04 and 06 were from sublingual and minor salivary glands like palate respectively. There were 25(59.52%) pleomorphic adenoma, 01(2.3%), 01(2.3%), 04(9.5%), 07(16.6%) were monomorphic adenoma, lymphoepithelioma, mucoepidermoid carcinoma, adenoid cystic carcinoma respectively. Only 04(9.5%) cases showed chronic sialadenitis.

scholarly journals Morphologic Characteristics of the Submandibular Salivary Gland of the Collared Peccary (Tayassu Tajacu)

2018 ◽  
Vol 35 (02) ◽  
pp. 116-121
Author(s):  
Gabriela de Souza Reginato ◽  
Cristina de Sousa Bolina ◽  
Moacir Franco Oliveira ◽  
Sonia Regina Yokomizo Almeida ◽  
Ii-sei Watanabe ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Salivary Gland ◽  
Salivary Glands ◽  
Secretory Granules ◽  
Morphological Characteristics ◽  
Acinar Cells ◽  
Collagen Fibers ◽  
Submandibular Salivary Gland ◽  
Ductal Cells ◽  
Collared Peccary

Introduction Most salivary glands is located on the inside and around the oral cavity, and are divided into major and minor salivary glands. The aim of the present study was to describe the structural and ultrastructural morphological characteristics of the lingual tissue of the submandibular glands of the collared peccary (Tayassu tajacu). Materials and Methods The submandibular glands (n = 10) of adult male collared peccaries ( T. tajacu) were used for histological and ultrastructural analysis. The techniques used were light microscopy, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Results The submandibular salivary glands of the collared peccary (T. tajacu) showed a capsule formed by a connective tissue containing the acinus and duct cells. Histologically, the nuclei located at the basal region of the cells was observed. The light polarized microscopy clearly showed the presence of type I and type III collagen. In the SEM image, the submandibular salivary gland revealed a round aspect separated in several lobules with bundles of collagen fibers. The vibratome sections showed the groupings of acinar cells, with intermingled secretory ducts containing vessels of different diameters. The secretory granules were noted in the apical portion of the acinar and ductal cells. The thick bundles of collagen fibers formed a glandular capsule and were identified around of the acinar and ductal cells in three-dimensional SEM images. The TEM images showed a number of secretory granules, especially in the apical region of the cytoplasm of the acinar cells and in the basal portion of the nuclei. The granular endoplasmic reticulum area, the euchromatic nuclei and the cytoplasmic projections may be seen. Mucous acinar cells separated by fine collagen fibers were also observed. Conclusion The morphological characteristics of the submandibular gland of the collared peccary is similar to that of other mammals with the same eating habits and habitat.

Exosomes Derived from Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSC) Protect Submandibular Glands in Diabetic Rats

2021 ◽  
Vol 11 (11) ◽  
pp. 2168-2173
Author(s):  
Cong Zhang ◽  
Xiaohong Zhang ◽  
Min Zhang
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Salivary Gland ◽  
Salivary Glands ◽  
Serum Amylase ◽  
Diabetic Rats ◽  
Submandibular Salivary Gland ◽  
Amylase Level ◽  
Group I

Our study assess whether exosomes derived from bone marrow mesenchymal stem cells (BM-MSC) ameliorates diabetic salivary gland complications. 10 SD rats were assigned into diabetes group I and exosome treatment group II. Diabetic rats were induced by streptozotocin (STZ) and injected with DMSO or exosomes through tail vein followed by collection of submandibular salivary gland samples for histological analysis and TGFβ, Smad2 and Smad3 level by PCR, saliva IgA and serum amylase level. Compared with control mice, exosome treatment mice showed less fibrosis of the submandibular salivary glands and duct components with a more complete structure. Exosome treatment inhibited TGFβ, Smad2 and Smad3 level to reduce diabetic salivary gland complications, effectively decreased blood sugar level, improved salivary glands function with significantly reduced serum amylase and salivary IgA levels. In conclusion, BM-MSC-derived exosomes may be a new therapeutic strategy for treating diabetic salivary gland complications.

In Vivo Accuracy of Ultrasound for Sizing Salivary Ductal Calculi

2020 ◽  
pp. 019459982093767
Author(s):  
Christopher D. Badger ◽  
Sahil Patel ◽  
Nahir J. Romero ◽  
Andrew Fuson ◽  
Arjun S. Joshi
Keyword(s):  
Salivary Gland ◽  
Clinical Decision Making ◽  
Pearson Correlation ◽  
Hospital Setting ◽  
Submandibular Salivary Gland ◽  
Ultrasound Evaluation ◽  
Accuracy Of Measurements ◽  
Salivary Calculi ◽  
Ultrasound Measurements

Objectives The present study was developed to evaluate the accuracy of in vivo ultrasound sizing for parotid and submandibular salivary gland calculi, as compared with ex vivo pathology sizing with a standard plastic ruler after extraction. Study Design Retrospective chart review. Setting Ultrasound is frequently used to size salivary calculi and make treatment decisions, but the accuracy of measurements from this modality has not been validated. Subjects and Methods We evaluated and reviewed the charts and ultrasound examinations of 167 patients who underwent procedures for the treatment of sialolithiasis involving the parotid and submandibular glands. US examinations were performed between 2009 and 2016 in a tertiary-level hospital setting by the senior author. Measurements were collected from ultrasound evaluation before sialolithotomy, and pathology measurements were taken after removal. Ultrasound measurements in millimeters were compared with the measurements collected with a ruler. The differences were calculated and compared. Results A total of 167 calculi measurements were compared. Good concurrent validity between pathology and ultrasound measurements was suggested by a Pearson correlation of 0.92 (95% CI, 0.887-0.937). On Bland-Altman plot, correlation of the difference between US and pathology measurements showed a mean difference of 0.095 mm (95% CI, –0.19 to 0.38 mm) with a limit of agreement ranging from –3.59 mm (95% CI, –3.84 to –3.34 mm) to +3.78 mm (95% CI, +3.53 to +4.03 mm). Conclusions Ultrasound is an accurate, relatively precise, and minimally invasive imaging tool for salivary gland sialolithiasis. Preoperative size of calculi can be used to guide management and clinical decision making. Level of Evidence 2C.

scholarly journals МІКРОСТРУКТУРНА ХАРАКТЕРИСТИКА ПІДНИЖНЬОЩЕЛЕПНОЇ СЛИННОЇ ЗАЛОЗИ ЩУРА В НОРМІ

World Science ◽  
2020 ◽  
Vol 2 (3(55)) ◽  
pp. 13-17
Author(s):  
Mykhalevych Marta ◽  
Paltov Yevgen ◽  
Kryvko Yurii
Keyword(s):  
Salivary Gland ◽  
Oral Cavity ◽  
Salivary Glands ◽  
Digestive System ◽  
Submandibular Salivary Gland ◽  
Horizontal Position ◽  
Submandibular Salivary Glands ◽  
Cervical Area ◽  
Upper Gastrointestinal ◽  
Functional Purpose

Macroanatomy, topography of the submandibular salivary glands in rats, the size and mechanisms of functioning, are determined by the characteristics of the structure of the skull and cervical area, and the horizontal position of the animal body and features of the functional purpose of the glands. Salivary glands ensure the consistency of homeostasis not only in the oral cavity, but also in the upper gastrointestinal tract, performing the primary enzymatic processing of food, helping the passage of food to the esophagus. Apparently, there are no other organs that perform as many functions (secretory, secretory, excretory, secretory) and have such a significant impact on the condition of the organism, oral cavity and digestive system as a whole.This publication demonstrates microstructures characteristics of submandibular salivary gland of rats.

Cytokeratin polypeptide expression during the histogenesis of guinea pig submandibular salivary gland

Development ◽  
1987 ◽  
Vol 100 (4) ◽  
pp. 699-711
Author(s):  
G. Marshak ◽  
O. Leitner ◽  
B. Geiger
Keyword(s):  
Monoclonal Antibodies ◽  
Salivary Gland ◽  
Guinea Pig ◽  
Salivary Glands ◽  
Broad Spectrum ◽  
Submandibular Salivary Gland ◽  
Basal Cells ◽  
Ductal Cells ◽  
Terminal Buds

The present study was directed towards the characterization of cell-specific histogenetic markers for the various epithelial elements of the adult and the developing guinea pig submandibular salivary gland. We have employed immunofluorescent labelling using three cytokeratin monoclonal antibodies, for which the polypeptide specificities towards guinea pig cytokeratins were determined. All the epithelial elements of the adult gland were positively labelled with two monoclonal antibodies, namely KG 8.13 (‘broad spectrum’ anti-cytokeratin) and antibody Ks B.18 (reactive with a simple cytokeratin-specific polypeptide of 49 X 10(3) Mr). Antibody KS 8.58 (reactive with a guinea pig cytokeratin polypeptide of 50 X 10(3) Mr) labelled the basal cells of the large ducts, as well as the myoepithelium. During development of the gland, the submandibular anlage and its primary and secondary branches with their terminal buds, were uniformly labelled with the three antibodies; however, the cytokeratin polypeptides reactive with antibody KS 8.58, which were apparently expressed in all cells of the developing ducts, gradually disappear from most of the ductal cells, starting at about 6 weeks of gestation, and remain only in the basal or reserve cells of the large ducts and the myoepithelium. These observations support the notion that the basal cells retain at least some of the properties of the embryonic glandular epithelium and could be considered as pluripotent reserve cells which may function as progenitors for other epithelial elements in the salivary glands epithelia.

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