Association of Low HDL of NAFLD Patients With or Without Metabolic Syndrome

2021 ◽  
Vol 6 (1) ◽  
Keyword(s):  
Metabolic Syndrome ◽  
Low Hdl

scholarly journals Association between the Mediterranean lifestyle, metabolic syndrome and mortality: a whole-country cohort in Spain

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Mercedes Sotos-Prieto ◽  
Rosario Ortolá ◽  
Miguel Ruiz-Canela ◽  
Esther Garcia-Esquinas ◽  
David Martínez-Gómez ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Mortality ◽  
Cardiovascular Health ◽  
Total Mortality ◽  
Hdl Cholesterol ◽  
Cardiometabolic Health ◽  
The Metabolic Syndrome ◽  
Mediterranean Countries ◽  
Low Hdl ◽  
The Mediterranean

Abstract Background Evidence is limited about the joint health effects of the Mediterranean lifestyle on cardiometabolic health and mortality. The aim of this study was to evaluate the association of the Mediterranean lifestyle with the frequency of the metabolic syndrome (MS) and the risk of all-cause and cardiovascular mortality in Spain. Methods Data were taken from ENRICA study, a prospective cohort of 11,090 individuals aged 18+ years, representative of the population of Spain, who were free of cardiovascular disease (CVD) and diabetes at 2008–2010 and were followed-up to 2017. The Mediterranean lifestyle was assessed at baseline with the 27-item MEDLIFE index (with higher score representing better adherence). Results Compared to participants in the lowest quartile of MEDLIFE, those in the highest quartile had a multivariable-adjusted odds ratio 0.73 (95% confidence interval (CI) 0.5, 0.93) for MS, 0.63. (0.51, 0.80) for abdominal obesity, and 0.76 (0.63, 0.90) for low HDL-cholesterol. Similarly, a higher MELDIFE score was associated with lower HOMA-IR and highly-sensitivity C-reactive protein (P-trend < 0.001). During a mean follow-up of 8.7 years, 330 total deaths (74 CVD deaths) were ascertained. When comparing those in highest vs. lowest quartile of MEDLIFE, the multivariable-adjusted hazard ratio (95% CI) was 0.58 (0.37, 0.90) for total mortality and 0.33 (0.11, 1.02) for cardiovascular mortality. Conclusions The Mediterranean lifestyle was associated with lower frequency of MS and reduced all-cause mortality in Spain. Future studies should determine if this also applies to other Mediterranean countries, and also improve cardiovascular health outside the Mediterranean basin.

Components Analysis of Metabolic Syndrome in Acute Myocardial Infarction Patients

2018 ◽  
Vol 29 (2) ◽  
pp. 6-10
Author(s):  
Khan MMR ◽  
Sana NK ◽  
PM Basak ◽  
BC Sarker ◽  
M Akhtarul Islam ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Acute Myocardial Infarction ◽  
High Blood Pressure ◽  
Abdominal Obesity ◽  
Premature Death ◽  
Medical College ◽  
The Metabolic Syndrome ◽  
Low Hdl

Background: Metabolic syndrome confers the risk of developing acute myocardial infarction which is the most common form of coronary heart disease and the single most important cause of premature death worldwide. The frequency and association of different components of metabolic syndrome on AMI are not well understood and has not been well evaluated.Objective: The aim of this study was to assess the components of the metabolic syndrome and its association with AMI patients. This study will help in awareness building in reducing AMI by early detection of components of metabolic syndrome.Patients and methods: This was a prospective observational study consisted of 325 AMI patients who were aged >20 years. Patients with first time AMI arriving in CCU of Rajshahi medical college during the period of 2012-2014, were included. Data were collected through interview, clinical examination, and laboratory tests within 24 hrs of AMI. Five components of metabolic syndrome were defined according to criteria set by modified NCEP ATP III (according to ethnic variation).Results: In AMI patients (n=325), no metabolic components were in 24 (7.4%) patients, one in 53 (16.3%), 2 components in 91(28.0%), 3 components were in 61(18.8%), 4 in 67(20.6%) and all 5 components were in 29 (8.9%) patients. In this study, there was no component in 7.4% of AMI patients, at least 1 component was 92.6%, at least 2 components were 76.3%, at least 3 components were 48.3%, at least 4 components were 29.5% and at least 5 components were 8.9%. The Metabolic syndrome was 48.3% (n=157). Among metabolic syndrome (≥3 components) in AMI (n=157, 48.3%) 4 components (20.6%) were more, next was 3 components (18.8%) and than 5 components (8.9%). Overall frequencies of components in acute myocardial infarction (n=325) were in order of abdominal obesity (54.8%) > high blood pressure (54.5%) > high FPG (54.2%) > Triglyceride (46.2%) and low HDL-C (46.2%) in acute myocardial infarction. Highest percentage was observed in abdominal obesity (54.8%) followed by high blood pressure (54.5%) and FPG (54.2%).TAJ 2016; 29(2): 6-10

scholarly journals Heritability of the metabolic syndrome and its components in the Tehran Lipid and Glucose Study (TLGS)

2012 ◽  
Vol 94 (6) ◽  
pp. 331-337 ◽  
Author(s):  
MARYAM ZARKESH ◽  
MARYAM SADAT DANESHPOUR ◽  
BITA FAAM ◽  
MOHAMMAD SADEGH FALLAH ◽  
NIMA HOSSEINZADEH ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Hdl Cholesterol ◽  
Age And Gender ◽  
The Metabolic Syndrome ◽  
Biological Parents ◽  
Heritability Estimation ◽  
Low Hdl ◽  
And Gender ◽  
Continuous Traits

SummaryGrowing evidence suggests that metabolic syndrome (MetS) has both genetic and environmental bases. We estimated the heritability of the MetS and its components in the families from the Tehran Lipid and Glucose Study (TLGS). We investigated 904 nuclear families in TLGS with two biological parents and at least one offspring (1565 parents and 2448 children), aged 3–90 years, for whom MetS information was available and had at least two members of family with MetS. Variance component methods were used to estimate age and sex adjusted heritability of metabolic syndrome score (MSS) and MetS components using SOLAR software. The heritability of waist circumference (WC), HDL-cholesterol (HDL-C), triglycerides (TGs), fasting blood sugar (FBS), systolic blood pressure (SBP) and diastolic blood pressure (DBP) as continuous traits after adjusting for age and gender were 27, 46, 36, 29, 25, 26 and 15%, respectively, and MSS had a heritability of 15%. When MetS components were analysed as discrete traits, the estimates of age and gender adjusted heritability for MetS, abdominal obesity, low HDL-C, high TG, high FBS and high blood pressure (BP) were 22, 40, 34, 38 and 23%, respectively (P < 0·05). Three factors were extracted from the six continuous traits of the MetS including factor I (BP), factor II (lipids) and factor III (obesity and FBS). Heritability estimation for these three factors were 7, 13 (P < 0·05) and 2%, respectively. The highest heritability was for HDL-C and TG. The results strongly encourage efforts to identify the underlying susceptibility genes.

scholarly journals Persistent metabolic syndrome and risk of cardiovascular disease in children and adolescents

2018 ◽  
Vol 71 (3) ◽  
pp. 1013-1021 ◽  
Author(s):  
Camilla Ribeiro Lima de Farias ◽  
Carla Campos Muniz Medeiros ◽  
Diogo Rodrigues Souza ◽  
Ivelise Fhrideraid Alves Furtado da Costa ◽  
Mônica Oliveira da Silva Simões ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Children And Adolescents ◽  
Demographic Characteristics ◽  
Multiple Logistic Regression ◽  
Overweight Children ◽  
Low Hdl ◽  
Score Method ◽  
Blood Variables ◽  
Age And Sex

ABSTRACT Objective: to verify persistence of metabolic syndrome (MetS) and components in overweight children and adolescents, as well as its relation to socioeconomic and demographic characteristics and to the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) score. Method: a two-point longitudinal study: at enrollment and after a 24-month interval, with 133 individuals ages from two to 18 years. The demographic anthropomorphic and blood variables were evaluated. Analysis was carried out by simple and paired association tests, as well as multiple logistic regression. Results: persistent MetS was observed in 38.3% of the sample, associated cardiovascular risk (ACR) in 79.7%, reduction in arterial pressure and do HDL-c. After adjusting for age and sex, excess weight (ExpB: 0.182; CI: 0.059-0.561), low HDL-c (ExpB: 9.247; CI: 1.157-73.930) and high LDL-c (ExpB:1.915; CI: 0.921-3.979) were associated with persistent MetS. Conclusion: persistent MetS was associated with obesity, HDL-c and LDL-c, but not with the PDAY score.

Association between metabolic syndrome and knee structural change on MRI

Rheumatology ◽  
2019 ◽  
Author(s):  
Feng Pan ◽  
Jing Tian ◽  
Siti Maisarah Mattap ◽  
Flavia Cicuttini ◽  
Graeme Jones
Keyword(s):  
Metabolic Syndrome ◽  
Relative Risk ◽  
Central Obesity ◽  
Cartilage Volume ◽  
Size Increase ◽  
Volume Loss ◽  
Tibial Cartilage ◽  
Knee Oa ◽  
Low Hdl ◽  
Cartilage Volume Loss

Abstract Objective To examine the association of metabolic syndrome (MetS) and its components with knee cartilage volume loss and bone marrow lesion (BML) change. Methods Longitudinal data on 435 participants from a population-based cohort study were analysed. Blood pressure, glucose, triglycerides and high-density lipoprotein (HDL) were collected. MetS was defined based on the National Cholesterol Education Program–Adult Treatment Panel III criteria. MRI of the right knee was performed to measure cartilage volume and BML. Radiographic knee OA was assessed by X-ray and graded using the Altman atlas for osteophytes and joint space narrowing. Results Thirty-two percent of participants had MetS and 60% had radiographic knee OA. In multivariable analysis, the following were independently associated with medial tibial cartilage volume loss: MetS, β = −0.30%; central obesity, β = −0.26%; and low HDL, β = −0.25% per annum. MetS, hypertriglyceridaemia and low HDL were also associated with higher risk of BML size increase in the medial compartment (MetS: relative risk 1.72, 95% CI 1.22, 2.43; hypertriglyceridaemia: relative risk 1.43, 95% CI 1.01, 2.02; low HDL: relative risk 1.67, 95% CI 1.18, 2.36). After further adjustment for central obesity or BMI, MetS and low HDL remained statistically significant for medial tibial cartilage volume loss and BML size increase. The number of components of MetS correlated with greater cartilage volume loss and BML size increase (both P for trend <0.05). There were no statistically significant associations in the lateral compartment. Conclusion MetS and low HDL are associated with medial compartment cartilage volume loss and BML size increase, suggesting that targeting these factors has the potential to prevent or slow knee structural change.

scholarly journals Metabolic characteristics and nutrition intake on women with normal body mass index

Food Research ◽  
2020 ◽  
Vol 4 (S3) ◽  
pp. 6-12
Author(s):  
D.Y. Fitranti ◽  
F.F. Dieny ◽  
D.M. Kurniawati ◽  
R. Purwanti ◽  
B. Kusumaningnastiti ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
Normal Weight ◽  
Normal Body Mass Index ◽  
Metabolic Characteristics ◽  
Low Hdl ◽  
Nutrition Intake

Metabolic syndrome can be found on an individual with normal weight (Metabolically Obese Normal Weight/MONW). Eating habits and lifestyle changing in early adulthood can be the risk of metabolic syndrome in person with a normal body mass index (BMI). The purpose of this study was to identify metabolic characteristics in women with normal BMI and to analyze the correlation of nutrition intake with metabolic syndrome on women with normal BMI. This is an observational study with a cross-sectional design at five offices in Semarang. The sample in this study was 64 subjects. Inclusion criteria of study subject were women aged 25-40 years and BMI <25 kg/m2 . Study subject was chosen by using a consecutive sampling method. The data of nutrition intake was obtained by using the Food Frequency Questionnaire. HDL cholesterol, fasting blood glucose and triglyceride were analyzed. Analysis data was conducted by using Pearson correlation and Rank Spearman. MONW was present in 10.9% and more than 50% had pre metabolic syndrome. A total of 51.6% of the subjects had central obese and 26.6% had low HDL cholesterol. About 14.1% of the subjects have hypertension. There was a positive correlation between energy, fat intake and waist circumference. Carbohydrate intake was positively correlated with fasting blood glucose and triglyceride. The higher protein intake, the higher HDL cholesterol. The most common indicator of metabolic syndrome on women with normal BMI was central obesity and low HDL cholesterol. The factors related to the prevalence of metabolic syndrome on women with normal BMI was macronutrient intake.

Abstract MP19: Higher Parity is Associated With Components of the Metabolic Syndrome Among U.S. Hispanic/Latina Women: Results From the HCHS/SOL Study

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Catherine J Vladutiu ◽  
Anna Maria Siega-Riz ◽  
Alison M Stuebe ◽  
Daniela Sotres-Alvarez ◽  
Andy Ni ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Hispanic Women ◽  
Hdl Cholesterol ◽  
Latina Women ◽  
Live Births ◽  
The Metabolic Syndrome ◽  
Elevated Glucose ◽  
Low Hdl

Background: Physiologic adaptations occurring across successive pregnancies may increase the risk of adverse cardiovascular health outcomes in later life. Previous studies have found an association between higher parity and the metabolic syndrome (MetS). However, no studies have examined this association in a Hispanic/Latina population. Hispanic women have a higher prevalence of the MetS and higher birth rates than non-Hispanic women. Hypothesis: We assessed the hypothesis that higher parity is associated with the prevalence of components of the MetS in a cohort of Hispanic/Latina women. Methods: There were 9,482 Hispanic/Latina women of diverse backgrounds, aged 18-74 years, who participated in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) from 2008-2011. Components of the MetS were defined according to the AHA/NHLBI criteria and included abdominal obesity (waist circumference ≥88cm), elevated triglycerides (≥150 mg/dL), low HDL cholesterol (<50mg/dL), high blood pressure (systolic ≥130mmHg or diastolic ≥85mmHg or on medication), and elevated fasting glucose (≥100mg/dL or on medication). Logistic regression models were used to estimate odds ratios for the association between parity and components of the MetS, adjusting for sociodemographic, behavioral, and reproductive characteristics, and accounting for the complex survey design and sampling weights. Results: At HCHS/SOL baseline, women reported none (19.2%), one (18.9%), two (25.3%), three (19.7%), four (9.3%), and five or more (7.6%) prior live births. Compared to women with only one live birth, women with four live births had the highest odds of abdominal obesity (OR=2.5, 95% CI 1.8, 3.3) and those with five or more live births had the highest odds of low HDL cholesterol (OR=1.5, 95% CI 1.2, 1.9), elevated glucose (OR=1.8, 95% CI 1.3, 2.3), elevated triglycerides (OR=1.4, 95% CI 1.01, 1.8), and high blood pressure (OR=1.5, 95% CI 1.1, 2.0), after adjusting for age, Hispanic background, education, marital status, income, nativity, smoking, physical activity, menopause status, oral contraceptive use, hormone replacement therapy, and field center. Further adjustment for body mass index attenuated these associations for all MetS components, including abdominal obesity (OR=1.5, 95% CI 1.1, 2.2), low HDL cholesterol (OR=1.3, 95% CI 1.03, 1.7), and elevated glucose (OR=1.6, 95% CI 1.2, 2.1), but the associations for triglycerides and blood pressure were no longer statistically significant. Conclusion: Higher parity is associated with the prevalence of selected components of the MetS among U.S. Hispanic/Latina women. High parity among Latinas with a high prevalence of abdominal obesity suggests a context of high risk for metabolic dysregulation. A better characterization of the links between pregnancy, adiposity, and body fat distribution is needed.

scholarly journals Prevalence of metabolic components in university students

2014 ◽  
Vol 22 (6) ◽  
pp. 1041-1047 ◽  
Author(s):  
Ana Roberta Vilarouca da Silva ◽  
Luana Savana Nascimento de Sousa ◽  
Telma de Sousa Rocha ◽  
Ramiro Marx Alves Cortez ◽  
Layla Gonçalves do Nascimento Macêdo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Fasting Blood Glucose ◽  
Significant Proportion ◽  
Hdl Cholesterol ◽  
Clinical Analysis ◽  
Abdominal Circumference ◽  
Sample Collection ◽  
Glucose Levels ◽  
Low Hdl

OBJECTIVE: to identify the frequency of components of Metabolic Syndrome (MetS) among university students.METHOD: descriptive study with 550 students, from various courses run by a public university. The socioeconomic data, lifestyle, and components of MetS were filled out using a questionnaire. Blood sample collection was undertaken in the university itself by a contracted clinical analysis laboratory.RESULTS: 66.2% were female, with a mean age of 22.6±4.41; 71.7% were sedentary; 1.8% stated that they smoke; and 48.5% were classified as at medium risk for alcoholism. 5.8% had raised abdominal circumference and 20.4% had excess weight; 1.3% and 18.9% had raised fasting blood glucose levels and triglycerides, respectively; 64.5% had low HDL cholesterol and 8.7% had blood pressure levels compatible with borderline high blood pressure. Thus, of the sample, 64.4% had at least one component for MetS; 11.6% had two, and 3.5% had three or more.CONCLUSION: a significant proportion of the population already has the components for metabolic syndrome, and this profile reinforces the importance of early diagnosis so as to reduce the risk of developing chronic comorbidities.

scholarly journals COMPARISON OF DIFFERENT CRITERIA IN THE PREVALENCE OF METABOLIC SYNDROME IN STUDENTS FROM PARANAVAÍ, PARANÁ

2019 ◽  
Vol 37 (3) ◽  
pp. 332-337 ◽  
Author(s):  
Flávio Ricardo Guilherme ◽  
Matheus Amarante do Nascimento ◽  
Carlos Alexandre Molena-Fernandes ◽  
Vânia Renata Guilherme ◽  
Stevan Ricardo dos Santos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Confidence Interval ◽  
Children And Adolescents ◽  
Diagnostic Criteria ◽  
Public And Private ◽  
Significant Difference ◽  
Low Hdl ◽  
The Difference

ABSTRACT Objective: To investigate the difference in the proportion of students with metabolic syndrome, diagnosed according to different criteria. Methods: The sample consisted of 241 students (136 boys and 105 girls) aged 10 to 14 years, from public and private schools in Paranavaí, Paraná. We used three distinct diagnostic criteria for metabolic syndrome, considering the presence of at least three of the following risk factors: increased waist circumference, hypertension, fasting hyperglycemia, low HDL-C, and elevated triglycerides. Results: The prevalence of metabolic syndrome found was 1.7% (confidence interval of 95% - 95%CI 0-3.3) for the IDF criterion; 3.3% (95%CI 1.0-5.6) for Cook; and 17.4% (95%CI 12.6-22.3) for Ferranti. Analyzing the criteria in pairs, the agreement between IDF and Cook was 97.5% (k=0.95); between IDF and Ferranti, 83.4% (k=0.67); and between Cook and Ferranti, 85.9% (k=0.72). Onlyone student (0.4%) was diagnosed with metabolic syndrome solely by the IDF criterion, while 34 (14.1%) were diagnosed exclusively by Ferranti. The comparison of the three criteria showed that Ferranti presented the highest proportion of metabolic syndrome (p<0.001), and Cook had a greater proportion than IDF (p<0.001). Conclusions: We found a significant difference in the proportion of metabolic syndrome in the three criteria. The choice of which criterion to use can compromise not only the percentage of metabolic syndrome prevalence but also interfere in strategies of intervention and prevention in children and adolescents with and without metabolic syndrome, respectively.

scholarly journals Development of a Genetic Score to Predict an Increase in HDL Cholesterol Concentration After a Dietary Intervention in Adults with Metabolic Syndrome

2019 ◽  
Vol 149 (7) ◽  
pp. 1116-1121 ◽  
Author(s):  
Martha Guevara-Cruz ◽  
Isabel Medina-Vera ◽  
Adriana Flores-López ◽  
Miriam Aguilar-López ◽  
Caren E Smith ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Dietary Intervention ◽  
Saturated Fat ◽  
Hdl Cholesterol ◽  
Cholesterol Concentration ◽  
Genetic Score ◽  
Before And After ◽  
Low Hdl ◽  
Genetic Predisposition Score ◽  
Mexican Adults

ABSTRACT Background Dietary intervention (DI) is a primary strategy to attenuate some of the metabolic abnormalities associated with metabolic syndrome (MetS), including low HDL cholesterol. There is no biomarker that can identify individuals who respond to DI by increasing HDL cholesterol. Objective The aim of this study was to assess the predictive power of a genetic predisposition score (GPS) in Mexican adults with MetS to identify HDL cholesterol responders to DI. Methods This study followed a prospective cohort design. Sixty-seven Mexican adults aged 20–60 y (21% men) with BMI ≥25 and ≤39.9 kg/m², who had at least 3 of 5 positive criteria for MetS, were included. Participants consumed a low saturated fat diet for 2.5 mo (<7% energy as saturated fat, <200 mg of cholesterol/d) and reduced their usual diet by ∼440 kcal/d, a reduction in total energy intake of about 25%. Anthropometry and serum biochemical markers, including HDL cholesterol, were measured before and after DI. A multilocus GPS was constructed using previously reported genetic variants associated with response to diet in subjects with MetS. GPS values, designed to predict the response of HDL cholesterol to the DI, were computed for each individual as the sum of the number of effect alleles across 14 SNPs. Results Individuals were dichotomized as high and low GPS according to median GPS (−2.12) and we observed a difference in HDL cholesterol changes on DI of +3 mg/dL (6.3%) in subjects with low GPS, whereas those with high GPS had HDL cholesterol decreases of −3 mg/dL (−7.9%) (P = 0.04). Conclusions Individuals with low GPS showed greater increases in their HDL cholesterol than those with high GPS. Therefore, the GPS can be useful for predicting the HDL cholesterol response to diet.

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