Comparison of ratios combination calcium hydroxide Ca(OH)2 with red pine (Pinus densiflora) of viscosity

2021 ◽  
Vol 4 (1) ◽  
pp. 26
Author(s):  
Dian Agustin Wahjuningrum ◽  
Latief Mooduto ◽  
Ari Subiyanto ◽  
Shafa Prasita ◽  
Tamara Yuanita
Keyword(s):  
Calcium Hydroxide ◽  
Pinus Densiflora ◽  
Antibacterial Properties ◽  
Positive Control ◽  
Red Pine ◽  
Control Group ◽  
Liquid Form ◽  
Low Viscosity ◽  
Group 3 ◽  
Group 2

Background: Calcium hydroxide is a gold standard for root canal sealing material. However, there are many defects in calcium hydroxide that have prompted many researchers to look for alternative materials, including natural origin ingredients. Red pine (Pinus densiflora) is often used in dentistry for its antioxidant and antibacterial properties. The mixture of calcium hydroxide and red pine has never been achieved before. One of the criteria for material sealing is that the channel should be fully sealed with high flow ability and low viscosity. Therefore, this research is performed to analyze the viscosity value of the mixture of calcium hydroxide and red pine (Pinus densiflora). Purpose: Knowing the difference in viscosity of the combination of calcium hydroxide and red pine with a ratio of 1:1, 1:1.5, and 1:2. Methods: This study used four treatment groups, with each group consisting of 8 replications. Group 1 was a combination of calcium hydroxide and red pine with a 1: 1, group 2 the ratio was 1: 1.5, group 3 had the ratio 1: 2, and the positive control group used calcium hydroxide and a sterile aquadest. Calcium hydroxide in powder form and an extract of red pine in liquid form are mixed according to the ratio. The viscosity value is measured using a viscosity tester, namely the Brookfield Viscometer. Results: The control group had a lower viscosity than group 3, group 3, and group 2 than group1. Conclusion: Combination of calcium hydroxide and red pine with a ratio of 1:2, the lowest viscosity was obtained compared to the ratio of 1: 1 and 1: 1.5.

scholarly journals Comparison of ratios combination calcium hydroxide Ca(OH)2 with red pine (Pinus densiflora) of viscosity

2021 ◽  
Vol 11 (2) ◽  
pp. 50
Author(s):  
Latief Mooduto ◽  
Ari Subiyanto ◽  
Shafa Prasita
Keyword(s):  
Calcium Hydroxide ◽  
Pinus Densiflora ◽  
Antibacterial Properties ◽  
Positive Control ◽  
Red Pine ◽  
Control Group ◽  
Liquid Form ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Background: Calcium hydroxide is a gold standard for root canal sealing material. However, there are many defects in calcium hydroxide that have prompted many researchers to look for alternative materials, including natural origin ingredients. Red pine (Pinus densiflora) is often used in dentistry for its antioxidant and antibacterial properties. The mixture of calcium hydroxide and red pine has never been achieved before. One of the criteria for material sealing is that the channel should be fully sealed with high flow ability and low viscosity. Therefore, this research is performed to analyze the viscosity value of the mixture of calcium hydroxide and red pine (Pinus densiflora). Purpose: Knowing the difference in viscosity of the combination of calcium hydroxide and red pine with a ratio of 1:1, 1:1.5, and 1:2. Methods: This study used four treatment groups, with each group consisting of 8 replications. Group 1 was a combination of calcium hydroxide and red pine with a 1: 1, group 2 the ratio was 1: 1.5, group 3 had the ratio 1: 2, and the positive control group used calcium hydroxide and a sterile aquadest. Calcium hydroxide in powder form and an extract of red pine in liquid form are mixed according to the ratio. The viscosity value is measured using a viscosity tester, namely the Brookfield Viscometer. Results: The control group had a lower viscosity than group 3, group 3, and group 2 than group 1. Conclusion: Combination of calcium hydroxide and red pine with a ratio of 1:2, the lowest viscosity was obtained compared to the ratio of 1: 1 and 1: 1.5

scholarly journals ANTIBACTERICAL POTENCY OF CALCIUM HYDROXIDE AND PROPOLIS MIXTURE ON MIXED BACTERIA OF CARIOUS DENTIN

2019 ◽  
Vol 9 (1) ◽  
pp. 5
Author(s):  
Ruslan Effendy ◽  
Vita Ariesta ◽  
Widya Saraswati
Keyword(s):  
Calcium Hydroxide ◽  
Antibacterial Properties ◽  
Positive Control ◽  
Positive Control Group ◽  
Control Group ◽  
Group I ◽  
Carious Dentine ◽  
Group 3 ◽  
Mixed Bacteria ◽  
Group 2

Background: Calcium hydroxide has been known as the gold standard of pulp capping process, but still has some weaknesses such as a pH that is too high to be potentially toxic, resistant to certain bacteria, causing necrosis of the pulp, and causing a tunnel defect. This weakness causes researchers to look for alternative ingredients that have antibacterical properties that can be combined with calcium hydroxide. Propolis has antibacterial properties such as flavonoids, tannins, saponins, and terpenoids which can work as the best carrier that allows dissociation of ions from calcium hydroxide so the combination of both that has antibacterial power is expected to have an effective antibacterial potency against the number of bacterial colonization with mixed dentine carious. Aims: This study aims to determine the antibacterial potency produced by a combination of calcium hydroxide and propolis against mixed bacteria of carious dentine. Methods: The research was carried out using 4 treatment groups with each of 7 samples. Group I is a combination of calcium hydroxide and propolis with a ratio of 1: 1, group 2 with a ratio of 1: 1.5, group 3 with a ratio of 1: 2, and a positive control group. Each sample was put into a suspense of mixed bacteria of carious dentine, grown for 24 hours. Suspense is vortexed for 1 minute so the solution becomes homogeneous. Put 0.1 ml of suspended mixed bacteria of dentine carious from BHIB media, grown for 24 hours on MHA media and counted the number of colonies. Results: The highest number of colonies in the positive control group, then group 1, group 2, and the least number of colonies in group 3 with the most extract of propolis. Conclusion: The combination of calcium hydroxide and propolis with a ratio of 1: 2 has the best antibacterial power in inhibiting colonization of mixed bacteria of carious dentine.

scholarly journals Compressive Strength Test on Calcium Hydroxide with Propolis Combination

2019 ◽  
Vol 9 (1) ◽  
pp. 28
Author(s):  
Ira Widjiastuti ◽  
S. Setyabudi ◽  
M. Mudjiono ◽  
Erika Setyowati
Keyword(s):  
Compressive Strength ◽  
Calcium Hydroxide ◽  
Positive Control ◽  
Control Group ◽  
Propolis Extract ◽  
Pulp Capping ◽  
Alternative Ingredients ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Background: Calcium hydroxide is a dental material used as a gold standard for pulp capping materials. However, calcium hydroxide has several weaknesses which cause many researchers to look for alternative ingredients that come from nature. Propolis in the field of dentistry has long been used because of its ability as an anti-inflammatory, anti-microbial, anti-fungal, and can cure scars. The combination of calcium hydroxide and propolis is proven to have good biocompatibility and anti-bacterial properties. One of the requirements of pulp capping material is to have sufficient compressive strength. Therefore, a research to test the compressive strength value of the combination of calcium hydroxide with propolis is needed. Purpose: To find out the difference in compressive strength of the combination of calcium hydroxide-propolis with a ratio of 1: 1, 1: 1.5, and 1: 2. Methods: The study used 4 treatment groups with each group consisting of 6 replications. Group 1 is a combination of calcium hydroxide-propolis with a ratio of 1: 1, group 2 with a ratio of 1: 1.5, group 3 with a ratio of 1: 2, and a positive control group using calcium hydroxide - sterile aquadest. Calcium hydroxide powder and propolis extract liquid is mixed according to comparison and printed on a cylindrical mold with the size of 4 mm x 6 mm. Then, the compressive strength was tested using an Autograph test instrument. Result: Compressive strength was smaller in group 3 compared to group 2, group 2 compared to group 1, and group 1 compared to the control group. Conclusion: In calcium hydroxide-propolis combination, the more propolis extract used in the combination the lower the compressive strength of the combination will be.

scholarly journals Comparison of different irrigation and agitation methods for the removal of two types of calcium hydroxide medicaments from the root canal wall: An in-vitro study

2017 ◽  
Vol 90 (3) ◽  
pp. 327-332 ◽  
Author(s):  
Deepak Singh Kirar ◽  
Pradeep Jain ◽  
Pallav Patni
Keyword(s):  
Calcium Hydroxide ◽  
Root Canal ◽  
Positive Control ◽  
Positive Control Group ◽  
Control Group ◽  
Passive Ultrasonic Irrigation ◽  
Ultrasonic Irrigation ◽  
Group 2 ◽  
Group 1

Background and aim: Comparison of different irrigation and agitation methods for the removal of two types of calcium hydroxide medicaments from the root canal walls.Methods: Fifty extracted single rooted teeth were selected for this study. After decoronation, the root canals of these teeth were prepared to the size F3 (30 no.) using rotary ProTaper file system. These samples were randomly divided into four groups. Group 1 (n=20) were filled completely with water based calcium hydroxide (CH), Group 2 (n=20) were filled with oil based CH using lentulo spiral, Group 3 (n=5) - the positive control group received the CH as intracanal medication, but no subsequent removal, Group 4 (n=5) - the negative control did not receive CH placement. Further on, Group 1 and Group 2 were divided into four sub-groups (n=5). In sub-group A we performed conventional syringe irrigation with side-vented needle sub-group B) manual dynamic agitation, sub-group C sonic agitation using endoactivator, sub-group D passive ultrasonic irrigation (PUI). Roots were split longitudinally into mesial and distal halves. Digital images of the root canal walls were acquired by a Dental Operating Microscope (DOM) and assessed by using a scoring criteria at different thirds (coronal, middle and apical) of the root canal as follows: score 1, score 2, score 3, and score 4. Data were analyzed applying one-way analysis of variance (ANOVA) and Tukey’s multiple comparison tests at a 95% confidence interval (P < 0.05).Results: Statistically significant differences were not found between the experimental groups and the negative group in any one third of the root canal (P>0.05). However, a difference did exist between the experimental groups and the positive control group (P<0.05). None of the experimental groups totally removed CH substances from root canal walls.Conclusion: Among all experimental groups, removal of CH was best achieved by sonic agitation using endoactivator followed by passive ultrasonic irrigation (PUI), manual dynamic agitation and conventional syringe irrigation with side-vented needle.

Efficacy of Double Manual Cleaning Versus Automated Cleaning for Removal of Biofilm of Hinged Surgical Instruments

2020 ◽  
Vol 41 (S1) ◽  
pp. s518-s519
Author(s):  
Dayane Costa ◽  
Roel Castillo ◽  
Lillian Kelly Lopes ◽  
Anaclara Tipple ◽  
Honghua Hu ◽  
...  
Keyword(s):  
Protein Level ◽  
Positive Control ◽  
Surgical Instruments ◽  
Microbial Load ◽  
Positive Control Group ◽  
Control Group ◽  
Group 4 ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2

Objectives: To evaluate the efficacy of double manual cleaning (DMC) with enzymatic followed by alkaline detergent for removing biofilm on hinged surgical instruments compared to automated cleaning by the washer-disinfector. Methods: Biofilm of Staphylococcus aureus (ATCC 25923) was formed in vitro on hemostatic forceps (Fig. 1). Biofilm-covered forceps were rinsed in distilled water and subjected to one of the following cleaning regimes (n = 5 forceps each): Group 1 forceps were soaked in sterile water for 5 minutes. Group 2-DMC forceps were soaked in enzymatic detergent, brushed 5 times on each face, rinsed with filtrated water (0.2 µm), soaked in alkaline detergent, brushed 5 times each face, rinsed with filtrated water (0.2 µm), and dried with sterile cloth. For group 3-DMC plus hinge inner brushing (n = 5), the forceps were soaked in detergents and brushed as in group 2, including hinge inner brushing (2-mm lumen brush) (Fig. 1). In group 4 (automated cleaning in a washer/disinfector), forceps were prewashed, washed once, washed again, rinsed, thermally rinsed, and dried. After the treatments, forceps were evaluated for microbial load (counting of colony-forming units), residual protein (BCA protein assay kit), and biofilm (scanning electron microscopy). Results: There was no statistically significant differences between the microbial load and protein level contaminating the forceps subjected to DMC (group 2) and the positive control group. The DMC with hinge inner brushing group (group 3) and the automated cleaning group (group 4) demonstrated a significantly reduced microbial load: reduction averages of 2.8 log 10 (P = .038) and 7.6 log10 (P ≤ .001), respectively. The protein level remaining on the forceps also significantly decreased: 2.563 μg (P = .016) and 1,453 μg (P = .001), respectively, compared to the positive control group. There was no statistically significant difference between DMC with hinge inner brushing and automated cleaning (groups 3 and 4) for all of the tests performed. None of the cleaning methods completely removed biofilm and/or soil from the forceps hinge internal region (Fig. 1). Conclusions: Automated cleaning had the best efficacy for removing biofilm. However, DMC with hinge inner brushing was an acceptable alternative cleaning method for sterilizing service units with only manual cleaning available, as is the case in most low- and middle-income countries. Neither automated nor any manual cleaning regimes were able to completely remove biofilm and soil from the forceps hinged area, and the amount of protein left after automated and DMC plus hinge brushing was higher than the recommended. Cleaning is the most important step for the reprocessing of reusable medical devices; thus, efforts must be undertaken to improve cleaning in different social and economic realities and scenarios.Funding: This study was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES.Disclosures: None

scholarly journals PENGARUH PEMBERIAN SUSU BEKATUL TERHADAP KONSENTRASI KOLESTEROL DAN TRIGLISERIDAPADA TIKUS PUTIH WISTAR DIABETES

2019 ◽  
Vol 12 (02) ◽  
Author(s):  
Husnul Khatimah ◽  
Saifuddin Sirajuddin ◽  
Zainal Zainal
Keyword(s):  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Cholesterol Concentration ◽  
Control Group ◽  
Group 4 ◽  
White Rats ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

ABSTRACT In diabetics there is usually an increase in free fatty acids in the blood and increases the concentration of cholecerols and triglycerides, this condition is called diabetes dyshidemia. This study aimed to find out at the effect of bran milk treatment on the changes of the concetration of cholesterol and triglycerides in diabetetic white wistar rats. Conducted on May 15 until 15 August 2018. Experimental research pre-post test with control design. Subjects of twenty wistar white rats were made diabetic by injecting alloxan 140mg / kg. After being declared diabetic, the rats were divided into four groups, namely group 1 (negative control), group 2 (positive control), group 3 (bran milk 0.54g / 200 gr) and group 4 (bran milk 1.08g / 200gr). The intervention was given for fourteen days. The data analysis used the paired T-test to test the subject before and afterthe treatment and the One-Way ANOVA test was used to test the difference between the groups. The research results indicated that  the treatment with bran milk there were no significant differences in cholesterol and triglyceride concentrations in the four groups. But when viewed from changes before and after the intervention showed that group 4 (bran milk 1.08g / 200gr) decreased cholesterol concentration and in group 3 (bran milk 0.54g / 200gr) a decrease in triglycerides was better than group 1 (control negative) and group 2 (positive control). It was concluded that the administration of bran milk can reduce the concentration of cholesterol and triglycerides in wistar diabetic white rats.Keywords : Bran milk, Cholesterol, Triglycerides, Rats, Diabetic

scholarly journals Antibacterial power effectiveness of calcium hydroxide and propolis mixture on Fusobacterium nucleatum bacteria

2019 ◽  
Vol 9 (1) ◽  
pp. 1
Author(s):  
Ira Widjiastuti ◽  
S. Sukaton ◽  
Agnes Melinda Wong ◽  
Nanik Zubaidah
Keyword(s):  
Calcium Hydroxide ◽  
Root Canal ◽  
Fusobacterium Nucleatum ◽  
Positive Control ◽  
Test Tube ◽  
Control Group ◽  
Natural Material ◽  
Hard Tissue ◽  
Alternative Ingredients ◽  
Group 2

Background: Calcium hydroxide is a root canal dressing material that is widely used in dentistry because of its ability to regenerate hard tissue and eliminate bacteria. According to Ferreira et al. (2015), Fusobacterium nucleatum was found in 90% of teeth that had a root canal treatment done using calcium hydroxide as an intracanal medication. Due to this shortcoming of the antibacterial power of calcium hydroxide, additional research on alternative ingredients that can be combined with calcium hydroxide to improve its antibacterial power is necessary. Propolis is a natural material that has high antibacterial power and has long been used in dentistry. The addition of propolis to calcium hydroxide is expected to improve the antibacterial power of calcium hydroxide without eliminating its function in terms of regenerating hard tissue. Purpose: To find out how effective is the antibacterial power of a combination of calcium hydroxide and propolis against Fusobacterium nucleatum. Methods: The research was carried out using 4 treatment groups consisting of 6 samples for each group. Group 1 is given a combination of calcium hydroxide and propolis with a ratio of 1:1, group 2 with a ratio of 1:1.5, group 3 with a ratio of 1:2, and group 4 is a positive control of calcium hydroxide and sterile aquadest suspension. Each sample was put into a test tube containing BHIB and a suspension of Fusobacterium nucleatum, incubated at 37ºC for 24 hours, and vortexed for 1 minute. A total of 0.1 ml of bacterial inoculum was taken from each sample and then put into the MHA and grown for 24 hours. The number of Fusobacterium nucleatum colonies grown on MHA was calculated and expressed using the Colony Forming Unit (CFU). Results: There were fewer colonies of Fusobacterium nucleatum in the treatment group compared to the control group. Conclusion: The combination of calcium hydroxide and propolis has an effective antibacterial power against Fusobacterium nucleatum which the ratio of 1:2 is more effective than ratio of 1:1,5 and 1:1.

scholarly journals EFEK PEMBERIAN SEDUHAN SERBUK HERBA SELEDRI (Apium graviolens L.) TERHADAP KADAR ASAM URAT SERUM DARAH AYAM LEGHORN JANTAN HIPERURIKEMIA

2021 ◽  
Vol 16 (1) ◽  
pp. 1652-1657
Author(s):  
Ani Kristiyani
Keyword(s):  
Uric Acid ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Oxidase Enzyme ◽  
Effective Doses ◽  
Group 3 ◽  
Group 2 ◽  
Control Group Group

Apium graviolens L. is a medicinal plant that is useful for treating gout. Flavonoids are components of chemical compounds found in celery because they can work as antioxidants and inhibit the action of the xanthine oxidase enzyme to form uric acid. This study aims to determine the effect of giving celery herb powder on the blood serum uric acid levels of hyperuricemia male leghorn chickens. This study used twenty-five male leghorn chickens which were randomly divided into 5 groups. All groups were made hyperuricemia by being given 100% chicken liver juice 5 mL/l kg BW once a day orally during treatment. Group 1 was given 0.5% CMC suspension solution as a negative control group. Group 2 was treated with allopurinol 14 mg/1.5 kg BW in CMC 0.5% as a positive control. Groups 3, 4, 5 received infusion of celery herb powder in the order of doses (0.6 g/1.5 kg BW), (1.2 g/1.5 kg BW), (1.8 g/1.5 kg BW). Examination of uric acid levels was carried out on days 0, 4, 8, 12. The results showed that steeping celery could reduce uric acid levels in proportion to the dose. The greater the dose given, the greater the decrease in uric acid levels. The dose of celery herb group 3 (1.8 g/1.5 kg BW) was the most effective doses because it had the same value as the positive control.

scholarly journals Evaluation of the Effect of Incorporation of Nano-fluorohydroxyapatite on Tensile Strength and Modulus of Elasticity of an Essix Plate

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Hooman Shafaee ◽  
Hamidreza Aboutorabzadeh ◽  
Hossein Bagheri ◽  
Banafsheh Yaloodbardan ◽  
Abdolrasoul Rangrazi
Keyword(s):  
Tensile Strength ◽  
Modulus Of Elasticity ◽  
Testing Machine ◽  
Antibacterial Properties ◽  
Control Group ◽  
P Value ◽  
Negative Effects ◽  
Significance Level ◽  
Group 3 ◽  
Group 2

Background: Nano-fluorohydroxyapatite (nano-FHA) is a caries preventive agent that is applied in many fields of dentistry and has the potential of being added to Essix retainers to create antibacterial properties. Objectives: The purpose of this study was to investigate the effect of nano-fluorohydroxyapatite addition on the tensile strength and modulus of elasticity of an Essix plate. Methods: The nano-fluorohydroxyapatite was synthesized and added to an Essix plate in various weight percentages: 0% (group1), 0.1% (group2) and 0.5% (group 3). We performed the measuring of flexural strength and modulus of elasticity for the experimented three groups using a universal testing machine. The data were analyzed through one-way ANOVA and Tukey’s test at the significance level of 0.05. Results: Accordingly, the obtained results were indicative of significant differences between the groups (P-value = 0.003); however, the difference between group 2 and control group was not statistically notable (P-value = 0.427). Furthermore, the tensile strength of group 3 significantly decreased (P-value = 0.04). In regards to the modulus of elasticity, the data were suggestive of significant differences between the groups (P-value = 0.002). Apparently, the modulus of elasticity of group 2 and group 3 decreased significantly compared to that of the control group (group 1). Conclusions: We can conclude that nano-FHA can be incorporated into Essix plates in concentrations of up to 0.1 wt% in order to create some caries preventing effects with no negative effects on tensile strength; however, adding nano-FHA to Essix plate will decrease modulus of elasticity.

scholarly journals Pengaruh Fraksi Jahe Gajah terhadap Kadar HDL dan LDL Mencit Model Dislipidemia

2019 ◽  
Vol 1 (1) ◽  
pp. 63-67
Author(s):  
Fenda Khafidhotenty ◽  
Santun Bhekti Rahimah ◽  
Maya Tejasari ◽  
Miranti Kania Dewi ◽  
Herri S. Sastramihardja ◽  
...  
Keyword(s):  
Zingiber Officinale ◽  
Positive Control ◽  
Control Group ◽  
Standard Diet ◽  
Water Fraction ◽  
Group 3 ◽  
Group 2 ◽  
Coa Reductase ◽  
And Control ◽  
One Way Anova

Penyakit tidak menular (PTM) yang menjadi penyebab kematian nomor satu setiap tahunnya adalah penyakit kardiovaskular dengan salah satu faktor risiko dislipidemia. Dislipidemia ditandai dengan peningkatan kadar LDL dan penurunan HDL. Salah satu bahan tradisonal yang digunakan sebagai terapi dislipidemia adalah jahe gajah (Zingiber officinale). Senyawa flavonoid pada jahe gajah memiliki kandungan antioksidan dan menekan aktivitas enzim HMG-CoA reduktase sehingga memiliki efek terhadap profil lipid tubuh. Tujuan penelitian ini mengetahui pengaruh fraksi air jahe gajah terhadap kadar HDL dan LDL pada mencit model dislipdemia. Penelitian dilaksanakan di Laboratorium Hewan Farmasi Institut Teknologi Bandung dan Laboratorium Hewan Fakultas Kedokteran Universitas Islam Bandung periode April–Juni 2018. Penelitian eksperimental ini menggunakan 15 ekor mencit jantan tua (45–49 minggu) yang terbagi menjadi 5 kelompok. Kelompok kontrol positif diberikan pakan standar dan pelarut fraksi, kelompok kontrol negatif diberikan pakan tinggi lemak dan pelarut fraksi, kelompok perlakuan 1 diberikan fraksi air jahe gajah 19,9 mg/20 gBB/hari, kelompok perlakuan 2 diberikan fraksi air jahe gajah 39,8 mg/20 gBB/hari, dan kelompok perlakuan 3 diberikan fraksi air  jahe gajah 79,6 mg/20 gBB/hari. Perlakuan dilakukan selama 28 hari. Hasil rerata kadar HDL setelah perlakuan adalah: 54,33 mg/dL; 35,00 mg/dL; 79,00 mg/dL; 81,57 mg/dL; dan 79, 67 mg/dL, sedangkan rerata kadar LDL adalah 6,53 mg/dL; 11,67 mg/dL; 33,33 mg/dL; 35,00 mg/dL, dan 21,33 mg/dL. Analisis statistik dengan one-way ANOVA pada pengukuran HDL bermakna signifikan (p<0,05) dan pengukuran LDL tidak signifikan (p>0,05) kelompok perlakuan dengan kelompok kontrol positif dan negatif. Hasil penelitian ini menunjukkan pengaruh fraksi air jahe gajah terhadap kadar HDL namun tidak terdapat pengaruh terhadap kadar LDL. THE EFFECT OF GINGER FRACTION ON HDL AND LDL LEVELS IN MICE WITH DYSLIPIDEMIA The main cause of death among non-communicable diseases every year is cardiovascular disease, with one of the risk factors is dyslipidemia. Dyslipidemia is characterized by increased levels of LDL and decreased HDL. Ginger (Zingiber officinale) is one of the traditional herbs used as a therapy in dyslipidemia. Flavonoid compounds in ginger contain antioxidants and suppress the activity of the enzyme HMG-CoA reductase that it has an effect on the body’s lipid profile. The purpose of this study was to determine the effect of ginger fraction on HDL and LDL levels in mice with dyslipidemia. This experimental study used 15 old male mice (45–49 weeks). Mice are divided into 5 groups. The positive control group was given standard diet and fraction solvents, the negatif control group was given high fat diet and fraction solvents, the group 1 was given the ginger  fraction 19.9 mg/20gBB/day, the group 2 was given ginger  fraction 39.8 mg/20 gBB/day, and the group 3 was given a fraction of ginger  79.6 mg/20 gBB/day. The treatment was carried out for 28 days. The average of HDL levels was: 54.33 mg/dL; 35.00 mg/dL; 79.00 mg/dL: 81.57 mg/dL; and 79, 67 mg/dL. While the average of LDL was 6.53 mg/dL; 11.67 mg/dL; 33.33 mg/dL; 35.00 mg/dL, and 21.33mg/dL. Statistical analysis with one-way ANOVA on HDL measurements was significant (p <0.05) and non-significant LDL measurements (p> 0.05) between treatment group and control groups. The conducted study showed an effect of the ginger water fraction on HDL levels and no effect on LDL levels.

Sign in / Sign up

Export Citation Format

Share Document