scholarly journals Effect of Aerobic Exercise on Brain-derived Neurotrophic Factor (BDNF) Serum Level in Stroke Subjects with Cognitive Function Impairment

2020 ◽  
Vol 2 (2) ◽  
pp. 42
Author(s):  
Vanydia Aisyah ◽  
Subagyo Subagyo ◽  
Imam Subadi

Background: Cognitive impairment is the most frequent complication of stroke. However, erobic exercise is considered to have potential effect in inhibiting the post-stroke cognitive degradation and increasing cognitive performance through neuroplasticity-influenced long term potentiation in hippocampus.Aim: To determine the effect of aerobic exercise on brain-derived neurotrophic factor (BDNF) serum level in stroke subjects with cognitive function impairment.Material and Methods: Experimental pre-post study on sub-acute stroke male and female, 12 subjects on each group. Intervention group given standard therapy and aerobic exercise using static cycle. Control group treated with standard therapy 30 minutes/session 3x/week, for 6 weeks. Parameter being evaluated was BDNF serum level.Result: No significant difference (p=0.21) in BDNF serum level in both control group (246.03±40.81 pg/ml) and intervention group (280.98±73.53 pg/ml) after treated with treatment. Although there was a significant increase of BDNF serum level in the intervention group (p<0.001) with pre-intervention mean value of 1.96±60.69 pg/ml and post-intervention mean value of 280.98±73.53 pg/ml. Similar to the intervention group, there was a significant increase in BDNF serum level (p<0,001) in control group, with pre-intervention mean value of 136.39±76.32 pg/ml and post-intervention mean value of 246.03±40.81 pg/ml.Conclusion: No significant difference in BDNF serum levels in intervention group after aerobic exercise program with a static cycle and standard therapy 3x/week for 6 weeks, when compared to the control group that only received standard therapy, although both control and intervention groups showed significant difference before and after the intervention.

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Younes Lotfi ◽  
Mahdieh Hasanalifard ◽  
Abdollah Moossavi ◽  
Enayatollah Bakhshi ◽  
Mohammad Ajalloueyan

Abstract Background The objective of this study was to evaluate the effect of “Spatially separated speech in noise” auditory training on the ability of speech perception in noise among bimodal fitting users. The assumption was that the rehabilitation can enhance spatial hearing and hence speech in noise perception. This study was an interventional study, with a pre/post-design. Speech recognition ability was assessed with the specific tests. After performing the rehabilitation stages in the intervention group, the speech tests were again implemented, and by comparing the pre- and post-intervention data, the effect of auditory training on the speech abilities was assessed. Twenty-four children of 8–12 years who had undergone cochlear implantation and continuously used bimodal fitting were investigated in two groups of control and intervention. Results The results showed a significant difference between the groups in different speech tests after the intervention, which indicated that the intervention group have improved more than the control group. Conclusion It can be concluded that “Spatially separated speech in noise” auditory training can improve the speech perception in noise in bimodal fitting users. In general, this rehabilitation method is useful for enhancing the speech in noise perception ability.


Author(s):  
Byamukama Topher ◽  
Keraka M. Margaret ◽  
Gitonga Eliphas

Background: Immunization is one of the most cost-effective public health interventions to reduce child mortality and morbidity associated with infectious diseases. The objective of this study was to determine the perceptions of caregivers on immunization in Ntungamo district.Methods: Quasi-experimental study was used with health centres assigned to intervention and control groups. Purposive sampling was used to select the two counties where the study was done. Proportional sampling was done to get study samples from each health facility, while systematic sampling was done to get study participants. A total of 787 children from twelve health facilities provided the study sample. A post intervention evaluation was conducted to determine the effect of these interventions. Association of variables was tested using Mann Whitney U-test and Chi-square.Results: On benefits, most caregivers in the intervention group (85.3%) and in the control group (54.3%) regarded immunization as very highly and moderately beneficial to their children respectively. On risks, most caregivers in the intervention group (85.5%) and control group (43.1%) regarded the risk factor associated with immunization as very low and moderate respectively. From hypothesis testing, there was a significant difference on the perceived benefits and risks of immunization between the intervention and control group.Conclusions: Most caregivers in the intervention and control group regarded immunization as very highly beneficial and moderately to their children respectively. Most of the caregivers in the intervention and control group regarded the risk factor associated with immunization as very low and moderate respectively. 


2020 ◽  
Author(s):  
Saeideh Shahsavari ◽  
Sakineh dadipoor ◽  
Mohtasham Ghaffari ◽  
Ali Safari-Moradabadi

Abstract Background: The aim of the present study was to assess readiness to become or stay physically active according to the Stages of Change Model.Methods: The present quasi-experimental study was conducted on 100 women working in the healthcare centres of Bandar Abbas, Iran. The sampling method is clustering in type. The subjects were assigned into two groups of intervention and control. The collected data were analysed by SPSS-16 software using descriptive and inferential statistics, including independent-sample t-test, paired-sample t-test and Chi-square test.Results: Before the educational intervention, 19 subjects (0.38%) from the intervention group showed to have regular physical activity (4-5 stages). This number changed to 29 (0.58%) and 25 (0.50%) after three months and six months of intervention. A statistically significant difference was found before the intervention and 3 and 6 months afterwards (P˂.001). In the control group, no statistically significant difference was found between the pre-intervention and post-intervention (three months (P=.351) and six months (P=.687).Conclusion: The educational intervention based on the stages of behaviour change model showed to be effective in promoting the physical activity of employed women. These findings may benefit health education researchers and practitioners who tend to develop innovative theory-based interventions and strategies to increase the level of physical activity in women.


2019 ◽  
Vol 29 (4) ◽  
pp. 249-255
Author(s):  
Gülzade Uysal ◽  
Duygu Sönmez Düzkaya ◽  
Tülay Yakut ◽  
Gülçin Bozkurt

The aim of this study was to determine the effectiveness of a pressure injury prevention guide used in a pediatric intensive care unit (PICU) on the occurrence of pressure injuries. The design is a pre-post intervention with a control group and a prospective intervention group. Pressure injuries occurred on 9.4% of children in the nontreatment group, and in 3.6% of children in the treatment group. There was a statistically significant difference in the occurrence of pressure injuries between the nontreatment group and the treatment group ( p = .033). The average Braden Q pressure injury score was 12.20 ± 2.280 at the beginning of the intensive care hospitalization, and 13.73 ± 3.312 at discharge in the treatment group ( p < .001). The results show that the risk of pressure injuries was reduced and pressure injuries occurred later when an evidence-based pressure injury prevention guide was used.


2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Roya Sheybani ◽  
Zahra Hosseini ◽  
Sayed Hossein Davoodi ◽  
Teamur Aghamolaei ◽  
Amin Ghanbarnejad

Abstract Background Evidence indicates the lower intake of fruits and vegetables than the recommended daily amount. Study aimed at determining the effects of peer education intervention on the consumption of fruits and vegetable in housewives. Methods A quasi-experimental was conducted with 130 housewives referring to health care centers in Bandar Abbas, Iran. Sixty-five subjects were recruited in each of the intervention and the control groups. Intervention group were divided into three subgroups each receiving a seven-sessions educational programs (lecturing and group discussion) through peers about the importance of benefits of fruits and vegetables consumption. Participants were followed for two months. Data were collected using a questionnaire in two stages of pre- and post-intervention. Differences in the outcome before and after the intervention were tested using T-test and paired T-test. Results The daily servings of fruits and vegetables in the intervention group increased from 1.73 to 4.20 and in the control group from 1.96 to 2.16; a statistically significant difference was also observed between the groups (P < 0.001). After the intervention benefits and self-efficacy of fruits and vegetables consumption significantly increased and perceived barriers of fruits and vegetables consumption significantly decreased in the intervention group (P < 0.001). Conclusion Peer education improves benefits and self-efficacy, reduces barriers, and increases the daily servings of fruits and vegetables in housewives.


2014 ◽  
Vol 54 (6) ◽  
pp. 351
Author(s):  
Yunita Fediani ◽  
Masayu Rita Dewi ◽  
Muhammad Irfannuddin ◽  
Masagus Irsan Saleh ◽  
Safri Dhaini

Background Nervous system development in early lifeinfluences the quality of cognitive ability during adulthood.Neuronal development and neurogenesis are highly influencedby neurotrophins. The most active neurotrophin is brain-derivedneurotrophic factor (BDNF). Physical activity has a positiveeffect on cognitive function. However, few experimental studieshave been done on children to assess the effect of aerobic regularexercise on BDNF levels.Objective To assess the effect of regular aerobic exercise onurinary BDNF levels in children.Methods This clinical study was performed in 67 children aged6-8 years in Palembang. The intervention group (n=34) engagedin aerobic gymnastics three times per week for 8 weeks, while thecontrol group (n=33) engaged in gymnastic only once per week.Measurements of urinary BDNF were performed on both groupsbefore and after intervention. Mann-Whitney and Wilcoxon ranktests were used to analyze the differences between groups.Results There was no difference in urinary BDNF levels betweenthe two groups prior to the intervention. After intervention,the mean urinary BDNF levels were significantly higher in theintervention group than in the control group, 230.2 (SD 264.4)pg/mL vs. 88.0 (SD 35.4) pg/mL, respectively (P=0.027). We alsofound that engaging in aerobic gymnastics significantly increasedurinary BDNF levels from baseline in both groups (P=0.001).Conclusion Regular aerobic exercise can increase urinary BDNFlevels and potentially improve cognitive function. Aerobic exerciseshould be a routine activity in school curriculums in combinationwith the learning process to improve children’s cognitive ability.


2017 ◽  
Vol 5 (1) ◽  
pp. 19-28 ◽  
Author(s):  
Judy A. Frain ◽  
Ling Chen

Objective: The purpose of this randomized-controlled pilot study was to explore the effectiveness of a home-based computerized cognitive training intervention in improving cognitive function in a population of older adults with mild cognitive impairment who are living with HIV. Methods: In all, 24 participants were enrolled in this study. All study participants were impaired [defined as Montreal Cognitive Assessment (MoCA) score < 26]; 12 were randomly assigned to a computer-training intervention group and 12 to a control group. The intervention group used a home-based computerized cognitive training program for 8 weeks, while the control group received health-related newsletter via email and follow-up phone calls. Cognitive function was measured at study entry, immediately post intervention, and 8 and 16 weeks post intervention Results: This study achieved a 92% retention rate, losing two persons from the intervention group. Participants in the intervention group scored significantly higher on cognitive testing immediately post intervention compared to the control group: F(1, 19) = 4.92, p = 0.04. The partial Eta squared of 0.32 indicates a small to moderate effect size. Discussion: Cognitive improvement was seen immediately after the intervention, and cognitive improvement was still evident 16 weeks post intervention. Cognitive training could be considered as an option for older adults with HIV experiencing mild cognitive impairment.


Jurnal NERS ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. 183
Author(s):  
Untung Sujianto

Introduction: HIV patients often experience psychological and physical disorders which greatly affect the adherence of people living with HIV/AIDS (PLWHA). This study aimed to assess the effects of aerobic exercise on the levels of depression and CD4 cell count of HIV patients.Methods: This study used a pre-post quasi-experimental design with a control group. The sampling technique was consecutive sampling, with a total sample of 52 HIV respondents. Depression level was measured using the Beck Depression Inventory (BDI), while CD4 count was measured using the Pyma analyser. The aerobic exercise intervention was given three times a week with a duration of 20-30 minutes each for four weeks. The collected data were analysed using a paired sample t-test and an independent sample t-test.Results: The results showed a significant difference in the mean value of depression before and after the intervention of aerobic exercise (M =25.15 and M=22.46, respectively) with p = 0.001. Similarly, there was a significant difference in the mean of CD4 counts between the control group (M=303.38) and the intervention group (M=305.38) after the intervention with p = 0.031.Conclusion: Aerobic exercise is effective in reducing depression levels and increasing CD4 counts in HIV patients. Immune system cells circulate more rapidly and there is a boost in the production of macrophages, cells that can attack bacteria.


2020 ◽  
Vol 18 (2) ◽  
Author(s):  
Zurainie Abllah ◽  
Syarifah Nurul Afifah Syed Ibrahim ◽  
Hamiza A Rahaman ◽  
Munirah Yaacob ◽  
Yunita Dewi Ardini

Introduction: Mechanical and chemical debridement had been practiced as one of the management for chronic periodontitis. Recent interest and advances in the field of alternative medicine has promoted the use of various herbal and natural products for multiple uses in the field of medicine. As for it, coconut water is one of the potential natural sources that have various health benefits.  Materials and method:  Randomized control study was chosen as study design in this research project. 12 patients who have moderate to severe chronic periodontitis were selected from patients whom attended Polyclinic Kulliyyah of Dentistry, IIUM Kuantan Campus from November 2016 to January 2018. After stratified random sampling done, the subjects divided into 2 groups; Intervention Group and Control Group. All patients will go for ultrasonic scaling and root planning by using hand instruments. 6 patients in Intervention Group were given fresh coconut water to drink during daytime. The first re-assessment was done after 6 weeks. The control group of another 6 patients didn’t receive any medicament. Paired sample t-test was used to analyse the pre and post intervention data. The study had obtained ethical approval from IREC (IREC 849).  Results:  Probing depth (PD) at mid-buccal site and bleeding on probing (BoP) shown significant result (p<0.05 ) in intervention group. There is no significant difference noted in the control groups, which are for PD, BoP and Plaque Score (PS) variables. Conclusion: Coconut water has potential benefit in reducing the periodontal pockets with chronic periodontitis as an adjunct after mechanical debridement.


2017 ◽  
Vol 03 ◽  
pp. 58
Author(s):  
Ogban E. Omoronyia ◽  

Cardiovascular diseases (CVDs) have continued to be a leading cause of death among adults. Civil servants constitute vital workforce, and high CVD burden in this group has implications for national productivity. Unfortunately, guided cardiovascular health education interventions are uncommon. This study assessed the effect of an educational intervention on knowledge and practice of CVD prevention among Nigerian civil servants. Quasi-experimental study design was employed among subjects in distant communities in Cross River State. Multistage technique was used to recruit 172 subjects into one control group (Ogoja) and two intervention groups (Calabar and Ikom). The first intervention group received 4-h daily, 5-day cardiovascular health education, with emphasis on burden, risk factors, and preventive measures including nutrition, stress, alcohol, medicals, exercise, and smoking. The second intervention group received the same content of education, but with the use of Food, Rest for stress management, Alcohol, Medicals, Exercise, and Smoking (FRAMES) as guide for delivery. Questionnaires were used to assess knowledge and practice at baseline and post-intervention. Data were analyzed using SPSS version 20.0. Knowledge scores and practice of CVD prevention were compared between study groups using inferential statistics. Mean age was 46.3 ± 7.4 years, and no significant difference in sociodemographic characteristics was observed by comparing the study groups (p > 0.05). Baseline knowledge and practice of preventive measures were generally poor, and no significant difference was observed by comparing the groups (p > 0.05). At 12 weeks post-intervention, knowledge of CVD was higher in the intervention groups compared with the control group (p < 0.05). Unlike control group, both intervention groups had improvement in physical exercise, medical screening, and fruit consumption (p < 0.05). There was no significant difference in postintervention knowledge and practice of CVD prevention by comparing both intervention groups (p > 0.05). For effective delivery of cardiovascular health education, the use of “FRAMES” is as effective as its nonuse. Further studies in other settings are recommended.


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