scholarly journals Current understanding on the role of cell cycle regulators in neuroblastoma cell differentiation

Med One ◽  
2017 ◽  
Keyword(s):  
Cell Cycle ◽  
Cell Differentiation ◽  
Neuroblastoma Cell ◽  
Current Understanding ◽  
Cell Cycle Regulators

scholarly journals The possible role of cell cycle regulators in multistep process of HPV-associated cervical carcinoma

2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Abeer A Bahnassy ◽  
Abdel Rahman N Zekri ◽  
Maha Saleh ◽  
Mohammad Lotayef ◽  
Manar Moneir ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cervical Carcinoma ◽  
Cell Cycle Regulators ◽  
Multistep Process

scholarly journals Intricate Regulatory Mechanisms of the Anaphase-Promoting Complex/Cyclosome and Its Role in Chromatin Regulation

2021 ◽  
Vol 9 ◽  
Author(s):  
Tatyana Bodrug ◽  
Kaeli A. Welsh ◽  
Megan Hinkle ◽  
Michael J. Emanuele ◽  
Nicholas G. Brown
Keyword(s):  
Cell Cycle ◽  
Signaling Pathways ◽  
Biological Process ◽  
Conformational Dynamics ◽  
Intimate Relationship ◽  
Regulatory Mechanisms ◽  
Cell Cycle Regulators ◽  
Chromatin Regulation ◽  
Anaphase Promoting Complex

The ubiquitin (Ub)-proteasome system is vital to nearly every biological process in eukaryotes. Specifically, the conjugation of Ub to target proteins by Ub ligases, such as the Anaphase-Promoting Complex/Cyclosome (APC/C), is paramount for cell cycle transitions as it leads to the irreversible destruction of cell cycle regulators by the proteasome. Through this activity, the RING Ub ligase APC/C governs mitosis, G1, and numerous aspects of neurobiology. Pioneering cryo-EM, biochemical reconstitution, and cell-based studies have illuminated many aspects of the conformational dynamics of this large, multi-subunit complex and the sophisticated regulation of APC/C function. More recent studies have revealed new mechanisms that selectively dictate APC/C activity and explore additional pathways that are controlled by APC/C-mediated ubiquitination, including an intimate relationship with chromatin regulation. These tasks go beyond the traditional cell cycle role historically ascribed to the APC/C. Here, we review these novel findings, examine the mechanistic implications of APC/C regulation, and discuss the role of the APC/C in previously unappreciated signaling pathways.

scholarly journals The Role of Phosphatases in Nuclear Envelope Disassembly and Reassembly and Their Relevance to Pathologies

Cells ◽  
2019 ◽  
Vol 8 (7) ◽  
pp. 687 ◽  
Author(s):  
Florentin Huguet ◽  
Shane Flynn ◽  
Paola Vagnarelli
Keyword(s):  
Cell Cycle ◽  
Cell Division ◽  
Nuclear Envelope ◽  
Current Understanding ◽  
The Past ◽  
Pathological Conditions ◽  
Regulation Of Cell Cycle

The role of kinases in the regulation of cell cycle transitions is very well established, however, over the past decade, studies have identified the ever-growing importance of phosphatases in these processes. It is well-known that an intact or otherwise non-deformed nuclear envelope (NE) is essential for maintaining healthy cells and any deviation from this can result in pathological conditions. This review aims at assessing the current understanding of how phosphatases contribute to the remodelling of the nuclear envelope during its disassembling and reformation after cell division and how errors in this process may lead to the development of diseases.

scholarly journals APC/C: current understanding and future perspectives

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 725 ◽  
Author(s):  
Hiroyuki Yamano
Keyword(s):  
Cell Cycle ◽  
Molecular Mechanisms ◽  
Current Understanding ◽  
Historical Background ◽  
Cell Cycle Regulators ◽  
Anaphase Promoting Complex ◽  
Electron Microscopy Analysis ◽  
Cellular Machinery ◽  
The Many ◽  
Ubiquitin Conjugating Enzymes

The separation of sister chromatids at anaphase, which is regulated by an E3 ubiquitin ligase called the anaphase-promoting complex/cyclosome (APC/C), is arguably the most important irrevocable event during the cell cycle. The APC/C and cyclin-dependent kinase 1 (Cdk1) are just two of the many significant cell cycle regulators and exert control through ubiquitylation and phosphorylation, respectively. The temporal and spatial regulation of the APC/C is achieved by multiple mechanisms, including phosphorylation, interaction with the structurally related co-activators Cdc20 and Cdh1, loading of distinct E2 ubiquitin-conjugating enzymes, binding with inhibitors and differential affinities for various substrates. Since the discovery of APC/C 25 years ago, intensive studies have uncovered many aspects of APC/C regulation, but we are still far from a full understanding of this important cellular machinery. Recent high-resolution cryogenic electron microscopy analysis and reconstitution of the APC/C have greatly advanced our understanding of molecular mechanisms underpinning the enzymatic properties of APC/C. In this review, we will examine the historical background and current understanding of APC/C regulation.

scholarly journals The role of SCF ubiquitin-ligase complex at the beginning of life

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Jiayan Xie ◽  
Yimei Jin ◽  
Guang Wang
Keyword(s):  
Cell Cycle ◽  
Ubiquitin Ligase ◽  
Cellular Proteins ◽  
Cell Cycle Regulators ◽  
Signal Transducers ◽  
E3 Ligases ◽  
Cellular Processes ◽  
Ubiquitin Ligase Complex ◽  
Scf Ubiquitin Ligase

AbstractAs the largest family of E3 ligases, the Skp1-cullin 1-F-box (SCF) E3 ligase complex is comprised of Cullins, Skp1 and F-box proteins. And the SCF E3 ubiquitin ligases play an important role in regulating critical cellular processes, which promote degradation of many cellular proteins, including signal transducers, cell cycle regulators, and transcription factors. We review the biological roles of the SCF ubiquitin-ligase complex in gametogenesis, oocyte-to-embryo transition, embryo development and the regulation for estrogen and progestin. We find that researches about the SCF ubiquitin-ligase complex at the beginning of life are not comprehensive, thus more in-depth researches will promote its eventual clinical application.

CELL CYCLE: The Expanding Role of Cell Cycle Regulators

Science ◽  
1998 ◽  
Vol 280 (5366) ◽  
pp. 1035-1036 ◽  
Author(s):  
T. Jacks
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Regulators

scholarly journals MicroRNAs Determining Carcinogenesis by Regulating Oncogenes and Tumor Suppressor Genes During Cell Cycle

MicroRNA ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 82-92 ◽  
Author(s):  
Fasoulakis Zacharias ◽  
Daskalakis George ◽  
Diakosavvas Michail ◽  
Papapanagiotou Ioannis ◽  
Theodora Marianna ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Suppressor ◽  
Tumor Suppressor Genes ◽  
Cancer Development ◽  
Cell Cycle Regulators ◽  
Suppressor Genes ◽  
Cyclin Dependent Kinases ◽  
Multiple Cell ◽  
Therapeutic Tools

Aim:: To provide a review considering microRNAs regulating oncogenes and tumor suppressor genes during the different stages of cell cycle, controlling carcinogenesis. Methods:: The role of microRNAs involved as oncogenes’ and tumor suppressor genes’ regulators in cancer was searched in the relevant available literature in MEDLINE, including terms such as “microRNA”, “oncogenes”, “tumor suppressor genes”, “metastasis”, “cancer” and others. Results:: MicroRNAs determine the expression levels of multiple cell cycle regulators, such as cyclins, cyclin dependent kinases and other major cell cycle activators including retinoblastoma 1 (RB- 1) and p53, resulting in alteration and promotion/inhibition of the cell cycle. Conclusion:: MicroRNAs are proven to have a key role in cancer pathophysiology by altering the expression profile of different regulator proteins during cell division cycle and DNA replication. Thus, by acting as oncogenes and tumor suppressor genes, they can either promote or inhibit cancer development and formation, revealing their innovative role as biomarkers and therapeutic tools.

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