scholarly journals Pulmonary Pathology of Early Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients with Lung Cancer

2020 ◽  
Author(s):  
Sufang Tian ◽  
Weidong Hu ◽  
Li Niu ◽  
Huan Liu ◽  
Haibo Xu ◽  
...  
Keyword(s):  
Early Phase ◽  
Giant Cells ◽  
Lung Pathology ◽  
The Novel ◽  
Cellular Infiltration ◽  
Multinucleated Giant Cells ◽  
Time Of Surgery ◽  
Pulmonary Pathology ◽  
Novel Coronavirus ◽  
Reactive Hyperplasia

There is currently a lack of pathologic data on the novel coronavirus (SARS-CoV-2) pneumonia, or COVID-19, from autopsy or biopsy. Two patients who recently underwent lung lobectomies for adenocarcinoma were retrospectively found to have had COVID-19 at the time of surgery. These two cases thus provide important first opportunities to study the pathology of COVID-19. Pathologic examinations revealed that, apart from the tumors, the lungs of both patients exhibited edema, proteinaceous exudate, focal reactive hyperplasia of pneumocytes with patchy inflammatory cellular infiltration, and multinucleated giant cells. Hyaline membranes were not prominent. Since both patients did not exhibit symptoms of pneumonia at the time of surgery, these changes likely represent an early phase of the lung pathology of COVID-19 pneumonia.

scholarly journals Pulmonary Pathology of Early Phase SARS-COV-2 Pneumonia

2020 ◽  
Author(s):  
Sufang Tian ◽  
Weidong Hu ◽  
Li Niu ◽  
Huan Liu ◽  
Haibo Xu ◽  
...  
Keyword(s):  
Early Phase ◽  
Giant Cells ◽  
Lung Pathology ◽  
Cellular Infiltration ◽  
Multinucleated Giant Cells ◽  
Time Of Surgery ◽  
Hyaline Membranes ◽  
Pulmonary Pathology

There is currently a lack of pathologic data on the SARS-CoV-2 pneumonia, or COVID-19, from autopsy or biopsy. Two patients who recently underwent lung lobectomies for adenocarcinoma were retrospectively found to have had COVID-19 at the time of surgery. These two cases thus provide important first opportunities to study the pathology of COVID-19. Pathologic examinations revealed that, apart from the tumors, the lungs of both patients exhibited edema, proteinaceous exudate with globules, focal hyperplasia of pneumocytes with only patchy inflammatory cellular infiltration, and multinucleated giant cells. Hyaline membranes were not prominent. Since both patients did not exhibit symptoms of pneumonia at the time of surgery, these changes likely represent an early phase of the lung pathology of COVID-19 pneumonia.

scholarly journals The Novel Coronavirus in Pediatric and Geriatric Population- What We Know

2021 ◽  
Vol 15 (1) ◽  
pp. 300-304
Author(s):  
Amit Reche ◽  
Anjali Nandanwar ◽  
Aniket Hedaoo ◽  
Kumar G. Chhbra ◽  
Punit Fulzele ◽  
...  
Keyword(s):  
Older Adults ◽  
Lung Diseases ◽  
Heart Diseases ◽  
Treatment Modalities ◽  
Renal Diseases ◽  
The Novel ◽  
Geriatric Population ◽  
Pulmonary Pathology ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)is a virus responsible for the coronavirus infection that is currently causing a severe outbreak of the disease in the world, infecting and killing thousands to lacs of people. The pediatric and geriatric population is no exception to this. Children and older adults have less immunity, which makes them more susceptible to infection than other populations. But still the number of cases of Children where less as compared to adults and those having underlying pulmonary pathology or immunocompromising conditions are more vulnerable to infection. Some studies have shown that this virus causes more death in the older age population as compared to adults or children. Patients having any systemic conditions like diabetes, raised blood pressure, heart diseases, lung diseases and chronic renal diseases were more vulnerable to this infection. In this article, we will outline the epidemiology, symptoms, diagnosis, and treatment modalities of the novel coronavirus-2019(COVID 19) infection in humans, with more focusing on infection in children as well as in older adults.

scholarly journals Chest MRI of a pregnant woman with COVID-19 pneumonia

2020 ◽  
Vol 1 (1) ◽  
pp. 61-68
Author(s):  
Yuriy A. Vasilev ◽  
Alexander V. Bazhin ◽  
Amir G. Masri ◽  
Yulia N. Vasileva ◽  
Olga Yu. Panina ◽  
...  
Keyword(s):  
Pregnant Woman ◽  
Ionizing Radiation ◽  
Risk Groups ◽  
Diagnostic Information ◽  
The Novel ◽  
Lung Condition ◽  
Pulmonary Pathology ◽  
Novel Coronavirus ◽  
Bilateral Lesions ◽  
Pcr Test

This paper presents a clinical case of a 39-year-old pregnant woman with respiratory signs of the novel coronavirus Covid-19 infection. Chest MRI showed bilateral lesions in basal segments. The PCR test was positive. A lung condition was assessed without loss of significant diagnostic information. Besides that, the absence of exposure to ionizing radiation allowed to avoid a high loading dose on the patient and the fetus. This case reveals potential opportunities of MRI in the diagnosis of pulmonary pathology without exposure to ionizing radiation, especially in patient risk groups (children, pregnant women, etc.).

scholarly journals Pulmonary Pathology of Early-Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients With Lung Cancer

2020 ◽  
Vol 15 (5) ◽  
pp. 700-704 ◽  
Author(s):  
Sufang Tian ◽  
Weidong Hu ◽  
Li Niu ◽  
Huan Liu ◽  
Haibo Xu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Early Phase ◽  
Pulmonary Pathology ◽  
Novel Coronavirus

scholarly journals Changes in Interventional Pain Physician Decision-Making, Practice Patterns, and Mental Health During the Early Phase of the SARS-CoV-2 Global Pandemic

Pain Medicine ◽  
2020 ◽  
Vol 21 (12) ◽  
pp. 3585-3595 ◽  
Author(s):  
Andrew A Joyce ◽  
Aaron Conger ◽  
Zachary L McCormick ◽  
Richard W Kendall ◽  
Graham Wagner ◽  
...  
Keyword(s):  
Mental Health ◽  
Decision Making ◽  
Early Phase ◽  
Practice Patterns ◽  
Prescribing Patterns ◽  
The Novel ◽  
Physician Decision Making ◽  
Spine Intervention ◽  
Novel Coronavirus ◽  
The Impact

Abstract Background and Objectives The novel coronavirus outbreak (SARS-CoV-2) began in late 2019 and dramatically impacted health care systems. This study aimed to describe the impact of the early phase of the pandemic on physician decision-making, practice patterns, and mental health. Methods An anonymous survey was distributed to physician members of the Spine Intervention Society (SIS) on March 24 and April 7, 2020. Respondents provided information regarding changes in clinical volume, treatment, and mental health (Patient Health Questionnaire [PHQ-4]) before April 10, 2020. Results Of the 1,430 individuals who opened the survey, 260 completed it (18.2%). Overall clinical and procedural volume decreased to 69.6% and 13.0% of prepandemic volume, respectively. Mean in-person clinic visits were reduced to 17.7% of total prepandemic clinic volume. Ongoing clinical visits were predominantly completed via telemedicine (video) or telephone (74.5%), rather than in-person (25.5%). Telemedicine and telephone visits represented 24.6% and 27.3% of prepandemic clinical volume, respectively. Respondents decreased in-person visits of select groups of high-risk patients by 85.8–94.6%. Significantly more providers reported increasing rather than decreasing prescriptions of the following medications: opioids (28.8% vs 6.2% of providers, P < 0.001), muscle relaxants (22.3% vs 5.4%, P < 0.001), neuropathic pain medications (29.6% vs 3.8%, P < 0.001), and acetaminophen (26.2% vs 4.2%, P < 0.001). Respondents’ mean PHQ-4 score was 3.1, with 19% reporting moderate or severe psychological distress. Several demographic factors were significantly associated with practice changes. Conclusions The novel coronavirus pandemic dramatically altered the practice and prescribing patterns of interventional pain physicians.

scholarly journals Cellular Composition of Calcified Bioprosthetic Heart Valves

2015 ◽  
Vol 70 (6) ◽  
pp. 662-668 ◽  
Author(s):  
Rinat Avkhadievich Mukhamadiyarov ◽  
Natal'ya Vital'evna Rutkovskaya ◽  
Ol'ga Dmitrievna Sidorova ◽  
Leonid Semenovich Barbarash
Keyword(s):  
Smooth Muscle ◽  
Heart Valves ◽  
Plasma Cells ◽  
Giant Cells ◽  
Cellular Infiltration ◽  
Cellular Composition ◽  
Multinucleated Giant Cells ◽  
Bioprosthetic Heart Valves ◽  
Calcium Deposits ◽  
Multiple Cells

With the aim to assess the mechanisms of the structural dysfunctions associated with xenograft tissue calcification, we investigated the cellular composition of the explanted xenoaortic epoxy-treated bioprosthetic heart valves. In the leaflets, we revealed multiple cells with retained internal structure. Most of them located on the leaflet surface, at the areas of collagen destruction, and near calcium deposits. Monocytes were the predominant cell fraction on the leaflet surface whilst immune (macrophages, multinucleated giant cells, plasma cells, neutrophils) and connective tissue (fibroblasts, fibrocytes, endothelial, and smooth muscle cells) cells prevailed at the areas of collagen destruction and near calcium deposits. Calcification of the leaflets was accompanied by cellular infiltration, therefore suggesting that pathological mineralization may be associated with cell-mediated processes.

DUAL-ENERGY CT WITH XENON IN PATIENTS WITH LUNG PATHOLOGY. FIRST DATA

2018 ◽  
pp. 47-51
Author(s):  
O. E. Karpov ◽  
O. Yu. Bronov ◽  
V. M. Kitaev ◽  
P. S. Vetshev ◽  
D. A. Pikhuta ◽  
...  
Keyword(s):  
Surgical Intervention ◽  
Lung Ventilation ◽  
Dual Energy ◽  
Diagnostic Methods ◽  
Dual Energy Ct ◽  
Lung Pathology ◽  
Preoperative Preparation ◽  
Before And After ◽  
Pulmonary Pathology ◽  
Postoperative Lung Function

Routine diagnostic methods have limitations in terms of predicting the ventilation function of the lungs before and after surgery. It was decided to investigate the possibilities of dual-energy CT (DECT) using xenon in assessment of lung ventilation function.Objective: to master the methods of examination of patients with pulmonary pathology, evaluate the possibility of justifying the volume of operative intervention and prediction of postoperative lung function based on the hybrid images.Materials and methods. For the study, 12 patients with different pulmonary pathologies were selected (COPD – 5, lung cancer – 4, bronchiectasis – 3). Results. It was found that the use of DECT with xenon reflects the functional state of lung tissue.Conclusions. DECT with xenon have potential for planning surgical intervention and introducing the method into modern protocols of preoperative preparation.

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