Immunomodulatory Effect and Supportive Role of Traditional Herbs, Spices and Nutrients in Management of COVID-19

World Health ◽

Treatment Modalities ◽

Corona Virus ◽

Herbs And Spices

Corona Virus disease 2019 (COVID-19) is a new strain of coronavirus that causes respiratory illnesses with a start of flu like symptoms. This disease is fatal and is spread all over the world. The Scientist are working day and night to find vaccine or a cure. World Health Organisation has declared COVID-19 as pandemic [1]. In the view of the pandemic many treatments are being tried on the patients and various treatment modalities are being followed, the traditional medicine has shown a major role to manage this disease. The traditional medicines include the use of herbs, nutrition and spices that are freely available in Asian countries. These are used in day to day life by Asian population [2]. In this paper we have compiled and reviewed the role of various herbs and spices such as Oregano, Ashwagandha, Ginseng, Basil, Sage, Curcumin, Fenugreek, Ginger and Garlic in building immunity and also in curing pathogenic invasions based on evidence based researches. As there is no cure available for COVID-19 till now so supportive therapy is playing a major role for the patients to fight with this pandemic. The AYUSH ministry has also promoted the use of above herbs for a patient suffering from this disease. The corona virus is present in respiratory system as shown by different studies and it has different strains. The guidelines laid by the ICMR and WHO shows that use of herbs, spices and nutrients can be helpful to manage this virus by increasing the immunity in patients. Hence we are not claiming any cures but the herbs and spices used in day to day life are very much effective in management of COVID-19. World Health Organisation (WHO) has recognised the use of alternative and traditional medicine in the management of COVID-19 but the herbs should be used in prescribed amounts and overdose of them can be harmful for health [1,3]. Therefore the present article will enlighten the readers about the role of herbs, spices and nutrients in improving the conditions in COVID-19.

Upaya Pemenuhan Vaksin Covid-19 Untuk Memutus Rantai Penyebaran Covid-19

10.31219/osf.io/4kyq8 ◽

2021 ◽

Author(s):

Sulton Ali Ma'ruf

Keyword(s):

Virus Disease ◽

World Health ◽

Tahun 2019 akhir, dunia digemparkan dengan kemunculan virus Corona Virus Disease 2019. Virus ini berasal dari kota Wuhan Provinsi Hubei, China. Perkembangan virus ini tergolong sangat cepat, oleh karena itu World Health Organisation (WHO) menyatakan Covid-19 sebagai pandemi global pada tanggal 11 Maret 2020. Penyebaran virus ini melalui udara atau droplet yang dihasilkan saat batuk ataupun saat bersin. Untuk mempercepat penanggulangan pandemi Covid-19, strategi yang dilakukan adalah pemberian vaksin untuk memberikan imun kepada setiap warga Negara. Pemberian vaksin ini adalah upaya Negara dalam melindungi hak atas kesehatan bagi setiap warga Negara di masa pandemic. Namun masih banyak masyarakat diindonesia yang menolak untuk diberikan vaksinasi Covid-19 karena beredarnya berita HOAX tentang vaksinasi Covid-19 yang menyebabkan masyarakat takut dan ragu untuk dilakukan vaksinasi karena masyarakat beranggapan bahwa vaksinasi Covid-19 itu berbahaya dan dapat menimbulkan kematian. Namun masyarakat Indonesia harus sadar bahwa vaksin Covid-19 sangat penting.

Upaya Pemenuhan Vaksin Covid-19 Untuk Memutus Rantai Penyebaran Covid-19

10.31219/osf.io/7scn9 ◽

2021 ◽

Author(s):

Sulton Ali Ma'ruf

Keyword(s):

Virus Disease ◽

World Health ◽

Protease Inhibitors: Strategy to Disrupt COVID 19 Contagion

10.21203/rs.3.rs-34183/v1 ◽

2020 ◽

Author(s):

Dhiman C Paul ◽

minakshi bhattacharjee ◽

Manash P Sarma

Keyword(s):

Drug Targets ◽

Virus Disease ◽

In Silico Analysis ◽

World Health ◽

Plant Origin ◽

Furin Cleavage ◽

Corona Virus ◽

Furin Cleavage Site ◽

Therapeutic Measures

Abstract Background: The COVID 2019 (Corona Virus Disease) has been currently going pandemic as per WHO (World Health Organisation) situation reports. The major differentiating point in this virus is the presence of a unique furin cleavage site. Our insilico study points out to the effectiveness of a potent plant origin furin inhibitor. We exploited the aspect of the cleavage machinery of furin which is critical and indispensible for the entry of SARS-CoV-2 (Severe Acute Respiratory Syndrome –Corona Virus 2) in human cells and subsequent massive contagion. Most of the drugs are presently targeting ACEII (Angiotensin Converting Enzyme 2) receptor. But these options have injurious effects in diabetics and cardiac patients. Repurposing of old drugs are the current undergoing therapeutic measures as per the EUA (Emergency Usage Administration) of Food and Drug Administration. These aspects could be avoided if we develop a better and safer strategized drug . Methods In silico analysis of plant based protein analogs to inhibit furin protein. Results Significant interactions of proposed analogs of protease inhibitor of plant origin against furin protein. Furin inhibitors would be incredible drug targets against cancers, MERS CoV (Middle East Respiratory Syndrome) and most urgently SARS- CoV-2. Conclusion We report the first of its kind of furin inhibitor and believe that this major finding would fast track arenas for drug trials.

COVID-19: An Epidemiological Puzzle

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2020/45749.14294 ◽

2020 ◽

Author(s):

Subrata Baidya ◽

Debosmita Paul ◽

Purvita Chowdhury

Keyword(s):

Short Communication ◽

Virus Disease ◽

World Health ◽

The Novel ◽

Unknown Aetiology ◽

Corona Virus ◽

Agent Interaction ◽

Epidemiological Characteristics ◽

Associated Variables

A cluster of pneumonia cases of unknown aetiology was reported from Wuhan, Hubei province of China on 31st December, 2019. The World Health Organisation (WHO) declared the outbreak a Public Health Emergency of International Concern (PHEIC) on 30th January, 2020. Thereafter, it has spread through China and reached the level of a pandemic expanding to 210 countries with 77.9M confirmed cases and 1.71M deaths as per Corona virus Disease (COVID-19) situation report issued by WHO based on data received upto 23rdDecember, 2020. A number of questions remain unanswered regarding pathogen-associated variables for amplification dynamics, host environment and agent interaction. This short communication makes an effort to compile the information gathered from published articles of renowned journals and newsletters to explore the epidemiological characteristics of COVID-19. Hereby in this article, authors have tried to assemble the epidemiological lacunae created by the novel characteristics of the SARS-CoV-2 (Severe Acute Respiratory Syndrome-Corona Virus-2) which presently pose a rather puzzling transmission dynamics of COVID-19 that still remain unanswered.

Optimasi Peran Negara Menghadapi Pandemi Corona Virus Disease 2019 dalam Perspektif Hukum Tata Negara Darurat

SALAM Jurnal Sosial dan Budaya Syar i ◽

10.15408/sjsbs.v7i7.15379 ◽

2020 ◽

Vol 7 (7) ◽

Author(s):

Rezky Panji Perdana Martua Hasibuan ◽

Anisa Ashari

Keyword(s):

Virus Disease ◽

The State ◽

World Health ◽

Reference Source ◽

State Law ◽

Corona Virus ◽

Library Research ◽

Role Of The State ◽

Health Organization

AbstractCorona Virus Disease 2019 or known as Covid-19 has been declared as a pandemic established by World Health Organization (WHO). In addition to causing health emergencies, the presence of this virus also has implications for several sectors such as finance that have an unstable economy. Based on this the role of the state is needed to ensure its prevention and treatment. Indonesia as a state of law must actually guarantee the certainty and protection of its citizens through the handling set forth in a regulation and the establishment of central and regional synergy. This study will comprehensively examine the situation of the covid-19 pandemic in Indonesia and the role of the state in handling this pandemic both at the central and regional levels, even through handling in the perspective of emergency state law. This research uses a normative juridical research type through the legislation approach and obtained through library research as a reference source. The results of this study are to explain and explain the role and effort of the state in carrying out the handling of a pandemic as a manifestation of the purpose of the state's presence to protect the entire Indonesian nation. Keyword : The Role of the State, Corona Virus Disease 2019, Regulation, Emergency State Law

ROLE OF AYURVEDA AND YOGA FOR COVID-19

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamj2808082020 ◽

2020 ◽

Vol 8 (8) ◽

pp. 4211-4215

Author(s):

Priyanka V ◽

Yogesh Jakhar ◽

Anupam Pathak

Keyword(s):

Immune System ◽

Virus Disease ◽

Nasal Congestion ◽

Antiviral Treatment ◽

Medical Science ◽

Scientific Basis ◽

World Health ◽

Treatment Modalities ◽

Major Drawback ◽

The outbreak of Corona virus disease (COVID-19) has been recently declared as Public Health Emergency of International Concern (PHEIC) by World Health Organization and the virus has now spread beyond the boundaries of countries and continents. At present, no specific antiviral treatment or vaccine is available or recommended to counter the COVID-19, and the potential therapy is still symptomatic. The outbreak of the Corona virus was begun in Wuhan, China in December 2019. The most common symptoms are fever, tiredness and dry cough. Some individuals also develop aches and pains, nasal congestion, runny nose, sore throat, or diarrhea. It was reported that traditional remedies may alleviate the symptoms of COVID19. Ayurveda is the world’s oldest medical system that can manage any disease without side effects. Ayurveda is equipped with varieties of treatment modalities to handle with any type of deadly diseases. However, a major drawback is a lack of adequate scientific basis. In recent time, a branch of modern medical science has developed and is known as Psycho- Neuro -Immunology. It deals with the phenomenon of how our thoughts and emotions can affect our immune system. Stress, fear and negative emotions are known to weaken our immune system while Yoga (including meditation), mindfulness, positive emotions, and relaxa-tion strengthen it. Yoga plays an important role to strengthen our immune system.

International Journal of Advanced Research in Science, Communication and Technology ◽

Combat to Corona Virus Disease 2019 COVID-19 Pandemic

10.48175/ijarsct-1022 ◽

2021 ◽

pp. 406-409

Author(s):

Arvind Sakwar

Keyword(s):

Preventive Measures ◽

Virus Disease ◽

Mutant Virus ◽

World Health ◽

Who Guidelines ◽

This paper describes the information of Covid-19 its emergence and declaration of Pandemic by WHO (World Health Organisation). The symptoms and the precautions are also being discussed here. Covid-19 is highly mutant virus that transmits so rapidly and no particular treatment is there to stop it except preventive measures. The initiatives taken by Govt of India are being briefly explained along with WHO guidelines to stopping the expansion of Covid-19.

ASSESSMENT OF PREVAILING FEAR OF CORONA VIRUS DISEASE - 19 IN THE INDIAN POPULATION TOFACILITATE LOCKDOWN RELAXATIONS USING THE FEAR OF COVID-19 SCALE-A STATISTICALAPPROACH.

10.36106/ijsr/0401080 ◽

2021 ◽

pp. 33-36

Author(s):

Siva Surya Narayan.S.T.G ◽

Padmini Sekar ◽

Venkatesan S

Keyword(s):

Global Health ◽

Indian Population ◽

Virus Disease ◽

World Health ◽

Corona Virus ◽

The World

The ongoing Coronavirus Disease–2019 (COVID-19) pandemic was declared a global health emergency by the World Health Organisation (WHO, 2020)

CONCEPTUAL REVIEW ON THE POTENTIAL OF PUNARNAVADYA GHRITA IN TACKLING THE SYMPTOMS OF COVID-19

International Journal of Research in Ayurveda and Pharmacy ◽

10.7897/2277-4343.120393 ◽

2021 ◽

Vol 12 (3) ◽

pp. 157-163

Author(s):

G Siva Ram

Keyword(s):

Cannabis Sativa ◽

Virus Disease ◽

World Health ◽

Corona Virus ◽

Global Pandemic ◽

Phytochemical Compounds ◽

Effective Remedy

COVID-19 disease has created panic among all with respect to health and economy. On 11th March 2020 WHO (world health organisation) declared novel corona virus outbreak as global pandemic. Confirmed effective remedy to prevent or treat COVID-19 is not yet established. Ayurveda, the Indian system of medicine is the oldest medicinal literature known to mankind as old as 3000 BC and is recognised as medical system by WHO. There is a need to investigate time tested potent classical Ayurvedic formulations backed by contemporary scientific studies in treating symptoms of COVID-19 disease. Vijaya (Cannabis sativa Linn.) in Ayurveda notable for its Vyavayi (quick absorption) and Yogavahi (synergetic action) properties said to be originated from ambrosia as per Vedic mythology. Recent scientific research on the phytochemicals of Cannabis plant showed promising results in decreasing the pro-inflammatory cytokine storm and to an extent halting the replication of SARS-CoV-2. We have put forward one such classical Cannabis Ayurvedic formulation Punarnavadya Ghrita available in market which can be useful as an alternative remedy for prophylactic and curative to the symptoms of novel corona virus disease whose individual herbal phytochemical compounds are studied through in silico, in vitro and in vivo methods in treating COVID-19 with positive outcomes.

Corona virus epidemiology: a review article

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20205207 ◽

2020 ◽

Vol 7 (12) ◽

pp. 5219

Author(s):

Kamlesh Sharma ◽

Ram Lal Sharma ◽

Vanita Sharma

Keyword(s):

Distress Syndrome ◽

Preventive Measures ◽

Virus Disease ◽

Specific Treatment ◽

Face Mask ◽

World Health ◽

Shortness Of Breath ◽

Corona Virus ◽

Respiratory Droplets

Corona virus disease-2019 is an infectious disease caused by SARS-Co-2. The disease started in December 2019 in Wuhan, China resulting in pandemic. Common symptoms are fever, cough and shortness of breath. Loss of apetite, anosmia, conjunctivitis and diarrhoea are fewer common symptoms. The disease is mild in most people but may progress to pneumonia, acute respiratory distress syndrome in elderly patients and those with co-morbidities. The infection is spread from one person to another via respiratory droplets or contact with infected droplets. Preventive measures include frequent and thorough hand washing, maintaining distance from potential transmitter and not touching one’s face. Mask is recommended to suspects and to their caregivers. Presently there is no vaccine or specific treatment for COVID-19. Management involves treatment of symptoms, supportive care. World health organisation declared the 2019-2020 CoV outbreak a pandemic and a Public Health Emergency of International concern with death rate of 3.4%.