scholarly journals Morphological Integration in Human Skull and Its Possible Role in Etiogenesis of Neuropsychiatric Disorders: Deciphering the Link between Evolution, Development and Disease

2020 ◽  
Author(s):  
Ashutosh Kumar ◽  
Sada N. Pandey ◽  
Muneeb A. Faiq ◽  
Vikas Pareek ◽  
Ravi K. Narayan
Keyword(s):  
Embryonic Development ◽  
Structural Features ◽  
Morphological Integration ◽  
Therapeutic Interventions ◽  
Phenotypic Traits ◽  
Human Skull ◽  
Evolution And Development ◽  
Consequent Effect ◽  
The Brain ◽  
Selection Of

Structure - function interdependence is a universal phenomenon in biological systems. Any alteration in structural features may result in change in functions–leading to natural selection of a particular trait, or dysfunctions thereof. Many such alterations arise during the course of evolution of a species and may meticulously be traced during embryonic development of an organism. Through the theoretical construct of morphological integration, a set of phenotypic traits alter in a coordinated and integrated manner during evolution and embryonic development of an organism yielding efficient environmentally adapted physiological functions pertinent to those structures. Such integration may go awry sometimes, setting the basis for genesis of diseases. Morphological integration in human skull has been established through various methods. The brain-skull co-development is handcuffed through evolution and development, and the very basis of a neuro-psychiatric disorder could be underlying in dysmorphogenesis of the skull, its consequent effect on structures, and thus functions of the pertinent brain components. Here we propose that morphological integration in human skull may be mechanistically implied in etiogenesis of certain neuro-psychiatric disorders and should be borne in mind during clinical diagnosis and therapeutic interventions.

scholarly journals Morphological integration in human skull and its possible role in etiogenesis of neuropsychiatric disorders: Deciphering the link between evolution, development and disease

2017 ◽  
Author(s):  
Etiologically Elusive Disorders Research Network Kumar A.
Keyword(s):  
Embryonic Development ◽  
Neuropsychiatric Disorders ◽  
Structural Features ◽  
Morphological Integration ◽  
Therapeutic Interventions ◽  
Phenotypic Traits ◽  
Human Skull ◽  
Evolution And Development ◽  
The Brain ◽  
Selection Of

Structure-function interdependence is a universal phenomenon in biological systems. Any alteration in structural features may result in change in functions–leading to natural selection of a particular trait, or dysfunctions thereof. Many such alterations arise during the course of evolution of a species and may meticulously be traced during embryonic development of an organism. Through, the theoretical construct of morphological integration, a set of phenotypic traits alter in a coordinated and integrated manner during evolution and embryonic development of an organism yielding efficient and environmentally adapted physiological functions pertinent to those structures. Such integration may go awry sometimes, setting the basis for genesis of diseases.Morphological integration in human skull has been established through various methods. The brain-skull co-development is handcuffed through evolution and development, and the very basis of a neuropsychiatric disorder could be underlying in dysmorphogenesis of the skull, its consequent effect on structures, and thus functions of the pertinent brain components. Here we propose that morphological integration in human skull may be mechanistically implied in etiogenesis of certain neuropsychiatric disorders and should be borne in mind during clinical diagnosis and therapeutic interventions.

Magnetoencephalography and the Cortical Dynamics of Language Processing

2019 ◽  
pp. 114-153
Author(s):  
Riitta Salmelin ◽  
Jan Kujala ◽  
Mia Liljeström
Keyword(s):  
Language Processing ◽  
Language Disorders ◽  
Scientific Data ◽  
Neural Processing ◽  
Powerful Method ◽  
Cortical Dynamics ◽  
Brain Correlates ◽  
Adults And Children ◽  
The Brain ◽  
Selection Of

When seeking to uncover the brain correlates of language processing, timing and location are of the essence. Magnetoencephalography (MEG) offers them both, with the highest sensitivity to cortical activity. MEG has shown its worth in revealing cortical dynamics of reading, speech perception, and speech production in adults and children, in unimpaired language processing as well as developmental and acquired language disorders. The MEG signals, once recorded, provide an extensive selection of measures for examination of neural processing. Like all other neuroimaging tools, MEG has its own strengths and limitations of which the user should be aware in order to make the best possible use of this powerful method and to generate meaningful and reliable scientific data. This chapter reviews MEG methodology and how MEG has been used to study the cortical dynamics of language.

scholarly journals Genomic Analysis, Progress and Future Perspectives in Dairy Cattle Selection: A Review

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 599
Author(s):  
Miguel A. Gutierrez-Reinoso ◽  
Pedro M. Aponte ◽  
Manuel Garcia-Herreros
Keyword(s):  
Dairy Cattle ◽  
Production Efficiency ◽  
Association Studies ◽  
Phenotypic Traits ◽  
Progeny Testing ◽  
Genome Wide Association Studies ◽  
Genetic Progress ◽  
Breeding Programs ◽  
Increased Risk ◽  
Selection Of

Genomics comprises a set of current and valuable technologies implemented as selection tools in dairy cattle commercial breeding programs. The intensive progeny testing for production and reproductive traits based on genomic breeding values (GEBVs) has been crucial to increasing dairy cattle productivity. The knowledge of key genes and haplotypes, including their regulation mechanisms, as markers for productivity traits, may improve the strategies on the present and future for dairy cattle selection. Genome-wide association studies (GWAS) such as quantitative trait loci (QTL), single nucleotide polymorphisms (SNPs), or single-step genomic best linear unbiased prediction (ssGBLUP) methods have already been included in global dairy programs for the estimation of marker-assisted selection-derived effects. The increase in genetic progress based on genomic predicting accuracy has also contributed to the understanding of genetic effects in dairy cattle offspring. However, the crossing within inbred-lines critically increased homozygosis with accumulated negative effects of inbreeding like a decline in reproductive performance. Thus, inaccurate-biased estimations based on empirical-conventional models of dairy production systems face an increased risk of providing suboptimal results derived from errors in the selection of candidates of high genetic merit-based just on low-heritability phenotypic traits. This extends the generation intervals and increases costs due to the significant reduction of genetic gains. The remarkable progress of genomic prediction increases the accurate selection of superior candidates. The scope of the present review is to summarize and discuss the advances and challenges of genomic tools for dairy cattle selection for optimizing breeding programs and controlling negative inbreeding depression effects on productivity and consequently, achieving economic-effective advances in food production efficiency. Particular attention is given to the potential genomic selection-derived results to facilitate precision management on modern dairy farms, including an overview of novel genome editing methodologies as perspectives toward the future.

Connotative Meaning of Time in Therapists' Conceptualization of Psychotherapeutic Interventions

1993 ◽  
Vol 72 (3_suppl) ◽  
pp. 1211-1221
Author(s):  
Dawn S. O'Neil ◽  
Anthony F. Grasha
Keyword(s):  
Subjective Experience ◽  
Specific Treatment ◽  
Therapeutic Interventions ◽  
Semistructured Interview ◽  
Connotative Meaning ◽  
Treatment Interventions ◽  
Psychotherapeutic Interventions ◽  
Experience Of Time ◽  
Perception Of Time ◽  
Selection Of

This study examined the connotative meaning which beginner ( n = 15), intermediate ( n = 14), and advanced ( n = 15) therapists assigned to time in psychotherapy and their perception of time as a factor in designing therapeutic interventions. Therapists' conceptualization of the subjective experience of time as a component of psychotherapeutic interventions was assessed by examining their selection of metaphors for time, their semantic differential assessments of past, present, and future perspectives, and through their responses to a semistructured interview. Therapists at all three levels of experience appeared to view time for their clients as moving slowly, promoting growth, and allowing progress, with an emphasis on the importance of future time-based interventions for growth while the clients' past was viewed as reflective of distress. Responses appeared to be atheoretical and idiosyncratic, showing lack of clear integration of time with specific treatment interventions.

scholarly journals Optimization of Magnetic Properties of Magnetic Microwires by Post-Processing

Processes ◽  
2020 ◽  
Vol 8 (8) ◽  
pp. 1006
Author(s):  
Valentina Zhukova ◽  
Paula Corte-Leon ◽  
Lorena González-Legarreta ◽  
Ahmed Talaat ◽  
Juan Maria Blanco ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Chemical Composition ◽  
Hysteresis Loops ◽  
Structural Features ◽  
Post Processing ◽  
Soft Magnetic ◽  
Magnetic Microwires ◽  
Prepared State ◽  
Induced Magnetic Anisotropy ◽  
Selection Of

The influence of post-processing conditions on the magnetic properties of amorphous and nanocrystalline microwires has been thoroughly analyzed, paying attention to the influence of magnetoelastic, induced and magnetocrystalline anisotropies on the hysteresis loops of Fe-, Ni-, and Co-rich microwires. We showed that magnetic properties of glass-coated microwires can be tuned by the selection of appropriate chemical composition and geometry in as-prepared state or further considerably modified by appropriate post-processing, which consists of either annealing or glass-coated removal. Furthermore, stress-annealing or Joule heating can further effectively modify the magnetic properties of amorphous magnetic microwires owing to induced magnetic anisotropy. Devitrification of microwires can be useful for either magnetic softening or magnetic hardening of the microwires. Depending on the chemical composition of the metallic nucleus and on structural features (grain size, precipitating phases), nanocrystalline microwires can exhibit either soft magnetic properties or semi-hard magnetic properties. We demonstrated that the microwires with coercivities from 1 A/m to 40 kA/m can be prepared.

scholarly journals Understanding Mental Health and Cognitive Restructuring With Ecological Neuroscience

2021 ◽  
Vol 12 ◽  
Author(s):  
James Crum
Keyword(s):  
Mental Health ◽  
Near Infrared ◽  
Ecological Validity ◽  
Experimental Designs ◽  
Functional Near Infrared Spectroscopy ◽  
Practical Applications ◽  
Recent Developments ◽  
The Brain ◽  
Neuroimaging Techniques ◽  
Selection Of

Neuroimaging and neuropsychological methods have contributed much toward an understanding of the information processing systems of the human brain in the last few decades, but to what extent do cognitive neuroscientific findings represent and generalize to the inter- and intra-brain dynamics engaged in adapting to naturalistic situations? If it is not marked, and experimental designs lack ecological validity, then this stands to potentially impact the practical applications of a paradigm. In no other domain is this more important to acknowledge than in human clinical neuroimaging research, wherein reduced ecological validity could mean a loss in clinical utility. One way to improve the generalizability and representativeness of findings is to adopt a more “real-world” approach to the development and selection of experimental designs and neuroimaging techniques to investigate the clinically-relevant phenomena of interest. For example, some relatively recent developments to neuroimaging techniques such as functional near-infrared spectroscopy (fNIRS) make it possible to create experimental designs using naturalistic tasks that would otherwise not be possible within the confines of a conventional laboratory. Mental health, cognitive interventions, and the present challenges to investigating the brain during treatment are discussed, as well as how the ecological use of fNIRS might be helpful in bridging the explanatory gaps to understanding the cultivation of mental health.

scholarly journals Modulating the Blood-Brain Barrier by Light Stimulation of Molecular-Targeted Nanoparticles

2020 ◽  
Author(s):  
Xiaoqing Li ◽  
Vamsidhara Vemireddy ◽  
Qi Cai ◽  
Hejian Xiong ◽  
Peiyuan Kang ◽  
...  
Keyword(s):  
Tight Junction ◽  
Tight Junctions ◽  
Blood Brain Barrier ◽  
Therapeutic Interventions ◽  
Brain Barrier ◽  
Light Stimulation ◽  
Targeted Nanoparticles ◽  
Blood Brain ◽  
The Brain ◽  
Stimulation Of

AbstractThe blood-brain barrier (BBB) tightly regulates the entry of molecules into the brain by tight junctions that seals the paracellular space and receptor-mediated transcytosis. It remains elusive to selectively modulate these mechanisms and to overcome BBB without significant neurotoxicity. Here we report that light stimulation of tight junction-targeted plasmonic nanoparticles selectively opens up the paracellular route to allow diffusion through the compromised tight junction and into the brain parenchyma. The BBB modulation does not impair vascular dynamics and associated neurovascular coupling, or cause significant neural injury. It further allows antibody and adeno-associated virus delivery into local brain regions. This novel method offers the first evidence of selectively modulating BBB tight junctions and opens new avenues for therapeutic interventions in the central nervous system.One Sentence SummaryGentle stimulation of molecular-targeted nanoparticles selectively opens up the paracellular pathway and allows macromolecules and gene therapy vectors into the brain.

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