scholarly journals Coronary Heart Disease: Diagnosis and Therapy

2021 ◽  
Vol 1 (2) ◽  
pp. 74
Author(s):  
Iin Novita Nurhudayati Mahmuda ◽  
Nanda Nurkusumasari ◽  
Fakhri Nofaldi ◽  
Prihatin Puji Astuti ◽  
Ferika Dian Syafitri ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Communicable Disease ◽  
Developed Countries ◽  
Disease Diagnosis ◽  
Lifestyle Changes ◽  
World Health ◽  
Coronary Syndrome ◽  
Health Organization

<p>Coronary heart disease (CHD), is one of the non-communicable diseases that has a tendency to increase every year and have an impact not only on developed countries, but also in developing countries. According to the World Health Organization (WHO), in 2012 there were 56 million deaths worldwide caused by non-communicable disease and heart disease contributed 46.2% or caused 17.5 million deaths. This review article to give brief explanation about CHD from risk factors, diagnosed criteria, management therapy and prognosis. Risk factors for CHD can be distinguished into major risk factors and minor risk factors. Symptoms of CHD are discomfort in the chest ranging from pain crushed during activity and improved with rest to continuous chest pain. The diagnosis of CHD is established based on anamnesis, physical examination, and laboratory examination. The CHD classification consists  of Stable Angina Pectoris (APS) and Acute Coronary Syndrome (ACS). Lifestyle changes accompanied<em> </em>by right medication can reduce complications caused             by CHD.</p>

scholarly journals ANALISIS FAKTOR RISIKO MODIFIKASI PENYAKIT JANTUNG KORONER DI RSU HAJI SURABAYA TAHUN 2019

2021 ◽  
Vol 10 (1) ◽  
pp. 47
Author(s):  
Citra Rachmawati ◽  
Santi Martini ◽  
Kurnia Dwi Artanti
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Smoking Behavior ◽  
World Health ◽  
P Value ◽  
Health Organization ◽  
Diabetes Melitus

ABSTRAKLatar Belakang: Pola penyakit saat ini mengalami transisi epidemiologi, salah satunya dibuktikan oleh perkembangan dari penyakit tidak menular yaitu penyakit jantung. Penyakit jantung khususnya jantung koroner ini termasuk penyakit yang menduduki tingkat nomor satu di dunia.. Diperkirakan angka kematian akibat penyakit Jantung Koroner akan mengalami peningkatan hingga 23,3 juta pada tahun 2030 (World Health Organization 2013). Penelitian ini membahas mengenai faktor risiko PJK yaitu hipertensi, diabetes melitus, aktivitas fisik, dan perilaku merokok.Tujuan: Penelitian ini bertujuan untuk menganalisis faktor risiko hipertensi, diabetes melitus, aktivitas fisik, dan perilaku merokok pada pasien penyakit jantung koroner di Rsu Haji Surabaya tahun 2019.Metode: Penelitian ini merupakan penelitian observasional dan bersifat analitik. Desain penelitian yang digunakan adalah case control.Hasil: Penelitian ini menunjukkan bahwa variabel hipertensi memiliki hubungan (p-value = 0,0 ; p<0,05) terhadap penyakit jantung koroner, variabel diabetes melitus memiliki hubungan (p-value= 0,00 ; p<0,05) terhadap penyakit jantung koroner dan variabel aktifitas fisik memiliki hubungan yang signifikan (p-value = 0,017; OR = 0,184; 95%CI =0,039-0,861) dengan kejadian penyakit jantung koroner. Sedangkan hasil yang tidak beruhubungan yaitu pada variabel perilaku merokok (p-value = 0,250; OR = 1,463; 95%CI=0,764-2,802) terhadap penyakit jantung koroner. Kesimpulan: Berdasarkan hasil dan pembahasan dapat disimpulkan bahwa hipertensi, diabetes melitus, dan aktifitas fisik memiliki hubungan dan termasuk faktor risiko kejadian penyakit jantung koroner. Sedangkan perilaku merokok tidak menunjukkan adanya hubungan yang signifikan dengan kejadian penyakit jantung koroner. Kata kunci: Penyakit jantung, jantung koroner dan faktor risiko ABSTRACTBackground: The pattern of disease is currently undergoing an epidemiological transition, one of which is evidenced by the development of non-communicable diseases, namely heart disease. Heart disease, especially coronary heart disease, is a disease that ranks number one in the world. It is estimated that the death rate due to coronary heart disease will increase to 23.3 million in 2030 (World Health Organization 2013). This study discusses the risk factors for CHD, namely hypertension, diabetes mellitus, physical activity, and smoking behavior. Purpose: The purpose of this study was to analyze the risk factors for hypertension, diabetes mellitus, physical activity, and smoking behavior in coronary heart disease patients at Rsu Haji Surabaya in 2019. Methods: This study was an observational and analytical study. The research design used was case-control. Results: The results of this study indicate that the hypertension variable has a relationship (p-value = 0.00; p <0.05) on coronary heart disease, the diabetes mellitus variable has a relationship (p-value = 0.00; p <0.05) on coronary heart disease and the activity variable physical had a significant relationship (p-value = 0.017; OR = 0.184; 95% CI=0.039-0.861) with the incidence of coronary heart disease. While the results that were not related were the smoking behavior variable (p-value = 0.250; OR = 1.463; 95% CI=0.764-2.802) on coronary heart disease.Conclusion: Based on the results and discussion, it can be concluded that hypertension, diabetes mellitus, and physical activity have a relationship and include risk factors for coronary heart disease. Meanwhile, smoking behavior does not show a significant relationship with the incidence of coronary heart disease. Keywords: Cardiovascular diseas, coronary heart and  risk factors.

scholarly journals Safety and Efficacy of Ranolazine for the Treatment of Chronic Angina Pectoris

2013 ◽  
Vol 5 ◽  
pp. CMT.S7824 ◽  
Author(s):  
Mohammed Aldakkak ◽  
David F. Stowe ◽  
Amadou K.S. Camara
Keyword(s):  
Coronary Heart Disease ◽  
Blood Flow ◽  
Heart Disease ◽  
Supply And Demand ◽  
Chronic Stable Angina ◽  
The United States ◽  
Lifestyle Changes ◽  
Channel Blockers ◽  
Coronary Syndrome ◽  
Chronic Angina

Coronary heart disease is a global malady and it is the leading cause of death in the United States. Chronic stable angina is the most common manifestation of coronary heart disease and it results from the imbalance between myocardial oxygen supply and demand due to reduction in coronary blood flow. Therefore, in addition to lifestyle changes, commonly used pharmaceutical treatments for angina (nitrates, β-blockers, Ca2+ channel blockers) are aimed at increasing blood flow or decreasing O2 demand. However, patients may continue to experience symptoms of angina. Ranolazine is a relatively new drug with anti-anginal and anti-arrhythmic effects. Its anti-anginal mechanism is not clearly understood but the general consensus is that ranolazine brings about its anti-anginal effects by inhibiting the late Na+ current and the subsequent intracellular Ca2+ accumulation. Recent studies suggest other effects of ranolazine that may explain its anti-anginal and anti-arrhythmic effects. Nonetheless, clinical trials have proven the efficacy of ranolazine in treating chronic angina. It has been shown to be ineffective, however, in treating acute coronary syndrome patients. Ranolazine is a safe drug with minimal side effects. It is metabolized mainly in the liver and cleared by the kidney. Therefore, caution must be taken in patients with impaired hepatic or renal function. Due to its efficacy and safety, ranolazine was approved for the treatment of chronic angina by the Food and Drug Administration (FDA) in 2006.

Heart Disease Diagnosis Using Fuzzy Supervised Learning Based on Dynamic Reduced Features

2014 ◽  
Vol 5 (3) ◽  
pp. 78-101 ◽  
Author(s):  
Walid Moudani ◽  
Mohamad Hussein ◽  
Mariam abdelRazzak ◽  
Félix Mora-Camino
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Potential Risk ◽  
Heart Attack ◽  
Rough Set Theory ◽  
Disease Diagnosis ◽  
Fuzzy Classification ◽  
Classification Problems ◽  
Potential Risk Factors

The health industry collects huge amounts of health data which, unfortunately, are not mined to discover hidden information. However, there is a lack of effective analytical tools to discover hidden relationships and trends in data. Information technologies can provide alternative approaches to the diagnosis of the heart attach disease. In this study, a proficient methodology for the extraction of significant patterns from the Coronary Heart Disease warehouses for heart attack prediction, which unfortunately continues to be a leading cause of mortality in the whole world, has been presented. For this purpose, we propose to develop an innovative fuzzy classification solution approach based on dynamic reduced sets of potential risk factors using the promising Rough Set theory which is a new mathematical approach to data analysis based on classification of objects. Therefore, we propose to validate the classification using Multi-classifier decision tree to identify the risky heart disease cases. This work is based on a dataset collected from several clinical institutions based on the medical profile of patient. Moreover, the experts' knowledge in this field has been taken into consideration in order to define the disease, its risk factors, to follow up the issue results, and to establish significant knowledge relationships between medical factors related to Coronary Heart Disease. To identify cases of heart attack, experiments of several classification techniques have been performed leading to rank the suitable techniques. The reduction of potential risk factors contributes to enumerate dynamically one or more optimal subsets of the potential risk factors of high interest which implicitly leads to reduce the complexity of the classification problems while maintaining the prediction classification quality. The performance of the proposed model is analyzed and evaluated based on set of benchmark techniques applied in this classification problem.

scholarly journals Prevention of Diabetes and Cardiovascular Disease in Obesity

2020 ◽  
Vol 21 (21) ◽  
pp. 8178
Author(s):  
Lucia La Sala ◽  
Antonio E. Pontiroli
Keyword(s):  
Risk Factors ◽  
Diabetes Prevention ◽  
Diabetes Prevention Program ◽  
Cardiovascular Complications ◽  
Lifestyle Changes ◽  
World Health ◽  
Lower Body Weight ◽  
Cardiovascular Morbidity And Mortality ◽  
Bariatric Metabolic Surgery ◽  
Health Organization

Obesity is one of the major risk factors for the development of both impaired glucose tolerance (IGT, or prediabetes) and type 2 diabetes (T2D), and its prevalence worldwide drives toward an increased rate of cardiovascular morbidity and mortality. Given the estimations of the World Health Organization (WHO) and the recommendation of the Diabetes Prevention Program (DPP), where IGT and diabetes are considered as risk factors for the development of cardiovascular complications and obesity, the development of diabetes should be treated because of its potential reversibility. In this view, several interventions such as diet, lifestyle changes, and pharmacological treatment are effective, including bariatric metabolic surgery (BMS), which is the most incisive way to efficiently lower body weight. In this review, we sought to summarize some of the major aspects linked to diabetes prevention in overweight/obesity, focusing on the use of surgery; we also attempted to elucidate molecular pathways involved in a variety of obesity-induced processes able to favor the progression of chronic diseases, such as diabetes and its complications.

scholarly journals Risk Factors for Acute Coronary Syndrome in Upper Gastrointestinal Bleeding Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Tianyu Chi ◽  
Quchuan Zhao ◽  
Peili Wang
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Acute Coronary Syndrome ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Heart Disease ◽  
Gastrointestinal Bleeding ◽  
Upper Gastrointestinal Bleeding ◽  
Coronary Syndrome ◽  
Upper Gastrointestinal

Background. Upper gastrointestinal bleeding (UGIB) is a common critical disease with a certain fatality rate. Acute coronary syndrome (ACS), another critical ill condition, is a regular occurrence in the UGIB. We identified risk factors for ACS in UGIB. Methods. 676 patients diagnosed with UGIB were enrolled retrospectively. We assessed the occurrence of ACS in UGIB patients and identified the risk factors for ACS by logistic regression analysis and random forest analysis. Results. After propensity score matching (PSM), the ACS group ( n = 69 ) and non-ACS group ( n = 276 ) were analyzed. Logistic regression analysis showed that syncope ( P = 0.001 ), coronary heart disease history ( P = 0.001 ), Glasgow Blatchford score ( P ≤ 0.001 ), Rockall risk score ( P = 0.004 ), red blood cell distribution width (RDW) ( P ≤ 0.001 ), total bilirubin (TBil) ( P = 0.046 ), fibrinogen ( P ≤ 0.001 ), and hemoglobin ( P = 0.001 ) had important roles in ACS patients. With Mean Decrease Gini (MDG) sequencing, fibrinogen, RDW, and hemoglobin were ranked the top three risk factors associated with ACS. In ROC analysis, fibrinogen ( AUC = 0.841 , 95% CI: 0.779-0.903) and RDW ( AUC = 0.826 , 95% CI: 0.769-0.883) obtained good discrimination performance. According to sensitivity > 80 %, the pAUC of fibrinogen and RDW were 0.077 and 0.101, respectively, and there was no significant difference ( P = 0.326 ). However, according to specificity > 80 %, the pAUC of fibrinogen was higher than that of RDW (0.126 vs. 0.088, P = 0.018 ). Conclusion. Fibrinogen and RDW were important risk factors for ACS in UGIB. Additionally, combination with coronary heart disease, syncope, hemoglobin, and TBil played important roles in the occurrence of ACS. Meanwhile, it was also noted that Rockall score and Glasgow Blatchford score should be performed to predict the risk.

scholarly journals THE DESCRIPTION OF MODIFIABLE RISK FACTORS IN CORONARY HEART DISEASE AT DR. SOETOMO REGIONAL PUBLIC HOSPITAL

2019 ◽  
Vol 7 (2) ◽  
pp. 85
Author(s):  
Mayla Renata Sandi ◽  
Santi Martini ◽  
Kurnia Dwi Artanti ◽  
Sri Widati
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Public Hospital ◽  
Communicable Disease ◽  
Univariate Analysis ◽  
Sampling Technique ◽  
Primary Data ◽  
Modifiable Risk Factors ◽  
Cross Sectional

Background: Coronary heart disease (CHD) is a non-communicable disease that causes the highest mortality in the world, including in Indonesia. Risk factors for CHD are divided into modifiable and non- modifiable risk factors. Purpose: This study aims to discover the description of risk factors that are modifiable in coronary heart disease patients at Dr Soetomo Regional Public Hospital. Methods: It was a descriptive observational study with cross sectional study design. The study population was coronary heart disease patients who were doing outpatient treatment at the Integrated Heart Service Center (PPJT) of Dr. Soetomo Regional Public Hospital. The number of study sample was 72 respondents using accidental sampling technique. Data sources used are primary data using questionnaires and secondary data using medical record. Data were collected during November 2018. The location of this study was Dr. Soetomo Regional Public Hospital. The data analysis technique chosen was univariate analysis and presented in the form of a frequency distribution table. Results: The results of the study showed that the characteristics of respondents were mostly between 56-65 years old (43,05%) and male (70,84%). Risk factors found on the respondents were smoking (84,72%), hypertension (72,22%), hyperlipidemia (68,05%), diabetes mellitus (81,94%) and poor physical activity (77,77%). Conclusion: Modifiable risk factor that was mostly found on coronary heart patients was smoking, while least one was hiperlipidemia.

scholarly journals Sedentary lifestyle among office workers and coronary heart disease risk factors due to the COVID-19 quarantine

Work ◽  
2020 ◽  
Vol 67 (2) ◽  
pp. 281-283
Author(s):  
Mahboubeh Ghayour Najafabadi ◽  
Amir Sobhrakhshan Khah ◽  
Mitch Rostad
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Sedentary Lifestyle ◽  
Disease Risk ◽  
Office Workers ◽  
World Health ◽  
Daily Movement ◽  
Work From Home ◽  
Home Based ◽  
Health Organization

The COVID-19 pandemic has affected the entire world. It is difficult to follow protocols and regulations set forth by governments, designed by the World Health Organization. The most common protocol set forth by governments is quarantining at home. Many occupations must stay home to comply with this protocol. Among these occupations, office workers are the most common group to comply and work from home. This has led to a lack of daily movement and increased sedentary lifestyle, which has made employees prone to developing coronary heart disease (CHD). Additionally, obesity is a known risk factor for this group. This commentary presents feasible protocols aimed at helping home-based office workers stay healthy and decrease the risk of developing CHD.

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