scholarly journals Laboratory Diagnosis of Rabies. Current State and Trends in Development

2021 ◽  
pp. 6-15
Author(s):  
S. V. Borisevich ◽  
M. N. Pistsov ◽  
V. V. Rubtsov ◽  
D. A. Kutaev ◽  
A. V. Surovyatkin ◽  
...  
Keyword(s):  
Russian Federation ◽  
Laboratory Diagnosis ◽  
Lessons Learned ◽  
Epidemiological Surveillance ◽  
Laboratory Diagnostics ◽  
Rt Pcr ◽  
The Russian Federation ◽  
Biological Protection ◽  
State Registration ◽  
Rabies Diagnosis

The review considers the relevant aspects of laboratory diagnosis of rabies. The methods of laboratory diagnostics of rabies infection, standardized by WHO in 2018, and their use in the Russian Federation are presented. The scheme of laboratory diagnostics of rabies, applied by specialists of the “48th CRI” of the Ministry of Defense of Russia, for the study of biological samples from deceased people is outlined. Between 2002 and 2018, the study of biomaterial was carried out using molecular-biological, virological methods of diagnosis and in some cases electron microscopy, which allowed to detect and identify the pathogen in 257 samples from 71 people, to certify and deposit new isolates of the rabies virus. Accumulation and analysis of the lessons learned in the application of molecular-biological method of rabies diagnosis allows us to recommend the use of RT-PCR, real-time RT-PCR sets (having a certificate of state registration) in healthcare and veterinary medicine practice to identify the causative agent of rabies infection. The use of molecular-biological methods is promising in terms of the development of rabies diagnosis to improve epidemiological surveillance and raise the efficiency of the biological protection of the population of the Russian Federation. 

scholarly journals Analysis of Q Fever Incidence in the Russian Federation Between 1957 and 2019

2021 ◽  
pp. 141-146
Author(s):  
S. N. Shpynov ◽  
N. V. Rudakov ◽  
S. Yu. Zelikman
Keyword(s):  
Russian Federation ◽  
Q Fever ◽  
Farm Animals ◽  
Epidemiological Surveillance ◽  
Morbidity Rate ◽  
Laboratory Diagnostics ◽  
Leningrad Region ◽  
North Caucasus ◽  
The North ◽  
The Russian Federation

Objective of the study was to analyze the long-term incidence of Q fever in the Russian Federation, to recommend approaches to improve epizootiological and epidemiological surveillance of this infection, taking into account the current state of laboratory diagnostics and monitoring of foci.Materials and methods. A retrospective epidemiological analysis of the Q fever incidence using the data contained in Form No 2 of the state statistical report «Information on infectious and parasitic diseases» was conducted in the Russian Federation for the period of 1957– 2019, by the Federal Districts (FD) and administrative territories, and based on the results of the research of the Reference Center for Rickettsioses of the Omsk Research Institute of Natural Focal Infections.Results and discussion. Between 1957 and 2019, 13 836 cases of Q fever were officially registered in the Russian Federation. The maximum value of the morbidity rate per 100 thousand of the population was registered in 1957 (1.0 0/0000), the minimum one – in 2008 (0.01 0/0000). From 1997 to 2019, out of 2672 registered in 24 entities of the Russian Federation cases of Q fever, 2224 (83.20 %) occurred in the Southern FD with 2106 (78.8 %) cases in the Astrakhan Region. In the Stavropol Territory of the North Caucasus FD, 173 (6.47 %) cases of the disease were detected. 112 (4.19 %) cases were registered in the Central FD, with the maximum number in the Voronezh Region (82). In the Volga FD, 81 (3.03 %) cases were identified, 54 of which in the Ulyanovsk Region. 42 (1.61 %) cases of the disease were registered in the North-Western FD, 33 – in the Leningrad Region and St. Petersburg. In the Siberian FD, 39 (1.46 %) cases of Q fever were reported, 24 were diagnosed in the Novosibirsk Region. In the Ural FD, 1 (0.04 %) case of infection was detected. In the Far Eastern FD, there is no registration of Q fever. Presented are medical products for Q fever diagnostics authorized in Russia. Sanitation of the foci among farm animals should be carried out in accordance with the current sanitary-epidemiological and veterinary-sanitary rules.

Molecular Epidemiological Monitoring of Circulation of Coxsackievirus A10

2021 ◽  
pp. 43-49
Author(s):  
LN Golitsyna ◽  
VV Zverev ◽  
NV Ponomareva ◽  
NI Romanenkova ◽  
Thao Thanh Thi Nguyen ◽  
...  
Keyword(s):  
Russian Federation ◽  
Molecular Genetic ◽  
Clinical Manifestations ◽  
Foot And Mouth Disease ◽  
Sewage Water ◽  
Epidemiological Surveillance ◽  
Molecular Monitoring ◽  
South Vietnam ◽  
Epidemiological Monitoring ◽  
The Russian Federation

Background: Coxsackievirus A10 (CV-A10) is currently one of the most common etiological agents of enterovirus infection (EVI). Over the past decade, severe and fatal cases of CV-A10 infection have become more frequent while clinical manifestations of the disease are similar to those of Enterovirus A71 infection. The objective of our study was to characterize circulation of Coxsackievirus A10 in the Russian Federation in 2008–2019 and to study the phylogenetic relationships of strains isolated in Russia and Vietnam. Materials and methods: In 2008–2019, 220 CV-A10 strains were isolated from patients with various clinical manifestations of EVI and from sewage water samples taken in the Russian Federation and then studied using molecular genetic methods. In addition to that, we analyzed 26 CV-A10 strains isolated from patients with hand, foot, and mouth disease (HFMD) and acute flaccid paralysis in South Vietnam in 2018–2019. Results: We established a two-year periodicity of CV-A10 active circulation in Russia. In the structure of clinical forms of CV-A10 infection, herpetic angina prevailed (30.8 %), followed by minor illness (25.25 %), respiratory diseases (15.66 %), exanthema (14.65 %), gastrointestinal disorders (8.08 %), and asymptomatic infections (2.02 %). Symptoms of CNS damage (meningitis, meningoencephalitis) were observed in 3.53 % of cases. Most CV-A10 strains from Vietnam were isolated from patients with CNS affection of varying degrees of severity. During the study period, CV-A10 strains of genotypes C, E, and F3 circulated in the territory of the Russian Federation whereas the strains from South Vietnam were represented by genotypes F3 and F1. The studied strains showed a genetic relationship with those of CV-A10 circulating in different countries. Vietnamese and some Russian strains of the F3 genotype were genetically close to the strains isolated from severe cases. Conclusions: Molecular monitoring of CV-A10 circulation is an important component of the global epidemiological surveillance of EVI.

New draft Federal law "Land Management" Is full of flaws

2021 ◽  
Author(s):  
I.D. Stafiychuk ◽  
A.N. Kutliyarov ◽  
D.N. Kutliyarov ◽  
A.D. Lukmanova ◽  
R.R. Khisamov ◽  
...  
Keyword(s):  
Natural Resources ◽  
Land Management ◽  
Russian Federation ◽  
Industrial Complex ◽  
Federal Law ◽  
Land Relations ◽  
The Russian Federation ◽  
The Government ◽  
Wide Experience ◽  
State Registration

The article considers a new version of the draft Federal Law "Land Management" finalized after consideration with the Federal Service for State Registration, Cadastre and Cartography (Rosreestr) of the Department of Natural Resources, Land Relations and Agro-Industrial Complex of the Government of Russia and submitted on December 11, 2020 for approval in the Ministry of Agriculture of the Russian Federation. The article contains critical remarks and proposals, and also underlines the necessity to take wide experience of our country into account.

The current state of the pharmaceutical market for anthelmintic drugs for veterinary use

2021 ◽  
Vol 1 (9) ◽  
pp. 37-44
Author(s):  
A. K. Klyueva ◽  
◽  
A. A. Deltsov ◽  
K. O. Belova ◽  
◽  
...  
Keyword(s):  
Russian Federation ◽  
Wide Spectrum ◽  
Pharmaceutical Market ◽  
The Past ◽  
Veterinary Medicines ◽  
Current State ◽  
Prevention And Treatment ◽  
The Russian Federation ◽  
State Registration ◽  
Anthelmintic Drugs

This paper presents an analysis of the range of veterinary medicines registered in the territory of the Russian Federation and used for the prevention and treatment of helminthiasis. The Russian Federation is a leader in the development and production of anthelmintic medicines registered on its territory. Antiparasitic medicines used for the prevention and treatment of helminthiasis are divided according to the spectrum of action depending on the class of helminths. It was revealed that the majority of medicines (89 medicines – 58,17%) have a wide spectrum of action. Of these, 62 medicines (40,52% of the total amount of anthelmintic medicines) are intended for the treatment of nematodes and cestodoses. When distributing anthelmintic medicines among target animals, it was found that 75 medicines (49.02%) are intended for the treatment of productive animals, and 78 medicines (50,98%) are intended for the treatment of unproductive animals. When assessing the dynamics of state registration of anthelmintic medicines for veterinary use, it can be noted that over the past 4 years there has been a tendency towards an increase in the average annual registration.

PROBLEMS RELATED TO FIRST AID EQUIPMENT: ORGANIZATIONAL AND LEGAL ASPECT

2020 ◽  
Vol 66 (5) ◽  
pp. 10-10
Author(s):  
L.I. Dezhurny ◽  
◽  
A.Yu. Zakurdaeva ◽  
Keyword(s):  
Public Health ◽  
Russian Federation ◽  
Medical Devices ◽  
First Aid ◽  
Health Protection ◽  
Federal Law ◽  
Ministry Of Health ◽  
The Russian Federation ◽  
State Registration ◽  
Public Health Protection

The article examines organizational and legal problems related to state registration, production, procurement and use of medical devices for first aid. The study significance is accounted for by the need to find solutions to problems related to equipping first aid activities with medical devices, which is becoming extremely important for the modern Russian society. Moreover, a comprehensive study of these issues has not been undertaken so far. The purpose of the study is to develop a set of proposals of an organizational and legal nature to improve quality of medical devices for first aid and equipping all potential participants of first aid delivery with such devices. To eliminate the problem of low equipment of potential participants of first aid delivery with the means of delivery, the composition of first-aid kits, packs, sets, and packages for all categories of participants have to be approval by the Ministry of Health of the Russian Federation. The authors also propose organizational and legal measures to improve interdepartmental and intradepartmental cooperation in this direction with the Russian Ministry of Health playing the coordinating role. The authors have also identified the need for improving the procedure for state registration of the production of first aid devices either though amending the Federal Law "On the Basics of Public Health Protection in the Russian Federation" regarding the provision that first-aid kits, packs, sets, and packages equipped with medical devices registered in the prescribed manner are not subject to state registration. As an alternative, the authors propose amendments and additions to the Rules of the state registration of medical devices, providing for a simplified state registration of first-aid kits, packs, sets, and packages. In addition, the authors name arguments in favor of improving the clinical trial procedure for first aid medical devices and propose changes to Article 38 of the Federal Law “On the Basics of Public Health Protection in the Russian Federation” in terms of eliminating the problems of legal techniques in the definition of the term “medical device” regarding first aid. Keywords: First aid; first aid kits; first aid equipment; medical devices.

scholarly journals Features of the Epidemiological Situation on Siberian Tick Typhus and other Tick-Borne Ricketsioses in the Russian Federation, Prognosis for 2019

2019 ◽  
pp. 89-97 ◽  
Author(s):  
N. V. Rudakov ◽  
S. N. Shpynov ◽  
D. V. Trankvilevsky ◽  
N. D. Pakskina ◽  
D. A. Savel’ev ◽  
...  
Keyword(s):  
Russian Federation ◽  
Far East ◽  
Laboratory Diagnostics ◽  
The Far East ◽  
Natural Foci ◽  
Causative Agents ◽  
Risk Areas ◽  
The Russian Federation ◽  
Very High ◽  
Epidemiological Situation

The review presents an analysis of the epidemic situation on infections of rickettsial etiology, the causative agents of which are transmitted by Ixodidae ticks in the territory of the Russian Federation. The data obtained through molecular-biological verification allow to unite under the name of “tick-borne ricketsioses” a group of infections caused by R. sibirica subsp. sibirica, R. conorii, R. heilongjiangensis and other species of rickettsiae circulating in natural foci of various regions of Russia. Cases of tick-borne rickettsioses in Siberia and the Far East, caused by various species of rickettsiae, are registered under the name of “Siberian tick-borne typhus” due to the lack of available methods of differential laboratory diagnostics. The paper presents the assessment of the incidence of Siberian tick-borne typhus, indicating not only the varying degrees of epidemic hazard of endemic regions, but also changes in the distribution of risk areas, including the identification of new, epidemically significant foci. In accordance with the risk-oriented approach to prophylaxis, forecasting of epidemic situation on tick-borne rickettsioses was given and differentiation of the endemic territories of the Russian Federation as regards Siberian tick-borne typhus was carried out with distinguishing of epidemiological zones of low, medium, above average, high and very high risk of population infection.

scholarly journals PROCEDURE FOR ASSESSING RISK OF DEVELOPING AN ADVERSE EPIDEMIC SITUATION FOR ENTEROBIASIS IN THE CONSTITUENT ENTITIES OF THE RUSSIAN FEDERATION

2020 ◽  
pp. 16-24
Author(s):  
И.А. Абрамов ◽  
◽  
O.P. Chernjavskaja ◽  
Keyword(s):  
Russian Federation ◽  
Rapid Assessment ◽  
Epidemiological Surveillance ◽  
Moscow Oblast ◽  
Omsk Oblast ◽  
Unknown Risk ◽  
High Prevalence ◽  
Risk Areas ◽  
The Russian Federation ◽  
The Republic

The article presents a method for assessing the risk of an unfavorable epidemic situation for a parasitic disease using the example of enterobiasis in the constituent entities of the Russian Federation and a forecast for 2020. The method is based on a point assessment of internal risks developed on the basis of the document «Rapid assessment of events posing an immediate threat to public health. WHO-2012». All constituent entities of the Russian Federation were assessed and divided into three categories: high, medium and low risk of an unfavorable epidemic situation for enterobiasis. According to the results of the assessment, the «risk areas» in 2020 are Moscow, St. Petersburg, Sevastopol, the Republic of Tatarstan, Sverdlovsk Oblast, Khanty-Mansi Autonomous Okrug, Arkhangelsk Oblast, Kemerovo Oblast, Moscow Oblast, Omsk Oblast, Chelyabinsk Oblast. In the Republic of Sakha (Yakutia) and the Republic of Altai, a high prevalence of the population was revealed with low indicators of other criteria, which may indicate an insufficient epidemiological surveillance of enterobiasis, or about unaccounted or unknown risk factors for the disease.

scholarly journals CRITERIA OF RATIONAL PHARMACOTHERAPY: EVIDENCE FROM HIV TREATMENT

2018 ◽  
Vol 63 (1) ◽  
pp. 41-47
Author(s):  
N. B. Rostova ◽  
N. A. Gudilina
Keyword(s):  
Hiv Infection ◽  
Russian Federation ◽  
Clinical Laboratory ◽  
Antiretroviral Drugs ◽  
Hiv Treatment ◽  
Laboratory Diagnostics ◽  
Minimum Potential ◽  
The Russian Federation ◽  
Potential Impact ◽  
The Impact

Results of evaluation of the impact of drugs on indicators of clinical laboratory diagnostics as a criterion of safety of therapy are presented. Antiretroviral therapy for HIV infection was chosen as an example. Information from official sources (summary of product characteristics and medicinal product labels) on the potential impact of antiretroviral drugs registered in the Russian Federation on indicators of clinical laboratory diagnostics was analyzed and systematized. Individual INN and antiretroviral regimens recommended by WHO documents and protocols of follow-up and treatment of patients with HIV infection in the Russian Federation with the maximum and minimum potential impact on indicators of clinical laboratory diagnostics were revealed. The research results can be used to develop recommendations for the rational choice, prescription and use of medicines.

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