scholarly journals Regarding Coinfection With Denge Viruses and Agents of Hemocontact Infections in the Socialist Republic of Vietnam

2021 ◽  
pp. 6-12
Author(s):  
Yu. V. Ostankova ◽  
E. V. Naidenova ◽  
E. N. Serikova ◽  
A. N. Schemelev ◽  
D. E. Valutite ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Dengue Fever ◽  
The Body ◽  
Endemic Region ◽  
Socialist Republic ◽  
Dengue Viruses ◽  
Sick People ◽  
Viral Hepatitis B ◽  
Simultaneous Infection ◽  
Epidemiological Situation

According to the WHO, there is an increase in the number of cases of dengue fever worldwide. In many countries, where dengue fever is an endemic disease, blood-borne infections associated with hepatitis B and C viruses and HIV are widespread. The Socialist Republic of Vietnam is an endemic region for these pathogens. The unique epidemiological situation in the country provides an excellent opportunity to study the interaction between Arboviruses, agents of parenteral viral hepatitis B and C, and HIV infection in the body of sick people.The aim of this review was to analyze the literature data on the detection of cases of simultaneous infection with Dengue viruses of 1–4 types and agents of blood-borne infections in sick people in the Socialist Republic of Vietnam. Despite the fact that the simultaneous circulation of these pathogens in the patient's body can affect the pathophysiological mechanisms of the disease development, there were very few works devoted to co-infection with Dengue viruses and HIV, hepatitis C or B viruses, including in the regions adjacent to Vietnam. Therefore, research in this direction is promising for both fundamental science and practical medicine.

scholarly journals The main aspects of the immunoprophylaxis of infectious diseases in the Republic of Dagestan

2019 ◽  
Vol 18 (3) ◽  
pp. 42-45
Author(s):  
N. S. Karnayeva ◽  
L. U. Ulukhanova ◽  
A. G. Gadzhimirzaevа ◽  
S. G. Agaevа
Keyword(s):  
Hepatitis B ◽  
Infectious Diseases ◽  
Viral Hepatitis ◽  
Viral Hepatitis B ◽  
The Republic ◽  
Vaccine Prophylaxis ◽  
Religious Reasons ◽  
To Receive ◽  
Positive Effect ◽  
Epidemiological Situation

The analysis of the epidemiological situation of vaccine-preventable infections in the Republic of Dagestan. The introduction of mass vaccine prophylaxis had a positive effect on reducing the incidence of infections such as poliomyelitis, diphtheria, tetanus, rubella, and viral hepatitis B in the Republic of Dagestan. However, despite the ongoing routine immunization of the population for “controlled” infections, the incidence of measles and parotitis infection remains high in 2018, this is due to an increase in the number of people who refuse to receive preventive vaccinations, in most cases, for religious reasons.

scholarly journals PARENTERAL VIRAL HEPATITISES IN THE IRKUTSK REGION

2018 ◽  
Vol 3 (5) ◽  
pp. 148-153 ◽  
Author(s):  
E. D. Savilov ◽  
N. N. Chemezova ◽  
V. A. Astafev ◽  
I. V. Malov ◽  
S. I. Malov ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
Federal District ◽  
Disease Rates ◽  
Irkutsk Region ◽  
Viral Hepatitis C ◽  
Viral Hepatitis B ◽  
Epidemiological Risk ◽  
Epidemiological Situation

From all group of infectious pathology viral hepatitises, from which the most priority are the parenteral hepatitises B and С, are essential for health of mankind, also the Irkutsk region isn’t an exception.The aim of the study:to assess an epidemiological situation in sharp and chronic forms of the viral hepatitises B and С in the territory of the Irkutsk region for the long-term period.Materials and methods. The retrospective analysis of an epidemiological situation on viral hepatitises B and C in Russia, Siberian Federal District and in the Irkutsk region for 2008–2016 is carried out.Results.The expressed decrease in incidence of acute viral hepatitis B is noted, at a chronic form of this disease rates of decrease had less expressed character that can be connected with carrying out by mass vaccinal prevention. The carried-out ranged distribution of territories for all forms of viral hepatitis B and viral hepatitis C in the Irkutsk region has allowed to reveal territories of risk.Conclusion.Parenteral viral hepatitises (sharp and chronic forms) are widespread in the territory of the Irkutsk region. From 43 administrative territories of the area, 24 belong to unsuccessful on incidences from which five are to territories of high epidemiological risk: cities of Irkutsk, Angarsk and Ust-Ilimsk and also Katangsky and Shelekhovsky districts.

Epidemiological situation of hepatitis B in the Samara region

2020 ◽  
pp. 9-16
Author(s):  
O. Churbakova ◽  
V. Akimkin ◽  
D. Pechkurov
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Chronic Hepatitis B ◽  
Causative Agent ◽  
Child Population ◽  
Acute Hepatitis B ◽  
Viral Hepatitis B ◽  
Epidemiological Situation

The article presents an analysis of the primary incidence of hepatitis B in the Samara region from 1997 to 2018. It was noted that during the 1997–2000 period there was an increase in the carrying levels of viral hepatitis B agent, the incidence of acute hepatitis B, first detected by chronic hepatitis B. Since 2000–2001, there has been a dynamic decrease in the incidence of hepatitis B. It should be noted that from the 2006 (beginning of immunoprophylaxis) to 2018. in the Samara region more intensive decrease in indicators of incidence of hepatitis B was noted. Rates of decrease in incidence of an acute hepatitis In from 2006 to 2018 in the Samara region from 7,10 ⁄ 0000 to 0,70 ⁄ 0000v 10,1 times were observed (p < 0.01). Decrease in incidence of chronic hepatitis B was noted from 2006 to 2018 by 1.4 times (p < 0.01) from 14,50 ⁄ 0000 to 10,30 ⁄ 0000. Decrease in indicators of carriage of the causative agent of viral hepatitis B from 2006 to 2018 happened more in high gear, in comparison with indicators of incidence of chronic hepatitis B to 55,60 ⁄ 0000 to 6,60 ⁄ 0000 by 8.4 times (p < 0.01). From 2008 to 2018, the vaccination coverage against hepatitis B of the child population was 99.3–99.5 %, which led to a significant decrease in the incidence of hepatitis B in the Samara region. From 2011 to 2018, no cases of acute hepatitis B of the child population of the Samara region were registered. In the last three years, no cases of chronic hepatitis B of the child population have been recorded in the Samara region.

scholarly journals THE INVESTIGATION OF DNA DAMAGE IN LYMPHOCYTES BY COMET ASSAY IN CHRONIC VIRAL HEPATITIS B PATIENTS

2017 ◽  
Vol 22 (2) ◽  
pp. 64-68
Author(s):  
A. O Mikhailov ◽  
A. F Popov ◽  
N. S Ivanova ◽  
A. I Simakova
Keyword(s):  
Dna Damage ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Comet Assay ◽  
Viral Hepatitis ◽  
Chronic Viral Hepatitis ◽  
The Body ◽  
Control Group ◽  
Blood Samples ◽  
Viral Hepatitis B

The investigation of the degree of the lymphocyte DNA damage in chronic viral hepatitis B (HBV) patients is of interest for several reasons. Firstly, it is possible to judge indirectly about the depth of the pathological process at the level of the whole organism, with bearing in mind features of the pathogenic replication of hepatitis B virus. Secondly, it is possible to give an estimation of the degree of genotoxic impact of the virus on blood cells that plays an essential role in the shaping of the immune response of the body. The study was executed on 50 blood samples from HBV patients, divided in 5 groups on the fibrosis grade according to METAVIR score: F0 (n = 10), F1 (N = 10), F2 (N = 10), F3 (n = 10), F4 (n = 10). The control group was consisted of 43 volunteers matched by the age and gender without concomitant diseases. From blood samples taken at the time of the admission to the hospital lymphocytes were isolated by density gradient on Ficoll-urografin. The degree of DNA damage in lymphocytes was determined by virtue of alkaline version of the DNA comet assay. There was noted the direct relationship between an increase in % DNA in the tail of comets and the grade of liver fibrosis. So in the control group, % DNA in the tail accounted for 3.75 ± 1.44. In the F0 group % of DNA in the tail was 5.07 ± 1.25, F1 - 6.79 ± 1.79, F2 - 7.65 ± 1.62, F3 - 8.05 ± 1.18, F4 - 9.84 ± 3.09. It is noteworthy that in groups F2, F3, F4 differences were statistically significant in comparison with the control group. Also there was noted the presence of apoptotic cells in F3, F4 groups: 1 and 0.88%, respectively. Identified changes are both important in the description of to molecular patterns of the pathogenesis of chronic hepatitis B associated with damage, and also can serve as an indirect indication of the stage of liver fibrosis.

scholarly journals Trends for incidence of chronic hepatitis B monoinfection and chronic hepatitis B+D co-infection in the Kyrgyz Republic for the period of 2010-2012

2014 ◽  
Vol 95 (6) ◽  
pp. 921-924 ◽  
Author(s):  
K A Nogoybaeva ◽  
S T Tobokalova ◽  
K T Kasymbekova ◽  
G M Zairova
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Viral Hepatitis ◽  
Chronic Hepatitis B ◽  
Medical Information ◽  
Chronic Viral Hepatitis ◽  
Kyrgyz Republic ◽  
Hepatitis D ◽  
Viral Hepatitis B ◽  
Epidemiological Situation

Aim. To assess the trends for the epidemiological situation of chronic hepatitis B monoinfection and chronic hepatitis B+D co-infection in the Kyrgyz Republic for the period of 2010-2012 for the development of anti-epidemic measures depending on the intensity of the process. Methods. The analysis of a database of national reporting forms on the treated cases of chronic viral hepatitis B monoinfection and chronic hepatitis B+D co-infection in primary health care units, cumulated by Republican Medical Information Center of the Ministry of Healthcare of the Kyrgyz Republic for the period of 2010-2012 was performed. Results. The incidence of chronic viral hepatitis D is identical to that of chronic viral hepatitis B (23 and 21 per 100 000 of population respectively) in the Kyrgyz Republic. Over the period of 2010-2012 the high level of total chronic hepatitis B incidence was reported in the northern part of the country (the Issyk-Kul region, 71 per 100 000, and chronic hepatitis D - in the southern part of the country (Osh, 62 per 100 000 of population). Statistically significant increase in the incidence of chronic hepatitis B in almost all regions of the country was recorded whereas only an upward trend was revealed in chronic hepatitis D incidence. Conclusion. Separate registration of patients with chronic viral hepatitis B and D in the Kyrgyz Republic starting from 2010 allowed evaluating the trends for the epidemiological situation of these diseases in different areas and developing preventive and anti-epidemic measures in regions of Kyrgyz Republic.

THE PREVALENCE OF HEPATITIS B REACTIVATION (HBV) IN CANCER PATIENTS TREATING WITH CHEMOTHERAPY

2016 ◽  
pp. 74-80
Author(s):  
Phuong Phung ◽  
Thi Thuy Nguyen
Keyword(s):  
Breast Cancer ◽  
Lung Cancer ◽  
Hepatitis B ◽  
Cancer Patients ◽  
Positive Control ◽  
High Dose ◽  
Hbv Reactivation ◽  
Endemic Region ◽  
Hepatitis B Reactivation ◽  
Cancer Breast

ackground and Objectives: Nowadays, the incidence of cancer is constantly increasing in the world as well as in Vietnam. The treatment of cancer is based on multimodality principle. Among those principal modalities, chemotherapy is widely used for different purposes such as neoadjuvant, andjuvant and palliation. However, chemotherapy can induce activation of latent infections, including hepatitis B. Vietnam is in the endemic region of hepatitis B so the reactivation of hepatitis B on cancer patients with chemotherapy has emerged a concerned problem. However, few interests were gained on this problem in the aspect of clinical setting or researching. Aims: to determine the prevalence of hepatitis B reactivation (HBV) in cancer patients treating with chemotherapy and to detect some risks factors of this situation. Subjects and methods: descriptive prospective. The study included 33 cancer patients with inactive HBV infection who are treating with chemotherapy. We define HBV reactivation by ALT > 3 ULN and HBV DNA copies > 10 positive control limit. Results: We found 6 patients with reactivated HBV, accounting for 18.18 %. Among reactivated HBV patients, age less than 60 accounts 83,33%. Rate of reactivated HBV in males was 25,00% while this rate in females was 14,28%. Rate of reactivated HBV in lymphoma, lung cancer and breast cancer was 33,33%, 25% và 22,22% respectively. Clinial manifestation of reactivated HBV includes jaundice (33,33%), fulminant hepatic failure (6%) and death (5%). The reactivated rate was higher in patients got high dose of corticoid (28,57%) vs low dose (15,38%). This rate was 29,41% in patients treated with anthracyclines which was higher than in group without anthracyclines. The reactivated rate of HBV was dramatically higher in patients treated with rituximab (75%). Conclusion: the reactivation of hepatitis B on cancer patients with chemotherapy is common. We found 6 patients with reactivated HBV of 33 subjects of the study which accounts 18.18 %. We recognized that reactivated HBV rate was higher subgroups of age < 60 years old, males, patients with lymphoma, lung cancer, breast cancer. Reactivated HBV may be more prevalent in patients with high-dose corticotherapy, anthracyclines and Rituximab. Key words: HBV reactivation, chemotherapy, cancer, hepatitis B

scholarly journals Clinical and biochemical manifestation of acute viral hepatitis B in Republic of Moldova

2014 ◽  
Vol 14 (S7) ◽  
Author(s):  
Lilia Cojuhari ◽  
Victor Pântea ◽  
Gheorghe Plăcintă ◽  
Valentin Cebotarescu ◽  
Olga Chirita ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
Acute Viral Hepatitis ◽  
Republic Of Moldova ◽  
Viral Hepatitis B
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