scholarly journals Efficacy of florpyrauxifen-benzyl on dioecious hydrilla and hybrid water milfoil - concentration and exposure time requirements

2021 ◽  
Author(s):  
Christopher Mudge ◽  
Bradley Sartain ◽  
Kurt Getsinger ◽  
Michael Netherland
Keyword(s):  
Invasive Species ◽  
Exposure Time ◽  
Dry Weight ◽  
Small Scale ◽  
Low Doses ◽  
Nontarget Species ◽  
Time Requirements ◽  
Indoor Conditions ◽  
Plant Control

This study conducted small-scale trials under various concentration and exposure time (CET) scenarios to determine florpyrauxifen-benzyl activity on dioecious hydrilla and hybrid watermilfoil and determine impact on water stargrass and elodea. Hydrilla treated with 12, 24, or 36 μg active ingredient (a.i.) L⁻¹ florpyrauxifen-benzyl and exposed for 12, 24, or 48 hr under outdoor mesocosm conditions was reduced in biomass by 30-75% at 8 weeks after treatment (WAT). An additional hydrilla trial at the same herbicide concentrations, but under longer exposures (24, 72, or 168 hr), resulted in 33–85% plant control. Under indoor conditions, hybrid watermilfoil dry weight decreased 98–100% with subsurface applications of florpyrauxifen-benzyl under CET scenarios of 3–12 μg a.i. L⁻¹ at 3–24 hr exposure times in a growth chamber trial. Under shorter exposure periods (0.5–4 hr) in a follow-up trial, low doses (3–9 μg a.i. L⁻¹) achieved 50–100% control of hybrid watermilfoil. In the same trial, the nontarget species water stargrass and elodea proved relatively tolerant to the florpyrauxifen-benzyl at doses up to 6 μg a.i. L⁻¹ (4 hr exposure) and 9 μg a.i. L⁻¹ (1 hr exposure). These small-scale trials demonstrate florpyrauxifen-benzyl’s potential to selectively manage invasive species.

scholarly journals Adverse reactions to oxacillin in hospitalized children: a prospective study

2007 ◽  
Vol 7 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Mariana de Oliveira Brizeno de Souza ◽  
Maria da Conceição Castro de Araújo ◽  
Raquel Araújo de Santiago ◽  
Helena Lutéscia Luna Coelho ◽  
Marta Maria de França Fonteles
Keyword(s):  
Exposure Time ◽  
Treatment Duration ◽  
Adverse Reactions ◽  
Therapeutic Interventions ◽  
Hospitalized Children ◽  
Significant Relation ◽  
Moderate Severity ◽  
A Prospective Study ◽  
Established Treatment

OBJECTIVES: follow-up of children exposed to oxacillin during hospitalization focusing on adverse reactions. METHODS: patients were selected from the pediatric wards of two hospitals in Fortaleza (Hospital Universitário Walter Cantídio-HUWC and Hospital Infantil Albert Sabin-HIAS) from the first oxacillin prescription with a prospective cohort study between October, 2000 and July, 2001 (HUWC) and July/2001 and March, 2002 (HIAS). Patients' follow-up was performed by daily visits to the wards and medical charts and prescription analysis. Suspected oxacillininduced adverse reactions (OxAR cases) were notified and classified according to causality and severity. Related statistic tests were completed. RESULTS: of the 130 patients exposed to oxacillin, 27 had OxAR (20.8%). Fever was the most frequent reaction (50%) followed by rash (35.7%). The majority of reactions were considered Probable, for oxacillin was the only medication involved and 92.6% of the cases had Moderate severity with the need of therapeutic interventions caused by OxAR. A significant relation between oxacillin exposure time and OxAR was determined as well as hospitalization time and the appearance of adverse reactions. Exposure time over 14 days to oxacillin was established as a risk factor for OxAR (relative risk = 5.49). CONCLUSIONS: careful administration of oxacillin in children is recommended with established treatment duration. Empiric and prolonged use must be avoided.

scholarly journals SPORTS ACTIVITY AND HIP, KNEE, SHOULDER AND INTERVERTEBRAL DISC ARTHROPLASTIES

2018 ◽  
Vol 26 (5) ◽  
pp. 350-355 ◽  
Author(s):  
Diogo Lino Moura ◽  
Fernando Pereira Fonseca
Keyword(s):  
Intervertebral Disc ◽  
Scientific Evidence ◽  
Small Scale ◽  
Early Failure ◽  
Level Of Evidence ◽  
Sports Activity ◽  
Joint Replacement Surgery ◽  
Replacement Surgery ◽  
Prosthesis Durability

ABSTRACT The success of joint replacement surgery has been responsible for raising patients' expectations regarding the procedure. Many of these procedures are currently designed not only to relive the pain caused by arthrosis, but also to enable patients to achieve functional recovery and to engage in some degree of physical activity and sports. However, as physical exercise causes an increase in forces exercised through the articular prosthesis, it can be an important risk factor for its early failure. Scientific literature on sports after arthroplasty is limited to small-scale retrospective studies with short-term follow-up, which are mostly insufficient to evaluate articular prosthesis durability. This article presents a review of the literature on sports in the context of hip, knee, shoulder and intervertebral disc arthroplasty, and puts forward general recommendations based on the current scientific evidence. Systematic Review, Level of Evidence III.

scholarly journals Soft bodies make estimation hard: correlations among body dimensions and weights of multiple species of sea cucumbers

2015 ◽  
Vol 66 (10) ◽  
pp. 857 ◽  
Author(s):  
James Prescott ◽  
Shijie Zhou ◽  
Andhika P. Prasetyo
Keyword(s):  
Power Function ◽  
Body Length ◽  
Sea Cucumber ◽  
Dry Weight ◽  
Basic Knowledge ◽  
Small Scale ◽  
Body Width ◽  
Sea Cucumbers ◽  
Body Dimensions ◽  
Wet Weight

Tropical sea cucumbers are commonly exploited by small-scale, poorly managed fisheries. A fundamental problem in managing sea cucumber fisheries is the lack of basic knowledge of important life history characteristics for most species. As a result of plastic body dimensions, biological research on this group of animals becomes exceptionally challenging. To improve our understanding of essential biological parameters, we conducted a study to investigate correlations among various body measurements. We analysed a total of 18 sea cucumber species and more than 6600 individuals collected at Scott Reef in the Timor Sea, north-west Australia. We used hierarchical Bayesian errors-in-variables models to specifically take into account measurement errors that are obviously unavoidable. The measures included three types of weights (wet weight, gutted weight and dry weight) and two body dimensions (length and width). The modelling reveals that using both body length and width as independent variables, wet weight increases approximately linearly with body length, but is a power function (~1.6) of body width, although variability exists among species. Dry weight tends to increase more slowly with body length, but has a similar power function of body width. Linear relationships are established between the three types of weights. On average, ~11% of a live specimen and ~16% of a gutted specimen is processed to the commercially traded dry body wall. Our results can be applied to sea cucumbers in other areas and can be useful for data standardisation and size-based fisheries management.

scholarly journals COVID-19 Conversion after Exposure in a Semiprivate Room at a Tertiary Care Center in Iowa, July–December 2020

2021 ◽  
Vol 1 (S1) ◽  
pp. s20-s21
Author(s):  
Alexandra Trannel ◽  
Takaaki Kobayashi ◽  
Oluchi Abosi ◽  
Kyle Jenn ◽  
Holly Meacham ◽  
...  
Keyword(s):  
Exposure Time ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
University Of Iowa ◽  
Subsequent Conversion ◽  
Risk Of Exposure ◽  
Polymerase Chain ◽  
The University

Background: Hospital semiprivate rooms may lead to coronavirus disease 2019 (COVID-19) patient exposures. We investigated the risk of COVID-19 patient-to-patient exposure in semiprivate rooms and the subsequent risk of acquiring COVID-19. Methods: The University of Iowa Hospitals & Clinics is an 811-bed tertiary care center. Overall, 16% of patient days are spent in semiprivate rooms. Most patients do not wear masks while in semiprivate rooms. Active COVID-19 surveillance included admission and every 5 days nasopharyngeal SARS-CoV-2 polymerase chain reaction (PCR) testing. We identified inpatients with COVID-19 who were in semiprivate rooms during their infectious periods during July–December 2020. Testing was repeated 24 hours after the first positive test. Cycle threshold (Ct) values of the two tests (average Ct <30), SARS-CoV-2 serology results, clinical assessment, and COVID-19 history were used to determine patient infectiousness. Roommates were considered exposed if in the same semiprivate room with an infectious patient. Exposed patients were notified, quarantined (private room), and follow-up testing was arranged (median seven days). Conversion was defined as having a negative test followed by a subsequent positive within 14 days after exposure. We calculated the risk of exposure: number of infectious patients in semiprivate rooms/number of semiprivate patient-days (hospitalization days in semiprivate rooms). Results: There were 16,427 semiprivate patient days during July–December 2020. We identified 43 COVID-19 inpatients who roommates during their infectious periods. Most infectious patients (77%) were male; the median age was 67 years; and 22 (51%) were symptomatic. Most were detected during active surveillance: admission testing (51%) and serial testing (28%). There were 57 exposed roommates. The risk of exposure was 3 of 1,000 semiprivate patient days. In total, 16 roommates (28%) did not complete follow-up testing. Of 41 exposed patients with follow-up data, 8 (20%) converted following their exposure. Median time to conversion was 5 days. The risk of exposure and subsequent conversion was 0.7 of 1,000 semiprivate patient days. Median Ct value of the source patient was 20 for those who converted and 23 for those who did not convert. Median exposure time was 45 hours (range, 3–73) for those who converted and 12 hours (range, 1–75) for those who did not convert. Conclusions: The overall risk of exposure in semiprivate rooms was low. The conversion rate was comparable to that reported for household exposures. Lower Ct values and lengthier exposures may be associated with conversion. Active COVID-19 surveillance helps early detection and decreases exposure time.Funding: NoDisclosures: None

scholarly journals Development of Skill Assessment Instrument Service Volly 6th Grade in Physical Education

2019 ◽  
Vol 2 (4) ◽  
pp. 634-641
Author(s):  
Moh. Noer ◽  
Ali Maksum ◽  
Anung Priambodo
Keyword(s):  
Large Scale ◽  
Assessment Tools ◽  
Assessment Instrument ◽  
Skill Assessment ◽  
Small Scale ◽  
Service Reliability ◽  
School Students ◽  
Assessment Guidelines ◽  
Initial Attitude

This research aims to develop instruments for assessing lower and upper service engineering skills in volleyball games for 6th-grade students in elementary schools. This research uses research and development methods, with the following development steps: (1) information gathering in the field, (2) analyze the information collected, (3) developing initial products, (4) expert validation and revision, (5) small-scale trials and revisions, (6) large-scale trials and revisions, (7) manufacturing of final products. The subject of this research is 6th-grade students of elementary students. Data analysis for the validity test was carried out with CVR (content validity ratio) and reliability using Alpha Cronbach. This research resulted in a handbook of instrument assessment tools for service techniques of lower and upper service in volleyball games for 6th-grade elementary school students, which contained instructions for use, student assignments sheets, assessment guidelines, assessment rubrics, and scoring tables, which have high validity. (1) And under service reliability initial attitude: r = 0.975, implementation: r = 0.961, follow-up motion: r = 0, 955. Upper Service for initial attitude: r = 0.961, implementation: r = 0.974, follow-up motion: r = 0.989.

scholarly journals Electromagnetic Fields (0.04 to 0.39) mT effect on cellular growth cycles of Saccharomyces cerevisiae wine strains

2019 ◽  
Vol 17 (2) ◽  
pp. 196
Author(s):  
Eliseo Amado-González ◽  
Alveiro Álvarez Ovallos ◽  
Alfonso Quijano Parra
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Electromagnetic Fields ◽  
Biomass Production ◽  
Exposure Time ◽  
Culture Media ◽  
Dry Weight ◽  
Cellular Growth ◽  
Biomass Growth ◽  
Yeast Saccharomyces Cerevisiae ◽  
Growth Cycles

Low frecuency electromagnetic fields effect (EMF) on growth cycles of yeast Saccharomyces cerevisiae wine strains Rv1 and Rhône were studied.  A cylindrical coil induced magnetic fields with inductions up to 0,39 mT. Exposure time to EMF varied between (1 – 10) min at 30 °C.  The biomass growth were monitored in the reactor culture media (yeast extract + by measurement optical density from (0 to 32) h. The biomass was found by dry weight. After yeast expose to the different EMF, the number of growth cycles decreased from 4 cycles to 2 or 1. However, the biomass production increased almost 50 %.  The best biomass production was found at 0.39 mT and 10 min exposure time.  Keywords: Electromagnetic fields, Saccharomyces cerevisiae, biomass production, RV1

Effects of iron overload and hepatitis C virus positivity in determining progression of liver fibrosis in thalassemia following bone marrow transplantation

Blood ◽  
2002 ◽  
Vol 100 (1) ◽  
pp. 17-21 ◽  
Author(s):  
Emanuele Angelucci ◽  
Pietro Muretto ◽  
Antonio Nicolucci ◽  
Donatella Baronciani ◽  
Buket Erer ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Iron Overload ◽  
Iron Content ◽  
Hazard Rate ◽  
Iron Concentration ◽  
Dry Weight ◽  
Interquartile Range ◽  
Hepatic Iron ◽  
Fibrosis Progression

Abstract To identify the role of iron overload in the natural history of liver fibrosis, we reviewed serial hepatic biopsy specimens taken annually from patients cured of thalassemia major by bone marrow transplantation. The patients underwent transplantation between 1983 and 1989 and did not receive any chelation or antiviral therapy. Two hundred eleven patients (mean age, 8.7 ± 4 years) were evaluated for a median follow-up of 64 months (interquartile range, 43-98 months) by a median number of 5 (interquartile range, 3-6) biopsy samples per patient. Hepatic iron concentration was stratified by tertiles (lower, 0.5-5.6 mg/g; medium, 5.7-12.7 mg/g; upper, 12.8-40.6 mg/g dry weight). Forty-six (22%) patients showed signs of liver fibrosis progression; the median time to progression was 51 months (interquartile range, 36-83 months). In a multivariate Cox proportional hazard model, the risk for fibrosis progression correlated to medium hepatic iron content (hazard rate, 1.9; 95% confidence interval [CI], 0.74-5.0), high hepatic iron content (hazard rate, 8.7; 95% CI, 3.6-21.0) and hepatitis C virus (HCV) infection (hazard rate, 3.1; 95% CI, 1.5-6.5). A striking increase in the risk for progression was found in the presence of both risk factors. None of the HCV-negative patients with hepatic iron content lower than 16 mg/g dry weight showed fibrosis progression, whereas all the HCV-positive patients with hepatic iron concentration greater than 22 mg/g dry weight had fibrosis progression in a minimum follow-up of 4 years. Thus, iron overload and HCV infection are independent risk factors for liver fibrosis progression, and their concomitant presence results in a striking increase in risk.

Long-term outcome of pallidal stimulation for Meige syndrome

2018 ◽  
Vol 130 (1) ◽  
pp. 84-89 ◽  
Author(s):  
Shiro Horisawa ◽  
Taku Ochiai ◽  
Shinichi Goto ◽  
Takeshi Nakajima ◽  
Nobuhiko Takeda ◽  
...  
Keyword(s):  
Rating Scale ◽  
Small Scale ◽  
Initial Symptom ◽  
Long Term Outcome ◽  
Time Points ◽  
Meige Syndrome ◽  
Pallidal Stimulation ◽  
The Mean

OBJECTIVEMeige syndrome is characterized by blepharospasm and varied subphenotypes of craniocervical dystonia. Current literature on pallidal surgery for Meige syndrome is limited to case reports and a few small-scale studies. The authors investigated the clinical outcomes of deep brain stimulation (DBS) of the globus pallidus internus (GPi) in patients with Meige syndrome.METHODSSixteen patients who underwent GPi DBS at the Tokyo Women’s Medical University Hospital between 2002 and 2015 were included in this study. Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) movement subscale (BFMDRS-M) scores (range 0–120) obtained at the following 3 time points were included in this analysis: before surgery, 3 months after surgery, and at the most recent follow-up evaluation.RESULTSThe patients’ mean age (± SD) at symptom onset was 46.7 ± 10.1 years, and the mean disease duration at the time of the authors’ initial evaluation was 5.9 ± 4.1 years. In 12 patients, the initial symptom was blepharospasm, and the other 4 patients presented with cervical dystonia. The mean postoperative follow-up period was 66.6 ± 40.7 months (range 13–150 months). The mean total BFMDRS-M scores at the 3 time points were 16.3 ± 5.5, 5.5 ± 5.6 (66.3% improvement, p < 0.001), and 6.7 ± 7.3 (58.9% improvement, p < 0.001).CONCLUSIONSThe results indicate long-term efficacy for GPi DBS for the majority of patients with Meige syndrome.

scholarly journals Root Microbiome Modulates Plant Growth Promotion Induced by Low Doses of Glyphosate

mSphere ◽  
2020 ◽  
Vol 5 (4) ◽  
Author(s):  
Dario X. Ramirez-Villacis ◽  
Omri M. Finkel ◽  
Isai Salas-González ◽  
Connor R. Fitzpatrick ◽  
Jeffery L. Dangl ◽  
...  
Keyword(s):  
Plant Growth ◽  
Root Growth ◽  
Growth Inhibition ◽  
Growth Promotion ◽  
Action Spectrum ◽  
Dry Weight ◽  
Agricultural Fields ◽  
Low Doses ◽  
Shoot Dry Weight ◽  
Root Microbiome

ABSTRACT Glyphosate is a commonly used herbicide with a broad action spectrum. However, at sublethal doses, glyphosate can induce plant growth, a phenomenon known as hormesis. Most glyphosate hormesis studies have been performed under microbe-free or reduced-microbial-diversity conditions; only a few were performed in open systems or agricultural fields, which include a higher diversity of soil microorganisms. Here, we investigated how microbes affect the hormesis induced by low doses of glyphosate. To this end, we used Arabidopsis thaliana and a well-characterized synthetic bacterial community of 185 strains (SynCom) that mimics the root-associated microbiome of Arabidopsis. We found that a dose of 3.6 × 10−6 g acid equivalent/liter (low dose of glyphosate, or LDG) produced an ∼14% increase in the shoot dry weight (i.e., hormesis) of uninoculated plants. Unexpectedly, in plants inoculated with the SynCom, LDG reduced shoot dry weight by ∼17%. We found that LDG enriched two Firmicutes and two Burkholderia strains in the roots. These specific strains are known to act as root growth inhibitors (RGI) in monoassociation assays. We tested the link between RGI and shoot dry weight reduction in LDG by assembling a new synthetic community lacking RGI strains. Dropping RGI strains out of the community restored growth induction by LDG. Finally, we showed that individual RGI strains from a few specific phyla were sufficient to switch the response to LDG from growth promotion to growth inhibition. Our results indicate that glyphosate hormesis was completely dependent on the root microbiome composition, specifically on the presence of root growth inhibitor strains. IMPORTANCE Since the introduction of glyphosate-resistant crops, glyphosate has become the most common and widely used herbicide around the world. Due to its intensive use and ability to bind to soil particles, it can be found at low concentrations in the environment. The effect of these remnants of glyphosate in plants has not been broadly studied; however, glyphosate 1,000 to 100,000 times less concentrated than the recommended field dose promoted growth in several species in laboratory and greenhouse experiments. However, this effect is rarely observed in agricultural fields, where complex communities of microbes have a central role in the way plants respond to external cues. Our study reveals how root-associated bacteria modulate the responses of Arabidopsis to low doses of glyphosate, shifting between growth promotion and growth inhibition.

Iron chelation with deferasirox in adult and pediatric patients with thalassemia major: efficacy and safety during 5 years' follow-up

Blood ◽  
2011 ◽  
Vol 118 (4) ◽  
pp. 884-893 ◽  
Author(s):  
M. Domenica Cappellini ◽  
Mohamed Bejaoui ◽  
Leyla Agaoglu ◽  
Duran Canatan ◽  
Marcello Capra ◽  
...  
Keyword(s):  
Adverse Events ◽  
Iron Concentration ◽  
Iron Chelation ◽  
Dry Weight ◽  
Thalassemia Major ◽  
Efficacy And Safety ◽  
Liver Iron ◽  
Median Serum

Abstract Patients with β-thalassemia require lifelong iron chelation therapy from early childhood to prevent complications associated with transfusional iron overload. To evaluate long-term efficacy and safety of once-daily oral iron chelation with deferasirox, patients aged ≥ 2 years who completed a 1-year, phase 3, randomized trial entered a 4-year extension study, either continuing on deferasirox (deferasirox cohort) or switching from deferoxamine to deferasirox (crossover cohort). Of 555 patients who received ≥ 1 deferasirox dose, 66.8% completed the study; 43 patients (7.7%) discontinued because of adverse events. In patients with ≥ 4 years' deferasirox exposure who had liver biopsy, mean liver iron concentration significantly decreased by 7.8 ± 11.2 mg Fe/g dry weight (dw; n = 103; P < .001) and 3.1 ± 7.9 mg Fe/g dw (n = 68; P < .001) in the deferasirox and crossover cohorts, respectively. Median serum ferritin significantly decreased by 706 ng/mL (n = 196; P < .001) and 371 ng/mL (n = 147; P < .001), respectively, after ≥ 4 years' exposure. Investigator-assessed, drug-related adverse events, including increased blood creatinine (11.2%), abdominal pain (9.0%), and nausea (7.4%), were generally mild to moderate, transient, and reduced in frequency over time. No adverse effect was observed on pediatric growth or adolescent sexual development. This first prospective study of long-term deferasirox use in pediatric and adult patients with β-thalassemia suggests treatment for ≤ 5 years is generally well tolerated and effectively reduces iron burden. This trial was registered at www.clinicaltrials.gov as #NCT00171210.

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